Carlson® Tocotrienols

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Item #686164

Size: 90 Soft Gels

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Product Information

Description

with Natural Vitamin E
Dietary Supplement
Supports a Healthy Cardiovascular System*
Potency & Quality Guaranteed
Carlson Tocotrienols provides 200 mg of palm oil concentrate (from the Elaeis guineensis plant). Each soft gel contains 40 mg of tocotrienols per serving and is an excellent source of the natural form of vitamin E. Vitamin E, a powerful antioxidant, together with tocotrienols, helps to maintain a healthy heart.*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Label

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Supplement Facts

Serving Size 1 Soft Gel
Servings Per Container 90
Amount Per Serving % DV
Vitamin E (as d-Alpha Tocopherol) 100.00 IU333%
Gamma Tocotrienol 18.00 mg**
alpha tocopherol 12.00 mg**
Delta and Beta Tocotrienols 10.00 mg **
** Daily Value (DV) not established

Product Directions / Additional Info

Take one soft gel once or twice daily, at mealtime.

Other Ingredients: Palm Oil Concentrate, Soft Gel Shell: Beef gelatin, glycerin, water

Gluten Free, Sugar-free, Preservative-free

Dist. by Carlson Division of J.R. Carlson Laboratories, Inc.
Arlington Heights, IL 60004

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Health Notes

Tocotrienols

Tocotrienols
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Atherosclerosis
Dose: 200 mg daily
Tocotrienols are potent antioxidants that may help slow down the build-up of plaque in the arteries.(more)
High Cholesterol
Dose: 200 mg daily
Tocotrienols may lower cholesterol levels. Tocotrienols inhibited cholesterol synthesis in test-tube studies, and two trials found that tocotrienols reduced cholesterol levels by 13-15%.(more)
Stroke
Dose: Refer to label instructions
In one trial, people with atherosclerosis, a condition that may contribute to stroke, who were given a palm oil extract containing tocotrienols saw significant improvement.(more)
Atherosclerosis
Dose: 200 mg daily

Tocotrienols may offer protection against atherosclerosis by preventing oxidative damage to LDL cholesterol.1 In a double-blind trial in people with severe atherosclerosis of the carotid artery-the main artery supplying blood to the head-tocotrienol administration (200 mg per day) reduced the level of lipid peroxides in the blood. Moreover, people receiving tocotrienols for 12 months had significantly more protection against atherosclerosis progression, and in some cases reductions in the size of their atherosclerotic plaques, compared with those taking a placebo.2

References

1. Suarna C, Hood RL, Dean RT, Stocker R. Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins. Biochim Biophys Acta 1993;1166:163-70.

2. Tomeo AC, Geller M, Watkins TR, et al. Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. Lipids 1995;30:1179-83.

High Cholesterol
Dose: 200 mg daily

Tocotrienols, a group of food-derived compounds that resemble vitamin E, may lower blood levels of cholesterol, but evidence is conflicting. Although tocotrienols inhibited cholesterol synthesis in test-tube studies,1, 2 human trials have produced contradictory results. Two double-blind trials found that 200 mg per day of either gamma-tocotrienol3 or total tocotrienols4 were more effective than placebo, reducing cholesterol levels by 13-15%. However, in another double-blind trial, 200 mg of tocotrienols per day failed to lower cholesterol levels,5 and a fourth double-blind trial found 140 mg of tocotrienols and 80 mg of vitamin E (d-alpha-tocopherol) daily resulted in no changes in total cholesterol, LDL cholesterol, or HDL cholesterol levels.6

References

1. Parker RA, Pearce BC, Clark RW, et al. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 1993;268(15):11230-8.

2. Pearce BC, Parker RA, Deason ME, et al. Hypocholesterolemic activity of synthetic and natural tocotrienols. J Med Chem 1992;35:3595-606.

3. Qureshi AA, Bradlow BA, Brace L, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 1995;30:1171-7.

4. Qureshi AA, Qureshi N, Wright JJ, et al. Lowering serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). Am J Clin Nutr 1991;53:1021-6S.

5. Wahlqvist ML, Krivokuca-Bogetic A, Lo CS, et al. Differential serum response of tocopherols and tocotrienols during vitamin supplementation in hypercholesterolemic individuals without change in coronary risk factors. Nutr Res 1992;12:S181-201.

6. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9.

Stroke
Dose: Refer to label instructions

In a double-blind trial, people with atherosclerosis in the carotid arteries were given a palm oil extract containing 160-240 mg of tocotrienols (a vitamin E-like supplement) and approximately 100-150 IU vitamin E per day. After 18 months, they had significantly less atherosclerosis or less progression of atherosclerosis compared to a group receiving placebo.1 Vitamin E plus aspirin, has been more effective in reducing the risk of strokes and other related events than has aspirin, alone.2 However, most preliminary trials have shown no protective effects from antioxidant supplementation.3, 4, 5, 6, 7, 8 A large Finnish trial concluded that supplementation with either vitamin E or beta-carotene conferred no protection against stroke in male smokers,9 although a later review of the study found that those smokers who have either hypertension (high blood pressure) or diabetesdo appear to have a reduced risk of stroke when taking vitamin E.10

People with high risk for stroke, such as those who have had TIAs or who have a heart condition known as atrial fibrillation,11 are often given aspirin or anticoagulant medication to reduce blood clotting tendencies. Some natural inhibitors of blood clotting such as garlic,12, 13, 14fish oil,15 and vitamin E,16, 17 may have protective effects, but even large amounts of fish oil are known to be less potent than aspirin.18 Whether any of these substances is an adequate substitute to control risk of stroke in high-risk people is unknown, and anyone taking anticoagulant medication should advise their prescribing doctor before beginning use of these natural substances.

References

1. Tomeo AC, Geller M, Watkins TR, et al. Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. Lipids 1995;30:1179-83.

2. Steiner M, Glantz M, Lekos A. Vitamin E plus aspirin compared with aspirin alone in patients with transient ischemic attacks. Am J Clin Nutr 1995;62(6 Suppl):1381-4S.

3. Blot WJ, Li JY, Taylor PR, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993;85:1483-92.

4. Gaziano JM, Manson JE, Ridker PM, et al. Beta-carotene therapy for chronic stable angina. Circulation 1990;82(Suppl III):III-201 [abstract].

5. Ascherio A, Rimm EB, Hernan MA, et al. Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Ann Intern Med 1999;130:963-70.

6. Mark SD, Wang W, Fraumeni JF Jr, et al. Do nutritional supplements lower the risk of stroke or hypertension? Epidemiology 1998;9:9-15.

7. Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996;334:1145-9.

8. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35.

9. Leppala JM, Virtamo J, Fogelholm R, et al. Controlled trial of alpha-tocopherol and beta-carotene supplements on stroke incidence and mortality in male smokers. Arterioscler Thromb Vasc Biol 2000;20:230-5.

10. Leppala JM, Virtamo J, Fogelholm R, et al. Vitamin E and beta carotene supplementation in high risk for stroke: a subgroup analysis of the alpha-tocopherol, beta-carotene cancer prevention study. Arch Neurol 2000;57:1503-9.

11. Kopecky SL, Gersh BJ, McGoon MD, et al. Lone atrial fibrillation in elderly persons: a marker for cardiovascular risk. Arch Intern Med 1999;159:1118-22.

12. Bordia A, Verma SK, Srivastava KC. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 1998;58:257-63.

13. Berthold HK, Sudhop T. Garlic preparations for prevention of atherosclerosis. Curr Opin Lipidol 1998;9:565-9 [review].

14. Kiesewetter H, Jung F, Pindur G, et al. Effect of garlic on thrombocyte aggregation, microcirculation and other risk factors. Int J Pharm Ther Toxicol 1991;29(4):151-5.

15. Leaf A, Weber PC. Cardiovascular effects of n-3 fatty acids. N Engl J Med 1988;318:549-57 [review].

16. Calzada C, Bruckdorfer KR, Rice-Evans CA. The influence of antioxidant nutrients on platelet function in healthy volunteers. Atherosclerosis 1997;128:97-105.

17. Steiner M. Vitamin E: more than an antioxidant. Clin Cardiol 1993;16:I16-8 [review].

18. Heemskerk JW, Vossen RC, van Dam-Mieras MC. Polyunsaturated fatty acids and function of platelets and endothelial cells. Curr Opin Lipidol 1996;7:24-9 [review].

Tocotrienols are members of the vitamin E family. Like vitamin E, tocotrienols are potent antioxidants against lipid peroxidation (the damaging of fats by oxidation).1, 2

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The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2017.