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Description
Supports energy production and natural resistance

Timed-Release

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take 1 caplet daily.

Serving Size 1 Caplet
Servings Per Container 60
Amount Per Serving % DV
Vitamin C (as Ascorbic Acid) 125.00 mg 208%
Thiamin (Vitamin B-1) (as Thiamin Mononitrate) 125.00 mg 8333%
Riboflavin (Vitamin B-2) 125.00 mg 7353%
Vitamin B-6 (as Pyridoxine Hydrochloride) 125.00 mg 6250%
Folic Acid 400.00 mcg 100%
Vitamin B-12 (as Cyanocobalamin) 125.00 mcg 2083%
Biotin 125.00 mcg 42%
Pantothenic Acid (as Calcium d-Pantothenate) 125.00 mg 1250%
Choline Bitartrate 125.00 mg **
Inositol 125.00 mcg **
Para-Aminobenzoic Acid (PABA) 75.00 mg **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Dicalcium Phosphate, Rose Hips Powder (Rosa Canina)

No Sugar, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Soy, No Dairy, Yeast Free.

Storage Instructions: Store in a cool, dry place.

Warning: Keep out of reach of children.

Distributed by: General Nutrition Corporation, Pittsburgh, PA 15222

Health Notes

Vitamin B-Complex

Vitamin B-Complex
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Wound Healing
Dose: Follow label directions
Thiamine (vitamin B1), pantothenic acid (vitamin B5), and other B vitamins have all been shown to play a role in wound healing. For this reason, some healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing.(more)
Acne Rosacea
Dose: Refer to label instructions
The relationship between B vitamins and rosacea is unclear, one study found it caused rocacea-like symptoms, other preliminary reports have found benefits.(more)
Vitiligo
Dose: Refer to label instructions
PABA, a compound commonly found in B-complex vitamins, has been shown to repigment skin affected by vitiligo.(more)
Wound Healing
Dose: Follow label directions
Thiamine (vitamin B1), pantothenic acid (vitamin B5), and other B vitamins have all been shown to play a role in wound healing. For this reason, some healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing.(more)
Canker Sores
Dose: 300 mg B1 daily, 20 mg B2 daily, 150 mg B6 daily
People with recurrent canker sores may have a B vitamin deficiency. Supplementing with vitamins B1, B2, and B6 has been reported to provide relief.(more)
Athletic Performance
Dose: Refer to label instructions
B-complex vitamins are needed to produce energy from carbohydrates. Exercisers may have slightly increased requirements for some of the B vitamins, including vitamins B2, B6, and B5, athletic performance can suffer if these slightly increased needs are not met.(more)
Indigestion, Heartburn, and Low Stomach Acidity
Dose: Refer to label instructions
People with achlorhydria (no stomach acid) or hypochlorhydria may not metabolize B vitamins properly, putting them at risk of developing various nutritional deficiencies, which could presumably contribute to the development of a wide range of health problems.(more)
Indigestion, Heartburn, and Low Stomach Acidity, and Vitamin B12 Deficiency
Dose: Refer to label instructions
For people who have inadequate absorption of vitamin B12 due to low stomach acid, supplementing with vitamin B complex can help correct a deficiency.(more)
Attention Deficit-Hyperactivity Disorder
Dose: Refer to label instructions
B vitamins have been used for ADHD. High amounts of B vitamins have shown mixed results in relieving ADHD symptoms.(more)
Premenstrual Syndrome
Dose: Refer to label instructions
Research has linked B vitamin deficiencies to PMS, so some women may benefit from supplementing with B-complex vitamins for symptom relief.(more)
Premenstrual Syndrome
Dose: Refer to label instructions
Research has linked B vitamin deficiencies to PMS, so some women may benefit from supplementing with B-complex vitamins for symptom relief.(more)
Osteoporosis
Dose: Refer to label instructions
In one trial postmenopausal women who combined hormone replacement therapy with B vitamins and other nutrients and dietary changes increased their bone density by a remarkable 11%.(more)
Hives
Dose: Refer to label instructions
In one study, treatment with a hydrochloric acid supplement and a vitamin B-complex supplement helped to treat people with hives.(more)
Anxiety
Dose: Refer to label instructions
Double-blind research suggests that supplementing with vitamin B-complex multivitamin may reduce feelings of anxiety, perceived stress, and tiredness. (more)
Anxiety
Dose: Refer to label instructions
Double-blind research suggests that supplementing with vitamin B-complex multivitamin may reduce feelings of anxiety, perceived stress, and tiredness. (more)
Wound Healing
Dose: Follow label directions

Thiamine (vitamin B1),1pantothenic acid (vitamin B5),2 and other B vitamins3 have all been shown to play a role in wound healing in animal studies. For this reason, although human research is lacking, some alternative healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing.

References

1. Alvarez OM, Gilbreath RL. Effect of dietary thiamine on intermolecular collagen cross-linking during wound repair: a mechanical and biochemical assessment.J Trauma 1982;22:20-4.

2. Aprahamian M, Dentinger A, Stock-Damge C, et al. Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit. Am J Clin Nutr 1985;41:578-89.

3. Bosse MD, Axelrod AE. Wound healing in rats with biotin, pyridoxin, or riboflavin deficiencies. ProcSoc Exp Biol Med 1948;67:418-21.

Acne Rosacea
Dose: Refer to label instructions

Preliminary reports in the 1940s claimed that rosacea improved with oral supplements or injections of B vitamins1, 2, 3 On the other hand, one report exists of rosacea-like symptoms in a patient taking 100 mg per day of vitamin B6 and 100 mcg per day of vitamin B12; these symptoms subsided when the supplements were discontinued.4 More research is needed to evaluate the potential benefits or hazards of B vitamins for rosacea.

References

1. Tulipan L. Acne rosacea: a vitamin B complex deficiency. Arch Dermatol Syphilol 1947;56:589.

2. Stillians AW. Pyridoxine in treatment of acne vulgaris. J Invest Dermatol 1946;7:150-1.

3. Johnson L, Eckardt R. Rosacea keratitis and conditions with vascularization of the cornea treated with riboflavin. Arch Ophthamol 1940;23:899-907.

4. Sherertz EF. Acneiform eruption due to "megadose" vitamins B6 and B12. Cutis 1991;48:119-20.

Vitiligo
Dose: Refer to label instructions

An early report described the use of PABA (para-aminobenzoic acid)-a compound commonly found in B-complex vitamins-for vitiligo. Consistent use of 100 mg of PABA three or four times per day, along with an injectable form of PABA and a variety of hormones tailored to individual needs, resulted, in many cases, in repigmentation of areas affected by vitiligo.1

References

1. Sieve BF. Further investigations in the treatment of vitiligo. Virginia Med Monthly 1945;Jan:6-17.

Wound Healing
Dose: Follow label directions

Thiamine (vitamin B1),1pantothenic acid (vitamin B5),2 and other B vitamins3 have all been shown to play a role in wound healing in animal studies. For this reason, although human research is lacking, some alternative healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing.

References

1. Alvarez OM, Gilbreath RL. Effect of dietary thiamine on intermolecular collagen cross-linking during wound repair: a mechanical and biochemical assessment.J Trauma 1982;22:20-4.

2. Aprahamian M, Dentinger A, Stock-Damge C, et al. Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit. Am J Clin Nutr 1985;41:578-89.

3. Bosse MD, Axelrod AE. Wound healing in rats with biotin, pyridoxin, or riboflavin deficiencies. ProcSoc Exp Biol Med 1948;67:418-21.

Canker Sores
Dose: 300 mg B1 daily, 20 mg B2 daily, 150 mg B6 daily

Several preliminary studies,1, 2, 3, 4 though not all,5 have found a surprisingly high incidence of iron and B vitamin deficiency among people with recurrent canker sores. Treating these deficiencies has been reported in preliminary6, 7 and controlled8 studies to reduce or eliminate recurrences in most cases. Supplementing daily with B vitamins-300 mg vitamin B1, 20 mg vitamin B2, and 150 mg vitamin B6-has been reported to provide some people with relief.9 Thiamine (B1) deficiency specifically has been linked to an increased risk of canker sores.10 The right supplemental level of iron requires diagnosis of an iron deficiency by a healthcare professional using lab tests.

References

1. Porter SR, Scully C, Flint S. Hematologic status in recurrent aphthous stomatitis compared to other oral disease. Oral Surg Oral Med Oral Pathol 1988;66:41-4.

2. Palopoli J, Waxman J. Recurrent aphthous stomatitis and vitamin B12 deficiency. South Med J 1990;83:475-7.

3. Wray D, Ferguson MM, Hutcheon WA, Dagg JH. Nutritional deficiencies in recurrent aphthae. J Oral Pathol 1978;7:418-23.

4. Barnadas MA, Remacha A, Condomines J, de Moragas JM. [Hematologic deficiencies in patients with recurrent oral aphthae]. Med Clin (Barc) 1997;109:85-7 [in Spanish].

5. Olson JA, Feinberg I, Silverman S, et al. Serum vitamin B12, folate, and iron levels in recurrent aphthous ulceration. Oral Surg Oral Med Oral Pathol 1982;54:517-20.

6. Weusten BL, van de Wiel A. Aphthous ulcers and vitamin B12 deficiency. Neth J Med 1998;53:172-5.

7. Porter S, Flint S, Scully C, Keith O. Recurrent aphthous stomatitis: the efficacy of replacement therapy in patients with underlying hematinic deficiencies. Ann Dent 1992;51:14-6.

8. Wray D, Ferguson MM, Mason DK, et al. Recurrent aphthae: treatment with vitamin B12, folic acid, and iron. Br Med J 1975;2(5969):490-3.

9. Nolan A, McIntosh WB, Allam BF, Lamey PJ. Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. J Oral Pathol Med 1991;20:389-91.

10. Haisraeli-Shalish M, Livneh A, Katz J, et al. Recurrent aphthous stomatitis and thiamine deficiency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:634-6.

Athletic Performance
Dose: Refer to label instructions

The B-complex vitamins are important for athletes, because they are needed to produce energy from carbohydrates. Exercisers may have slightly increased requirements for some of the B vitamins, including vitamin B2, vitamin B6, and vitamin B5 (pantothenic acid);1 athletic performance can suffer if these slightly increased needs are not met.2 However, most athletes obtain enough B vitamins from their diet without supplementation,3 and supplementation studies have found no positive effect on performance measures for vitamin B2,4, 5 vitamin B3 (niacin),6 or vitamin B6.7 On the contrary, large amounts of niacin have been shown to impair endurance performance.8

References

1. Keith R, Alt L. Riboflavin status of female athletes consuming normal diets. Nutr Res 1991;11:727-34.

2. Van der Beek EJ, Van Dokkum W, Wedel M, et al. Thiamin, riboflavin and vitamin B6: impact of restricted intake on physical performance in man. J Am Coll Nutr 1994;13:629-40.

3. Van der Beek EJ. Vitamin supplementation and physical exercise performance. J Sports Sci 1991;9:77-90 [review].

4. Winters LR, Yoon JS, Kalkwarf HJ, et al. Riboflavin requirements and exercise adaptation in older women. Am J Clin Nutr 1992;56:526-32.

5. Tremblay A, Boiland F, Breton M, et al. The effects of riboflavin supplementation on the nutritional status and performance of elite swimmers. Nutr Res 1984;4:201-8.

6. Murray R, Bartoli WP, Eddy DE, et al. Physiological and performance responses to nicotinic-acid ingestion during exercise. Med Sci Sports Exerc 1995;27:1057-62.

7. Manore MM. Vitamin B6 and exercise. Int J Sport Nutr 1994;4:89-103.

8. Murray R, Bartoli WP, Eddy DE, et al. Physiological and performance responses to nicotinic-acid ingestion during exercise. Med Sci Sports Exerc 1995;27:1057-62.

Indigestion, Heartburn, and Low Stomach Acidity
Dose: Refer to label instructionsMany minerals and vitamins appear to require adequate concentrations of stomach acid to be absorbed optimally-examples are iron,1 zinc,2 and B-complex vitamins,3 including folic acid.4 People with achlorhydria (no stomach acid) or hypochlorhydria may therefore be at risk of developing various nutritional deficiencies, which could presumably contribute to the development of a wide range of health problems.
References

1. Murray MJ, Stein N. A gastric factor promoting iron absorption. Lancet 1968;1:614.

2. Sturniolo GC, Montino MC, Rossetto L, et al. Inhibition of gastric acid secretion reduces zinc absorption in man. J Am Coll Nutr 1991;10:372-5.

3. Allison JR. The relation of hydrochloric acid and vitamin B complex deficiency in certain skin diseases. South Med J 1945;38:235-41.

4. Russell RM, Krasinski SD, Samloff IM. Correction of impaired folic acid (Pte Glu) absorption by orally administered HCl in subjects with gastric atrophy. Am J Clin Nutr 1984;39:656.

Indigestion, Heartburn, and Low Stomach Acidity, and Vitamin B12 Deficiency
Dose: Refer to label instructionsVitamin B12 supplementation may be beneficial for a subset of people suffering from indigestion: those with delayed emptying of the stomach contents in association with Helicobacter pylori infection and low blood levels of vitamin B12. In a double-blind study of people who satisfied those criteria, treatment with vitamin B12 significantly reduced symptoms of dyspepsia and improved stomach-emptying times.1
References

1. Gumurdulu Y, Serin E, Ozer B, et al. The impact of B12 treatment on gastric emptying time in patients with Helicobacter pylori infection. J Clin Gastroenterol 2003;37:230-3.

Attention Deficit-Hyperactivity Disorder
Dose: Refer to label instructions

B vitamins, particularly vitamin B6, have also been used for ADHD. Deficient levels of vitamin B6 have been detected in some ADHD patients.1 In a study of six children with low blood levels of the neurotransmitter (chemical messenger) serotonin, vitamin B6 supplementation (15-30 mg per 2.2 pounds of body weight per day) was found to be more effective than methylphenidate (Ritalin(R)). However, lower amounts of vitamin B6 were not beneficial.2 The effective amount of vitamin B6 in this study was extremely large and could potentially cause nerve damage, although none occurred in this study. A practitioner knowledgeable in nutrition must be consulted when using high amounts of vitamin B6. High amounts of other B vitamins have shown mixed results in relieving ADHD symptoms.3, 4

References

1. Bhagavan HN, Coleman M, Coursin DB. The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children. Pediatrics 1975;55:437-41.

2. Coleman M, Steinberg G, Tippett J, et al. A preliminary study of the effect of pyridoxine administration in a subgroup of hyperkinetic children: a double-blind crossover comparison with methylphenidate. Biol Psychiatry 1979;14:741-51.

3. Brenner A. The effects of megadoses of selected B complex vitamins on children with hyperkinesis: controlled studies with long term followup. J Learning Dis 1982;15:258-64.

4. Haslam RHA. Is there a role for megavitamin therapy in the treatment of attention deficit hyperactivity disorder? Adv Neurol 1992;58:303-10.

Premenstrual Syndrome
Dose: Refer to label instructions

Many years ago, research linked B vitamin deficiencies to PMS in preliminary research.1, 2 Based on that early work, some doctors recommend B-complex vitamins for women with PMS.3

References

1. Biskind MS. Nutritional deficiency in the etiology of menorrhagia, metrorrhagia, cystic mastitis and premenstrual tension: treatment with vitamin B-complex. J Clin Endocrinol Metabol 1943;3:227-34.

2. Biskind MS, Biskind GR, Biskind LH. Nutritional deficiency in the etiology of menorrhagia, metrorrhagia, cystic mastitis and premenstrual tension. Surg Gynecol Obstet 1944;78:49-57.

3. Piesse JW. Nutritional factors in the premenstrual syndrome. Int Clin Nutr Rev 1984;4(2):54-80 [review].

Premenstrual Syndrome
Dose: Refer to label instructions

Many years ago, research linked B vitamin deficiencies to PMS in preliminary research.1, 2 Based on that early work, some doctors recommend B-complex vitamins for women with PMS.3

References

1. Biskind MS. Nutritional deficiency in the etiology of menorrhagia, metrorrhagia, cystic mastitis and premenstrual tension: treatment with vitamin B-complex. J Clin Endocrinol Metabol 1943;3:227-34.

2. Biskind MS, Biskind GR, Biskind LH. Nutritional deficiency in the etiology of menorrhagia, metrorrhagia, cystic mastitis and premenstrual tension. Surg Gynecol Obstet 1944;78:49-57.

3. Piesse JW. Nutritional factors in the premenstrual syndrome. Int Clin Nutr Rev 1984;4(2):54-80 [review].

Osteoporosis
Dose: Refer to label instructions

One trial studying postmenopausal women combined hormone replacement therapy with magnesium (600 mg per day), calcium (500 mg per day), vitamin C, B vitamins, vitamin D, zinc, copper, manganese, boron, and other nutrients for an eight- to nine-month period.1 In addition, participants were told to avoid processed foods, limit protein intake, emphasize vegetable over animal protein, and limit consumption of salt, sugar, alcohol, coffee, tea, chocolate, and tobacco. Bone density increased a remarkable 11%, compared to only 0.7% in women receiving hormone replacement alone.

References

1. Abraham GE, Grewal H. A total dietary program emphasizing magnesium instead of calcium. J Reprod Med 1990;35:503-7.

Hives
Dose: Refer to label instructions

According to preliminary studies from many years ago, lack of hydrochloric acid (HCl) secretion by the stomach was associated with chronic hives, presumably as a result of increasing the likelihood of developing food allergies. In one such study, 31% were diagnosed as having achlorhydria (no gastric acid output), and 53% were shown to be hypochlorhydric (having low gastric acid output).1 In a related study, treatment with an HCl supplement and a vitamin B-complex supplement helped to treat people with hives.2Betaine HCl is the most common hydrochloric acid-containing supplement; it comes in tablets or capsules measured in grains or milligrams. One or more tablets or capsules, each containing 5-10 grains (325-650 mg) are typically taken with a meal that contains protein. Diagnosis of a deficiency of HCl and supplementation with HCl should be supervised by a doctor.

References

1. Rawls WB, Ancona VC. Chronic urticaria associated with hypochlorhydria or achlorhydria. Rev Gastroenterol 1951;18:267-71.

2. Allison JR. The relation of hydrochloric acid and vitamin B complex deficiency in certain skin diseases. South Med J 1945;38:235-41.

Anxiety
Dose: Refer to label instructionsIn one double-blind study, 80 healthy male volunteers (aged 18 to 42 years) were randomly assigned to receive a daily multivitamin-mineral formula or placebo for 28 days.1 The multi contained the following: thiamine (15 mg), riboflavin (15 mg), niacin (50 mg), pantothenic acid (23 mg), vitamin B6 (10 mg), biotin (150 mcg), folic acid (400 mcg), vitamin B12 (10 mcg), vitamin C (500 mg), calcium (100 mg), magnesium (100 mg), and zinc (10 mg). Compared with the placebo group, the multivitamin group experienced consistent and statistically significant reductions in anxiety and perceived stress, as determined by questionnaires measuring psychological state. This group also tended to rate themselves as less tired and better able to concentrate.
References

1. Carroll D, Ring C, Suter M, Willemsen G. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology(Berl) 2000;150:220-5.

Anxiety
Dose: Refer to label instructionsIn one double-blind study, 80 healthy male volunteers (aged 18 to 42 years) were randomly assigned to receive a daily multivitamin-mineral formula or placebo for 28 days.1 The multi contained the following: thiamine (15 mg), riboflavin (15 mg), niacin (50 mg), pantothenic acid (23 mg), vitamin B6 (10 mg), biotin (150 mcg), folic acid (400 mcg), vitamin B12 (10 mcg), vitamin C (500 mg), calcium (100 mg), magnesium (100 mg), and zinc (10 mg). Compared with the placebo group, the multivitamin group experienced consistent and statistically significant reductions in anxiety and perceived stress, as determined by questionnaires measuring psychological state. This group also tended to rate themselves as less tired and better able to concentrate.
References

1. Carroll D, Ring C, Suter M, Willemsen G. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology(Berl) 2000;150:220-5.

The vitamin B-complex refers to all of the known essential water-soluble vitamins except for vitamin C. These include thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin, folic acid and the cobalamins (vitamin B12).

"Vitamin B" was once thought to be a single nutrient . Researchers later discovered these extracts contained several vitamins, which were given distinguishing numbers, leading many people to the erroneous conclusion that these vitamins have a special relationship to each other. Further adding to confusion has been the "unofficial" designation of other, non-essential vitamins, as members of the B-complex, such as choline, inositol, and para-aminobenzoic acid (PABA).

Each member of the B-complex has a unique structure and performs unique functions in the human body. Vitamins B1, B2, B3, and biotin participate in different aspects of energy production, vitamin B6 is essential for amino acid metabolism, and vitamin B12 and folic acid facilitate steps required for cell division.

Each of these vitamins has many additional functions, though none that require all B-complex vitamins simultaneously. Human requirements for each B vitamin vary considerably-from 3 mcg per day for vitamin B12 to 18 mg per day for vitamin B3 in adult males, for example. So, taking equal amounts of each one-as provided in many B-complex supplements-makes little sense. Megadoses of B-complex vitamins sometimes taken to combat everyday stress, boost energy, or control food cravings, do not appear to offer benefit unless a person is deficient in one or more of them.

Most multivitamin-mineral products contain the B-complex along with the rest of the essential vitamins and minerals. Since they are more complete than B-complex vitamins alone, multiple vitamin-mineral supplements are recommended to improve overall micronutrient intake and prevent deficiencies.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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