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GNC Glucosamine 1000 MG

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90 Vegetarian Caplets

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Description
  • Non-shellfish
  • Helps promote joint flexability*
  • Supports healthy joint function

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take one caplet twice daily. For maximum support, take as directed every day.

Serving Size 1 Caplet
Servings Per Container 90
Amount Per Serving % DV
d-Glucosamine Hydrochloride (Non-Shellfish) 1000.00 mg **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Titanium Dioxide (Natural Mineral Whitener), Vegetable Acetoglycerides

No Sugar, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Soy, No Dairy, Yeast Free.

Warning: KEEP OUT OF REACH OF CHILDREN

Distributed by: General Nutrition Corporation Pittsburgh, PA 15222

Health Notes

Glucosamine

Glucosamine
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Osteoarthritis
Dose: 1,500 mg daily
Glucosamine sulfate is necessary for joint cartilage synthesis and repair. It has been shown to significantly reduce osteoarthritis symptoms and appears to be virtually free of side effects. (more)
Rheumatoid Arthritis
Dose: Refer to label instructions
Taking glucosamine hydrochloride improved pain in people with rheumatoid arthritis in one study. (more)
Osteoarthritis
Dose: Refer to label instructions
Studies have shown glucosamine hydrochloride to be effective at reducing pain and improving symptoms in people with osteoarthritis.(more)
Minor Injuries
Dose: Refer to label instructions
(more)
Knee Pain
Dose: Refer to label instructions
(more)
Sprains and Strains
Dose: Refer to label instructions
Glucosamine sulfate may promote healing after injury by providing the raw material needed by the body to manufacture molecules found in skin, tendons, ligaments, and joints.(more)
Wound Healing
Dose: Refer to label instructions
Supplementing with glucosamine sulfate may promote wound healing by providing the raw material needed by the body to manufacture connective tissue.(more)
Wound Healing
Dose: Refer to label instructions
Supplementing with glucosamine sulfate may promote wound healing by providing the raw material needed by the body to manufacture connective tissue.(more)
Brittle Nails
Dose: 1,500 mg daily
One doctor has observed that taking glucosamine sulfate can increase the nail growth and strength.(more)
Autism
Dose: 250 mg with morning and evening meals
Some autistic children suffer from chronic diarrhea. In one study, supplementing with glucosamine eliminated the diarrhea in five of six children with autism, possibly by blocking the effect of certain dietary components on the intestinal tract.(more)
Diarrhea
Dose: 250 mg with morning and evening meals
Some autistic children suffer from chronic diarrhea. In one study, supplementing with glucosamine eliminated the diarrhea in five of six children with autism, possibly by blocking the effect of certain dietary components on the intestinal tract.(more)
Osteoarthritis
Dose: 1,500 mg daily Glucosamine sulfate (GS), a nutrient derived from seashells, is a building block needed for the synthesis and repair of joint cartilage. GS supplementation has significantly reduced symptoms of osteoarthritis in uncontrolled1, 2 and single-blind trials.3, 4 Many double-blind trials have also reported efficacy.5, 6, 7, 8, 9, 10 One published trial has reported no effect of GS on osteoarthritis symptoms,11 and GS has been found to be ineffective for low back pain related to lumbar spine osteoarthritis.12 While most research trials use 500 mg GS taken three times per day, results of a three-year, double-blind trial indicate that 1,500 mg taken once per day produces significant reduction of symptoms and halts degenerative changes seen by x-ray examination.13 GS does not cure people with osteoarthritis, and they may need to take the supplement for the rest of their lives in order to maintain benefits. Fortunately, GS appears to be virtually free of side effects, even after three or more years of supplementation. Benefits from GS generally become evident after three to eight weeks of treatment.
References

1. Tapadinhas MJ, Rivera IC, Bignamini AA. Oral glucoseamine sulfate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherapeutica 1982;3:157-68.

2. Giordano N, Nardi P, Senesi M, et al. The efficacy and safety of glucosamine sulfate in the treatment of gonarthritis. Clin Ter 1996;147:99-105.

3. D'Ambrosio E, Casa B, Bompani G, et al. Glucosamine sulphate: a controlled clinical investigation in arthrosis. Pharmatherapeutica 1981;2(8):504-8.

4. Crolle G, DiEste E. Glucosamine sulfate for the management of arthrosis. Curr Ther Res 1980;7:104-9.

5. Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998;48:469-74.

6. Reichelt A, Forster KK, Fischer M, et al. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. Arzneimittelforschung 1994;44:75-80.

7. Drovanti A, Bignamini AA, Rovati AL. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: a placebo-controlled double-blind investigation. Clin Ther 1980;3:260-72.

8. Vaz AL. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthritis of the knee in out-patients. Curr Med Res Opin 1982;8:145-9.

9. Pujalte JM, Llavore EP, Ylescupidez FR. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin 1980;7(2):110-4.

10. Poolsup N, Suthisisang C, Channark P, Kittikulsuth W. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials. Ann Pharmacother 2005;39:1080-7.

11. Rindone RP. Randomized controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med 2000;172:91-4.

12. Wilkens P, Scheel IB, Grundnes O, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial. JAMA 2010;304:45-52.

13. Reginster JY, Deroisy R, Rovati L, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 2001;357:251-6.

Rheumatoid Arthritis
Dose: Refer to label instructionsIn a preliminary trial, supplementation with glucosamine hydrochloride (1,500 mg per day) for 12 weeks produced a small but statistically significant improvement of pain in people with rheumatoid arthritis. However, other measures of disease activity, such as the number of swollen and painful joints did not improve.1
References

1. Nakamura H, Masuko K, Yudoh K, et al. Effects of glucosamine administration on patients with rheumatoid arthritis. Rheumatol Int 2007;27:213-8.

Osteoarthritis
Dose: Refer to label instructionsA few trials have evaluated glucosamine hydrochloride (GH), another form of glucosamine sulfate (GS), as a single remedy for osteoarthritis. One trial found only minor benefits from 1,500 mg per day of GH for 8 weeks in people with osteoarthritis of the knee.1 However, these people were also taking up to 4,000 mg per day of acetaminophen for pain relief, and that treatment might have masked a beneficial effect of GH. In another study, supplementing with GH (2,000 mg each morning for 12 weeks) significantly improved symptoms, compared with a placebo, in people with knee pain due to cartilage damage or osteoarthritis.2 In a four-week study from China, GH was as effective as GS in people with osteoarthritis of the knee.3 Another study found that the combination of GH and chondroitin sulfate was more effective than a placebo in people with moderate to severe knee pain from osteoarthritis, but not in those with mild pain.4 Despite the reported beneficial effects of GH, some investigators believe that the sulfate component of GS itself helps relieve osteoarthritis, and that GS would therefore be more effective than GH.5
References

1. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.

2. Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med 2003;37:45-9.

3. Qiu GX, Weng XS, Zhang K, et al. A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulfate in the treatment of knee osteoarthritis. Zhonghua Yi Xue Za Zhi 2005;85:3067-70 [in Chinese].

4. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;795-808.

5. Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.

Minor Injuries
Dose: Refer to label instructions
Knee Pain
Dose: Refer to label instructions
Sprains and Strains
Dose: Refer to label instructions

Glucosamine sulfate and chondroitin sulfate may both play a role in wound healing by providing the raw material needed by the body to manufacture molecules called glycosaminoglycans found in skin, tendons, ligaments, and joints.1 Test tube and animal studies have found that these substances, and others like them, can promote improved tissue healing.2, 3, 4, 5 Injectable forms of chondroitin sulfate have been used in Europe for various types of sports-related injuries to tendons and joints,6, 7, 8, 9 and one preliminary trial reported reduced pain and good healing in young athletes with chondromalacia patella (cartilage softening in the knee) who were given 750-1,500 mg per day of oral glucosamine sulfate.10 However, specific human trials of glucosamine and chondroitin sulfate for healing sprains and strains are lacking.

References

1. Morrison LM, Murata K. Absorption, distribution, metabolism and excretion of acid mucopolysaccharides administered to animals and patients. In: Morrison LM, Schjeide OA, Meyer K. Coronary heart disease and the mucopolysaccharides (glycosaminoglycans). Springfield: Charles C. Thomas, 1974, 109-27.

2. Denuziere A, Ferrier D, Damour O, et al. Chitosan-chondroitin sulfate and chitosan-hyaluronate polyelectrolyte complexes: biological properties. Biomaterials 1998;19:1275-85.

3. McCarty MF. Glucosamine for wound healing. Med Hypotheses 1996;47:273-5 [review].

4. Glade MJ. Polysulfated glycosaminoglycan accelerates net synthesis of collagen and glycosaminoglycans by arthritic equine cartilage tissues and chondrocytes. Am J Vet Res 1990;51:779-85.

5. Prudden JF, Wolarsky ER, Balassa L. The acceleration of healing. Surg Gynecol Obstet 1969;128:1321-6 [review].

6. Bucci L. Nutrition applied to injury rehabilitation and sports medicine. Boca Raton, FL: CRC Press, 1995, 193.

7. Sprengel H, Franke J, Sprengel A. Personal experiences in the conservative therapy of patellar chondropathy. Beitr Orthop Traumatol 1990;37:259-66 [in German].

8. Lysholm J. The relation between pain and torque in an isokinetic strength test of knee extension. Arthroscopy 1987;3:182-4.

9. Ziegler R, Rau R. Conservative or operative treatment for chondropathia patellae? Beitr Orthop Traumatol 1980;27:201-11 [in German].

10. Bohmer D, Ambrus P, Szogy A, et al. Treatment of chondropathia patellae in young athletes with glucosamine sulfate. In: Bachl N, Prokop L, Suckert R, eds. Current topics in sports medicine. Vienna: Urban & Schwarzenberg, 1984, 799.

Wound Healing
Dose: Refer to label instructions

Glucosamine sulfate and chondroitin sulfate may both play a role in wound healing by providing the raw material needed by the body to manufacture connective tissue found in skin, tendons, ligaments, and joints.1 Test tube and animal studies have found that these substances, and others like them, can promote improved tissue healing.2, 3, 4, 5, 6 One controlled trial in humans found that wounds healed with greater strength when they were treated topically with a chondroitin sulfate-containing powder.7 However, no research has investigated the value of oral supplements of glucosamine or chondroitin for wound healing in humans.

References

1. Morrison LM, Murata K. Absorption, distribution, metabolism and excretion of acid mucopolysaccharides administered to animals and patients. In: Morrison LM, Schjeide OA, Meyer K. Coronary heart disease and the mucopolysaccharides (glycosaminoglycans). Springfield: Charles C. Thomas, 1974, 109-27.

2. Denuziere A, Ferrier D, Damour O, et al. Chitosan-chondroitin sulfate and chitosan-hyaluronate polyelectrolyte complexes: biological properties. Biomaterials 1998;19:1275-85.

3. McCarty MF. Glucosamine for wound healing. Med Hypotheses 1996;47:273-5 [review].

4. Glade MJ. Polysulfated glycosaminoglycan accelerates net synthesis of collagen and glycosaminoglycans by arthritic equine cartilage tissues and chondrocytes. Am J Vet Res 1990;51:779-85.

5. Prudden JF, Wolarsky ER, Balassa L. The acceleration of healing. Surg Gynecol Obstet 1969;128:1321-6 [review].

6. Suyama T, Iga Y, Shirakawa H. The acceleration of wound healing with chondroitin sulfate A and its acidic hydrolysates. Jpn J Exp Med 1966;36:449-52.

7. Prudden JF, Allen J. The clinical acceleration of healing with a cartilage preparation; a controlled study. JAMA 1965;192:352-6.

Wound Healing
Dose: Refer to label instructions

Glucosamine sulfate and chondroitin sulfate may both play a role in wound healing by providing the raw material needed by the body to manufacture connective tissue found in skin, tendons, ligaments, and joints.1 Test tube and animal studies have found that these substances, and others like them, can promote improved tissue healing.2, 3, 4, 5, 6 One controlled trial in humans found that wounds healed with greater strength when they were treated topically with a chondroitin sulfate-containing powder.7 However, no research has investigated the value of oral supplements of glucosamine or chondroitin for wound healing in humans.

References

1. Morrison LM, Murata K. Absorption, distribution, metabolism and excretion of acid mucopolysaccharides administered to animals and patients. In: Morrison LM, Schjeide OA, Meyer K. Coronary heart disease and the mucopolysaccharides (glycosaminoglycans). Springfield: Charles C. Thomas, 1974, 109-27.

2. Denuziere A, Ferrier D, Damour O, et al. Chitosan-chondroitin sulfate and chitosan-hyaluronate polyelectrolyte complexes: biological properties. Biomaterials 1998;19:1275-85.

3. McCarty MF. Glucosamine for wound healing. Med Hypotheses 1996;47:273-5 [review].

4. Glade MJ. Polysulfated glycosaminoglycan accelerates net synthesis of collagen and glycosaminoglycans by arthritic equine cartilage tissues and chondrocytes. Am J Vet Res 1990;51:779-85.

5. Prudden JF, Wolarsky ER, Balassa L. The acceleration of healing. Surg Gynecol Obstet 1969;128:1321-6 [review].

6. Suyama T, Iga Y, Shirakawa H. The acceleration of wound healing with chondroitin sulfate A and its acidic hydrolysates. Jpn J Exp Med 1966;36:449-52.

7. Prudden JF, Allen J. The clinical acceleration of healing with a cartilage preparation; a controlled study. JAMA 1965;192:352-6.

Brittle Nails
Dose: 1,500 mg daily

One doctor has observed that supplementation with glucosamine sulfate (amount not specified) can increase the growth rate and strength of fingernails and toenails;1however, no controlled trials have been done.

References

1. Swinburne LM. Glucosamine sulphate and osteoarthritis. Lancet2001;357:1617 [Letter].

Autism
Dose: 250 mg with morning and evening meals

Some autistic children suffer from chronic diarrhea. In a study of children with autistic spectrum disorders and persistent diarrhea for many years, supplementing with 500 mg of glucosamine per day (spread over the morning and evening meal) for 30 days eliminated the diarrhea in five of six cases.1 The authors hypothesized that glucosamine worked by blocking the effect of certain dietary components on the intestinal tract.

References

1. Danczak E. Glucosamine and plant lectins in autistic spectrum disorders: an initial report on 6 children with uncontrolled diarrhoea. J Nutr Environ Med2004;14:327-330.

Diarrhea
Dose: 250 mg with morning and evening meals

Some autistic children suffer from chronic diarrhea. In a study of children with autistic spectrum disorders and persistent diarrhea for many years, supplementing with 500 mg of glucosamine per day (spread over the morning and evening meal) for 30 days eliminated the diarrhea in five of six cases.1 The authors hypothesized that glucosamine worked by blocking the effect of certain dietary components on the intestinal tract.

References

1. Danczak E. Glucosamine and plant lectins in autistic spectrum disorders: an initial report on 6 children with uncontrolled diarrhoea. J Nutr Environ Med2004;14:327-330.

Glucosamine is an important building block needed by the body to manufacture specialized molecules called glycosaminoglycans, found in cartilage.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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    Comments about GNC Glucosamine 1000 MG:

    My mom has used it for a long time. she loves it very much because it helps her feel better.

     
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      Comments about GNC Glucosamine 1000 MG:

      I take two tables per day. I have been taking it for two months. I feel more healthy than before. I walk for an hour every day. I don't feel tried.

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      GNC Glucosamin 1000 MG by GNC

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        I USE DE PRODUCT EVERY DAY AND I FEEL THAT IS GREAT

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