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GNC Herbal Plus® Bilberry Extract & Lutein

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Description
  • For Eye Health and Vision*
  • Proven Superior Absorption*
  • Vegetarian Standardized Herb

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take one capsule daily.

Serving Size 1 Capsule
Servings Per Container 60
Amount Per Serving % DV
Bilberry Fruit Extract (Vaccinium myrtillus)(25% Anthocyanidins = 25 mg) 100.00 mg **
Lutemax 2020™ Lutein 10.00 mg **
Zeaxanthin 2.00 mg **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Vegetable Cellulose Capsule

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.

Distributed by: General Nutrition Corporation Pittsburgh, PA 15222

Health Notes

Bilberry

Bilberry
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Glaucoma
Dose: Refer to label instructions
In a preliminary study, supplementation with a product that provided Pycnogenol (a maritime pine bark extract) and a standardized bilberry extract significantly decreased intraocular pressure in people who had elevated intraocular pressure.(more)
Retinopathy
Dose: 360 to 600 mg daily of an extract standardized for 25% anthocyanosides
Bilberry extract has been shown to strengthen blood vessels in the eye and improve vision in people with diabetic and hypertensive retinopathy.(more)
Macular Degeneration
Dose: Refer to label instructions
Supplementing with bilberry may help prevent and treat early-stage macular degeneration.(more)
Glaucoma
Dose: 60 mg twice a day
In a preliminary trial, supplementing with anthocyanins (flavonoids found in bilberry) improved symptoms in people with normal-tension glaucoma.(more)
Cataracts
Dose: Refer to label instructions
Bilberry is high in flavonoids called anthocyanosides, which may protect both the lens and retina from oxidative damage and reduce the risk of cataracts.(more)
Night Blindness
Dose: Refer to label instructions
Bilberry is high in flavonoids that speed the regeneration of the pigment used by eye for night vision. Supplementing with bilberry has been shown to improve dark adaptation in people with poor night vision.(more)
Type 2 Diabetes
Dose: 160 mg twice per day of an herbal extract containing 25% anthocyanosides
Bilberry may lower the risk of some diabetic complications, such as diabetic cataracts and retinopathy.(more)
Retinopathy
Dose: 360 to 600 mg daily of an extract standardized for 25% anthocyanosides
Bilberry extract has been shown to strengthen blood vessels in the eye and improve vision in people with diabetic and hypertensive retinopathy.(more)
Type 1 Diabetes
Dose: 160 mg twice per day of an herbal extract containing 25% anthocyanosides
Bilberry may lower the risk of some diabetic complications, such as diabetic cataracts and retinopathy.(more)
Atherosclerosis
Dose: Refer to label instructions
Bilberry has been shown to prevent platelet aggregation.(more)
Edema
Dose: Refer to label instructions
Because coumarin, hydroxyethylrutosides, and diosmin are not widely available in, flavonoids such as anthocyanosides (from bilberry), have been substituted by doctors. The effects of these flavonoids against edema has not been well studied. (more)
Macular Degeneration
Dose: Refer to label instructions
Supplementing with bilberry may help prevent and treat early-stage macular degeneration.(more)
Night Blindness
Dose: Refer to label instructions
Bilberry is high in flavonoids that speed the regeneration of the pigment used by eye for night vision. Supplementing with bilberry has been shown to improve dark adaptation in people with poor night vision.(more)
Diarrhea
Dose: Refer to label instructions
Bilberry has been used traditionally in Germany for adults and children with diarrhea. Only dried berries or juice should be used-fresh berries may worsen diarrhea.(more)
Glaucoma
Dose: Refer to label instructionsIn a preliminary study, supplementation with a product that provided daily 80 mg of Pycnogenol (a maritime pine bark extract) and 160 mg of a standardized bilberry extract for two months significantly decreased intraocular pressure in people who had elevated intraocular pressure.1
References

1. Steigerwalt RD, Gianni B, Paolo M, et al. Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. Mol Vis 2008;14:1288-92.

Retinopathy
Dose: 360 to 600 mg daily of an extract standardized for 25% anthocyanosides

Bilberry extracts standardized to contain 25% anthocyanosides have been suggested as a treatment for people with early-stage diabetic or hypertensive retinopathy. In a small preliminary trial, people with various types of retinopathy, including diabetic retinopathy and macular degeneration, were given 600 mg of bilberry extract per day for one month.1 While researchers found that the tendency to hemorrhage in the eye was reduced and that blood vessels were strengthened, there were no reports of improved vision. A small double-blind trial found that 160 mg of bilberry extract taken twice per day for one month led to similar improvements in blood-vessel health in the eye and slightly improved vision in people with diabetic and/or hypertensive retinopathy.2 Larger and longer clinical trials are needed to establish the effectiveness of bilberry for treating retinopathies.

References

1. Scharrer A, Ober M. Anthocyanosides in the treatment of retinopathies. Klin Monatsblatt Augenheilk 1981;178:386-9.

2. Perossini M, Guidi G, Chiellini S, Siravo D. Diabetic and hypertensive retinopathy therapy with Vaccinium myrtillus anthocyanosides (Tegens(R)): Double-blind, placebo-controlled clinical trial. Ann Ottalmol Clin Ocul 1987;113:1173-7 [in Italian].

Macular Degeneration
Dose: Refer to label instructions

Bilberry's active flavonoid compounds, anthocyanosides, act as antioxidants in the retina of the eye. Therefore, supplementing with bilberry would theoretically be of value for the prevention or treatment of early-stage macular degeneration.1 Bilberry has also been shown to strengthen capillaries and to reduce bleeding in the retina.2 A typical amount of bilberry used in studies was 480-600 mg per day of an extract standardized to contain 25% anthocyanosides, taken in capsules or tablets.

References

1. Scharrer A, Ober M. Anthocyanosides in the treatment of retinopathies. Klin Monatsblatt Augenheilk 1981;178:386-9.

2. Mian E, Curri SB, Lietti A, Bombardelli E. Anthocyanosides and the walls of microvessels: Further aspects of the mechanism of action of their protective in syndromes due to abnormal capillary fragility. Minerva Med 1977;68:3565-81.

Glaucoma
Dose: 60 mg twice a dayIn a preliminary trial, supplementing with anthocyanins (a group of flavonoids found in bilberry and certain other plant foods) improved visual acuity and partially reversed visual field damage in patients with normal-tension glaucoma (a type of glaucoma associated with normal intraocular pressure). The amount used was 60 mg twice a day for an average of two years.1
References

1. Shim SH, Kim JM, Choi CY, et al. Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma. J Med Food 2012;15:818-23.

Cataracts
Dose: Refer to label instructions

Bilberry, a close relative of blueberry, is high in flavonoids called anthocyanosides.1 Anthocyanosides may protect both the lens and retina from oxidative damage. The potent antioxidant activity of anthocyanosides may make bilberry useful for reducing the risk of cataracts.2, 3 Doctors sometimes recommend 240 to 480 mg per day of bilberry extract, capsules or tablets standardized to contain 25% anthocyanosides.

References

1. Van Acker SA, van den Berg DJ, Tromp MN, et al. Structural aspects of antioxidant activity of flavonoids. Free Rad Biol Med1996; 20:331-42.

2. Salvayre R, Braquet P, Perruchot T, DousteBlazy L. Comparison of the scavenger effect of bilberry anthocyanosides with various flavonoids. Proceed Intl Bioflavonoids Symposium, Munich, 1981, 437-42.

3. Bravetti G. Preventive medical treatment of senile cataract with vitamin E and anthocyanosides: Clinical evaluation. Ann Ottalmol Clin Ocul 1989;115:109 [in Italian].

Night Blindness
Dose: Refer to label instructions

Bilberry, a close relative of the blueberry, is high in flavonoids known as anthocyanosides. Anthocyanosides speed the regeneration of rhodopsin, the purple pigment that is used by the rods in the eye for night vision.1 Supplementation with bilberry has been shown in early studies to improve dark adaptation in people with poor night vision.2, 3 However, two newer studies found no effect of bilberry on night vision in healthy people.4, 5 Bilberry extract standardized to contain 25% anthocyanosides may be taken in capsule or tablet form. Doctors typically recommend 240 to 480 mg per day.

References

1. Alfieri R, Sole P. Influencedes anthocyanosides admintres parvoie parenterale su l'adaptoelectroretinogramme du lapin. CR Soc Biol 1964;15:2338 [in French].

2. Jayle GE, Aubry M, Gavini H, et al. Study concerning the action of anthocyanoside extracts of Vaccinium myrtillus on night vision. Ann Ocul 1965;198:556-62 [in French].

3. Belleoud L, Leluan D, Boyer YS. Study on the effects of anthocyanin glycosides on the nocturnal vision of air controllers. Rev Med Aeronaut Spatiale 1966;18:3-7.

4. Zadok D, Levy Y, Glovinsky Y. The effect of anthocyanosides in a multiple oral dose on night vision. Eye 1999;13:734-6.

5. Muth ER, Laurent JM, Jasper P. The effect of bilberry nutritional supplementation on night visual acuity and contrast sensitivity. Altern Med Rev 2000;5:164-73.

Type 2 Diabetes
Dose: 160 mg twice per day of an herbal extract containing 25% anthocyanosidesBilberry may lower the risk of some diabetic complications, such as diabetic cataracts and retinopathy. One preliminary trial found that supplementation with a standardized extract of bilberry improved signs of retinal damage in some people with diabetic retinopathy.1
References

1. Scharrer A, Ober M. Anthocyanosides in the treatment of retinopathies. Klin Monatsblatt Augenheilk 1981;178:386-9.

Retinopathy
Dose: 360 to 600 mg daily of an extract standardized for 25% anthocyanosides

Bilberry extracts standardized to contain 25% anthocyanosides have been suggested as a treatment for people with early-stage diabetic or hypertensive retinopathy. In a small preliminary trial, people with various types of retinopathy, including diabetic retinopathy and macular degeneration, were given 600 mg of bilberry extract per day for one month.1 While researchers found that the tendency to hemorrhage in the eye was reduced and that blood vessels were strengthened, there were no reports of improved vision. A small double-blind trial found that 160 mg of bilberry extract taken twice per day for one month led to similar improvements in blood-vessel health in the eye and slightly improved vision in people with diabetic and/or hypertensive retinopathy.2 Larger and longer clinical trials are needed to establish the effectiveness of bilberry for treating retinopathies.

References

1. Scharrer A, Ober M. Anthocyanosides in the treatment of retinopathies. Klin Monatsblatt Augenheilk 1981;178:386-9.

2. Perossini M, Guidi G, Chiellini S, Siravo D. Diabetic and hypertensive retinopathy therapy with Vaccinium myrtillus anthocyanosides (Tegens(R)): Double-blind, placebo-controlled clinical trial. Ann Ottalmol Clin Ocul 1987;113:1173-7 [in Italian].

Type 1 Diabetes
Dose: 160 mg twice per day of an herbal extract containing 25% anthocyanosidesBilberry may lower the risk of some diabetic complications, such as diabetic cataracts and retinopathy. One preliminary trial found that supplementation with a standardized extract of bilberry improved signs of retinal damage in some people with diabetic retinopathy.1
References

1. Scharrer A, Ober M. Anthocyanosides in the treatment of retinopathies. Klin Monatsblatt Augenheilk 1981;178:386-9.

Atherosclerosis
Dose: Refer to label instructions

Turmeric's active compound curcumin has shown potent anti-platelet activity in animal studies.1 It has also demonstrated this effect in preliminary human studies.2 In a similar vein, bilberry has been shown to prevent platelet aggregation3 as has peony.4 However, none of these three herbs has been documented to help atherosclerosis in human trials.

References

1. Srivastava R, Dikshit M, Srimal RC, Dhawan BN. Anti-thrombotic effect of curcumin. Thromb Res 1985;40:413-7.

2. Srivastava KC, Bordia A, Verma SK. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prost Leuk Essen Fat Acids. 1995;52:223-7.

3. Pulliero G, Montin S, et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus (bilberry) anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.

4. Liu J. Effect of Paeonia obovata 801 on metabolism of thromboxane B2 and arachidonic acid and on platelet aggregation in patients with coronary heart disease and cerebral thrombosis. Chin Med J 1983;63:477-81 [in Chinese].

Edema
Dose: Refer to label instructionsBecause coumarin, hydroxyethylrutosides, and diosmin are not widely available in the United States, other flavonoids, such as quercetin, rutin, or anthocyanosides (from bilberry), have been substituted by doctors in an attempt to obtain similar benefits. The effect of these other flavonoids against edema has not been well studied. Also, optimal amounts are not known. However, in one study, quercetin in amounts of 30-50 mg per day corrected abnormal capillary permeability (leakiness),1 an effect that might improve edema. A similar effect has been reported with rutin at 20 mg three times per day.2 Doctors often recommend 80 to 160 mg of a standardized extract of bilberry, three times per day.
References

1. Griffith JQ. Clinical application of quercetin: preliminary report. J Am Pharm Assoc 1953;42:68-9.

2. Shanno RL. Rutin: a new drug for the treatment of increased capillary fragility. Am J Med Sci 1946;211:539-43.

Macular Degeneration
Dose: Refer to label instructions

Bilberry's active flavonoid compounds, anthocyanosides, act as antioxidants in the retina of the eye. Therefore, supplementing with bilberry would theoretically be of value for the prevention or treatment of early-stage macular degeneration.1 Bilberry has also been shown to strengthen capillaries and to reduce bleeding in the retina.2 A typical amount of bilberry used in studies was 480-600 mg per day of an extract standardized to contain 25% anthocyanosides, taken in capsules or tablets.

References

1. Scharrer A, Ober M. Anthocyanosides in the treatment of retinopathies. Klin Monatsblatt Augenheilk 1981;178:386-9.

2. Mian E, Curri SB, Lietti A, Bombardelli E. Anthocyanosides and the walls of microvessels: Further aspects of the mechanism of action of their protective in syndromes due to abnormal capillary fragility. Minerva Med 1977;68:3565-81.

Night Blindness
Dose: Refer to label instructions

Bilberry, a close relative of the blueberry, is high in flavonoids known as anthocyanosides. Anthocyanosides speed the regeneration of rhodopsin, the purple pigment that is used by the rods in the eye for night vision.1 Supplementation with bilberry has been shown in early studies to improve dark adaptation in people with poor night vision.2, 3 However, two newer studies found no effect of bilberry on night vision in healthy people.4, 5 Bilberry extract standardized to contain 25% anthocyanosides may be taken in capsule or tablet form. Doctors typically recommend 240 to 480 mg per day.

References

1. Alfieri R, Sole P. Influencedes anthocyanosides admintres parvoie parenterale su l'adaptoelectroretinogramme du lapin. CR Soc Biol 1964;15:2338 [in French].

2. Jayle GE, Aubry M, Gavini H, et al. Study concerning the action of anthocyanoside extracts of Vaccinium myrtillus on night vision. Ann Ocul 1965;198:556-62 [in French].

3. Belleoud L, Leluan D, Boyer YS. Study on the effects of anthocyanin glycosides on the nocturnal vision of air controllers. Rev Med Aeronaut Spatiale 1966;18:3-7.

4. Zadok D, Levy Y, Glovinsky Y. The effect of anthocyanosides in a multiple oral dose on night vision. Eye 1999;13:734-6.

5. Muth ER, Laurent JM, Jasper P. The effect of bilberry nutritional supplementation on night visual acuity and contrast sensitivity. Altern Med Rev 2000;5:164-73.

Diarrhea
Dose: Refer to label instructions

Astringent herbs traditionally used for diarrhea include blackberry leaves, blackberry root bark, blueberry leaves, and red raspberry leaves.1 Raspberry leaves are high in tannins and, like blackberry, may relieve acute diarrhea. A close cousin of the blueberry, bilberry, has been used traditionally in Germany for adults and children with diarrhea.2 Only dried berries or juice should be used-fresh berries may worsen diarrhea.

Cranesbill has been used by several of the indigenous tribes of North America to treat diarrhea. The tannins in cranesbill likely account for the anti-diarrheal activity3-although there has been little scientific research to clarify cranesbill's constituents and actions.

References

1. Tyler VE. Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York: Pharmaceutical Products Press, 1994, 51-4.

2. Weiss RF. Herbal Medicine. Gothenburg, Sweden: Ab Arcanum and Beaconsfield, UK: Beaconsfield Publishers Ltd, 1988, 101-2.

3. Duke JA. CRC Handbook of Medicinal Plants. Boca Raton, FL: CRC Press, 1985, 209.

Parts Used & Where Grown

A close relative of American blueberry, bilberry grows in northern Europe, Canada, and the United States. The ripe berries are primarily used in modern herbal extracts.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC HERBAL PLUS STANDARDIZEDGNC Herbal Plus® Bilberry Extract & Lutein
 
5.0

(based on 4 reviews)

100%

of respondents would recommend this to a friend.

Pros

  • Easy to swallow (4)
  • Effective (3)
  • Simple to take (3)

Cons

    Best Uses

    • Daily use (3)

    Reviewed by 4 customers

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    5.0

    Good for eye health

    By sandiehsu2008

    from Arlington, texas

    About Me Health Conscious

    See all my reviews

    Pros

    • Easy To Swallow
    • Effective
    • Simple To Take

    Cons

      Best Uses

      • Daily Use

      Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Bilberry Extract & Lutein:

      Great health product

       
      5.0

      good for eyes

      By whw7646

      from USA

      About Me First Time User

      See all my reviews

      Pros

      • Easy To Swallow

      Cons

        Best Uses

        • Daily Use

        Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Bilberry Extract & Lutein:

        Good for eyes. My daughter and I are taking it. I would by it again

         
        5.0

        good product

        By ZOE.CHINA415

        from OR

        See all my reviews

        Pros

        • Easy on Stomach
        • Easy To Swallow
        • Effective
        • Simple To Take

        Cons

          Best Uses

            Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Bilberry Extract & Lutein:

            i feel i see things much clear after taking this.

            (0 of 1 customers found this review helpful)

             
            5.0

            I would buy this product again and again

            By summeryuho

            from Denton, TX

            About Me Health Conscious

            See all my reviews

            Pros

            • Easy on Stomach
            • Easy To Swallow
            • Effective
            • Simple To Take

            Cons

              Best Uses

              • Children
              • Daily Use
              • Older People

              Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Bilberry Extract & Lutein:

              Very good product

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