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GNC Herbal PlusŪ Ginkgo Biloba 120 MG

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Description
May Support Mental Sharpness*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take one to two capsules daily.

Serving Size 1 Capsule
Servings Per Container 100
Amount Per Serving % DV
Ginkgo biloba Leaf Extract (24% Gingko Flavonglycosides = 28.8 mg)(6% Terpene Lactones = 7.2 mg) 120.00 mg **
** Daily Value (DV) not established

Other Ingredients: Dicalcium Phosphate, Vegetable Cellulose Capsule, Cellulose

No Sugar, No Artificial Colors, No Artificials Flavors, Sodium Free, No Wheat, No Gluten, No Soy, No Dairy, Yeast Free

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition. Discontinue use two weeks prior to surgery.

Distributed by: General Nutrition Corporation Pittsburgh, PA 15222

Health Notes

Ginkgo

Ginkgo
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Glaucoma
Dose: 120 mg daily of a standardized herbal extract
In cases of normal tension glaucoma; ginkgo may help improve vision.(more)
Macular Degeneration
Dose: 120 to 240 mg daily of a standardized herbal extract
Taking ginkgo may help treat early stage macular degeneration.(more)
Retinopathy
Dose: Refer to label instructions
Using a standardized extract of ginkgo has been reported to improve visual function in people with mild diabetic retinopathy.(more)
Age-Related Cognitive Decline
Dose: 120 to 160 daily
Most, but not all, clinical trials have found this herb to be a safe and effective treatment for ARCD. (more)
Macular Degeneration
Dose: 120 to 240 mg daily of a standardized herbal extract
Taking ginkgo may help treat early stage macular degeneration.(more)
Alzheimer's Disease
Dose: 120 to 240 mg of a standardized herbal extract daily
Ginkgo biloba extract is an approved treatment for early-stage Alzheimer's disease in Europe. It is thought to improve memory and quality of life and slow early disease progression. (more)
Intermittent Claudication
Dose: 120 to 160 mg daily
Studies have reported that people with intermittent claudication see improvements in pain-free walking distance when supplementing with ginkgo.(more)
Atherosclerosis
Dose: Refer to label instructions
The herb Ginkgo biloba may reduce atherosclerosis risk by stopping platelets from sticking together too much. It also increases blood circulation to the brain, arms, and legs. (more)
Raynaud's Disease
Dose: Refer to label instructions
The herb Ginkgo has been reported to improve the circulation in small blood vessels and reduce pain in people with Raynaud's disease.(more)
Age-Related Cognitive Decline
Dose: 120 to 160 daily
Most, but not all, clinical trials have found this herb to be a safe and effective treatment for ARCD. (more)
Memory Enhancement
Dose: Refer to label instructions
Ginkgo may enhance cognitive performance in healthy older adults as well as people experiencing cognitive decline.(more)
Erectile Dysfunction
Dose: 60 to 240 mg daily
The herb Ginkgo appears to increase blood flow to the penis.(more)
Erectile Dysfunction
Dose: 60 to 240 mg daily
The herb Ginkgo appears to increase blood flow to the penis.(more)
Vertigo
Dose: 120 to 160 mg a day of a standardized herbal extract
Taking ginkgo may help reduce symptoms.(more)
Tinnitus
Dose: Refer to label instructions
The herb ginkgo may be useful in treating tinnitus.(more)
Meniere's Disease
Dose: Refer to label instructions
Ginkgo has been reported to reduce symptoms of tinnitus, vertigo, and hearing loss due to unspecified inner ear disorders.(more)
Type 2 Diabetes
Dose: Refer to label instructions
Ginkgo may help prevent and treat early-stage diabetic neuropathy.(more)
Retinopathy
Dose: Refer to label instructions
Using a standardized extract of ginkgo has been reported to improve visual function in people with mild diabetic retinopathy.(more)
Type 1 Diabetes
Dose: Refer to label instructions
The herb ginkgo may help prevent and treat early-stage diabetic nerve damage.(more)
Premenstrual Syndrome
Dose: Refer to label instructions
Standardized herbal Ginkgo extract has been shown to alleviate PMS symptoms.(more)
Migraine Headache
Dose: Refer to label instructions
Ginkgo extract may also help because it inhibits the action of a substance known as platelet-activating factor, which may contribute to migraines.(more)
Premenstrual Syndrome
Dose: Refer to label instructions
Standardized herbal Ginkgo extract has been shown to alleviate PMS symptoms.(more)
Asthma
Dose: Refer to label instructions
Supplementing with the herb Ginkgo biloba may improve asthma, as its extracts block the action of a compound that contributes to asthma symptoms. (more)
Vitiligo
Dose: 120 mg daily of a standardized extract
Taking ginkgo may help improve repigmentation of skin.(more)
Glaucoma
Dose: 120 mg daily of a standardized herbal extract

In a double-blind study, supplementation with a standardized extract of Ginkgo biloba in the amount of 40 mg three times a day for four weeks partially reversed visual field damage in people with one type of glaucoma (normal tension glaucoma).1

References

1. Quaranta L, Bettelli S, Uva MG, et al. Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma. Ophthalmology 2003;110:359-62.

Macular Degeneration
Dose: 120 to 240 mg daily of a standardized herbal extract

Ginkgo(Ginkgo biloba) may help treat early-stage macular degeneration, according to small, preliminary clinical trials.1 Many healthcare professionals recommend 120 to 240 mg of standardized extract (24% ginkgo flavone glycosides and 6% terpene lactones) in capsules or tablets per day.

References

1. Lebuisson DA, Leroy L, Reigal G. Treatment of senile macular degeneration with Ginkgo biloba extract: a preliminary double-blind study versus placebo. In Rokan (Ginkgo biloba): Recent Results in Pharmacology and Clinic, Funfgeld FW, ed. Berlin: Springer-Verlag, 1988, 231-6.

Retinopathy
Dose: Refer to label instructions

The use of 160 mg per day of a standardized extract of Ginkgo biloba for six months has been reported in a small double-blind trial1 to improve impaired visual function in people with mild diabetic retinopathy.

References

1. Lanthony P, Cosson JP. The course of color vision in early diabetic retinopathy treated with Ginkgo biloba extract. A preliminary double-blind versus placebo study. J Fr Ophtalmol 1988;11:671-4 [in French].

Age-Related Cognitive Decline
Dose: 120 to 160 daily

Most1, 2, 3, 4, 5, 6, 7 but not all8 clinical trials, many of them double-blind, have found ginkgo supplementation to be a safe and effective treatment for ARCD.9

References

1. Allain H, Raoul P, Lieury A, et al. Effects of two doses of ginkgo biloba extract (EGb 761) on the dual-coding test in elderly subjects. Clin Ther 1993;15(3):549-58.

2. Rai GS, Shovlin C, Wesnes KA. A double-blind, placebo-controlled study of Ginkgo biloba extract ('tanakan') in elderly patients with mild to moderate memory impairment. Curr Med Res Opin 1991;12(6):350-5.

3. Brautigam MRH, Blommaert FA, Verleye G, et al. Treatment of age-related memory complaints with Ginkgo biloba extract: a randomized double-blind placebo-controlled study. Phytomedicine 1998;5:425-34.

4. Wesnes K, Simmons D, Rook M. A double-blind, placebo-controlled trial of Tanakan in the treatment of idiopathic impairment in the elderly. Human Psychopharmacol 1987;2:159-69.

5. Israel L, Dell'Accio E, Martin G, Hugonot R. Ginkgo biloba extract and memory training programs-comparative assessment on elderly outpatients. Psychologie Medicale 1987;19:1431-9.

6. Grabel E. The influence of Ginkgo biloba extract (EGb 761) on mental performance: A double-blind study under computerized measurement conditions in patients with cerebral insufficiency. Fortschr Med 1992;110:73-6.

7. Winther K, Randlov C, Rein E, Mehlsen J. Effects of Ginkgo biloba extract on cognitive function and blood pressure in elderly subjects. Curr Ther Res 1998;59:881-8.

8. van Dongen M, van Rossum E, Kessels A, et al. The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: New results of a randomized clinical trial. J Am Geriatr Soc 2000;48:1183-94.

9. Ihl R, Bachinskaya N, Korczyn AD, et al. Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial. Int J Geriatr Psychiatry 2011;26:1186-94.

Macular Degeneration
Dose: 120 to 240 mg daily of a standardized herbal extract

Ginkgo(Ginkgo biloba) may help treat early-stage macular degeneration, according to small, preliminary clinical trials.1 Many healthcare professionals recommend 120 to 240 mg of standardized extract (24% ginkgo flavone glycosides and 6% terpene lactones) in capsules or tablets per day.

References

1. Lebuisson DA, Leroy L, Reigal G. Treatment of senile macular degeneration with Ginkgo biloba extract: a preliminary double-blind study versus placebo. In Rokan (Ginkgo biloba): Recent Results in Pharmacology and Clinic, Funfgeld FW, ed. Berlin: Springer-Verlag, 1988, 231-6.

Alzheimer's Disease
Dose: 120 to 240 mg of a standardized herbal extract daily

An extract made from the leaves of the Ginkgo biloba tree is an approved treatment for early-stage Alzheimer's disease in Europe. While not a cure, Ginkgo biloba extract may improve memory and quality of life and slow progression in the early stages of the disease. In addition, several double-blind trials have shown that ginkgo is helpful for people in early stages of Alzheimer's disease, as well as for those experiencing another form of dementia known as multi-infarct dementia.1, 2, 3, 4, 5 Ginkgo has been found to be nearly as effective against Alzheimer's disease as donepezil, a prescription drug used to treat the condition.6 One trial reported no effect of ginkgo supplementation in the treatment of Alzheimer's disease, vascular dementia or age-associated memory impairment.7 However, the results of this trial have been criticized, since analysis of the results does not separate those patients with Alzheimer's disease or vascular dementia from those with age-associated memory impairment. A comparison of placebo-controlled trials of ginkgo for Alzheimer's disease concluded that the herb compared favorably with two prescription drugs, donepezil and tacrine, commonly used to treat the condition.8 Research studies have used 120 to 240 mg of ginkgo, standardized to contain 6% terpene lactones and 24% flavone glycosides per day, generally divided into two or three portions. Ginkgo may need to be taken for six to eight weeks before desired actions are noticed. Ginkgo was not effective for preventing Alzheimer's disease in elderly volunteers with normal cognitive function or in those with mild cognitive impairment.9

References

1. Le Bars PL, Katz MM, Berman N, et al. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA 1997;278:1327-32.

2. Hofferberth B. The efficacy of EGb 761 in patients with senile dementia of the Alzheimer type, a double-blind, placebo-controlled study on different levels of investigation. Hum Psychopharmacol 1994;9:215-22.

3. Kanowski S, Herrmann W, Stephan K, et al. Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 1996;29:47-56.

4. Maurer K, Ihl R, Dierks T, Frolich L. Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer's type. J Psychiatr Res 1997;31:645-55.

5. Bachinskaya N, Hoerr R, Ihl R. Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial. Neuropsychiatr Dis Treat 2011;7:209-15.

6. Mazza M, Capuano A, Bria P, Mazza S. Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled double-blind study. Eur J Neurol 2006;13:981-5.

7. van Dongen M, van Rossum E, Kessels A, et al. The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: New results of a randomized clinical trial. J Am Geriatr Soc 2000;48:1183-94.

8. Wettstein A. Cholinesterase inhibitors and Ginkgo extracts-are they comparable in the treatment of dementia? Comparison of published placebo-controlled efficacy studies of at least six months' duration. Phytomedicine 2000;6:393-401.

9. DeKosky ST, Williamson JD, Fitzpatrick AL, et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA 2008;300:2253-62.

Intermittent Claudication
Dose: 120 to 160 mg daily

Extensive studies have been done with Ginkgo biloba extracts (GBE) for treatment of intermittent claudication.1, 2 Two double-blind trials found that 120 mg of GBE per day increased pain-free and total walking distance among people with intermittent claudication.3, 4Similar results were seen in another double-blind trial using 160 mg of GBE per day.5 In yet another double-blind trial, two doses of ginkgo extract were compared for six months.6 The researchers studied 60 vs. 120 mg twice daily and found that, while both amounts resulted in significant improvements in pain-free walking distance, the improvements were more pronounced at the higher dose. One double-blind study found that ginkgo extract was not beneficial.7 However, that study lasted only three months, whereas the positive studies lasted six months. It may take longer than three months for ginkgo to have a beneficial effect in people with intermittent claudication.

References

1. Schneider B. Ginkgo biloba extract in peripheral arterial disease. Meta-analysis of controlled clinical trials. Arzneimittelforschung 1992;42:428-36 [in German].

2. Peters H, Kieser M, Holscher U. Demonstration of the efficacy of Ginkgo biloba special extract EGb 761(R) on intermittent claudication-a placebo-controlled, double-blind multicenter trial. VASA 1998;27:106-10.

3. Bauer U. Six-month double-blind randomised clinical trial of Ginkgo biloba extract versus placebo in two parallel groups in patients suffering from peripheral arterial insufficiency. Arzneimittelforsschung 1984;34:716-20 [in German].

4. Blume J, Kieser M, Holscher U. Placebo-controlled, double-blind study on the efficacy of Ginkgo biloba special extract EGb 761 in maximum-level trained patients with intermittent claudication. Vasa 1996;25:265-74.

5. Blume J, Kieser M, Holscher U. Efficacy of Ginkgo biloba special extract EGb 761 in peripheral occlusive disease. Fortschr Med 1998;116:137-43.

6. Schweizer J, Hautmann C. Comparison of two dosages of Ginkgo biloba extract EGb 761 in patients with peripheral arterial occlusive disease Fontaine's stage IIb. Arzneimittelforschung 1999;49:900-4.

7. Wang J, Zhou S, Bronks R, et al. Supervised exercise training combined with ginkgo biloba treatment for patients with peripheral arterial disease. .Clin Rehabil 2007;21:579-86.

Atherosclerosis
Dose: Refer to label instructions

Ginkgo may reduce the risk of atherosclerosis by interfering with a chemical the body sometimes makes in excess, called platelet activating factor (PAF).1 PAF stimulates platelets to stick together too much; ginkgo stops this from happening. Ginkgo also increases blood circulation to the brain, arms, and legs.2

Garlic and ginkgo also decrease excessive blood coagulation. Both have been shown in double-blind3 and other controlled4 trials to decrease the overactive coagulation of blood that may contribute to atherosclerosis.

Numerous medicinal plants and plant compounds have demonstrated an ability to protect LDL cholesterol from being damaged by free radicals. Garlic,5 ginkgo,6 and guggul7 are of particular note in this regard. Garlic and ginkgo have been most convincingly shown to protect LDL cholesterol in humans.

References

1. Braquet P, Touqui L, Shen TS, Vargaftig BB. Perspectives in platelet activating factor research. Pharmacol Rev 1987;39:97-210.

2. Brown DJ. Herbal Prescriptions for Better Health. Rocklin, CA: Prima Publishing, 1996, 119-28.

3. Kiesewetter H, Jung F, Mrowietz C, et al. Effects of garlic on blood fluidity and fibrinolytic activity: A randomised, placebo-controlled, double-blind study. Br J Clin Pract Suppl 1990;69:24-9.

4. Jung F, Mrowietz C, Kiesewetter H, Wenzel E. Effect of Ginkgo biloba on fluidity of blood and peripheral microcirculation in volunteers. Arzneimittelforschung 1990;40:589-93.

5. Phelps S, Harris WS. Garlic supplementation and lipoprotein oxidation susceptibility. Lipids 1993;28(5):475-7.

6. Yan LJ, Droy-Lefaix MT, Packer L. Ginkgo biloba extract (EGb 761) protects human low density lipoproteins against oxidative modification mediated by copper. Biochem Biophys Res Comm 1995;212:360-6.

7. Singh K, Chander R, Kapoor NK. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytother Res 1997;11:291-4.

Raynaud's Disease
Dose: Refer to label instructions

Ginkgo biloba has been reported to improve the circulation in small blood vessels.1 For that reason, some doctors recommend ginkgo for people with Raynaud's disease. One preliminary trial found that 160 mg of standardized ginkgo extract per day reduced pain in people with Raynaud's disease.2 Larger clinical trials are needed to confirm ginkgo's effectiveness for this condition. Ginkgo is often used as a standardized extract (containing 24% ginkgo flavone glycosides and 6% terpene lactones). Doctors who recommend use of ginkgo often suggest that people take 120-160 mg per day.

References

1. Kleijnen J, Knipschild P. Ginkgo biloba. Lancet 1992;340:1136-9 [review].

2. Clement JL, Livecchi G, Jimenez C, et al. Modifications vasomotrices des extremites lors l'exposition a des conditions thermiques defavorables. Methodologie et resultant de l'etude de l'extrait de Ginkgo biloba. Acutal Angiol 1982;7:3-8.

Age-Related Cognitive Decline
Dose: 120 to 160 daily

Most1, 2, 3, 4, 5, 6, 7 but not all8 clinical trials, many of them double-blind, have found ginkgo supplementation to be a safe and effective treatment for ARCD.9

References

1. Allain H, Raoul P, Lieury A, et al. Effects of two doses of ginkgo biloba extract (EGb 761) on the dual-coding test in elderly subjects. Clin Ther 1993;15(3):549-58.

2. Rai GS, Shovlin C, Wesnes KA. A double-blind, placebo-controlled study of Ginkgo biloba extract ('tanakan') in elderly patients with mild to moderate memory impairment. Curr Med Res Opin 1991;12(6):350-5.

3. Brautigam MRH, Blommaert FA, Verleye G, et al. Treatment of age-related memory complaints with Ginkgo biloba extract: a randomized double-blind placebo-controlled study. Phytomedicine 1998;5:425-34.

4. Wesnes K, Simmons D, Rook M. A double-blind, placebo-controlled trial of Tanakan in the treatment of idiopathic impairment in the elderly. Human Psychopharmacol 1987;2:159-69.

5. Israel L, Dell'Accio E, Martin G, Hugonot R. Ginkgo biloba extract and memory training programs-comparative assessment on elderly outpatients. Psychologie Medicale 1987;19:1431-9.

6. Grabel E. The influence of Ginkgo biloba extract (EGb 761) on mental performance: A double-blind study under computerized measurement conditions in patients with cerebral insufficiency. Fortschr Med 1992;110:73-6.

7. Winther K, Randlov C, Rein E, Mehlsen J. Effects of Ginkgo biloba extract on cognitive function and blood pressure in elderly subjects. Curr Ther Res 1998;59:881-8.

8. van Dongen M, van Rossum E, Kessels A, et al. The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: New results of a randomized clinical trial. J Am Geriatr Soc 2000;48:1183-94.

9. Ihl R, Bachinskaya N, Korczyn AD, et al. Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial. Int J Geriatr Psychiatry 2011;26:1186-94.

Memory Enhancement
Dose: Refer to label instructionsThe terpene lactones found in ginkgo extracts, known as ginkgolides and bilobalide, typically make up approximately 6% of the extract. They are associated with increasing circulation to the brain and other parts of the body and may exert a protective action on nerve cells.1 ginkgo regulates the tone and elasticity of blood vessels,2 making circulation more efficient.3 Ginkgo is also well-known for its effect on memory and thinking (cognitive function). It may enhance cognitive performance in healthy older adults,8 in people with age-related cognitive decline, and in people with Alzheimer's disease.
References

1. Krieglstein J. Neuroprotective properties of Ginkgo biloba-constituents. Zeitschrift Phytother 1994;15:92-6.

2. Clostre F. From the body to the cell membranes: the different levels of pharmacological action of Ginkgo biloba extract. In: Rokan(Ginkgo biloba): Recent Results in Pharmacology and Clinic. Funfgeld EW, ed. Berlin: Springer-Verlag, 1988, 180-98.

3. Jung F, Mrowietz C, Kiesewetter H, Wenzel E. Effect of Ginkgo biloba on fluidity of blood and peripheral microcirculation in volunteers. Arzneimittelforschung 1990;40:589-93.

Erectile Dysfunction
Dose: 60 to 240 mg daily

Ginkgo biloba may help some men with ED by increasing blood flow to the penis. One double-blind trial found improvement in men taking 240 mg per day of a standardized Ginkgo biloba extract (GBE) for nine months.1 A preliminary trial, involving 30 men who were experiencing ED as a result of medication use (selective serotonin reuptake inhibitors and other medications), found that approximately 200 mg per day of GBE had a positive effect on sexual function in 76% of the men.2

References

1. Sohn M, Sikora R. Ginkgo biloba extract in the therapy of erectile dysfunction. J Sex Educ Ther 1991;17:53-61.

2. Cohen AJ, Bartlik B. Ginkgo biloba for antidepressant-induced sexual dysfunction. J Sex Marital Ther 1998;24:139-43.

Erectile Dysfunction
Dose: 60 to 240 mg daily

Ginkgo biloba may help some men with ED by increasing blood flow to the penis. One double-blind trial found improvement in men taking 240 mg per day of a standardized Ginkgo biloba extract (GBE) for nine months.1 A preliminary trial, involving 30 men who were experiencing ED as a result of medication use (selective serotonin reuptake inhibitors and other medications), found that approximately 200 mg per day of GBE had a positive effect on sexual function in 76% of the men.2

References

1. Sohn M, Sikora R. Ginkgo biloba extract in the therapy of erectile dysfunction. J Sex Educ Ther 1991;17:53-61.

2. Cohen AJ, Bartlik B. Ginkgo biloba for antidepressant-induced sexual dysfunction. J Sex Marital Ther 1998;24:139-43.

Vertigo
Dose: 120 to 160 mg a day of a standardized herbal extract

In a preliminary clinical trial, a standardized extract of Ginkgo biloba (GBE) significantly reduced symptoms of vertigo in a group of elderly people with mild cognitive impairment.1 Participants were given 40 mg three times per day for one year. GBE has also been reported to significantly reduce vertigo of unknown cause in preliminary2 and double-blind3 trials. The amounts given were 120 mg and 160 mg per day, respectively, for three months.

References

1. Vorberg G. Ginkgo biloba extract (GBE): A long-term study of cerebral insufficiency in geriatric patients. Clin Trials J 1985;22:149-57.

2. Claussen CF. Diagnostic and practical values of craniocorpography in vertiginous syndromes. Presse Med 1986;15:1565-8 [in French].

3. Haguenauer JP, Cantenot F, Koskas H, Pierart H. Treatment of disturbances of equilibrium with Ginkgo biloba extract: A multicenter, double-blind, drug versus placebo study. Presse Med 1986;15:1569-72 [in French].

Tinnitus
Dose: Refer to label instructions

Ginkgo biloba has been used to treat tinnitus, with mixed results.1 The largest placebo-controlled trial to date failed to find any effect of 150 mg per day of ginkgo extract in people with tinnitus.2 Two smaller, controlled trials have found that standardized ginkgo extract (120 mg per day, containing 24% flavone glycosides and 6% terpene lactones), was effective at relieving the symptoms of tinnitus.3, 4 One trial failed to find ginkgo beneficial, but used less than 30 mg of ginkgo extract per day, an amount unlikely to have any therapeutic effect.5

References

1. Ernst E, Stevinson C. Ginkgo biloba for tinnitus: a review. Clin Otolaryngol 1999;24:164-7.

2. Drew S, Davies E. Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo-controlled trial. BMJ 2001;322:1-6.

3. Meyer B. A multicenter randomized double-blind study of Ginkgo biloba extract versus placebo in the treatment of tinnitus. In Rokan (Ginkgo biloba): Recent Results in Pharmacology and Clinic, ed. EW Funfgeld. New York: Springer-Verlag, 1988, 245-50.

4. Morgenstern C, Biermann E. Ginkgo biloba special extract EGb 761 in the treatment of tinnitus aurium: Results of a randomized, double-blind, placebo-controlled study. Fortschr Med 1997;115:7-11.

5. Holgers K, Axelsson A, Pringle I. Ginkgo biloba extract from the treatment of tinnitus. Audiol 1994;33:85-92.

Meniere's Disease
Dose: Refer to label instructions

Although Ginkgo biloba extract (GBE) has not been studied specifically for its effects in MD, in preliminary studies it has been reported to reduce symptoms of tinnitus, vertigo, and hearing loss due to unspecified inner ear disorders.1 Controlled research using GBE is needed to determine whether it is a treatment option specifically for MD.

References

1. Clostre F. Ginkgo biloba extract (EGb 761). State of knowledge in the dawn of the year 2000. Ann Pharm Fr 1999 ;57:1S8-88 [review; in French].

Type 2 Diabetes
Dose: Refer to label instructionsGinkgo biloba extract may prove useful for prevention and treatment of early-stage diabetic neuropathy, though research is at best very preliminary in this area.1
References

1. Koltringer P, Langsteger W, Lind P, et al. [Ginkgo biloba extract and folic acid in the therapy of changes caused by autonomic neuropathy]. Acta Med Austriaca 1989;16:35-7 [in German].

Retinopathy
Dose: Refer to label instructions

The use of 160 mg per day of a standardized extract of Ginkgo biloba for six months has been reported in a small double-blind trial1 to improve impaired visual function in people with mild diabetic retinopathy.

References

1. Lanthony P, Cosson JP. The course of color vision in early diabetic retinopathy treated with Ginkgo biloba extract. A preliminary double-blind versus placebo study. J Fr Ophtalmol 1988;11:671-4 [in French].

Type 1 Diabetes
Dose: Refer to label instructionsGinkgo biloba extract may prove useful for prevention and treatment of early-stage diabetic nerve damage (neuropathy), though research is at best very preliminary in this area.1
References

1. Koltringer P, Langsteger W, Lind P, et al. [Ginkgo biloba extract and folic acid in the therapy of changes caused by autonomic neuropathy]. Acta Med Austriaca 1989;16:35-7 [in German].

Premenstrual Syndrome
Dose: Refer to label instructions

A double-blind trial has shown that standardized Ginkgo biloba extract, when taken daily from day 16 of one menstrual cycle to day 5 of the next menstrual cycle, alleviates congestive and psychological symptoms of PMS better than placebo.1 The trial used 80 mg of a ginkgo extract two times per day.

References

1. Tamborini A, Taurelle R. Value of standardized Ginkgo biloba extract (EGb 761) in the management of congestive symptoms of premenstrual syndrome. Rev Fr Gynecol Obstet 1993;88:447-57 [in French].

Migraine Headache
Dose: Refer to label instructions

Ginkgo biloba extract may also help because it inhibits the action of a substance known as platelet-activating factor,1 which may contribute to migraines. No clinical trials have examined its effectiveness in treating migraines, however.

References

1. Chung KF, McCusker M, Page CP, et al. Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet 1987;i:248-51.

Premenstrual Syndrome
Dose: Refer to label instructions

A double-blind trial has shown that standardized Ginkgo biloba extract, when taken daily from day 16 of one menstrual cycle to day 5 of the next menstrual cycle, alleviates congestive and psychological symptoms of PMS better than placebo.1 The trial used 80 mg of a ginkgo extract two times per day.

References

1. Tamborini A, Taurelle R. Value of standardized Ginkgo biloba extract (EGb 761) in the management of congestive symptoms of premenstrual syndrome. Rev Fr Gynecol Obstet 1993;88:447-57 [in French].

Asthma
Dose: Refer to label instructions

Ginkgo biloba extracts have been considered a potential therapy for asthma. This is because the extracts block the action of platelet-activating factor (PAF), a compound the body produces that in part causes asthma symptoms. A trial using isolated ginkgolides from ginkgo (not the whole extract) found they reduced asthma symptoms.1 A controlled trial used a highly concentrated tincture of ginkgo leaf and found this preparation helped decrease asthma symptoms.2 For asthma, 120 to 240 mg of standardized ginkgo or 3 to 4 ml of regular tincture three times daily can be used.

References

1. Guinot P, Brambilla C, Dunchier J, et al. Effect of BN 52063, a specific PAF-ascether antagonist, on bronchial provocation test to allergens in asthmatic patients-a preliminary study. Prostaglandins 1987;34:723-31.

2. Li M, Yang B, Yu H, Zhang H. Clinical observation of the therapeutic effect of ginkgo leaf concentrated oral liquor on bronchial asthma. Chinese J Integrative & Western Med 1997;3:264-7.

Vitiligo
Dose: 120 mg daily of a standardized extract

In a double-blind study of 52 people with slowly spreading vitiligo, supplementation with Ginkgo biloba extract (standardized to contain 24% ginkgoflavonglycosides), in the amount of 40 mg three times per day for up to six months, resulted in marked to complete repigmentation in 40% of cases, compared with only 9% among those receiving a placebo.1 Ginkgo was also found to be effective in a preliminary trial.2

References

1. Parsad D, Pandhi R, Juneja A. Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo. Clin Exp Dermatol 2003;28:285-7.

2. Szczurko O, Shear N, Taddio A, Boon H. Ginkgo biloba for the treatment of vitilgo vulgaris: an open label pilot clinical trial. BMC Complement Altern Med 2011;11:21.

Parts Used & Where Grown

Ginkgo biloba is the world's oldest living species of tree. Individual trees live as long as 1,000 years. Ginkgo grows most predominantly in the southern and eastern United States, southern France, China, and Korea. The leaves of the tree are used in modern herbal medicine.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

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GNC HERBAL PLUS STANDARDIZEDGNC Herbal Plus® Ginkgo Biloba 120 MG
 
4.7

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100%

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      (0 of 1 customers found this review helpful)

       
      4.0

      good stuff

      By alenxucheng

      from China

      About Me First Time User, Health Conscious

      See all my reviews

      Pros

      • Easy on Stomach
      • Easy To Swallow
      • Simple To Take

      Cons

        Best Uses

        • Daily Use
        • Older People

        Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Ginkgo Biloba 120 MG:

        Good stuff with good price, $35 for 5, so far not see the obvious improvement on my mother becase just begin to take this pill. however not good smell when opening the bottle, not sure the smell is from pill or the plastic of bottle.

         
        5.0

        This product is very good!

        By jiij2008

        from ca

        About Me First Time User

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        Verified Buyer

        Pros

        • Easy on Stomach
        • Simple To Take

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          • Men

          Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Ginkgo Biloba 120 MG:

          This product is very good, was obvious stretch after you take it

          (1 of 1 customers found this review helpful)

           
          5.0

          Good products!

          By liuxun1987

          from Manchester, NH

          About Me Health Conscious

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          Pros

          • Effective
          • Simple To Take

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            • Older People

            Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Ginkgo Biloba 120 MG:

            One pill each day, makes me better than ever.

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