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GNC Herbal PlusŪ Standardized St. John's Wort

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Description
  • Provides dietary support for a positive mood balance.*
  • May help promote general well being.*
  • Each capsule contains 300 mg St. John's Wort herb extract guaranteed to provide a minimum of 0.3% Hypericum 0.9 mg.
  • Standardized herbs provide uniformity of a single plant chemical batch after batch. Each extract delivers a quantified and measurable level of the targeted active ingredient in every serving. This active ingredient is considered by science to be the key ingredient responsible for the herb's health benefits.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take one to three capsules daily.

Serving Size 1 Capsules
Servings Per Container 200
Amount Per Serving % DV
St. John's Wort Herb Extract (Hypericum perforatum)(0.3% Hypericin = 0.9mg) 300.00 mg **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Vegetable Cellulose Capsule

No Sugar, No Artificial Color, No Artificial Flavors, Sodium Free, No Wheat, No Gluten, No Soy, No Dairy, Yeast Free

Storage Instructions: Store in a cool dry place.

Warning: After opening, keep tightly closed in refrigerator or other cool place.

Consult your physician prior to using this product if you are pregnant, nursing or taking medication, or have a medical condition. Discontinue use two weeks prior to surgery. KEEP OUT OF REACH OF CHILDREN.

Consult your physician prior to using this product if you are pregnant or nursing, taking anti-depressants, birth control pills or other medication, or have a medical condition. Use of this product may cause your skin to be extra sensitive to UV sources, such as artificial or natural sunlight. Avoid excessive exposures from these sources. Discontinue use two weeks prior to surgery.

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Health Notes

St. John's Wort

St. John's Wort
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Depression
Dose: 600 to 1,200 mg daily of a standardized herbal extract containing of 0.3% hypericin, after consulting with a qualified healthcare professional
St. John's wort can help with mild to moderate depression-but talk to your doctor first as St. John's wort can interact with certain medications.(more)
Anxiety
Dose: Refer to label instructions
St. John's wort has been reported in one double-blind study to reduce anxiety.(more)
Seasonal Affective Disorder
Dose: Consult a qualified healthcare practitioner
St. John's wort, an herb well known for its antidepressant activity, may improve SAD symptoms.(more)
Eczema
Dose: Apply a cream containing 5% of an herbal extract standardized to 1.5% hyperforin twice per day
A topical cream containing St. John's wort was shown in one study to greatly improve the severity of eczema. The herb appears to have anti-inflammatory and antibacterial effects.(more)
Wound Healing
Dose: Refer to label instructions
Topically applied St. John's wort can be used to speed wound healing.(more)
Anxiety
Dose: Refer to label instructions
St. John's wort has been reported in one double-blind study to reduce anxiety.(more)
Cold Sores
Dose: Refer to label instructions
In traditional herbal medicine, tinctures of various herbs including St. John's wort have been applied topically to herpes outbreaks in order to promote healing.(more)
Infection
Dose: Refer to label instructions
St. John's wort is an herb that directly attack microbes.(more)
HIV and AIDS Support
Dose: Refer to label instructions
A preliminary trial found that people infected with HIV who took hypericin, a constituent from St. John's wort, had some improvements in CD4+ cell counts.(more)
Menopause and Depression
Dose: Two tablets twice a day for 8 weeks, then one tablet twice a day for 8 weeks, each tablet supplying 1 mg of triterpene glycosides from black cohosh and 0.25 mg of hypericin from St. John's wort
Menopausal and depression symptoms improved in post-menopausal women after they took a combination of black cohosh and St. John's wort. (more)
Menopause
Dose: Refer to label instructions
Supplementing with St. John's wort may improve psychological symptoms, including sexual well-being, in menopausal women.(more)
Menopause and Depression
Dose: Two tablets twice a day for 8 weeks, then one tablet twice a day for 8 weeks, each tablet supplying 1 mg of triterpene glycosides from black cohosh and 0.25 mg of hypericin from St. John's wort
Menopausal and depression symptoms improved in post-menopausal women after they took a combination of black cohosh and St. John's wort. (more)
Menopause
Dose: Refer to label instructions
Supplementing with St. John's wort may improve psychological symptoms, including sexual well-being, in menopausal women.(more)
Ulcerative Colitis
Dose: Refer to label instructions
St. John's wort, administered as an enema, may be beneficial for people with ulcerative colitis.(more)
Ear Infections
Dose: Refer to label instructions
Ear drops with mullein, St. John's wort, and garlic in an oil or glycerin base are traditional remedies used to alleviate symptoms, particularly pain, during acute ear infections.(more)
Cold Sores
Dose: Refer to label instructions
In traditional herbal medicine, tinctures of various herbs including St. John's wort have been applied topically to herpes outbreaks in order to promote healing.(more)
Wound Healing
Dose: Refer to label instructions
Topically applied St. John's wort can be used to speed wound healing.(more)
Ear Infections
Dose: Refer to label instructions
Ear drops with mullein, St. John's wort, and garlic in an oil or glycerin base are traditional remedies used to alleviate symptoms, particularly pain, during acute ear infections.(more)
Depression
Dose: 600 to 1,200 mg daily of a standardized herbal extract containing of 0.3% hypericin, after consulting with a qualified healthcare professional

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

St. John's wort extracts are among the leading medicines used in Germany by medical doctors for the treatment of mild to moderate depression. Using St. John's wort extract can significantly relieve the symptoms of depression. People taking St. John's wort show an improvement in mood and ability to carry out their daily routine. Symptoms such as sadness, hopelessness, worthlessness, exhaustion, and poor sleep also decrease.2, 3, 4

St. John's wort extract has been compared to the prescription tricyclic antidepressants imipramine (Tofranil),5, 6, 7 amitriptyline (Elavil),8 fluoxetine (Prozac(R)),9 and maprotiline (Ludiomil).10 The improvement in symptoms of mild to moderate depression was similar, with notably fewer side effects, in people taking St. John's wort.

In a double-blind trial using standard amounts of fluoxetine (Prozac)-20 mg per day-St. John's wort extract in the amount of 400 mg twice daily was equally effective at relieving depression in people aged 60-80 years.11 Another trial found that 250 mg of St. John's wort extract two times per day was also as effective as 20 mg of fluoxetine in treating adults with mild to moderate depression.12 In both trials comparing St. John's wort to fluoxetine, there were far fewer side effects reported by people taking St. John's wort.

One clinical trial compared a higher amount of the St. John's wort extract LI 160 (1,800 mg per day) with a higher amount of imipramine (150 mg per day) in more severely depressed people.13 Again, the improvement was virtually the same for both groups with far fewer side effects for the St. John's wort group. While this may point to St. John's wort as a possible treatment for more severe cases of depression, this treatment should only be pursued under the guidance of a healthcare professional.

Two well-publicized double-blind studies published in the Journal of the American Medical Association (JAMA) concluded that St. John's wort is not an effective treatment for depression. However, each of these studies had potential flaws. In the first study,14 900-1,200 mg of St. John's wort per day was slightly more effective than a placebo, as assessed by the Hamilton Rating Scale for Depression. However, the difference was not statistically significant. Although the remission rate was significantly greater with St. John's wort than with placebo, only 14.3% of the patients who received the herb went into remission, causing the authors of the report to question St. John's wort's efficacy. However, the 4.9% remission rate in the placebo group was far below the placebo response rate seen in other studies of depression. That finding suggests that many of the patients recruited for this study would have been unlikely to respond to any treatment.

In the second JAMA study, depressed patients were given one of three treatments: St. John's wort, placebo, or an antidepressant medication with proven efficacy (e.g., sertraline; Zoloft). Although St. John's wort was no more effective than the placebo, by many measures neither was sertraline.15 The relatively poor outcome with sertraline makes one wonder whether the design of the study, or the criteria used to select participants, may have somehow skewed the results to make St. John's wort appear less effective than it really is.

Despite these two negative studies, the bulk of the scientific evidence indicates that St. John's wort is an effective treatment for mild to moderate depression.

Recent European trials have successfully treated mild to moderate depression using 500 to 1,050 mg of St. John's wort per day. As an antidepressant, St. John's wort should be taken for four to six weeks before judging its effectiveness.

References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

2. Harrer G, Sommer H. Treatment of mild/moderate depressions with Hypericum. Phytomedicine 1994;1:3-8.

3. Ernst E. St. John's wort, an antidepressant? A systemic, criteria-based review. Phytomedicine 1995;2:67-71.

4. Kasper S, Anghelescu IG, Szegedi A, et al. Superior efficacy of St John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]. BMC Med 2006 Jun 23;4:14.

5. Vorbach EU, Hubner WD, Arnoldt KH. Effectiveness and tolerance of the Hypericum extract LI 160 in comparison with imipramine: Randomized double-blind study with 135 outpatients. J Geriatr Psychiatry Neurol 1994;7(suppl):S19-23.

6. Philipp M, Kohnen R, Hiller KO. Hypericum extract versus imipramine or placebo in patients with moderate depression: randomized multicenter study of treatment for eight weeks. BMJ 1999;319:1534-9.

7. Woelk H. Comparison of St. John's wort and imipramine for treating depression: Randomized controlled trial. BMJ 2000;321:536-9.

8. Wheatley D. LI 160, an extract of St. John's wort versus amitriptyline in mildly to moderately depressed outpatients-controlled six week clinical trial. Pharmacopsychiatry 1997;30(suppl):77-80.

9. Volz HP, Laux P. Potential treatment for subthreshold and mild depression: a comparison of St. John's wort extracts and fluoxetine. Compr Psychiatry 2000;41(2 Suppl 1):133-7 [review].

10. Harrer G, Hubner WD, Poduzweit H. Effectiveness and tolerance of the Hypericum extract LI 160 compared to maprotiline: A multicenter double-blind study. J Geriatr Psychiatry Neurol 1994;7(suppl 1);S24-8.

11. Harrer G, Schmidt U, Kuhn U, Biller A. Comparison of equivalence between the St. John's wort extract LoHyp-57 and fluoxetine. Arzneimittelforschung 1999;49:289-96.

12. Schrader D. Equivalence of St. John's wort extract (ZE 117) and fluoxetine: a randomized, controlled study in mild - moderate depression. International Clin Psychopharmacol 2000;15:61-8.

13. Vorbach EU, Arnoldt KH, Hubner WD. Efficacy and tolerability of St. John's wort extract LI 160 versus imipramine in patients with severe depressive episodes according to ICD-10. Pharmacopsychiatry 1997;30(suppl):81-5.

14. Shelton RC, Keller MB, Gelenberg A, et al. Effectiveness of St John's wort in major depression: a randomized controlled trial. JAMA 2001;285:1978-86.

15. Hypericum Depression Trial Study Group. Effect of Hypericum perforatum (St John's Wort) in major depressive disorder: a randomized controlled trial. JAMA 2002;287:1807-14.

Anxiety
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

St. John's wort has been reported in one double-blind study to reduce anxiety.2

References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

2. Witte B, Harrer G, Kaptan T, et al. Treatment of depressive symptoms with a high concentration Hypericum preparation. A multicenter placebo-controlled double-blind study. Fortschr Med 1995;113:404-8 [in German].

Seasonal Affective Disorder
Dose: Consult a qualified healthcare practitioner

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

St. John's wort, an herb well known for its antidepressant activity,2 has been examined for its effectiveness in treating SAD. In a preliminary trial, patients with seasonal depression were given 900 mg per day of St. John's wort in addition to either bright light (3,000 lux for two hours) or a dim light (300 lux for two hours) placebo.3 Both groups had significant improvement in depressive symptoms, but there was no difference between the groups. The authors concluded that St. John's wort was beneficial with or without bright light therapy, but a placebo effect from the herb cannot be ruled out in this study. Another preliminary study asked 301 SAD patients to report the changes in their symptoms resulting from the use of St. John's wort at 300 mg three times daily.4 Significant overall improvement was reported by these patients. Some of the subjects used light therapy in addition to St. John's wort. They reported more improvement in sleep, but overall improvement was not significantly different from those using St. John's wort alone. Double-blind research is needed to confirm the usefulness of St. John's wort for treating SAD.

References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

2. Kim HL, Streltzer J, Goebert D. St. John's wort for depression: a meta-analysis of well-defined clinical trials. J Nerv Ment Dis 1999;187:532-8 [review].

3. Martinez B, Kasper S, Ruhrmann S, Moller HJ. Hypericum in the treatment of seasonal affective disorders. J Geriatr Psychiatry Neurol 1994;7:S29-33.

4. Wheatley D. Hypericum in seasonal affective disorder (SAD). Curr Med Res Opin 1999;15:33-7.

Eczema
Dose: Apply a cream containing 5% of an herbal extract standardized to 1.5% hyperforin twice per day

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

In a double-blind trial, people with eczema applied a cream containing an extract of St. John's wort to the affected areas on one side of the body, and a placebo (the same cream without the St. John's wort) to the other side. The treatment was administered twice a day for four weeks. The severity of the eczema improved to a significantly greater extent on the side treated with St. John's wort than on the side treated with placebo.2 Although the mechanism by which St. John's wort relieves eczema is not known, it might be due to the anti-inflammatory and antibacterial effects of hyperforin, one of its constituents. The cream used in this study contained 5% of an extract of St. John's wort (standardized to 1.5% hyperforin). As topical application of St. John's wort can cause sensitivity to the sun, care should be taken to avoid excessive sun exposure when using this treatment.
References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

2. Schempp CM, Windeck T, Hezel S, Simon JC. Topical treatment of atopic dermatitis with St. John's wort cream-a randomized, placebo controlled, double blind half-side comparison. Phytomedicine 2003;10(Suppl 4):31-7.

Wound Healing
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

Traditional herbalists sometimes recommend the topical use of herbs such as St. John's wort, calendula, chamomile, and plantain, either alone or in combination, to speed wound healing. Clinical trial in humans have not yet validated this traditional practice.
References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

Anxiety
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

St. John's wort has been reported in one double-blind study to reduce anxiety.2

References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

2. Witte B, Harrer G, Kaptan T, et al. Treatment of depressive symptoms with a high concentration Hypericum preparation. A multicenter placebo-controlled double-blind study. Fortschr Med 1995;113:404-8 [in German].

Cold Sores
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

In traditional herbal medicine, tinctures of various herbs, including St. John's wort, chaparral, goldenseal, myrrh, and echinacea, have been applied topically to herpes outbreaks in order to promote healing.

References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

Infection
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

Herbs that directly attack microbes include the following: chaparral, eucalyptus, garlic, green tea, lemon balm (antiviral), lomatium, myrrh, olive leaf, onion, oregano, pau d'arco (antifungal), rosemary, sage, sandalwood, St. John's wort, tea tree oil, thyme, and usnea.
References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

HIV and AIDS Support
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

A constituent from St. John's wort known as hypericin has been extensively studied as a potential way to kill HIV. A preliminary trial found that people infected with HIV who took 1 mg of hypericin per day by mouth had some improvements in CD4+ cell counts, particularly if they had not previously used AZT.2 A small number of people developed signs of mild liver damage in this study. Another much longer preliminary trial used injectable extracts of St. John's wort twice a week combined with three tablets of a standardized extract of St. John's wort taken three times per day by mouth. This study found not only improvements in CD4+ counts but only 2 of 16 participants developed opportunistic infections.3 No liver damage or any other side effects were noted in this trial. In a later study, much higher amounts of injectable or oral hypericin (0.25 mg/kg body weight or higher) led to serious side effects, primarily extreme sensitivity to sunlight.4 At this point, it is unlikely that isolated hypericin or supplements of St. John's wort extract supplying very high levels of hypericin can safely be used by people with HIV infection, particularly given St. John's wort's many drug interactions.
References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

2. Cooper WC, James J. An observational study of the safety and efficacy of hypericin in HIV+ subjects. Int Conf AIDS 1990;6:369 [abstract no. 2063].

3. Steinbeck-Klose A, Wernet P. Successful long term treatment over 40 months of HIV-patients with intravenous hypericin. Int Conf AIDS 1993;9:470 [abstract no. PO-B26-2012].

4. Gulick RM, McAuliffe V, Holden-Wiltse J, et al. Phase I studies of hypericin, the active compound in St. John's wort, as an antiretroviral agent in HIV-infected adults. AIDS clinical trial group protocols 150 and 258. Ann Intern Med 1999;130:510-4.

Menopause and Depression
Dose: Two tablets twice a day for 8 weeks, then one tablet twice a day for 8 weeks, each tablet supplying 1 mg of triterpene glycosides from black cohosh and 0.25 mg of hypericin from St. John's wort In a double-blind study of postmenopausal women who were experiencing psychological symptoms, a combination of black cohosh and St. John's wort was significantly more effective than a placebo in improving both menopausal symptoms and depression. The product used in this study contained (per tablet) black cohosh standardized to 1 mg of triterpene glycosides and St. John's wort standardized to 0.25 mg of hypericin. The amount taken was two tablets twice a day for eight weeks, followed by one tablet twice a day for eight weeks.1
References

1. Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006;107:247-55.

Menopause
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

In a double-blind study of postmenopausal women who were experiencing psychological symptoms, a combination of black cohosh and St. John's wort was significantly more effective than a placebo in improving both menopausal symptoms and depression. The product used in this study contained (per tablet) black cohosh standardized to 1 mg of triterpene glycosides and St. John's wort standardized to 0.25 mg of hypericin. The amount taken was two tablets twice a day for eight weeks, followed by one tablet twice a day for eight weeks.2

Preliminary evidence suggests that supplementation with St. John's wort extract (300 mg three times daily for 12 weeks) may improve psychological symptoms, including sexual well-being, in menopausal women.34

References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

2. Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006;107:247-55.

3. Grube B, Walper A, Wheatley D. St. John's Wort extract: efficacy for menopausal symptoms of psychological origin. Adv Ther 1999;16:177-86.

4. Al-Akoum M, Maunsell E, Verreault R, et al. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause 2009;16:307-14.

Menopause and Depression
Dose: Two tablets twice a day for 8 weeks, then one tablet twice a day for 8 weeks, each tablet supplying 1 mg of triterpene glycosides from black cohosh and 0.25 mg of hypericin from St. John's wort In a double-blind study of postmenopausal women who were experiencing psychological symptoms, a combination of black cohosh and St. John's wort was significantly more effective than a placebo in improving both menopausal symptoms and depression. The product used in this study contained (per tablet) black cohosh standardized to 1 mg of triterpene glycosides and St. John's wort standardized to 0.25 mg of hypericin. The amount taken was two tablets twice a day for eight weeks, followed by one tablet twice a day for eight weeks.1
References

1. Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006;107:247-55.

Menopause
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

In a double-blind study of postmenopausal women who were experiencing psychological symptoms, a combination of black cohosh and St. John's wort was significantly more effective than a placebo in improving both menopausal symptoms and depression. The product used in this study contained (per tablet) black cohosh standardized to 1 mg of triterpene glycosides and St. John's wort standardized to 0.25 mg of hypericin. The amount taken was two tablets twice a day for eight weeks, followed by one tablet twice a day for eight weeks.2

Preliminary evidence suggests that supplementation with St. John's wort extract (300 mg three times daily for 12 weeks) may improve psychological symptoms, including sexual well-being, in menopausal women.34

References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

2. Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006;107:247-55.

3. Grube B, Walper A, Wheatley D. St. John's Wort extract: efficacy for menopausal symptoms of psychological origin. Adv Ther 1999;16:177-86.

4. Al-Akoum M, Maunsell E, Verreault R, et al. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause 2009;16:307-14.

Ulcerative Colitis
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

Enemas of oil of St. John's wort may be beneficial for ulcerative colitis.2 Consult with a doctor before using St. John's wort oil enemas.
References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

2. Weiss RF. Herbal Medicine. Beaconsfield, UK: Beaconsfield Publishers Ltd, 1989, 114-5.

Ear Infections
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

Ear drops with mullein, St. John's wort, and garlic in an oil or glycerin base are traditional remedies used to alleviate symptoms, particularly pain, during acute ear infections. No clinical trials have investigated the effects of these herbs in people with ear infections. Moreover, oil preparations may obscure a physician's view of the ear drum and should only be used with a healthcare professional's directions.
References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

Cold Sores
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

In traditional herbal medicine, tinctures of various herbs, including St. John's wort, chaparral, goldenseal, myrrh, and echinacea, have been applied topically to herpes outbreaks in order to promote healing.

References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

Wound Healing
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

Traditional herbalists sometimes recommend the topical use of herbs such as St. John's wort, calendula, chamomile, and plantain, either alone or in combination, to speed wound healing. Clinical trial in humans have not yet validated this traditional practice.
References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

Ear Infections
Dose: Refer to label instructions

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.1 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

Ear drops with mullein, St. John's wort, and garlic in an oil or glycerin base are traditional remedies used to alleviate symptoms, particularly pain, during acute ear infections. No clinical trials have investigated the effects of these herbs in people with ear infections. Moreover, oil preparations may obscure a physician's view of the ear drum and should only be used with a healthcare professional's directions.
References

1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

Parts Used & Where Grown

St. John's wort is found in Europe and the United States. It is especially abundant in northern California and southern Oregon. The above-ground (aerial) parts of the plant are gathered during the flowering season.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC HERBAL PLUS STANDARDIZEDGNC Herbal Plus® Standardized St. John's Wort
 
4.5

(based on 24 reviews)

92%

of respondents would recommend this to a friend.

Pros

  • Effective (20)
  • Good value (10)
  • No side effects (9)
  • Long lasting (6)

Cons

    Best Uses

    • Daily use (21)
    • Good alternative (12)
    • Good supplement (10)
    • Preventative (3)
    • Recovery (3)
      • Reviewer Profile:
      • First time user (13), Health conscious (12)

    Reviewed by 24 customers

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    (8 of 8 customers found this review helpful)

     
    5.0

    Best St. John's Wort Supplement

    By bottexma

    from Midwest

    About Me Health Conscious

    See all my reviews

    Pros

    • Effective

    Cons

      Best Uses

      • Daily Use
      • Good Alternative
      • Good Supplement

      Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

      I have suffered from moderate depression for the past couple years. On top of that I also have Seasonal Affective Disorder (winter blues). This product works just as well as the antidepressants I used to take without side effects (and that weird wired feeling some people get). I take about 1 capsule a day, sometimes if I have a busy/long day I'll take an extra one in the afternoon.

      I've been taking it for 3 weeks and started noticing a big difference after like 10 days. I no longer suffer from fatigue, I sleep better, I have more energy throughout the day, and I can focus a lot better on my work! This product is wonderful & works way better than the St. John's Wort supplements I bought at the super market. Plus you're paying for 200 capsules, that's more than half a year's supply!

      (3 of 3 customers found this review helpful)

       
      5.0

      it works

      By wineylee

      from Madison, WI

      About Me First Time User

      See all my reviews

      Pros

      • Effective
      • No Side Effects

      Cons

        Best Uses

        • Daily Use
        • Good Alternative

        Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

        I've been troubled by crazy dreams for years. By crazy, I mean someone always dies in my dream then I end up waking up feeling so depressed and that feeling could haunt me for days.
        I've taken this for a month, 2 caps/day. I didn't notice too big of a change until I was cut off from it for two days then those depressing dreams came back.
        When I'm on it, I still make a lot of dreams but none of that would be that depressing. Now I'm planning on start taking 3 caps/day.

        (0 of 5 customers found this review helpful)

         
        1.0

        Didn't benefit sleep ???

        By MarkFred

        from Pittsburgh, PA

        See all my reviews

        Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

        I read comments around addressing sleep issues, which I have. I figured if I get some relief from these issues & improved mode; win-win. However, after taking this supplement for two weeks, I consistently experienced degraded sleep quality. It's definitely going back to the store.

        (2 of 2 customers found this review helpful)

         
        5.0

        absolutely love this product

        By frederickkenyon

        from binghamton,ny

        About Me Makes Me Feel More Balanc

        See all my reviews

        Pros

        • Effective
        • Evens Me Out
        • No Side Effects
        • Works great

        Cons

        • Very Pricery

        Best Uses

        • Daily Use
        • Good Supplement

        Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

        its very pricey but worth it I feel more balanced as far as it helps me be less cranky.it gives me more pep in the mornings to get my day started.

        (6 of 6 customers found this review helpful)

         
        5.0

        WARNING,don't take 6 3x's a day

        By peggyrawley

        from delaware

        About Me First Time User

        See all my reviews

        Pros

        • Effective
        • Good Value
        • Long Lasting

        Cons

        • Side Effects

        Best Uses

        • Daily Use
        • Good Alternative

        Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

        i did what one reviewer said(stupid me,i wanted to feel better quick ) took 6 3 x's a day. after 2 weeks,some of my body felt sunburnt. if i scratched my hands or arms w/fingernail,it was very painful.felt like being cut w/ a sharp knife. i stopped taking for few days,then took 3 a day.(like says on bottle)and have returned to normal. (so to speak lol). feel much better . the pills do work,i have very stressful job and has helped me alot.

        (5 of 5 customers found this review helpful)

         
        5.0

        Works

        By josephj

        from Florida

        About Me First Time User

        See all my reviews

        Verified Buyer

        Pros

        • Effective
        • Good Value
        • No Side Effects

        Cons

          Best Uses

          • Daily Use

          Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

          Use it for very very mild depression and it works great!

          (6 of 8 customers found this review helpful)

           
          4.0

          Well worth buy one get one 50%

          By bdangler2007

          from Columbus, Ohio

          About Me Health Conscious

          See all my reviews

          Pros

          • Effective
          • Good Value

          Cons

          • Poor Taste

          Best Uses

          • Daily Use

          Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

          Caution St. John's Wort Users: Other brands do not use a third party tester and can lie about what is really in your product. Use GNC or Nature's Made

          (3 of 4 customers found this review helpful)

           
          5.0

          St John Wart

          By raje9102

          from Tulsa, OK

          See all my reviews

          Verified Buyer

          Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

          Wondeful product...very competitively priced.

          (2 of 2 customers found this review helpful)

           
          5.0

          Awesome product

          By erik.goad

          from SF, CA

          See all my reviews

          Pros

          • Effective
          • Good Value
          • No Side Effects

          Cons

            Best Uses

            • Daily Use
            • Good Supplement

            Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

            Effective and easy to take. Buy one get one half off makes it super cost effective.

            (8 of 8 customers found this review helpful)

             
            5.0

            Amazing Product

            By cllabenz

            from Louisburg, NC

            About Me First Time User

            See all my reviews

            Verified Buyer

            Pros

            • Effective
            • Good Value
            • Long Lasting
            • No Side Effects

            Cons

              Best Uses

              • Daily Use
              • Preventative

              Comments about GNC HERBAL PLUS STANDARDIZED GNC Herbal Plus® Standardized St. John's Wort:

              I could sense a difference after taking the product for three days. It gives you an overall feeling of well being. Handling stress was accomplished much easier. I love this product!

              Displaying reviews 1-10

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