GNC SAM-e 400 mg

GNC SAM-e 400 mg
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GNC SAM-e 400 mg

30 Enteric Coated Tablets


Price: $38.99

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  • Promotes positive mood balance*
  • Clinically proven benefits for joint support*
  • Supports healthy liver function*
A report published by the US Department of Health and Human Services suggests that SAM-e provides clinically significant health benefits for individuals seeking mood support (1600 mg daily), joint comfort and healthy liver function (1200 mg daily).* SAM-e provides mood support, as well as relief to joint discomfort, and these benefits are comparable to conventional therapies.*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Supplement Facts
As a dietary supplement, take one tablet in the morning and one tablet in the afternoon for the first week. If after the first week the desired benefits are not achieved, then you may require a higher level of supplementation. Gradually increase the number of tablets up to four tablets in divided doses of two tablets (800 mg) throughout the day until benefits are achieved. Do not exceed four tablets daily.
Serving Size   1 Tablet
Servings Per Container  30
Amount Per Serving   % DV
SAM-e (S-adenosyl-methionine) (as Disulfate Monotosylate)    400.00 mg   ** 
 ** Daily Value (DV) not established

Other Ingredients:  Core: Microcrystalline Cellulose, Mannitol, Sodium Starch Glycolate, Silica, Glycerol Monostearate., Coating: Methacrylic Acid Copolymer, Glycerol Palmitostearate, Medium Chain Triglycerides, Titanium Dioxide, Silica, Talc, Triethyl Citrate, FD&C Yellow #5

Warning:  Do not use if pregnant or nursing. Do not exceed recommended dose. If you are taking medication or are under the care of a physician for depression or related disorder, contact your physician before using this product. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use. Caution: Do not use if tamper-evident printed foil seal over tablets is broken.

Distributed by: Gereral Nutrition Corporation Pittsburgh, PA 15222
Health Notes


  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Used for AmountWhy
Liver Cirrhosis
1,200 mg daily3 stars[3 stars]
Taking SAMe may improve liver function, bile flow, and survival.
1200 mg daily3 stars[3 stars]
SAMe has anti-inflammatory, pain-relieving, and tissue-healing properties that may help protect the health of joints and reduce osteoarthritis symptoms.
1,600 mg daily2 stars[2 stars]
SAMe appears to raise levels of dopamine, an important neurotransmitter in mood regulation.
800 mg daily2 stars[2 stars]
Supplementing with SAMe may increase serotonin levels in the blood and help relieve symptoms.
Hepatitis and Cholestasis
1,600 mg daily2 stars[2 stars]
Supplementing with SAMe may help resolve blocked bile flow.
Pregnancy and Postpartum Support and Cholestasis
Refer to label instructions 2 stars[2 stars]
SAMe (S-adenosylmethionine) supplementation has been shown to aid in the resolution of blocked bile flow (cholestasis), an occasional complication of pregnancy.34, 35
Bipolar Disorder
Refer to label instructions 1 star[1 star]
SAMe is an amino acid that has an impact on serotonin levels, it has shown significant antidepressant effects in clinical trials.
Male Infertility
Refer to label instructions 1 star[1 star]
Preliminary research suggests that oral SAMe may also increase sperm activity in infertile men.
Migraine Headache
Refer to label instructions 1 star[1 star]
Preliminary research suggests that supplementing with SAMe may reduce symptoms for some migraine sufferers.

S-adenosyl-l-methionine (SAMe) is an important biological agent in the human body, participating in over 40 essential biochemical reactions.

Copyright 2014 Aisle7. All rights reserved.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews


by PowerReviews

(based on 2 reviews)

Reviewed by 2 customers

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Love this stuff

By btessene

from Wisconsin

About Me Brand Buyer

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  • Easy To Use
  • Effective


    Best Uses

    • Daily Use

    Comments about MISCELLANEOUS GNC SAM-e 400 mg:

    I really like this Sam-E. It does not irritate my stomach. I started taking it to relieve pain in my legs from walking. Now It really puts me in a fantastic mood. I started out using it once a day now I take it morning and night. I also give it to my dog, he has bad hips and is always pulling muscles so I started him on it to. It works wonderful. With being in such a good mood and no more leg pains I can exercise even more. I also get a lot done around the house.

    (23 of 24 customers found this review helpful)



    By andershine

    from portland or



      • Stomach upset

      Best Uses

        Comments about MISCELLANEOUS GNC SAM-e 400 mg:

        They changed the ingrediants to contain mannitol which gives you stomach pain, bloating and gas!! NO THANK YOU GNC.. I was very pleased with thier Sam - e before they changed the formula, this is VERY DISSAPPOINTING.

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