As a dietary supplement, take two capsules before activity.
|Serving Size 2 Capsules|
|Servings Per Container 30|
|Amount Per Serving||% DV|
|Men's Staminol™ Proprietary Blend||200.00 mg||**|
|Maca Powder (Lepidium meyenii)||**|
|Kola Nut (Kola Nitida)||175.00 mg||**|
|Oat Straw Stems (Avena Sativa)||150.00 mg||**|
|GABA (gamma-Aminobutyric Acid)||100.00 mg||**|
|Nettle Leaf (Urtica dioica)||100.00 mg||**|
|Yohimbe Bark Extract (Pausinystalia yohimba) (bark)||60.00 mg||**|
|Horny Goat Weed (Epimedium sagittatum)||20.00 mg||**|
|Catuaba Bark (Erytroxylum catuaba)||10.00 mg||**|
|Muira Root (Ptychopetalum olacoides)||10.00 mg||**|
|Damiana Leaf (Turnera aphrodisiaca)||10.00 mg||**|
|Saw Palmetto Berry (Serenoa repens)||10.00 mg||**|
|** Daily Value (DV) not established|
Other Ingredients: Gelatin, Di-Calcium Phosphate
No Sugar, No Artificial Color, No Artificial Flavors, Sodium Free, No Soy, No Dairy, Yeast Free
Storage Instructions: Store in a cool, dry place.
Warning: Keep out of reach of children.
Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery. Use only as directed. Do not exceed recommended daily intake.
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General Nutrition Corporation
Pittsburgh, PA 15222
Dilation of blood vessels necessary for a normal erection depends on a substance called nitric oxide, and nitric oxide formation depends on the amino acid arginine. In a preliminary trial, men with ED were given 2,800 mg of arginine per day for two weeks. Six of the 15 men in the trial were helped, though none improved while taking placebo.1 In a larger double-blind trial, men with ED were given 1,670 mg of arginine per day or a matching placebo for six weeks.2 Arginine supplementation was found to be particularly effective at improving ED in men with abnormal nitric oxide metabolism. Although little is known about how effective arginine will be for men with ED or which subset of these men would be helped, available research looks promising and suggests that at least some men are likely to benefit.
1. Zorgniotti AW, Lizza EF. Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction. Int J Impot Res 1994;6:33-6.
2. Chen J, Wollman Y, Chernichovsky T, et al. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized study. BJU Int 1999;83:269-73.
Arginine, an amino acid found in many foods, is needed to produce sperm. Research, most of which is preliminary shows that several months of L-arginine supplementation increases sperm count, quality,1, 2, 3 and fertility.4, 5 However, when the initial sperm count was extremely low (such as less than 10 million per ml), L-arginine supplementation produced little or no benefit.6, 7 While some pregnancies have been attributed to arginine supplementation in preliminary reports,8 no controlled research has confirmed these claims. For infertile men with sperm counts greater than 10 million per milliliter, many doctors recommend up to 4 grams of L-arginine per day for several months.
1. De Aloysio D, Mantuano R, Mauloni M, Nicoletti G. The clinical use of arginine aspartate in male infertility. Acta Eur Fertil 1982;13:133-67.
2. Tanimura J. Studies on arginine in human semen. Part II. The effects of medication with L-arginine-HCl on male infertility. Bull Osaka Med School 1967;13:84-9.
3. Scibona M, Meschini P, Capparelli S, et al. L-arginine and male infertility. Minerva Urol Nefrol 1994;46:251-3.
4. Schacter A, Goldman JA, Zukerman Z. Treatment of oligospermia with the amino acid arginine. J Urol 1973;110:311-3.
5. Schacter A, Friedman S, Goldman JA, Eckerling B. Treatment of oligospermia with the amino acid arginine. Int J Gynaecol Obstet 1973;11:206-9.
6. Mroueh A. Effect of arginine on oligospermia. Fertil Steril 1970:21:217-9.
7. Pryor JP, Blandy JP, Evans P, et al. Controlled clinical trial of arginine for infertile men with oligozoospermia. Br J Urol 1978;50:47-50.
8. Aydin S, Inci O, Alagol B. The role of arginine, indomethacin and kallikrein in the treatment of oligoasthenospermia. Int Urol Nephrol 1995;27:199-202.
Nitroglycerin and similar drugs cause dilation of arteries by interacting with nitric oxide, a potent stimulus for dilation. Nitric oxide is made from arginine, a common amino acid. Blood cells in people with angina are known to make insufficient nitric oxide,1 which may in part be due to abnormalities of arginine metabolism. Taking 2 grams of arginine three times per day for as little as three days has improved the ability of angina sufferers to exercise.2 Seven of ten people with severe angina improved dramatically after taking 9 grams of arginine per day for three months in an uncontrolled study.3 Detailed studies have investigated the mechanism of arginine and have proven it operates by stimulating blood vessel dilation.4
1. Mollace V, Romeo F, Martuscelli E, et al. Low formation of nitric oxide in polymorphonuclear cells in unstable angina pectoris. Am J Cardiol 1994;74:65-8.
2. Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol 1997;80:331-3.
3. Blum A, Porat R, Rosenschein U, et al. Clinical and inflammatory effects of dietary L-arginine in patients with intractable angina pectoris. Am J Cardiol 1999;83:1488-90.
4. Egashira K, Hirooka Y, Kuga T, et al. Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. Circulation 1996;94:130-4.
The body needs arginine, another amino acid, to make nitric oxide, which increases blood flow. This process is impaired in people with CHF. Arginine supplementation (5.6-12.6 grams per day) has been used successfully in double-blind trials to treat CHF.1A double-blind trial has also found that arginine supplementation (5 grams three times daily) improves kidney function in people with CHF.2
1. Rector TS, Bank A, Mullen KA, et al. Randomized, double-blind, placebo controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
2. Watanabe G, Tomiyama H, Doba N. Effects of oral administration of L-arginine on renal function in patients with heart failure. J Hypertens 2000;18:229-34.
The amino acid arginine is needed by the body to make nitric oxide, a substance that allows blood vessels to dilate, thus leading to reduced blood pressure. Intravenous administration of arginine has reduced blood pressure in humans in some reports.1 In one controlled trial, people not responding to conventional medication for their hypertension were found to respond to a combination of conventional medication and oral arginine (2 grams taken three times per day.)2
1. Calver A, Collier J, Vallance P. Dilator actions of arginine in human peripheral vasculature. Clin Sci 1991;81:695-700.
2. Pezza V, Bernardini F, Pezza E, et al. Study of supplemental oral l-arginine in hypertensives treated with enalapril + hydrochlorothiazide. Am J Hypertens 1998;11:1267-70 [letter].
The amino acid arginine has a role in immune function, infection prevention, and tissue repair after injury, including surgery.1 Animal research suggests that supplemental arginine may improve the outcomes in cardiovascular2 and colon surgeries.3 Other animal studies suggest a possible role for arginine in prevention of adhesions, a painful type of internal scarring that can occur with surgery.4 Human trials of formulas including arginine are discussed below, but the benefits of supplemental arginine alone have not been studied in surgery patients.
1. Evoy D, Lieberman MD, Fahey TJ 3rd, Daly JM. Immunonutrition: the role of arginine. Nutrition 1998;14:611-7 [review].
2. Szabo G, Bahrle S, Batkai S, et al. L-arginine: effect on reperfusion injury after heart transplantation. World J Surg 1998;22:791-7.
3. Shashidharan M, Lin KM, Ternent CA, et al. Influence of arginine dietary supplementation on healing colonic anastomosis in the rat. Dis Colon Rectum 1999;42:1613-7.
4. Kaleli B, Ozden A, Aybek Z, Bostanci B. The effect of L-arginine and pentoxifylline on postoperative adhesion formation. Acta Obstet Gynecol Scand 1998;77:377-80.
The combination of glutamine, arginine, and the amino acid derivative, hydroxymethylbutyrate (HMB), may prevent loss of lean body mass in people with AIDS-associated wasting. In a double-blind trial, AIDS patients who had lost 5% of their body weight in the previous three months received either placebo or a nutrient mixture containing 1.5 grams of HMB, 7 grams of L-glutamine, and 7 grams of L-arginine twice daily for eight weeks.1 Those supplemented with placebo gained an average of 0.37 pounds, mostly fat, but lost lean body mass. Those taking the nutrient mixture gained an average of 3 pounds, 85% of which was lean body weight.
Various amino acids have shown promise for people with gastritis. In a double-blind trial, taking 200 mg of cysteine four times daily provided significant benefit for people with bleeding gastritis caused by NSAIDs (such as aspirin).1 Cysteine is a sulfur-containing amino acid that stimulates healing of gastritis. In a preliminary trial, 1-4 grams per day of NAC (N-acetyl cysteine) given to people with atrophic gastritis for four weeks appeared to increase healing.2Glutamine, another amino acid is a main energy source for cells in the stomach and supplementation may increase blood flow to this region.3 Patients in surgical intensive care units often develop gastrointestinal problems related to a glutamine deficiency.4 When burn victims were supplemented with glutamine, they did not develop stress ulcers, even after several operations.5 Nevertheless, it remains unclear to what extent glutamine supplementation might prevent or help existing gastritis. Preliminary evidence suggests the amino acid arginine may both protect the stomach and increase its blood flow,6 but research has yet to investigate the effects of arginine supplementation in people with gastritis.
1. Salim AS. Sulfhydryl-containing agents in the treatment of gastric bleeding induced by non-steroidal anti-inflammatory drugs. Can J Surg 1993;36(1):53-8.
2. Farinati F, Cardin R, Della Libera G, et al. Effects of N-acetyl-L-cysteine in patients with chronic atrophic gastritis and nonulcer dyspepsia: a phase III pilot study. Curr Ther Res 1997;58:724-33.
3. Houdijk AP, Van Leeuwen PA, Boermeester MA, et al. Glutamine-enriched enteral diet increases splanchnic blood flow in the rat. Am J Physiol 1994;267(6 Pt 1):G1035-40.
4. Wilmore DW, Smith RJ, O'Dwyer ST, et al. The gut: a central organ after surgical stress. Surgery 1988;104:917-23.
5. Yan R, Sun Y, Sun R. Early enteral feeding and supplement of glutamine prevent occurrence of stress ulcer following severe thermal injury. Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih 1995;11(3):189-92.
6. Brzozowski T, Konturek SJ, Sliwowski Z, et al. Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing. J Gastroenterol 1997;32(4):442-52.
Arginine supplementation increases protein synthesis and improves wound healing in animals.1 Two controlled trials have shown increased tissue synthesis in surgical wounds in people given 17-25 grams of oral arginine per day.2, 3
1. Barbul A, Rettura G, Levenson SM, et al. Wound healing and thymotropic effects of arginine: a pituitary mechanism of action. Am J Clin Nutr 1983;37:786-94.
2. Kirk SJ, Hurson M, Regan MC, et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery 1993;114:155-60.
3. Barbul A, Lazarou SA, Efron DT, et al. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery 1990;108:331-7.
At very high intakes (approximately 250 mg per 2.2 pounds of body weight), the amino acid arginine has increased growth hormone levels,1 an effect that has interested body builders due to the role of growth hormone in stimulating muscle growth.2 However, at lower amounts recommended by some manufacturers (5 grams taken 30 minutes before exercise), arginine failed to increase growth hormone release and may even have impaired the release of growth hormone in younger adults.3 Large quantities (170 mg per 2.2 pounds of body weight per day) of a related amino acid, ornithine, have also raised growth hormone levels in some athletes.4 High amounts of arginine or ornithine do not appear to raise levels of insulin,5, 6 another anabolic (bodybuilding) hormone. More modest amounts of a combination of these amino acids have not had measurable effects on any anabolic hormone levels during exercise.7, 8
Nonetheless, double-blind trials conducted by one group of researchers, combining weight training with either arginine and ornithine (500 mg of each, twice per day, five times per week) or placebo, found the amino-acid combination produced decreases in body fat,9 resulted in higher total strength and lean body mass, and reduced evidence of tissue breakdown after only five weeks.10
1. Besset A, Bonardet A, Rondouin G, et al. Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta Endocrinol 1982;99:18-23.
2. Macintyre JG. Growth hormone and athletes. Sports Med 1987;4:129-42 [review].
3. Marcell TJ, Taaffe DR, Hawkins SA, et al. Oral arginine does not stimulate basal or augment exercise-induced GH secretion in either young or old adults. J Gerontol A Biol Sci Med Sci 1999;54:M395-9.
4. Bucci L, Hickson JF, Pivarnik JF, et al. Ornithine ingestion and growth hormone release in body-builders. Nutr Res 1990;10:239-45.
5. Gater DR, Gater DA, Uribe JM, et al. Effects of arginine/lysine supplementation and resistance training on glucose tolerance. J Appl Physiol 1992;72:1279-84.
6. Bucci LR, Hickson JF Jr, Wolinsky I, et al. Ornithine supplementation and insulin release in bodybuilders. Int J Sport Nutr 1992;2:287-91.
7. Suminski RR, Robertson RJ, Goss FL, et al. Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men. Int J Sport Nutr 1997;7:48-60.
8. Fogelholm GM, Naveri HK, Kiilavuori KT, et al. Low-dose amino acid supplementation: no effects on serum human growth hormone and insulin in male weightlifters. Int J Sport Nutr 1993;3:290-7.
9. Elam RP. Morphological changes in adult males from resistance exercise and amino acid supplementation. J Sports Med Phys Fitness 1988;28:35-9.
10. Elam RP, Hardin DH, Sutton RA, et al. Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males. J Sports Med Phys Fitness 1989;29:52-6.
2. Macintyre JG. Growth hormone and athletes. Sports Med 1987;4:129-42 [review].
Supplementation with the amino acid, L-arginine (16 grams per day), has been shown to improve fertilization rates in women with a previous history of failed attempts at in vitro (test tube) fertilization.1
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