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GNC Total Lean™ Chitosan with Glucomannan

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120 Capsules

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Description
  • Proprietary fiber blend
  • Featuring all-natural marine fiber


Visit www.gnc.com.totallean for a complementary meal plan.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take two capsules with at least 8 fl. oz. of water or other fluid daily. Taking this product without enough liquid may cause choking. See warning.

Serving Size 2 Capsules
Servings Per Container 60
Amount Per Serving % DV
Total Carbohydrate 1.00 g 1%
Dietary Fiber 1.00 g 4%
Chitosan 1000.00 mg 0%
Proprietary Blend 400.00 mg 0%
 Psyllium Seed Husks Powder (Plantago ovata) **
 Glucomannan Powder (Amoraphophalllus konjac) **
 Inulin **
 Fructooligosaccharides (FOS) **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Gelatin

No Starch, No Artificial Colors, No Artificial Flavors, Sodium Free, No Wheat, No Gluten, No Corn, No Soy, No Dairy, Yeast Free

Storage Instructions: Store in a cool dry place.

Warning: Taking this product without adequate fluid may cause it to swell and block your throat or esophagus and may cause choking. Do not take this product if you have difficulty in swallowing. If you experience chest pain, vomiting, or difficulty in swallowing or breathing after taking this product, seek immediate medical attention.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.

Keep out of reach of children

Contains: Crustaceans (shrimp)

Distributed by:General Nutrition CorporationPittsburgh, PA 15222Made in the USA

Health Notes

Chitosan

Chitosan
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Obesity
Dose: Refer to label instructions
Chitosan is a fiber-like substance that may reduce fat absorption. One study found it to be an effective weight-loss aid.(more)
High Cholesterol
Dose: Refer to label instructions
Chitosan is a fiber-like supplement that has been shown to lower cholesterol and raise HDL ("good") cholesterol).(more)
Kidney Failure
Dose: Refer to label instructions
(more)
Obesity
Dose: Refer to label instructionsChitosan is a fiber-like substance extracted from the shells of crustaceans such as shrimp and crab. Animal studies suggested that chitosan supplementation reduces fat absorption, but controlled human trials have found no impairment of fat absorption from supplementation with 2,700 mg of chitosan per day for seven days or 5,250 mg per day for four days.1, 2 A double-blind study found that people taking 1,500 mg of chitosan three times per day during a weight-loss program lost significantly more weight than did people taking a placebo with the same program.3 Similar benefits were seen in another double-blind study that used 3,000 mg of chitosan per day.4 Other studies using smaller amounts of chitosan have reported no effects on weight loss.5, 6, 7
References

1. Gades MD, Stern JS. Chitosan supplementation does not affect fat absorption in healthy males fed a high-fat diet, a pilot study. Int J Obes Relat Metab Disord 2002;26:119-22.

2. Guerciolini R, Radu-Radulescu L, Boldrin M, et al. Comparative evaluation of fecal fat excretion induced by orlistat and chitosan. Obes Res 2001;9:364-7.

3. Zahorska-Markiewicz B, Krotkiewski M, Olszanecka-Glinianowicz M, Zurakowski A. Effect of chitosan in complex management of obesity. Pol Merkuriusz Lek 2002;13:129-32 [in Polish].

4. Kaats GR, Michalek JE, Preuss HG. Evaluating efficacy of a chitosan product using a double-blinded, placebo-controlled protocol. J Am Coll Nutr 2006;25:389-94.

5. Ho SC, Tai ES, Eng PH, et al. In the absence of dietary surveillance, chitosan does not reduce plasma lipids or obesity in hypercholesterolaemic obese Asian subjects. Singapore Med J 2001;42:006-10.

6. Pittler MH, Abbot NC, Harkness EF, Ernst E. Randomized, double-blind trial of chitosan for body weight reduction. Eur J Clin Nutr 1999;53:379-81.

7. Muzzarelli RA. Clinical and biochemical evaluation of chitosan for hypercholesterolemia and overweight control. EXS 1999;87:293-304 [review].

High Cholesterol
Dose: Refer to label instructions

The fiber-like supplement chitosan appears to reduce the absorption of bile acids or cholesterol; either of these effects may cause a lowering of blood cholesterol. 1 This effect has been repeatedly demonstrated in animals, and a preliminary human study showed that 3 to 6 grams per day of chitosan taken for two weeks resulted in a 6% drop in cholesterol and a 10% increase in HDL ("good") cholesterol.2 Another preliminary trial showed a 43% lowering of total cholesterol in people being treated for kidney failure with dialysis who took 4 grams per day of chitosan for 12 weeks. These people also appeared to have improved kidney function and less severe anemia after chitosan treatment. 3 In a double-blind trial, however, administration of 2.4 grams of chitosan per day for three months to people with high cholesterol had no effect on their cholesterol levels. 4 Another study also found no cholesterol-lowering effect of chitosan when taken in amounts up to 6.75 grams per day for 8 weeks.5

Chitosan in large amounts, given with vitamin C, has been shown to reduce dietary fat absorption in animals fed a high-fat diet.6, 7, 8 However, the absorption of minerals and fat-soluble vitamins was also reduced by feeding animals large amounts of chitosan.9 In studies in humans, chitosan did not reduce the absorption of dietary fat.10, 11

References

1. Koide SS. Chitin-chitosan: properties, benefits and risks. Nutr Res 1998;18:1091-101 [review].

2. Maezaki Y, Tsuji K, Nakagawa Y, et al. Hypocholesterolemic effect of chitosan in adult males. Biosci Biotech Biochem 1993;57:1439-44.

3. Jing SB, Li L, Ji D, et al. Effect of chitosan on renal function in patients with chronic renal failure. J Pharm Pharmacol 1997;49:721-3.

4. Metso S, Ylitalo R, Nikkila M, et al. The effect of long-term microcrystalline chitosan therapy on plasma lipids and glucose concentrations in subjects with increased plasma total cholesterol: a randomised placebo-controlled double-blind crossover trial in healthy men and women. Eur J Clin Pharmacol 2003;59:741-6.

5. Tapola NS, Lyyra ML, Kolehmainen RM, et al. Safety aspects and cholesterol-lowering efficacy of chitosan tablets. J Am Coll Nutr 2008;27:22-30.

6. Deuchi K, Kanauchi O, Imasato Y, et al. Effect of the viscosity or deacetylation degree of chitosan on fecal fat excreted from rats fed on a high-fat diet. Biosci Biotech Biochem 1995;59:781-5.

7. Deuchi K, Kanauchi O, Imasato Y, et al. Decreasing effect of chitosan on the apparent fat digestibility by rats fed on a high-fat diet. Biosci Biotech Biochem 1994;58:1613-6.

8. Kanauchi O, Deuchi K, Imasato Y, et al. Increasing effect of a chitosan and ascorbic acid mixture on fecal dietary fat excretion. Biosci Biotech Biochem 1994;58:1617-20.

9. Deuchi K, Kanauchi O, Shizukuishi M, et al. Continuous and massive intake of chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet. Biosci Biotech Biochem 1995;59:1211-6.

10. Gades MD, Stern JS. Chitosan supplementation and fecal fat excretion in men. Obes Res 2003;11:683-8.

11. Gades MD, Stern JS. Chitosan supplementation does not affect fat absorption in healthy males fed a high-fat diet, a pilot study. Int J Obes Relat Metab Disord 2002;26:119-22.

Kidney Failure
Dose: Refer to label instructions

Chitosan is a polysaccharide found in the shells of crustaceans.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC Total Lean™ Chitosan with Glucomannan
 
3.7

(based on 28 reviews)

81%

of respondents would recommend this to a friend.

Pros

  • Easy to use (18)
  • Effective (18)
  • Good value (17)
  • Lightweight (4)
  • Easy to take (3)

Cons

  • Not effective (4)

Best Uses

  • Daily use (17)
  • Women (5)
  • Everyday use (4)
    • Reviewer Profile:
    • Budget shopper (16), Work out regularly (3)
    • My Beauty Routine Takes:
    • 30 minutes (14)

Reviewed by 28 customers

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Displaying reviews 1-10

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(0 of 1 customers found this review helpful)

 
5.0

perfect

By 346057479

from Juan Juan Chen,WA

See all my reviews

Pros

  • Effective

Cons

    Best Uses

      Comments about GNC Total Lean™ Chitosan with Glucomannan:

      perfect

      (2 of 4 customers found this review helpful)

       
      4.0

      Effective product

      By erickasantillanes

      from albuquerque.nm

      About Me Work Out Regularly

      See all my reviews

      Pros

      • Easy To Take
      • Effective
      • Good Value
      • Nutritional
      • Tastes Good

      Cons

        Best Uses

        • Everyday Use

        Comments about GNC Total Lean™ Chitosan with Glucomannan:

        i take this product everyday and it's great and work in less then an hour. I feel great and with more energy

        (0 of 2 customers found this review helpful)

         
        4.0

        Would but product

        By erickasantillanes

        from albuquerque, nm

        About Me Work Out Regularly

        Pros

        • Effective
        • Good Value
        • Tastes Good

        Cons

          Best Uses

          • Everyday Use

          Comments about GNC Total Lean™ Chitosan with Glucomannan:

          Take 2 times a day along with exercising. Seeing results.

          (0 of 2 customers found this review helpful)

           
          3.0

          Product is going good

          By erickasantillanes

          from albuquerque, nm

          About Me Nutritionist, Work Out Regularly

          Pros

          • Easy To Take
          • Effective
          • Good Value
          • Nutritional
          • Tastes Good

          Cons

            Best Uses

            • Everyday Use
            • Meal Replacement
            • Weight Loss
            • Women

            Comments about GNC Total Lean™ Chitosan with Glucomannan:

            Still taking this product, but so far so good. I take two a day and exercise as I take them. It makes me work out longer and efficiently.

            (4 of 5 customers found this review helpful)

             
            4.0

            "I would buy this product again!"

            By gjcb4simmons

            from Syracuse, NY

            See all my reviews

            Pros

            • Easy To Take
            • Effective
            • Good Value
            • Nutritional

            Cons

            • None

            Best Uses

            • Everyday Use
            • Weight Loss

            Comments about GNC Total Lean™ Chitosan with Glucomannan:

            Helped me eat less at each meal and kept me full. Effective weight loss tool.

            (7 of 8 customers found this review helpful)

             
            4.0

            Meets expectations!

            By jillwhitecoffee

            from Atlanta, GA

            About Me Budget Buyer

            See all my reviews

            Pros

            • Easy To Use
            • Effective
            • Good Value

            Cons

            • Large pills

            Best Uses

            • Daily Use

            Comments about GNC Total Lean™ Chitosan with Glucomannan:

            I began using this 8/1/12 & noticed a difference immediately. Fiber allows you to use the bathroom, at least daily. Additionally, no stomach cramps, no rushing to the bathroom.

            • My Beauty Routine Takes:
            • 30 Minutes

            (1 of 8 customers found this review helpful)

             
            3.0

            just starting

            By stockdalei

            from Indianapolis, IN

            About Me Budget Buyer

            See all my reviews

            Pros

            • Easy To Use

            Cons

              Best Uses

              • Daily Use

              Comments about GNC Total Lean™ Chitosan with Glucomannan:

              I've only been trying this for a week so I'll be checking back in. I'm trying to lose about 20 lbs.
              I'm using this in combination with Beta Burn and my turbo fire workouts. so far no results

              • My Beauty Routine Takes:
              • 1+ Hour

              (8 of 8 customers found this review helpful)

               
              4.0

              Great Product

              By midwestcstrct

              from Florida

              About Me Budget Buyer

              See all my reviews

              Verified Buyer

              Pros

              • Effective
              • Good Value

              Cons

                Best Uses

                  Comments about GNC Total Lean™ Chitosan with Glucomannan:

                  Been taking this for years--I will cycle on/off once in awhile and go with a different fiber but seems to bind to fats and flushes them out to a certain degree and helps regulate sugars---obviously if you eat half a pizza it can only be so effective---take as prescribed--

                  (31 of 33 customers found this review helpful)

                   
                  5.0

                  Can't say to much about this product

                  By sikork

                  from Fort Worth, TX

                  About Me Budget Buyer

                  See all my reviews

                  Pros

                  • Easy To Use
                  • Effective
                  • Good Value

                  Cons

                    Best Uses

                    • Daily Use

                    Comments about GNC Total Lean™ Chitosan with Glucomannan:

                    My cholesterol was 239 about 6 years ago. doctor wanted me to take Lipitor and I said no. Started taking this product and as of two weeks ago my cholesterol is 110. No change in diet or life style. I researched it and it is all natural. Only thing to watch is if you are allergic to sea food, DO NOT take it if you are. Alot cheaper the any perscripition drug and no big warnings with it. Also does not interact with any medications, like blood pressure meds. I am a firm believer in this product.

                    (1 of 5 customers found this review helpful)

                     
                    4.0

                    Seems to work

                    By gemqueen4719

                    from Wisconsin

                    About Me Budget Buyer

                    See all my reviews

                    Pros

                    • Easy To Use
                    • Slows weight gain

                    Cons

                      Best Uses

                      • Daily Use

                      Comments about GNC Total Lean™ Chitosan with Glucomannan:

                      Easy to carry along

                      • My Beauty Routine Takes:
                      • 1+ Hour

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