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GNC Vitamin B-2 100 MG

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100 Vegetarian Tablets

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Description
Essential for the metabolism of fats, carbohydrates & protein*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take one tablet daily.

Serving Size 1 Tablets
Servings Per Container 100
Amount Per Serving % DV
Riboflavin (Vitamin B-2) 100.00 mg 5882%
** Daily Value (DV) not established

Other Ingredients: Dicalcium Phosphate, Cellulose, Vegetable Acetoglycerides, Whole Brown Rice Powder (Oryza sativa)

No sugar, no artificial colors, no artificial flavors, sodium free, no wheat, no gluten, no corn, no dairy, yeast free.

Warning: KEEP OUT OF REACH OF CHILDREN

Distributed by: General Nutrition Corporation Pittsburgh, PA 15222

Health Notes

Vitamin B2

Vitamin B2
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Migraine Headache
Dose: 400 mg daily
Studies have shown vitamin B2 to be effective at reducing the frequency and severity of migraine headaches. (more)
Anemia
Dose: 5 to 30 mg daily in divided doses
Vitamin B2 deficiency can contribute to anemia, supplementing with this vitamin may restore levels and improve symptoms.(more)
High Homocysteine
Dose: 1.6 mg daily
Vitamin B2 (riboflavin) supplementation has been shown to lower homocysteine levels in certain people.(more)
Preeclampsia
Dose: Refer to label instructions
Women who are deficient in vitamin B2 (riboflavin) are more likely to develop preeclampsia than women with normal levels. Supplementation may correct a deficiency.(more)
Cataracts
Dose: 3 mg daily with 40 mg daily vitamin B3
Vitamin B2 is needed to protect glutathione, an important antioxidant in the eye. In one study, supplementing with vitamin B2 prevented cataracts in people who were deficient.(more)
Night Blindness
Dose: The ideal level of intake is not known. The amounts found in many multivitamin supplements (20–25 mg) are more than adequate for most people.
(more)
Night Blindness
Dose: The ideal level of intake is not known. The amounts found in many multivitamin supplements (20–25 mg) are more than adequate for most people.
(more)
Migraine Headache
Dose: 400 mg daily

One group of researchers treated 49 migraine patients with large amounts of vitamin B2 (400 mg per day). Both the frequency and severity of migraines decreased by more than two-thirds.1 In a follow-up three-month, double-blind trial, the same researchers reported that 59% of patients assigned to receive vitamin B2 had at least a 50% reduction in the number of headache days, whereas only 15% of those assigned to receive a placebo experienced that degree of improvement.2 The effects of vitamin B2 were most pronounced during the final month of the trial.3 In a preliminary study, a much smaller amount of vitamin B2 (25 mg per day for three months) reduced the frequency of migraines by about one-third in chronic migraine sufferers.4

All of the studies that found riboflavin to be effective for preventing migraine were conducted in adults. In a double-blind trial, supplementation with 200 mg per day of riboflavin did not decrease the frequency or severity of migraines in children whose average age was 11 years.5

References

1. Schoenen J, Lenaerts M, Bastings E. High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study. Cephalalgia 1994;14:328-9.

2. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70.

3. Schoenen J, Jacquy, Lenaerts M. High-dose riboflavin as a novel prophylactic antimigraine therapy: results from a double-blind, randomized, placebo-controlled trial. Cephalalgia 1997;17:244 [abstract].

4. Maizels M, Blumenfeld A, Burchette R. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache2004;44:885-90.

5. MacLennan SC, Wade FM, Forrest KML, et al. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol 2008;23:1300-4.

Anemia
Dose: 5 to 30 mg daily in divided doses

Deficiencies of iron, vitamin B12, and folic acid are the most common nutritional causes of anemia.1 Although rare, severe deficiencies of several other vitamins and minerals, including vitamin A,2, 3vitamin B2,4vitamin B6,5, 6vitamin C,7 and copper,8, 9 can also cause anemia by various mechanisms. Rare genetic disorders can cause anemias that may improve with large amounts of supplements such as vitamin B1.10, 11

References

1. Little DR. Ambulatory management of common forms of anemia. Am Fam Physician 1999;59:1598-604 [review].

2. Hodges RE, Sauberlich HE, Canham JE, et al. Hematopoietic studies in vitamin A deficiency. Am J Clin Nutr 1978;31:876-85 [review].

3. Bloem MW. Interdependence of vitamin A and iron: an important association for programmes of anaemia control. Proc Nutr Soc 1995;54:501-8 [review].

4. Lane M, Alfrey CP. The anemia of human riboflavin deficiency. Blood 1965;25:432-42.

5. Orehek AJ, Kollas CD. Refractory postpartum anemia due to vitamin B6 deficiency. Ann Intern Med 1997;126(10):834-5 [letter].

6. Iwama H, Iwase O, Hayashi S, et al. Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency. Rinsho Ketsueki 1998;39:1127-30 [in Japanese].

7. Hirschmann JV, Raugi GJ. Adult scurvy. J Am Acad Dermatol 1999;41:895-906 [review].

8. Summerfield AL, Steinberg FU, Gonzalez JG. Morphologic findings in bone marrow precursor cells in zinc-induced copper deficiency anemia. Am J Clin Pathol 1992;97:665-8.

9. Freycon F, Pouyau G. Rare nutritional deficiency anemia: deficiency of copper and vitamin E. Sem Hop 1983;59:488-93 [review] [in French].

10. Borgna-Pignatti C, Marradi P, Pinelli L, et al. Thiamine-responsive anemia in DIDMOAD syndrome. J Pediatr 1989;114:405-10.

11. Neufeld EJ, Mandel H, Raz T, et al. Localization of the gene for thiamine-responsive megaloblastic anemia syndrome, on the long arm of chromosome 1, by homozygosity mapping. Am J Hum Genet 1997;61:1335-41.

High Homocysteine
Dose: 1.6 mg daily

Vitamin B2 (riboflavin) supplementation (1.6 mg per day) has been shown to lower homocysteine levels by 22 to 40% in a subset of the population that has a certain genetic variant of an enzyme involved in folic acid metabolism (the 677Ca T polymorphism for the methylenetetrahydrofolate reductase gene).1 Approximately 15 to 20% of the population carries this gene and could benefic from taking riboflavin. Since genetic testing is expensive and not readily available, it would seem reasonable for all people trying to lower their homocysteine levels to include riboflavin in their regimen of B vitamin supplementation.

References

1. McNulty H, Dowey LR, Strain JJ, et al. Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677Ca T polymorphism. Circulation2006;113:74-80.

Preeclampsia
Dose: Refer to label instructions

Women who are deficient in vitamin B2 (riboflavin) are more likely to develop preeclampsia than women with normal vitamin B2 levels.1 These results were observed in a developing country, where vitamin B2 deficiencies are more common than in the United States. Nevertheless, insufficient vitamin B2 may contribute to the abnormalities underlying the disease process.

References

1. Wacker J, Fruhauf J, Schulz M, et al. Riboflavin deficiency and preeclampsia. Obstet Gynecol 2000;96:38-44.

Cataracts
Dose: 3 mg daily with 40 mg daily vitamin B3

People with low blood levels of antioxidants and those who eat few antioxidant-rich fruits and vegetables have been reported to be at high risk for cataracts.1, 2

Vitamin B2 and vitamin B3 are needed to protect glutathione, an important antioxidant in the eye. Vitamin B2 deficiency has been linked to cataracts.3, 4 Older people taking 3 mg of vitamin B2 and 40 mg of vitamin B3 per day were partly protected against cataracts in one trial.5 However, the intake of vitamin B2 in China is relatively low, and it is not clear whether supplementation would help prevent cataracts in populations where vitamin B2 intake is higher.

References

1. Jacques PF, Chylack LT Jr. Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention. Am J Clin Nutr 1991;53:352S-5S.

2. Knekt P, Heliovaara M, Rissanen A, et al. Serum antioxidant vitamins and risk of cataract. BMJ 1992;305:1392-4.

3. Bhat KS. Nutritional status of thiamine, riboflavin and pyridoxine in cataract patients. Nutr Rep Internat 1987;36:685-92.

4. Prchal JT, Conrad ME, Skalka HW. Association of presenile cataracts with heterozygosity for galactosaemic states and with riboflavin deficiency. Lancet 1978; 1:12-3.

5. Sperduto RD, Hu TS, Milton RC, et al. The Linxian cataract studies. Arch Ophthalmol 1993;111:1246-53.

Night Blindness
Dose: The ideal level of intake is not known. The amounts found in many multivitamin supplements (20–25 mg) are more than adequate for most people.In a study of women in Nepal, where there is a high prevalence of iron and riboflavin deficiencies, supplementation with 30 mg per day of iron and 6 mg per day of riboflavin for six weeks enhanced the effectiveness of vitamin A in the treatment of night blindness.1 It is not known whether these nutrients would be helpful for night blindness in people who are not deficient.
References

1. Graham JM, Haskell MJ, Pandey P, et al. Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, nightblind Nepali women. Am J Clin Nutr 2007;85:1375-84.

Night Blindness
Dose: The ideal level of intake is not known. The amounts found in many multivitamin supplements (20–25 mg) are more than adequate for most people.In a study of women in Nepal, where there is a high prevalence of iron and riboflavin deficiencies, supplementation with 30 mg per day of iron and 6 mg per day of riboflavin for six weeks enhanced the effectiveness of vitamin A in the treatment of night blindness.1 It is not known whether these nutrients would be helpful for night blindness in people who are not deficient.
References

1. Graham JM, Haskell MJ, Pandey P, et al. Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, nightblind Nepali women. Am J Clin Nutr 2007;85:1375-84.

Vitamin B2 is a water-soluble vitamin needed to process amino acids and fats, activate vitamin B6 and folic acid, and help convert carbohydrates into the fuel the body runs on-adenosine triphosphate (ATP). Under some conditions, vitamin B2 can act as an antioxidant.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

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GNC Vitamin B-2 100 MG
 
5.0

(based on 2 reviews)

Reviewed by 2 customers

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(2 of 2 customers found this review helpful)

 
5.0

Take to prevent migraines

By lisaeichelberger

from atlanta, ga

About Me First Time User, Medical Professional

See all my reviews

Pros

  • Easy on Stomach
  • Easy To Swallow
  • Effective
  • Simple To Take
  • Tastes Good

Cons

    Best Uses

    • Daily Use

    Comments about GNC Vitamin B-2 100 MG:

    My neurologist prescribed this for my chronic migraines along with magnesium. I am to take 400 mg of B2 with 400 mg of magnesium daily to prevent my daily migraines. It has helped my daily migraines retreat back to one or two a week which is a huge improvement.

    (4 of 4 customers found this review helpful)

     
    5.0

    I would buy this product again

    By limida

    from CT

    About Me First Time User

    See all my reviews

    Pros

    • Easy on Stomach
    • Easy To Swallow
    • Effective
    • Simple To Take

    Cons

      Best Uses

      • Daily Use

      Comments about GNC Vitamin B-2 100 MG:

      Dr recommended I use this product for migraine headaches. I have used for 2 months and have seen some relief. Does not make me sick at all.

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