Jarrow Formulas® Pantethine 450 mg

Jarrow Formulas® Pantethine 450 mg - JARROW - GNC Zoom
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Item #401918

Size: 60 softgels

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Description

Coenzyme A Precursor
Supports Lipid Metabolism
Pantethine is a derivative of vitamin B5. Pantethine supports lipid metabolism by its ability to raise levels of Coenzyme a (CoA), a cofactor involved in several metabolic pathways including carbohydrate and lipid metabolism.* CoA combines with acetyl groups to form Acetyl CoA, a key participant in energy production via its role in the Krebs (citric acid) cycle within the mitochondria.*
Pantesin® is a trademark of Daiichi Pharmaceutical Co,. Ltd. and is licensed to Daiichi fine chemicals.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Label

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Supplement Facts

Serving Size 1 softgel
Servings Per Container 60
Amount Per Serving % DV
Pantethine 450.00 mg **
** Daily Value (DV) not established

Product Directions / Additional Info

Take 1 softgel per day with a meal or as directed by your qualified healthcare professional.

Other Ingredients: Softgel consists of gelatin, glycerin, water and annatto (as a light barrier)

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

Storage Instructions: Keep out of reach of children and pets.

Warning: Keep out of reach of children

If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your healthcare professional before using this product.

Jarrow Formulas®
P.O. Box 35994
Los Angeles, CA 90035-4317

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Health Notes

Pantothenic Acid

Pantothenic Acid
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

High Cholesterol
Dose: 300 mg pantethine taken two to four times per day
Pantethine, a byproduct of vitamin B5 (pantothenic acid), may help reduce the amount of cholesterol made by the body.(more)
High Triglycerides
Dose: 300 mg pantethine three times per day
Pantethine, a byproduct of pantothenic acid (vitamin B5), has been shown to lower triglyceride levels in several clinical trials.(more)
Rheumatoid Arthritis
Dose: 2,000 mg daily
People with rheumatoid arthritis may be partially deficient in pantothenic acid. In one trial, taking pantothenic acid resulted in less morning stiffness, disability, and pain.(more)
Acne Vulgaris
Dose: Refer to label instructions
In a preliminary trial, taking panthothenic acid supplements and applying a topical cream improved moderate acne in two months and severe acne within six months. (more)
High Cholesterol
Dose: 300 mg pantethine taken two to four times per dayPantethine, a byproduct of vitamin B5 (pantothenic acid), may help reduce the amount of cholesterol made by the body. Several preliminary and several controlled trials have found that pantethine (300 mg taken two to four times per day) significantly lowers serum cholesterol levels and may also increase HDL.1, 2, 3, 4, 5, 6, 7, 8, 9However, a double-blind trial in people whose high blood cholesterol did not change with diet and drug therapy, found that pantethine was also not effective.10 Common pantothenic acid has not been reported to have any effect on high blood cholesterol.
References

1. Galeone F, Scalabrino A, Giuntoli F, et al. The lipid-lowering effect of pantethine in hyperlipidemic patients: a clinical investigation. Curr Ther Res 1983;34:383-90.

2. Miccoli R, Marchetti P, Sampietro T, et al. Effects of pantethine on lipids and apolipoproteins in hypercholesterolemic diabetic and non diabetic patients. Curr Ther Res 1984;36:545-9.

3. Avogaro P, Bon B, Fusello M. Effect of pantethine on lipids, lipoproteins and apolipoproteins in man. Curr Ther Res 1983;33;488-93.

4. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.

5. Arsenio L, Bodria P, Magnati G, et al. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Clin Ther 1986;8:537-45.

6. Prisco D, Rogasi PG, Matucci M, et al. Effect of oral treatment with pantethine on platelet and plasma phospholipids in IIa hyperlipoproteinemia. Angiology 1987;38:241-7.

7. Gaddi A, Descovich GC, Noseda G, et al. Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia. Atherosclerosis 1984;50:73-83.

8. Rumberger JA, Napolitano J, Azumano I, et al. Pantethine, a derivative of vitamin B5 used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr Res 2011;31:608-15.

9. Evans M, Rumberger JA, Azumano I, et al. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vasc Health Risk Manag 2014;10:89?100.

10. Da Col PG, et al. Pantethine in the treatment of hyper-cholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314.

High Triglycerides
Dose: 300 mg pantethine three times per day

Pantethine is a byproduct of pantothenic acid (vitamin B5). Several clinical trials have shown that 300 mg of pantethine taken three times per day will lower TG levels.1, 2, 3 Pantothenic acid, which is found in most B vitamins, does not have this effect.

References

1. Arsenio L, Bodria P, Magnati G, et al. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Clin Ther 1986;8:537-45.

2. Avogaro P, Bon B, Fusello M. Effect of pantethine on lipids, lipoproteins and apolipoproteins in man. Curr Ther Res 1983;33;488-93.

3. Maggi GC, Donati C, Criscuoli G. Pantethine: a physiological lipomodulating agent, in the treatment of hyperlipidemias. Curr Ther Res 1982;32:380-6.

Rheumatoid Arthritis
Dose: 2,000 mg daily

Research suggests that people with RA may be partially deficient in pantothenic acid (vitamin B5).1 In one placebo-controlled trial, those with RA had less morning stiffness, disability, and pain when they took 2,000 mg of pantothenic acid per day for two months.2

References

1. Barton-Wright EC, Elliott WA. The pantothenic acid metabolism of rheumatoid arthritis. Lancet 1963;ii:862-3.

2. General Practitioner Research Group. Calcium pantothenate in arthritic conditions. Practitioner 1980;224:208-11.

Acne Vulgaris
Dose: Refer to label instructions

In a preliminary trial, people with acne were given 2.5 grams of pantothenic acid orally four times per day, for a total of 10 grams per day-a remarkably high amount.1 A cream containing 20% pantothenic acid was also applied topically four to six times per day. With moderate acne, near-complete relief was seen within two months, while severe conditions took at least six months to respond. Eventually, the intake of pantothenic acid was reduced to 1 to 5 grams per day-still a very high amount.

References

1. Leung LH. Pantothenic acid deficiency as the pathogenesis of acne vulgaris. Med Hypotheses 1995;44:490-2.

Pantothenic acid, also called vitamin B5, is a water-soluble vitamin involved in the Kreb's cycle of energy production and is needed to make the neurotransmitter acetylcholine. It is also essential in producing, transporting, and releasing energy from fats. Synthesis of cholesterol (needed to manufacture vitamin D and steroid hormones) depends on pantothenic acid. Pantothenic acid also activates the adrenal glands.1 Pantethine-a byproduct of pantothenic acid-has been reported to lower blood levels of cholesterol and triglycerides.

Copyright 2016 Healthnotes, Inc. All rights reserved. www.healthnotes.com

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The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2017.