Nature's Answer® Periwinkle 650mg

Nature's Answer® Periwinkle 650mg - NATURES ANSWER - GNC Zoom
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Size: 1 fl. oz. (30mL)

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Product Information

Description

Advanced Botanical Fingerprint™
Vinca minor
  • Our organic alcohol extracts are produced using our cold Bio-Chelated® proprietary extraction process, yielding a Holistically Balanced® Advanced Botanical Fingerprint™ extract in the same synergistic ratios as in the plant.
  • Our Facility is cGMP Certified, Organic and Kosher Certified.

    * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Label

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Supplement Facts

Serving Size 1 mL
Servings Per Container 30
Amount Per Serving % DV
Periwinkle (Vinca minor) Aerial Parts Extract 650.00 mg **
** Daily Value (DV) not established

Product Directions / Additional Info

As a dietary supplement, take 1/2-1 mL (14-28 drops) 2-3 times a day in a small amount of water.

Other Ingredients: Purified Water, Vegetable Glycerin, 12-15% Certified Organic Alcohol

Gluten Free

Warning: Shake Well. Keep out of reach of children. Warning: Do not use if pregnant or nursing. Do not use if safety seal is damaged or missing.

Nautre's Answer® Hauppauge, NY 11788-3943

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Customer Reviews

Health Notes

Periwinkle

Periwinkle
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Alzheimer's Disease
Dose: Refer to label instructions
Lesser periwinkle contains the alkaloid vincamine, which has shown some benefit to people with Alzheimer's disease. (more)
Glaucoma
Dose: Refer to label instructions
One double-blind and one preliminary study have found that brovincamine, a compound closely related to periwinkle's active constituent vinpocetine, was helpful in people with chronic glaucoma. Until studies have been conducted using actual vinpocetine, it is unknown whether it would be as effective as brovincamine. (more)
Canker Sores
Dose: Refer to label instructions
Periwinkle is an astringent herb that can be used as a mouth rinse to soothe the pain of canker sores. The herb contains tannins that can bind up fluids and possibly relieve inflammation.(more)
Tinnitus
Dose: Refer to label instructions
Periwinkle contains a compound that has been shown to reduce symptoms in people whose tinnitus is due to poor blood flow.(more)
Hearing Loss
Dose: Refer to label instructions
Periwinke's active constitent vinpocetine has been associated with beneficial effects on hearing loss due to aging (presbyacusis), tinnitus, and ethyl-apovincaminate (a vinca alkaloid) may reduce ringing in the ears (tinnitus). (more)
Menorrhagia
Dose: Refer to label instructions
Astringent herbs such as periwinkle have been traditionally used for heavy menstruation.(more)
Menorrhagia
Dose: Refer to label instructions
Astringent herbs such as periwinkle have been traditionally used for heavy menstruation.(more)
Vascular Dementia
Dose: Refer to label instructions
A closely related semisynthetic derivative of vincamine (periwinkle's active constituent) most widely used as medicine is known as ethyl-apovincaminate or vinpocetine. It has been shown in double-blind studies to help alleviate a type of dementia known as vascular dementia, in which the arteries supplying blood to the brain develop atherosclerotic plaques(more)
Diarrhea
Dose: Refer to label instructions
European herbalists have used periwinkle for conditions with a watery discharge, such as diarrhea.(more)
Kidney Dialysis
Dose: Refer to label instructions
One uncontrolled study found that vinpocetine, periwinkle's active constituent, for 3 to 12 months helps eliminate calcium buildup in people undergoing dialysis.(more)
Alzheimer's Disease
Dose: Refer to label instructions

Lesser periwinkle contains the alkaloid vincamine. Supplementation with a semi-synthetic derivative of vincamine, known as vinpocentine, showed no benefit for people with Alzheimer's disease in a preliminary study,1 but vincamine itself was shown to be beneficial in a later double-blind trial.2

References

1. Thal LJ, Salmon DP, Lasker B, et al. The safety and lack of efficacy of vinpocetine in Alzheimer's disease. J Am Geriatr Soc 1989;37:515-20.

2. Fischhof PK, Moslinger-Gehmayr R, Herrmann WM, et al. Therapeutic efficacy of vincamine in dementia. Neuropsychobiology 1996;34:29-35.

Glaucoma
Dose: Refer to label instructionsOne double-blind and one preliminary study have found that brovincamine, a compound closely related to periwinkle's active constituent vinpocetine, was helpful in people with chronic glaucoma.1, 2 Until studies have been conducted using actual vinpocetine, it is unknown whether it would be as effective as brovincamine.
References

1. Koseki N, Araie M, Yamagami J, et al. Effects of oral brovincamine on visual field damage in patients with normal-tension glaucoma with low-normal intraocular pressure. J Glaucoma 1999;8:117-23.

2. Sawada A, Kitazawa Y, Yamamoto T, et al. Prevention of visual field defect progression with brovincamine in eyes with normal-tension glaucoma. Ophthalmology 1996;103:283-8.

Canker Sores
Dose: Refer to label instructions

Historically, herbs known as astringents have been used to soothe the pain of canker sores. These herbs usually contain tannins that can bind up fluids and possibly relieve inflammation. They are used as a mouth rinse and then are spit out. None of these herbs has been studied in modern times. Examples of astringent herbs include agrimony, cranesbill, tormentil, oak, periwinkle, and witch hazel. Witch hazel is approved by the German Commission E for local inflammations of the mouth, presumably a condition that includes canker sores.

Tinnitus
Dose: Refer to label instructions

Lesser periwinkle(Vinca minor) contains a compound known as vincamine. Extracts containing vincamine have been used in Germany to help decrease tinnitus.1 Preliminary clinical trial data show that vinpocetine, a semi-synthetic version of vincamine, can help reduce symptoms in people whose tinnitus is due to poor blood flow.2 Because these extracts are not widely available outside of Germany, consult with a doctor knowledgeable in botanical medicine about obtaining them.

References

1. Weiss RF. Herbal Medicine. Gothenburg, Sweden: Ab Arcanum and Beaconsfield, UK: Beaconsfield Publishers Ltd, 1988, 181.

2. Ribari O, Zelen B, Kollar B. Ethyl apovincaminate in the treatment of sensorineural impairment of hearing. Arzneimittelforschung 1976;26:1977-80.

Hearing Loss
Dose: Refer to label instructionsOne double-blind study found that high amounts of vinpocetine (60 mg per day) could have a beneficial effect on hearing loss due to aging (presbyacusis).1 A preliminary study concluded that supplementation with ethyl-apovincaminate (a vinca alkaloid) may reduce symptoms of tinnitus (ringing in the ears) due to impaired blood flow to the inner ear.2 One review of the use of vinpocetine in people who have suffered strokes found that the only double-blind study did not show efficacy,3 though previous uncontrolled studies have suggested there might be a benefit.4, 5
References

1. Reinecke M. Double-blind comparison of vincamine and placebo in patients with presbyacusis. Arzneimittelforschung 1977;27:1294-8 [in German].

2. Ribari O, Zelen B, Kollar B. Ethyl apovincaminate in the treatment of sensorineural impairment of hearing. Arzneimittelforschung 1976;26:1977-80.

3. Bereczki D, Fekete I. A systematic review of vinpocetine therapy in acute ischaemic stroke. Eur J Clin Pharmacol 1999;55:349-52 [review].

4. Otomo E, Atarashi J, Araki G, et al. Comparison of vinpocetine with ifenprodil tartrate and dihydroergotoxine mesylate treatment and results of long-term treatment with vinpocetine. Curr Ther Res 1985;37:811-21.

5. Thiery E, Otte G, Vander Eecken H. Comparative study of the clinical effect of vincamine versus papaverine given parenterally in the acute phase of stroke. Arzneimittelforschung 1979;29:671-4.

Menorrhagia
Dose: Refer to label instructions

Cinnamon has been used historically for the treatment of various menstrual disorders, including heavy menstruation.1 This is also the case with shepherd's purse (Capsella bursa-pastoris).2 Other herbs known as astringents (tannin-containing plants that tend to decrease discharges), such as cranesbill, periwinkle, witch hazel, and oak, were traditionally used for heavy menstruation. Human trials are lacking, so the usefulness of these herbs is unknown. Black horehound was sometimes used traditionally for heavy periods, though this approach has not been investigated by modern research.

References

1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Foods, Drugs, and Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 168-70.

2. Ellingwood F. American Materia Medica, Therapeutics and Pharmacognosy. Sandy, OR: Eclectic Medical Publications, 1919, 1998, 354.

Menorrhagia
Dose: Refer to label instructions

Cinnamon has been used historically for the treatment of various menstrual disorders, including heavy menstruation.1 This is also the case with shepherd's purse (Capsella bursa-pastoris).2 Other herbs known as astringents (tannin-containing plants that tend to decrease discharges), such as cranesbill, periwinkle, witch hazel, and oak, were traditionally used for heavy menstruation. Human trials are lacking, so the usefulness of these herbs is unknown. Black horehound was sometimes used traditionally for heavy periods, though this approach has not been investigated by modern research.

References

1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Foods, Drugs, and Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 168-70.

2. Ellingwood F. American Materia Medica, Therapeutics and Pharmacognosy. Sandy, OR: Eclectic Medical Publications, 1919, 1998, 354.

Vascular Dementia
Dose: Refer to label instructionsA closely related semisynthetic derivative of vincamine most widely used as medicine is known as ethyl-apovincaminate or vinpocetine. It has vasodilating, blood thinning, and memory-enhancing actions. It has been shown in double-blind studies to help alleviate a type of dementia known as vascular dementia, in which the arteries supplying blood to the brain develop atherosclerotic plaques.123
References

1. Fischhof PK, Moslinger-Gehmayr R, Herrmann WM, et al. Therapeutic efficacy of vincamine in dementia. Neuropsychobiology 1996;34:29-35.

2. Balestreri R, Fontana L, Astengo F. A double-blind placebo controlled evaluation of the safety and efficacy of vinpocetine in the treatment of patients with chronic vascular senile cerebral dysfunction. J Am Geriatr Soc 1987;35:425-30.

3. Hindmarch I, Fuchs HH, Erzigkeit H. Efficacy and tolerance of vinpocetine in ambulant patients suffering from mild to moderate organic psychosyndromes. Int Clin Psychopharmacol 1991;6:31-43.

Diarrhea
Dose: Refer to label instructionsEuropean herbalists have used periwinkle for headaches, vertigo, and poor memory since medieval times.1 It was also considered a helpful remedy for conditions with a watery or bloody discharge such as diarrhea, bleeding gums, or menorrhagia.2
References

1. Weiss RF. Meuss AR, trans. Herbal Medicine. Gothenberg, Sweden: Ab Arcanum and Beaconsfield: Beaconsfield Publishers Ltd, 1985:180-2.

2. Hoffmann D. The New Holistic Herbal, 3rd ed. Shaftesbury, Dorset, UK: Element, 1990:223.

Kidney Dialysis
Dose: Refer to label instructionsVinpocetine tends to act as a calcium-chelating agent. One uncontrolled study found that use of vinpocetine for 3 to 12 months could eliminate calcium buildup in people undergoing dialysis.1 Further research is needed to determine whether this could be helpful in other conditions associated with excess calcium, or whether vinpocetine might interfere with calcium's beneficial actions.
References

1. Ueyoshi A, Ota K. Clinical appraisal of vinpocetine for the removal of intractable tumoral calcinosis in haemodialysis patients with renal failure. J Int Med Res 1992;20:435-43.

Parts Used & Where Grown

The flower and leaf of lesser periwinkle are used medicinally. Periwinkle is an evergreen shrub that grows in Europe, northwestern Africa, central Asia, and some parts of North America.

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The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2017.