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Description
MAY EXPERIENCE:
  • WEIGHT LOSS*
  • APPETITE SUPPORT
Garcinia cambogia is a type of fruit native to Indonesia, Asia, and Africa. Traditionally, it has been used to make different foods such as curry and soup and to make meals more filling. An active constituent of the fruit, HCA (hydroxycitric acid), is believed to have beneficial effects on appetite and weight management.*
Health Notes

Garcinia cambogia

Garcinia cambogia
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Obesity
Dose: Refer to label instructions
HCA may aid in weight loss by suppressing appetite and by reducing the conversion of carbohydrates into stored fat.(more)
Obesity
Dose: Refer to label instructions(-)-Hydroxycitric acid (HCA), extracted from the rind of the Garcinia cambogia fruit grown in Southeast Asia, has a chemical composition similar to that of citric acid (the primary acid in oranges and other citrus fruits). Preliminary studies in animals suggest that HCA may be a useful weight-loss aid.1, 2 HCA has been demonstrated in the laboratory (but not yet in clinical trials with people) to reduce the conversion of carbohydrates into stored fat by inhibiting certain enzyme processes.3, 4 Animal research indicates that HCA suppresses appetite and induces weight loss.5, 6, 7, 8 However, a double-blind trial found that people who took 1,500 mg per day of HCA while eating a low-calorie diet for 12 weeks lost no more weight than those taking a placebo.9 A double-blind trial of Garcinia cambogia (2.4 grams of dry extract, containing 50% hydroxycitric acid) found that the extract did not increase energy expenditure; it was therefore concluded that this extract showed little potential for the treatment of obesity at this amount.10 Nonetheless, another double-blind trial found that using the same amount of Garciniacambogia extract significantly improved the results of a weight-loss diet, even though the amount of food intake was not affected.11
References

1. Lowenstein JM. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J Biol Chem 1971;246:629-32.

2. Triscari J, Sullivan AC. Comparative effects of (-)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. Lipids 1977;12:357-63.

3. Cheema-Dhadli S, Harlperin ML, Leznoff CC. Inhibition of enzymes which interact with citrate by (-)hydroxycitrate and 1,2,3,-tricarboxybenzene. Eur J Biochem 1973;38:98-102.

4. Sullivan AC, Hamilton JG, Miller ON, et al. Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate. Arch Biochem Biophys 1972;150:183-90.

5. Greenwood MRC, Cleary MP, Gruen R, et al. Effect of (-)-hydroxycitrate on development of obesity in the Zucker obese rat. Am J Physiol 1981;240:E72-8.

6. Sullivan AC, Triscari J. Metabolic regulation as a control for lipid disorders. Am J Clin Nutr 1977;30:767-76.

7. Sullivan AC, Triscari J, Hamilton JG, et al. Effect of (-)-hydroxycitrate upon the accumulation of lipid in the rat: I. Lipogenesis. Lipids 1974;9:121-8.

8. Sullivan AC, Triscari J, Hamilton JG, et al. Effect of(-)-hydroxycitrate upon the accumulation of lipid in the rat: II. Appetite. Lipids1974;9:129-34.

9. Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitricacid) as a potential antiobesity agent: a randomized controlled trial. JAMA1998;280:1596-600.

10. Martinet A, Hostettmann K, Schultz Y. Thermogenic effects of commercially available plant preparations aimed at treating human obesity. Phytomedicine 1999;6:231-8.

11. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav 2000;71:87-94.

(-)-Hydroxycitric acid (HCA) is a compound found in Garcinia cambogia, a type of fruit. HCA has a chemical structure similar to that of citric acid (the primary acid in citrus fruits).

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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