Instaflex® Advanced | GNC

Instaflex® Advanced


Item # 452399


Size: 30 Capsules

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Featuring UC-II® Collagen
Doctor Formulated
  • Relieve Discomfort*
  • Improve Flexibility*
  • Joint Relief in 7 Days*
One Small Capsule Daily

Regain Mobility with Instaflex Advanced Just one small capsule once a day can lead to more comfortable joints in as little as 7 days. CLINICAL STUDIES SHOW:
  • Aprèsflex® improves joint stiffness and discomfort by more than 60% when compared to placebo after 90 days.*
  • UC-II® Collagen significantly reduces knee discomfort and is twice as effective as glucosamine plus chondroitin.*
  • BioPerine® significantly enhances the bioavailability of nutrients through increased absorption.*

Label (click image to enlarge)


As a dietary supplement take one (1) capsule a day with water.


Use only as directed. Consult a health care practitioner before use if you are pregnant or nursing, have a serious medical conditions or use prescription medications. For adult use only.

Other Ingredients

Gelatin, Cellulose, Magnesium Stearate, titanium dioxide, FD&C Blue #1


Keep product at room temperature and humidity(59-86F, 40% RH).
Distributed by Direct Digital LLC, Charlotte, NC 28202
ApresFlex® is a registered trademark of Laila Nutraceuticals exclusively licensed to PL Thomas - Laila Nutra LLC. Internation patents pending.
UC-II® is a registered trademark of InterHealth N.I.
Bioperine® is registered trademark of Sabinsa Corp.

Nutrition Facts

Serving Size  1 Capsule(s)
Servings Per Container  30

Amount Per Serving     % DV

Turmeric (rhizome)(standardized to min 95% curcuminoids)  200 mg   **
Resveratrol (from Polygonum cuspidatum root extract)  100 mg   **
Apresflex®-Boswellia serrata Extract (resin)  100 mg   **
UC-II® (10 mg total collagen, 3 mg undenatured type II collagen)  40 mg   **
Hyaluronic Acid (min 89%)  5 mg   **
Bioperine®-Black Pepper Extract (fruit)(standardized to min 95% piperine)  5 mg   **

** Daily Value (DV) not established.


3.9 / 5.0
76 Reviews
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
It really has not help
April 13, 2018
3 weeks ago
Unsure at this time if it works
I have only been using it a little over a week. I cannot see a difference yet. I am hopeful that it will help, but cannot say that at this time. It said in 7 days you should see a difference and it has been 9 days, so I feel it takes longer. I will contact you after I can determine if it helps. Not sharing a photo, but it looks like the package here showing.
April 13, 2018
1 week ago
Amazing results
I love Instaflex. I had inflammation and pain in my ankle due to heal spurs. Did physical therapy which helped slightly. Dr said may need surgery. Decided to try Instaflex and it was the best decision. No more pain or swelling. I’ve been taking for a couple years now and plan to continue.
April 2, 2018
1 month ago
Too expensive
March 25, 2018
1 month ago
I am 84yrs.old had 1 knee replaced yrs. ago the other knee is shot now and needs replacing. I was falling alot even using my walker, started on these pills and they work wonders. I recommend these to anyone who has knee problems. I will be buying a bottle each month still my time on earth ends.
March 15, 2018
1 month ago
So far so good. Knees feel better.
March 8, 2018
2 months ago
This product helps with joint stiffness and mobility. I think it is terribly overpriced and therefore I am always looking for a like product that is more affordable.
February 27, 2018
2 months ago
Works great, costs too much!
I love Instaflex Advanced! Three day and knee, back and joint pain gone! Unfortunately, sadly, the cost is way too high for my budget.
February 23, 2018
Buyer Beware
Unfortunately I had an allergic reaction to Instaflex. I checked the list of ingredients and Blue #1 was listed- I'm allergic to Red #40. I wondered if the Tumeric Extract might have Red #40 as an ingredient.
February 22, 2018
2 months ago
Give INSTAFLEX a Shot!
I have taken Osteo Bi-Flex, Triple Strength with Vitamin D, for years with excellent results for my painful 'Football Knees". Osteo Bi-Flex contained Glucosamine and Chondroitin. Within the last 6 months, Osteo Bi-Flex was no longer providing the needed relief for sore stiff knees. Switched to INSTAFLEX and within a week I found great relief. No more soreness or stiffness. Glad I switched!
February 14, 2018
Start typing your question and we'll check if it was already asked and answered. Learn More
Browse 22 questions Browse 22 questions and 22 answers
Why did you choose this?
GNC Store
works my joints feel alot better
t u on Apr 8, 2015
works my joints feel alot better
t u on Apr 8, 2015
side effects with this product?
A shopper on Mar 25, 2016
BEST ANSWER: None at all I have been taking it for over a year
what is the difference in purchasing Instaflex advanced from GNC and purchasing it from CVS?
A shopper on Jul 18, 2016
BEST ANSWER: I know for myself I feel more confident purchasing from GNC
Does Instaflex advanced Joint chews work the same as the pills?
A shopper on Mar 30, 2016
BEST ANSWER: No side effects at all. Yes the chews work just as well, I have tried both.
Can you find this in the gnc stores?
A shopper on Jun 27, 2016
Can this product be taken for a long

Can instaflex advanced be taken for more than four months .?
A shopper on Aug 20, 2016
BEST ANSWER: I have been taking Instaflex advanced for over a year with no problems
Would this product work with artificial knees?
A shopper on Jun 6, 2016
Do the Instaflex chews work as well as the capsules?
A shopper on Jun 17, 2016
BEST ANSWER: Yes both work just as well
I love instaflex---but I keep moving. How to stop monthly delivery?
A shopper on Sep 4, 2016
BEST ANSWER: go to the instaflex website, there is a # to call. this site will not allow me to put in the #. eight hundred,four three six, zero nine two zero
How do I stop monthly delivery?
A shopper on Sep 4, 2016
BEST ANSWER: call: eight hundred, four three six, zero nine two zero. select four and stop delivery.
is instaflex safe for your kidneys?
A shopper on Jan 27, 2017
I have diabetes, will this product effect my glucose levels?
A shopper on Jan 8, 2017
is it good for your hips?
A shopper on Nov 11, 2016
BEST ANSWER: the best thing I've tried for a knee and ankle, would think it would work for hips as well
Will this help the pain in a torn rotator cuff?
A shopper on Dec 29, 2016
BEST ANSWER: I can't really answer that, but I took this for a while for my knee, and I saw no improvement.
I am diabetic could Instaflex increase my sugar levels?
A C on Mar 17, 2017
BEST ANSWER: I am also a diabetic and I never had trouble with it increasing my sugars.
will instaflex cause colitis? or aggravate the condition of IBS-D?
A shopper on Jan 21, 2017
BEST ANSWER: possibly
what are the compounds found in Instaflex? Does Instaflex only affect only the knee joints, or other joints too?
A shopper on Jan 15, 2017
BEST ANSWER: My husband takes this product. He is 59 yrs old. He had been taking 1500mg of Glucosamine & 1200mg of Chondrotin for 19 years. He decided to try this product. He has been taking it about a year. He does does not want to go a day without it. He thinks it helps him all over his body but esp his knees.
Can I continue to take Glucosamine with Instaflex Advanced?
A shopper on Jan 12, 2017
BEST ANSWER: why not?
I have Sl joint pain will this help?
A shopper on Nov 1, 2016
BEST ANSWER: Didn't help me.
does instaflex advance chews work the same as the pills?
A shopper on Oct 5, 2016
BEST ANSWER: Yes. The chews are as effective as the pills.
I have no Cartlidge in my one knee will this product help with the pain and the stiffness and possibly remove the need for an operation ?
A shopper on Apr 10, 2018
Does this work with bursitis?
A shopper on Mar 28, 2018
does it work for bulging disc?
Linda M on Mar 28, 2018