Instaflex® Advanced | GNC


Product Information


Featuring UC-II® Collagen
Doctor Formulated
  • Relieve Discomfort*
  • Improve Flexibility*
  • Joint Relief in 7 Days*
One Small Capsule Daily

Regain Mobility with Instaflex Advanced Just one small capsule once a day can lead to more comfortable joints in as little as 7 days. CLINICAL STUDIES SHOW:
  • Aprèsflex® improves joint stiffness and discomfort by more than 60% when compared to placebo after 90 days.*
  • UC-II® Collagen significantly reduces knee discomfort and is twice as effective as glucosamine plus chondroitin.*
  • BioPerine® significantly enhances the bioavailability of nutrients through increased absorption.*

Label (click image to enlarge)


As a dietary supplement take one (1) capsule a day with water.


Use only as directed. Consult a health care practitioner before use if you are pregnant or nursing, have a serious medical conditions or use prescription medications. For adult use only.

Other Ingredients

Gelatin, Cellulose, Magnesium Stearate, titanium dioxide, FD&C Blue #1


Keep product at room temperature and humidity(59-86F, 40% RH).
Distributed by Direct Digital LLC, Charlotte, NC 28202
ApresFlex® is a registered trademark of Laila Nutraceuticals exclusively licensed to PL Thomas - Laila Nutra LLC. Internation patents pending.
UC-II® is a registered trademark of InterHealth N.I.
Bioperine® is registered trademark of Sabinsa Corp.

Nutrition Facts

Serving Size  1 Capsule(s)
Servings Per Container  30

Amount Per Serving     % DV

Turmeric (rhizome)(standardized to min 95% curcuminoids)  200 mg   **
Resveratrol (from Polygonum cuspidatum root extract)  100 mg   **
Apresflex®-Boswellia serrata Extract (resin)  100 mg   **
UC-II® (10 mg total collagen, 3 mg undenatured type II collagen)  40 mg   **
Hyaluronic Acid (min 89%)  5 mg   **
Bioperine®-Black Pepper Extract (fruit)(standardized to min 95% piperine)  5 mg   **

** Daily Value (DV) not established.


3.9 / 5.0
96 Reviews
5 Stars
4 Stars
3 Stars
2 Stars
1 Star
Excellent product
It did exactly as advertised. With in ONE week my joints were so much better. I can get out of bed easily now and walk with no stiffness . I have recommended it and will continue to do so.
July 10, 2018
1 month ago
Too expensive with marginal results.
Not sure it is worth the cost. Can't really tell the difference between Instaflex & Instaflex Advanced.
June 28, 2018
1 month ago
It’s OK, but not that great
June 22, 2018
1 month ago
Excellent....amazing..... can't say enough about the results,,just keep feeling better and better! I took advantage of buy two get one free but the price is still high! I will continue to buy!!!
June 9, 2018
2 months ago
Instaflex Advanced well worth the cost of relief!!!
I give it five stars.I noticed in a few days the relief in my joints. I have osteoarthritis in many of my joints and they do feel better. They seem to be more limber than before I started Instaflex advanced. The only thing I do not like is the expense of them. If it helps me out and keeps me limber, I will continue with them. Very good product. It works !!!!
June 4, 2018
2 months ago
Love this product!! I found it from my brother. It helps my knees so much! Not much works for them. I recommend this product to anyone who has arthritis or joint pain. It is he best.
June 3, 2018
2 months ago
I have recommended this product to several of my friends and family. Hopefully they are as satisfied as I am.
I have been taking Instaflex for several months now and am very pleased with this product. Finally have help with my pain!
May 29, 2018
2 months ago
i wont buy again
Its not working at all, after I spend all that money $121. The samples work, but these don't.
May 28, 2018
2 months ago
vitamin D did more good than this product and cost a whole lot less. All the hype about Instaflex advance is no more than false news!
May 26, 2018
2 months ago
This product has given myself and my husband relief in our joints, hands, knees, shoulders, and feet. I know it is a little pricey but I feel it is worth it.
May 21, 2018
2 months ago
Start typing your question and we'll check if it was already asked and answered. Learn More
Browse 25 questions Browse 25 questions and 29 answers
Why did you choose this?
GNC Store
works my joints feel alot better
t u on Apr 8, 2015
works my joints feel alot better
t u on Apr 8, 2015
what is the difference in purchasing Instaflex advanced from GNC and purchasing it from CVS?
A shopper on Jul 18, 2016
BEST ANSWER: I know for myself I feel more confident purchasing from GNC
side effects with this product?
A shopper on Mar 25, 2016
BEST ANSWER: None at all I have been taking it for over a year
Does Instaflex advanced Joint chews work the same as the pills?
A shopper on Mar 30, 2016
BEST ANSWER: No side effects at all. Yes the chews work just as well, I have tried both.
Can you find this in the gnc stores?
A shopper on Jun 27, 2016
BEST ANSWER: Yes....I purchase my Instaflex Advanced from GNC.
Can this product be taken for a long

Can instaflex advanced be taken for more than four months .?
A shopper on Aug 20, 2016
BEST ANSWER: I have been taking Instaflex advanced for over a year with no problems
Would this product work with artificial knees?
A shopper on Jun 6, 2016
BEST ANSWER: Absolutely!
Do the Instaflex chews work as well as the capsules?
A shopper on Jun 17, 2016
BEST ANSWER: Yes both work just as well
I love instaflex---but I keep moving. How to stop monthly delivery?
A shopper on Sep 4, 2016
BEST ANSWER: go to the instaflex website, there is a # to call. this site will not allow me to put in the #. eight hundred,four three six, zero nine two zero
How do I stop monthly delivery?
A shopper on Sep 4, 2016
BEST ANSWER: call: eight hundred, four three six, zero nine two zero. select four and stop delivery.
I have no Cartlidge in my one knee will this product help with the pain and the stiffness and possibly remove the need for an operation ?
A shopper on Apr 10, 2018
is instaflex safe for your kidneys?
A shopper on Jan 27, 2017
BEST ANSWER: Nothing I saw as ingredients, would lead to any type of kidney problem,.
Does this work if cartilage is almost gone in one knee?
A shopper on Jun 4, 2018
Will this help the pain in a torn rotator cuff?
A shopper on Dec 29, 2016
BEST ANSWER: I can't really answer that, but I took this for a while for my knee, and I saw no improvement.
Does this work with bursitis?
A shopper on Mar 28, 2018
is it good for your hips?
A shopper on Nov 11, 2016
BEST ANSWER: the best thing I've tried for a knee and ankle, would think it would work for hips as well
Can I continue to take Glucosamine with Instaflex Advanced?
A shopper on Jan 12, 2017
BEST ANSWER: why not?
I have diabetes, will this product effect my glucose levels?
A shopper on Jan 8, 2017
What does "flag as inappropriate ".mean?
A shopper on Apr 28, 2018
does this make you itch?
A shopper on May 19, 2018
BEST ANSWER: Did not make me itch at all.
does it work for bulging disc?
Linda M on Mar 28, 2018
BEST ANSWER: NO. Only surgery works for a bulging disk, Want minor relief, get an inversion table.
I am diabetic could Instaflex increase my sugar levels?
A C on Mar 17, 2017
BEST ANSWER: I am also a diabetic and I never had trouble with it increasing my sugars.
will instaflex cause colitis? or aggravate the condition of IBS-D?
A shopper on Jan 21, 2017
BEST ANSWER: possibly
what are the compounds found in Instaflex? Does Instaflex only affect only the knee joints, or other joints too?
A shopper on Jan 15, 2017
BEST ANSWER: My husband takes this product. He is 59 yrs old. He had been taking 1500mg of Glucosamine & 1200mg of Chondrotin for 19 years. He decided to try this product. He has been taking it about a year. He does does not want to go a day without it. He thinks it helps him all over his body but esp his knees.
I have Sl joint pain will this help?
A shopper on Nov 1, 2016
BEST ANSWER: Didn't help me.
does instaflex advance chews work the same as the pills?
A shopper on Oct 5, 2016
BEST ANSWER: Yes. The chews are as effective as the pills.