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GNC TriFlex™ Fast-Acting

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240 Caplets

Item #281422 See Product Details

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Description
  • Now with a joint cushioning blend including hyaluronic acid and vitamin C*
  • Maximum strength fast-acting support - works in days
  • Clinical strength for daily long-term useJoint comfort in days with GNC TriFlex™ Fast-Acting. This premium formula combines the full, clinically-tested amounts of glucosamine (1500 mg) and chondroitin (1200 mg) with a proprietary Fast-Acting Blend plus MSM to support joint comfort and flexibility and hyaluronic acid to help cushion joints.*
  • Clinically studied doses of glucosamine and chondroitin combined with MSM and proprietary herbal blend, which is shown to improve joint comfort and function.
  • Glucosamine and Chondroitin are natural building block components found in connective tissues and joint cartilage. Scientific research has shown that these building block compounds help to support the body's natural ability to regenerate cartilage and lubricate joints thus supporting joint health integrity and function.
  • Hyaluronic acid is an important structural component of body tissue, including the fluids surrounding the joints and collagen. Hyaluronic acid has the capacity to hold water, cushion joints and maintain the elastic integrity of skin.
  • Vitamin C is involved in the synthesis of collage.
  • * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

    Supplement Facts

    As a dietary supplement, take four caplets daily preferably with meals.

    Serving Size 4 Caplets
    Servings Per Container 60
    Amount Per Serving % DV
    Sodium 130.00 mg 5%
    Vitamin C (as Ascorbic Acid) 30.00 mg 50%
    Glucosamine Hydrochiorde 1500.00 mg **
    Chondroitin Sulfate Sodium 1200.00 mg **
    MSM (Methylsulfonyl-methane) 250.00 mg **
    Fast-Acting Comfort Blend 250.00 mg **
     Chinese Skullcap Root Extract (Scutellaria baicalensis) **
     Clutch Tree Wood& Bark Extract (Acacia catechu) **
    Hyaluronic Acid (HA) (as Sodium Hyaluronate) 5.00 mg **
    ** Daily Value (DV) not established

    Other Ingredients: Cellulose, Titanium Dioxide (Natural Mineral Whitener), Vegetable Acetoglycerides, Natural Vanilla Flavor, Riboflavin, Sucralose

    No Sugar, No Artificial Colors, No Artificial Flavors, No Preservatives,No Wheat, No Gluten, No Soy, No Dairy, Yeast Free.

    Storage Instructions: Store in a cool, dry place.

    Warning: Keep out of reach of children



    Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition. Discontinue use two weeks prior to surgery.

    CONTAINS: Crustaceans (Shrimp)

    GNC Quality Commitment
    GNC is the leader in the development and manufacture of dietary supplements, committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

    GNC Guarantee
    If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

    Distributed by: General Nutrition Corporation Pittsburgh, Pa 15222

    Health Notes

    Joint Health

    Joint Health
    • Reliable and relatively consistent scientific data showing a substantial health benefit.
    • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
    • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

    Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

    For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

    Osteoarthritis
    Dose: 800 to 1,200 mg a day
    Many trials have shown that supplementing with chondroitin sulfate reduces pain, increases joint mobility, and promotes healing within the joints.(more)
    Osteoarthritis
    Dose: 2.25 to 6.0 grams per day
    In one trial, supplementing with methyl-sulfonylmethane significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee. (more)
    Osteoarthritis
    Dose: Refer to label instructions
    Studies have shown glucosamine hydrochloride to be effective at reducing pain and improving symptoms in people with osteoarthritis.(more)
    Osteoarthritis
    Dose: 800 to 1,200 mg a day

    Chondroitin sulfate (CS) is a major component of the lining of joints. The structure of CS includes molecules related to glucosamine sulfate. CS levels have been reported to be reduced in joint cartilage affected by osteoarthritis. Possibly as a result, CS supplementation may help restore joint function in people with osteoarthritis.1 On the basis of preliminary evidence, researchers had believed that oral CS was not absorbed in humans;2 as a result, early double-blind CS research was done mostly by giving injections.3, 4 This research documented clinical benefits from CS injections. It now appears, however, that a significant amount of CS is absorbable in humans,5 though dissolving CS in water leads to better absorption than swallowing whole pills.6

    Strong clinical evidence now supports the use of oral CS supplements for osteoarthritis. Many double-blind trials have shown that CS supplementation consistently reduces pain, increases joint mobility, and/or shows evidence (including X-ray changes) of healing within joints of people with osteoarthritis.7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 Most trials have used 400 mg of CS taken two to three times per day. One trial found that taking the full daily amount (1,200 mg) at one time was as effective as taking 400 mg three times per day.18 Reduction in symptoms typically occurs within several months.

    References

    1. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

    2. Baici A, Horler D, Moser B, et al. Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate. Rheumatol Int 1992;12:81-8.

    3. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

    4. Rovetta G. Galactosaminoglycuronoglycan sulfate (Matrix) in therapy of tibiofibular osteoarhtirits of the knee. Drugs Exp Clin Res 1991;17:53-7.

    5. Conte A, Volpi N, Palmieri L, et al. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneimittelforschung 1995;45:918-25.

    6. Ronca F, Palmieri L, Panicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 1998;6(Supplement A):14-21.

    7. Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(Suppl A):39-46.

    8. Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage 1998;6(Suppl A):37-8.

    9. Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 1998;6(Suppl A):31-6.

    10. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

    11. Pipitone V, Ambanelli U, Cervini C, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Curr Ther Res 1992;52:608-38.

    12. Bazieres B, Loyau G, Menkes CJ, et al. Le chondroitine sulfate dans le traitement de la gonarthrose et de la coxarthrose. Rev Rhum Mal Osteoartic 1992;59:466-72 [in French].

    13. Conrozier T, Vignon E. Die Wirkung von Chondroitinsulfat bei der Behandlung der Huft Gelenksarthrose. Eine Doppelblindstudie gegen Placebo. Litera Rheumatologica 1992;14:69-75 [in German].

    14. L'Hirondel JL. Klinische Doppelblind-Studie mit oral verabreichtem Chondroitinsulfat gegen Placebo bei der tibiofermoralen Gonarthrose (125 Patienten). Litera Rheumatologica 1992;14:77-82 [in German].

    15. Morreale P, Manopulo R, Galati M, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-91.

    16. Leeb BF, Petera P, Neumann K. Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints. Wien Med Wochenschr 1996;146:609-14.

    17. Wildi LM, Raynauld JP, Martel-Pelletier J, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis 2011;70:982-9.

    18. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

    Osteoarthritis
    Dose: 2.25 to 6.0 grams per dayAccording to a small double-blind trial, 2,250 mg per day of oral methylsulfonylmethane (MSM), a variant of DMSO, reduced osteoarthritis pain after six weeks.1 In another double-blind trial, supplementation with 3 grams of MSM twice a day for 12 weeks significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee.2
    References

    1. Lawrence RM. Methylsulfonylmethane (MSM): a double-blind study of its use in degenerative arthritis. Int J of Anti-Aging Med 1998;1:50.

    2. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94.

    Osteoarthritis
    Dose: Refer to label instructionsA few trials have evaluated glucosamine hydrochloride (GH), another form of glucosamine sulfate (GS), as a single remedy for osteoarthritis. One trial found only minor benefits from 1,500 mg per day of GH for 8 weeks in people with osteoarthritis of the knee.1 However, these people were also taking up to 4,000 mg per day of acetaminophen for pain relief, and that treatment might have masked a beneficial effect of GH. In another study, supplementing with GH (2,000 mg each morning for 12 weeks) significantly improved symptoms, compared with a placebo, in people with knee pain due to cartilage damage or osteoarthritis.2 In a four-week study from China, GH was as effective as GS in people with osteoarthritis of the knee.3 Another study found that the combination of GH and chondroitin sulfate was more effective than a placebo in people with moderate to severe knee pain from osteoarthritis, but not in those with mild pain.4 Despite the reported beneficial effects of GH, some investigators believe that the sulfate component of GS itself helps relieve osteoarthritis, and that GS would therefore be more effective than GH.5
    References

    1. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.

    2. Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med 2003;37:45-9.

    3. Qiu GX, Weng XS, Zhang K, et al. A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulfate in the treatment of knee osteoarthritis. Zhonghua Yi Xue Za Zhi 2005;85:3067-70 [in Chinese].

    4. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;795-808.

    5. Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.

    Copyright 2014 Aisle7. All rights reserved. Aisle7.com

    The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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    Ratings and Reviews

    REVIEW SNAPSHOT®

    by PowerReviews
    GNC TriFlex™ Fast-Acting
     
    4.3

    (based on 35 reviews)

    94%

    of respondents would recommend this to a friend.

    Pros

    • Effective (27)
    • Easy to swallow (17)
    • Simple to take (17)
    • Easy on stomach (14)

    Cons

    • Complicated to take (4)

    Best Uses

    • Older people (20)
    • Men (11)
    • Daily use (10)
    • Women (9)
      • Reviewer Profile:
      • First time user (18), Health conscious (10)

    Reviewed by 35 customers

    Sort by

    Displaying reviews 1-10

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    5.0

    Really helps!!

    By SHADYR

    from Orlando, FL

    About Me First Time User

    See all my reviews

    Pros

    • Easy on Stomach
    • Easy To Swallow
    • Effective
    • Simple To Take

    Cons

      Best Uses

      • Older People

      Comments about GNC TriFlex™ Fast-Acting:

      I have been taking Triflex or one of its predecessors for a couple of years now for knee stiffness and pain. Over a period of several months, I began reducing the daily dosage from 4 to 3 to 2 and finally 1 pill per day. Basically, at 1 per day I am on a maintenance schedule which still solves my knee joint pain. I am very pleased with the results.

       
      4.0

      I would buy this product again and again

      By spgns2

      from portland

      About Me Health Conscious

      See all my reviews

      Pros

      • Effective

      Cons

        Best Uses

        • Older People

        Comments about GNC TriFlex™ Fast-Acting:

        it's good to my mother!!

         
        5.0

        Very good product!!

        By edwards0322

        from Los Angeles, CA

        See all my reviews

        Pros

        • Easy To Swallow
        • Effective
        • Simple To Take

        Cons

          Best Uses

          • Daily Use
          • Men
          • Older People
          • Women

          Comments about GNC TriFlex™ Fast-Acting:

          MY entire family is using this, and my parents love it so much. it helped their joints a lot. just simply work.

           
          4.0

          It is good, but shipping box too large

          By henanxi.dalian

          from Singapore

          About Me First Time User

          See all my reviews

          Pros

          • Effective

          Cons

          • Complicated To Take

          Best Uses

          • Older People
          • Women

          Comments about GNC TriFlex™ Fast-Acting:

          It is effective, will purchase again.

           
          5.0

          It's good for me

          By zhfjkc

          from Long island,New York

          About Me First Time User

          See all my reviews

          Pros

          • Effective

          Cons

          • Complicated To Take

          Best Uses

          • Men

          Comments about GNC TriFlex™ Fast-Acting:

          It is very good for me,that make me very comfortable.

          (1 of 1 customers found this review helpful)

           
          5.0

          Good product for parents

          By ch20070723

          from New york, Ny

          About Me Health Conscious, Medical Professional

          See all my reviews

          Pros

          • Effective

          Cons

            Best Uses

            • Older People

            Comments about GNC TriFlex™ Fast-Acting:

            I gave my parents to take this daily, and they told me this works. Therefore, I would buy them to be a gift if I need to send gift to elders.

            (1 of 1 customers found this review helpful)

             
            5.0

            Great product

            By chris5200

            from New Brunswick,NJ

            See all my reviews

            Pros

            • Effective

            Cons

              Best Uses

              • Older People

              Comments about GNC TriFlex™ Fast-Acting:

              My father really likes it. It is very effective. He feels better.

               
              4.0

              Triflex fast acting

              By tdoan

              from Saint Petersburg,FL

              About Me First Time User

              See all my reviews

              Pros

              • Easy To Swallow
              • Simple To Take

              Cons

                Best Uses

                • Older People

                Comments about GNC TriFlex™ Fast-Acting:

                It helps my knee and my joint feel better as I take it, but it is very expensive compare to the other products.

                (1 of 3 customers found this review helpful)

                 
                3.0

                I would buy this product again and agai

                By 157634073

                from ROWLAND HEIGHTS,CA

                See all my reviews

                Comments about GNC TriFlex™ Fast-Acting:

                Things that are great about it

                 
                4.0

                wd be better if cheaper

                By whbintexas

                from houston, tx

                About Me First Time User

                See all my reviews

                Pros

                • Effective

                Cons

                • Hard To Swallow

                Best Uses

                • Daily Use

                Comments about GNC TriFlex™ Fast-Acting:

                way too expensive.

                but effective.

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