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Natrol® Melatonin TR

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Description
Natrol® Melatonin 5 mg Time Release offers a biphasic delivery system which releases melatonin quickly to help you fall asleep fast and then steadily to help you stay asleep all night. Melatonin helps establish normal sleep patterns to promote a more restful, relaxing sleep and better overall health. The body naturally produces melatonin and Vitamin B6 is essential for melatonin production

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

Take 1 tablet 20 minutes before bedtime.

Serving Size 1 Tablet
Servings Per Container 100
Amount Per Serving % DV
Vitamin B-6 (from Pyridoxine Hydrochloride) 10.00 mg **
Melatonin (synthetic) 5.00 mg **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Dibasic Calcium Phosphate, Hypromellose, Stearic Acid, Magnesium Stearate, Silica, Methylcellulose, Glycerin

NO Yeast, Wheat, Corn, Milk, Egg, Soy, Glutens, Artificial Colors or Flavors, Added Sugar, Starch or Preservatives

Storage Instructions: STORE IN A COOL, DRY PLACE. CONTENTS SOLD BY WEIGHT NOT VOLUME.

Warning: You may experience some residual drowsiness. If you take this product you may sleep for a full 8 hours. If you are under medical supervision or using any tranquilizers or sedatives, seek the advice of your healthcare professional prior to using. Consult your physician before using if you have an autoimmune condition depressive disorder or are pregnant or lactating. Not for use by children under 12 years of age. Do not take when operating machinery or driving a vehicle.

Manufactured by NATROL, Inc. Chatsworth, CA 91311

Health Notes

Melatonin

Melatonin
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Macular Degeneration
Dose: Take under medical supervision: 3 mg daily at bedtime
In one trial, melatonin improved eye abnormalities in the majority of cases. It appears to work by regulating eye pigmentation and by functioning as an antioxidant.(more)
Alzheimer's Disease
Dose: Refer to label instructions
(more)
Age-Related Cognitive Decline
Dose: Refer to label instructions
Cognitive function is linked to adequate sleep and normal sleep-wake cycles, which are partially regulated by the hormone melatonin. The long-term effects of melatonin are unknown, use under a doctor's supervision.(more)
Cluster Headache
Dose: Take under medical supervision: 10 mg daily in the evening
Taking melatonin before bedtime has been shown to reduce the frequency of cluster headaches.(more)
Migraine Headache
Dose: Refer to label instructions
Pineal gland function and melatonin secretion may be disturbed in people with migraine headaches. Taking melatonin may correct this problem and reduce symptoms.(more)
Fibromyalgia
Dose: Refer to label instructions
In one study, supplementing with melatonin reduced tender points and improved sleep in people with fibromyalgia.(more)
Insomnia
Dose: Take under medical supervision: 0.5 to 3.0 mg daily one to two hours before bedtime
Taking melatonin before bedtime may help reset your body's internal clock. (more)
Jet Lag
Dose: Take under medical supervision: 0.5 mg daily at bedtime for four days after arriving at your destination
Taking melatonin at bedtime may improve sleep quality and daytime alertness.(more)
Insomnia and Tinnitus
Dose: Take under medical supervision: 3 mg daily at bedtime
Supplementing with melatonin may improve sleep quality and relieve other symptoms of severe tinnitus.(more)
Sunburn
Dose: Apply a formula containing 2% vitamin E, 5% vitamin C, and 1% to 2.5% melatonin before sun exposure
A topically applied combination of melatonin, vitamin C, and vitamin E may boost the protection from traditional sunscreens.(more)
Macular Degeneration
Dose: Take under medical supervision: 3 mg daily at bedtime
In one trial, melatonin improved eye abnormalities in the majority of cases. It appears to work by regulating eye pigmentation and by functioning as an antioxidant.(more)
Glaucoma
Dose: Refer to label instructions
Supplementing with melatonin lowered intraocular pressure of healthy people in one study.(more)
Irritable Bowel Syndrome
Dose: Take under medical supervision: 3 mg daily at bedtime
Melatonin helps regulate gastrointestinal function and sensation. In one trial, people with irritable bowel syndrome who took melatonin experienced significantly less severe abdominal pain.(more)
Hypertension
Dose: Take under medical supervision: 2 mg daily of sustained-released supplment at night
For people with nighttime hypertension, supplementing with melatonin may reduce nighttime systolic blood pressure.(more)
Tinnitus
Dose: Take under medical supervision: 3 mg dailly at bedtime
Supplementing with melatonin may improve sleep quality and relieve other symptoms of severe tinnitus.(more)
Age-Related Cognitive Decline
Dose: Refer to label instructions
Cognitive function is linked to adequate sleep and normal sleep-wake cycles, which are partially regulated by the hormone melatonin. The long-term effects of melatonin are unknown, use under a doctor's supervision.(more)
Macular Degeneration
Dose: Take under medical supervision: 3 mg daily at bedtime

In a preliminary trial, supplementation with melatonin (3 mg per day at bedtime for at least three months) resulted in an improvement in the abnormalities observed on eye examination in the majority of cases.1 Melatonin is believed to work by regulating eye pigmentation (and, consequently, the amount of light reaching the retina) and by functioning as an antioxidant.

References

1. Yi C, Pan X, Yan H, et al. Effects of melatonin in age-related macular degeneration. Ann N Y Acad Sci 2005;1057:384-92.

Alzheimer's Disease
Dose: Refer to label instructions
Age-Related Cognitive Decline
Dose: Refer to label instructions

Melatonin is a hormone secreted by the pineal gland in the brain. It is partially responsible for regulating sleep-wake cycles. Cognitive function is linked to adequate sleep and normal sleep-wake cycles. Cognitive benefits from melatonin supplementation have been suggested by preliminary research in a variety of situations and may derive from the ability of melatonin to prevent sleep disruptions.1, 2, 3, 4 A double-blind trial of ten elderly patients with mild cognitive impairment showed that 6 mg of melatonin taken two hours before bedtime significantly improved sleep, mood, and memory, including the ability to remember previously learned items.5 However, in a double-blind case study of one healthy person, 1.6 mg of melatonin had no immediate effect on cognitive performance.6

The long-term effects of regularly taking melatonin supplements remain unknown, and many healthcare practitioners recommend that people take no more than 3 mg per evening. A doctor familiar with the use of melatonin should supervise people who wish to take it regularly.

References

1. Myers BL, Badia P. Changes in circadian rhythms and sleep quality with aging: mechanisms and interventions. Neurosci Biobehav Rev 1995;19(4):553-71. Published erratum appears in Neurosci Biobehav Rev 1996;20(2):I-IV.

2. Dollins AB, Zhdanova IV, Wurtman RJ, et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci U S A 1994;91(5):1824-8.

3. Dori D, Casale G, Solerte SB, et al. Chrono-neuroendocrinological aspects of physiological aging and senile dementia. Chronobiologia 1994;21(1-2):121-6.

4. Comperatore CA, Lieberman HR, Kirby AW, et al. Melatonin efficacy in aviation missions requiring rapid deployment and night operations. Aviat Space Environ Med 1996;67(6):520-4.

5. Jean-Louis G, von Gizycki H, Zizi F. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res 1998;25(3):177-83.

6. Slotten HA, Krekling S. Does melatonin have an effect on cognitive performance? Psychoneuro-endocrinology 1996;21(8):673-80.

Cluster Headache
Dose: Take under medical supervision: 10 mg daily in the evening

Researchers have found low levels of the hormone melatonin in cluster headache patients.1, 2, 3, 4 In a small double-blind trial, a group of cluster headache sufferers took a 10 mg evening dose of melatonin for 14 days. About half of the group saw a significant decrease in the frequency of their headaches within three to five days, after which no further headaches occurred until melatonin was discontinued.5 Melatonin appears to be effective against both types of cluster headache (e.g., episodic and chronic). 6 More research is needed to establish the long-term effects of melatonin supplementation on cluster headache.

References

1. Chazot G, Claustrat B, Brun J, et al. A chronobiological study of melatonin, cortisol, growth hormone, and prolactin secretion in cluster headache. Cephalalgia 1984;4:213-20.

2. Waldenlind E, Gustafsson SA, Ekbom KA, Wetterberg L. Circadian secretion of cortisol and melatonin during active cluster periods and remission. J Neurol Neurosurg Psychiatry 1987;50:207-13.

3. Leone M, Lucini V, D'Amico D, et al. Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache. Cephalalgia 1995;15:224-9.

4. Leone M, Lucini V, D'Amico D, et al. Abnormal 24-hour urinary excretory pattern of 6-sulphatoxymelatonin in both phases of cluster headache. Cephalalgia 1998;18:664-7.

5. Leone M, D'Amico D, Moschiano F, et al. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia 1996;16:494-6.

6. Peres MFP, Rozen TD. Melatonin in the preventive treatment of chronic cluster headache. Cephalalgia 2001;21:993-5.

Migraine Headache
Dose: Refer to label instructions

The function of the pineal gland and its cyclic secretion of melatonin may be disturbed in people with migraine headaches.1 Preliminary evidence suggests that 5 mg per day of melatonin, taken 30 minutes before bedtime, may reduce symptoms of migraine headache.2 However, a double-blind trial found that taking 2 mg of melatonin 1 hour before bedtime each day for 8 weeks was not more effective than a placebo for decreasing migraine frequency.3

References

1. Claustrat B, Brun J, Geoffriau M, et al. Nocturnal plasma melatonin profile and melatonin kinetics during infusion in status migrainosus. Cephalalgia 1997;17:511-7 (discussion 487).

2. Nagtegaal JE, Smits MG, Swart AC, et al. Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. Headache 1998;38:303-7.

3. Alstadhaug KB, Odeh F, Salvesen R, Bekkelund SI. Prophylaxis of migraine with melatonin: a randomized controlled trial. Neurology 2010;75:1527-32.

Fibromyalgia
Dose: Refer to label instructions

Melatonin supplementation may be useful in the treatment of fibromyalgia. In a preliminary trial, 3 mg of melatonin at bedtime was found to reduce tender points and to improve sleep and other measures of disease severity, though pain and fatigue improved only slightly.1

References

1. Citera G, Arias MA, Maldonado-Cocco JA, et al. The effect of melatonin in patients with fibromyalgia: a pilot study. Clin Rheumatol 2000;19:9-13.

Insomnia
Dose: Take under medical supervision: 0.5 to 3.0 mg daily one to two hours before bedtime

Caution: Melatonin is a potent hormone and its long-term safety is not established. Melatonin should only be taken with medical supervision.

Melatonin is a natural hormone that regulates the human biological clock. The body produces less melatonin with advancing age, which may explain why elderly people often have difficulty sleeping1 and why melatonin supplements improve sleep in the elderly.2

Middle-aged adults (average age, 54 years) with insomnia also have lower melatonin levels, compared with people of the same age without insomnia.3 However, there is not much research on the use of melatonin for sleep problems in middle-aged people.

Double-blind trials have shown that melatonin facilitates sleep in young adults without insomnia,4 but not in young people who suffer from insomnia.5However, one trial found that children with sleep disturbances stemming from school phobia had improved sleep after taking 1 mg of melatonin per night for one week, then 5 mg per night for one week, then 10 mg per night for a third week.6

The results of one double-blind trial also indicate that a controlled release melatonin supplement providing 2 mg per day improves sleep quality in people with schizophrenia.7

Normally, the body makes melatonin for several hours per night-an effect best duplicated with controlled-release supplements. Trials using timed-release melatonin for insomnia have reported good results.8 Many doctors suggest taking 0.5 to 3 mg of melatonin one and a half to two hours before bedtime. However, because melatonin is a potent hormone, the long-term effects of which are unknown, it should be taken only with the supervision of a doctor.

References

1. Haimov I, Laudon M, Zisapel N, et al. Sleep disorders and melatonin rhythms in elderly people. BMJ 1994;309:167.

2. Singer C, McArthur A, Hughes R, et al. Melatonin and sleep in the elderly. J Am Geriatr Soc 1996;44:51 [abstr #A1].

3. Attenburrow MEJ, Dowling BA, Sharpley AL, Cowen PJ. Case-control study of evening melatonin concentration in primary insomnia. BMJ 1996;312:1263-4.

4. Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995;57:552-8.

5. James SP, Sack DA, Rosenthal NE, Mendelson WB. Melatonin administration in insomnia. Neuropsychopharmacology 1989;3:19-23.

6. Tomoda A, Miike T, Iwatani N, et al. Effect of long-term melatonin administration on school-phobic children and adolescents with sleep disturbances. Curr Ther Res 1999;60:607-12.

7. Shamir E, Laudon M, Barak Y, et al. Melatonin improves sleep quality of patients with chronic schizophrenia. J Clin Psychiatry 2000;61:373-7.

8. Garfinkel D, Laudon M, Nof D, Zisapel N. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 1995;346:541-4.

Jet Lag
Dose: Take under medical supervision: 0.5 mg daily at bedtime for four days after arriving at your destination

Melatonin is a natural hormone that regulates the human biological clock and may be helpful in relieving symptoms of jet lag, according to some,1, 2 though not all,3, 4 double-blind studies. One double-blind trial, involving international flight crew members, found that melatonin supplementation was helpful when started after arriving at the destination but not when started three days before leaving.5 Another double-blind study compared various amounts and forms of melatonin taken at bedtime for four days after the flight by people who traveled through six to eight time zones.6 Fast-release melatonin supplements were found to be more effective than the controlled-release supplements. A 5 mg and 0.5 mg fast-release melatonin were almost equally effective for improving sleep quality, time it took to fall asleep, and daytime sleepiness.

References

1. Petrie K, Conaglen JV, Thompson L, Chamberlain K. Effect of melatonin on jet lag after long haul flights. BMJ 1989;298:705-7.

2. Claustrat B, Brun J, David M, et al. Melatonin and jet lag: confirmatory result using a simplified protocol. Biol Psychiatry 1992;32:705-11.

3. Edwards BJ, Atkinson G, Waterhouse J, et al. Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics 2000;43:1501-13.

4. Spitzer RL, Terman M, Williams JB, et al. Jet lag: clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trial. Am J Psychiatry 1999;156:1392-6.

5. Petrie K, Dawson AG, Thompson L, et al. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Bio Psych 1993;33(7):526-30.

6. Suhner A, Schlagenhauf P, Johnson R, et al. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int 1998;15:655-66.

Insomnia and Tinnitus
Dose: Take under medical supervision: 3 mg daily at bedtime

Caution: Melatonin is a potent hormone and its long-term safety is not established. Melatonin should only be taken with medical supervision.

In a double-blind trial, melatonin supplementation (3 mg taken nightly) improved symptoms of tinnitus.1 Although improvement did not reach statistical significance for all participants, the results were significant in those who reported more severe symptoms (such as two-sided vs. one-sided tinnitus). Among participants who had difficulty sleeping due to tinnitus, 47% of those who took melatonin reported sleep improvement after one month, compared with only 20% of those who took the placebo. Similar improvements in tinnitus were reported in a preliminary trial that used 3 mg of melatonin each night for four weeks.2

References

1. Rosenberg SI,Silverstein H,Rowan PT, et al. Effect of melatonin on tinnitus. The Laryngoscope. 1998 Mar;108(3):305-10

2. Megwalu UC,Finnell JE,Piccirillo JF. The effects of melatonin on tinnitus and sleep. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2006 Feb;134(2):210-3

Sunburn
Dose: Apply a formula containing 2% vitamin E, 5% vitamin C, and 1% to 2.5% melatonin before sun exposure

Antioxidants have been studied as topical agents for protection against sunburn. Animal studies have found sunscreen-like effects from topical application of a vitamin C and vitamin E combination, and a controlled human study reported ultraviolet protection from the use of a lotion containing 0.02% to 0.05% of the selenium-containing amino acid known as selenomethionine.1, 2 The topical use of the hormone melatonin has been shown to protect human skin against ultraviolet rays in double-blind research.3, 4 A double-blind human trial tested topical vitamins C and E and melatonin, alone and in combinations, and found the highest degrees of protection from combination formulations containing 2% vitamin E, 5% vitamin C, and 1% to 2.5% melatonin.5 Other studies in which topical antioxidants were applied after ultraviolet exposure have found no benefits.6, 7

References

1. Lin JY, Selim MA, Shea CR, et al. UV photoprotection by combination topical antioxidants vitamin C and vitamin E. J Am Acad Dermatol 2003;48:866-74.

2. Burke KE, Burford RG, Combs GF Jr, et al. The effect of topical L-selenomethionine on minimal erythema dose of ultraviolet irradiation in humans. Photodermatol Photoimmunol Photomed 1992;9:52-7.

3. Bangha E, Elsner P, Kistler GS. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). Influence of the application time point. Dermatology 1997;195:248-52.

4. Bangha E, Elsner P, Kistler GS. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). A dose response study. Arch Dermatol Res 1996;288:522-6.

5. Dreher F, Gabard B, Schwindt DA, Maibach HI. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo. Br J Dermatol 1998;139:332-9.

6. Dreher F, Denig N, Gabard B, et al. Effect of topical antioxidants on UV-induced erythema formation when administered after exposure. Dermatology 1999;198:52-5.

7. Fuchs J. Potentials and limitations of the natural antioxidants RRR-alpha-tocopherol, L-ascorbic acid and beta-carotene in cutaneous photoprotection. Free Radic Biol Med 1998;25:848-73 [review].

Macular Degeneration
Dose: Take under medical supervision: 3 mg daily at bedtime

In a preliminary trial, supplementation with melatonin (3 mg per day at bedtime for at least three months) resulted in an improvement in the abnormalities observed on eye examination in the majority of cases.1 Melatonin is believed to work by regulating eye pigmentation (and, consequently, the amount of light reaching the retina) and by functioning as an antioxidant.

References

1. Yi C, Pan X, Yan H, et al. Effects of melatonin in age-related macular degeneration. Ann N Y Acad Sci 2005;1057:384-92.

Glaucoma
Dose: Refer to label instructions

Supplementing with 0.5 mg of melatonin lowered intraocular pressure of healthy people,1 but there have been no studies on the effects of melatonin in people with glaucoma.

References

1. Samples JR, Krause G, Lewy AJ. Effect of melatonin on intraocular pressure. Curr Eye Res 1988;7:649-53.

Irritable Bowel Syndrome
Dose: Take under medical supervision: 3 mg daily at bedtime

Melatonin plays a role in the regulation of gastrointestinal function and sensation. In a double-blind trial, people with irritable bowel syndrome and associated sleep disturbances received 3 mg of melatonin or a placebo at bedtime for two weeks. Compared with the placebo, melatonin significantly decreased the severity of abdominal pain, although it did not affect bloating, stool frequency, or sleep patterns.1 Melatonin was also effective in another double-blind trial.2

References

1. Song GH, Leng PH, Gwee KA, et al. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study. Gut 2005;54:1402-7.

2. Saha L, Malhotra S, Rana S, et al. A preliminary study of melatonin in irritable bowel syndrome. J Clin Gastroenterol 2007;41:29-32.

Hypertension
Dose: Take under medical supervision: 2 mg daily of sustained-released supplment at night

In a double-blind study, supplementation with 2 mg of sustained-release melatonin each night for four weeks significantly reduced nighttime systolic blood pressure, compared with a placebo, in people with nocturnal hypertension.1 Normally, blood pressure declines at night. People with hypertension who do not have this nighttime blood pressure decline are at increased risk of developing and dying from heart disease. Melatonin supplementation may therefore be beneficial for this subgroup of people with hypertension.

References

1. Grossman E, Laudon M, Yalcin R, et al. Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am J Med 2006;119:898-902.

Tinnitus
Dose: Take under medical supervision: 3 mg dailly at bedtime

Caution: Melatonin is a potent hormone and its long-term safety is not established. Melatonin should only be taken with medical supervision.

In a double-blind trial, melatonin supplementation (3 mg taken nightly) improved the symptoms of tinnitus.1 Although improvement did not reach statistical significance for all participants, the results were significant in those who reported more severe symptoms (such as two-sided vs. one-sided tinnitus). Among participants who had difficulty sleeping due to tinnitus, 47% of those who took melatonin reported sleep improvement after one month, compared with only 20% of those who took placebo. Similar improvements in tinnitus were reported in a preliminary trial that used 3 mg of melatonin each night for four weeks.2

References

1. Rosenberg SI,Silverstein H,Rowan PT, et al. Effect of melatonin on tinnitus. The Laryngoscope. 1998 Mar;108(3):305-10

2. Megwalu UC,Finnell JE,Piccirillo JF. The effects of melatonin on tinnitus and sleep. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2006 Feb;134(2):210-3

Age-Related Cognitive Decline
Dose: Refer to label instructions

Melatonin is a hormone secreted by the pineal gland in the brain. It is partially responsible for regulating sleep-wake cycles. Cognitive function is linked to adequate sleep and normal sleep-wake cycles. Cognitive benefits from melatonin supplementation have been suggested by preliminary research in a variety of situations and may derive from the ability of melatonin to prevent sleep disruptions.1, 2, 3, 4 A double-blind trial of ten elderly patients with mild cognitive impairment showed that 6 mg of melatonin taken two hours before bedtime significantly improved sleep, mood, and memory, including the ability to remember previously learned items.5 However, in a double-blind case study of one healthy person, 1.6 mg of melatonin had no immediate effect on cognitive performance.6

The long-term effects of regularly taking melatonin supplements remain unknown, and many healthcare practitioners recommend that people take no more than 3 mg per evening. A doctor familiar with the use of melatonin should supervise people who wish to take it regularly.

References

1. Myers BL, Badia P. Changes in circadian rhythms and sleep quality with aging: mechanisms and interventions. Neurosci Biobehav Rev 1995;19(4):553-71. Published erratum appears in Neurosci Biobehav Rev 1996;20(2):I-IV.

2. Dollins AB, Zhdanova IV, Wurtman RJ, et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci U S A 1994;91(5):1824-8.

3. Dori D, Casale G, Solerte SB, et al. Chrono-neuroendocrinological aspects of physiological aging and senile dementia. Chronobiologia 1994;21(1-2):121-6.

4. Comperatore CA, Lieberman HR, Kirby AW, et al. Melatonin efficacy in aviation missions requiring rapid deployment and night operations. Aviat Space Environ Med 1996;67(6):520-4.

5. Jean-Louis G, von Gizycki H, Zizi F. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res 1998;25(3):177-83.

6. Slotten HA, Krekling S. Does melatonin have an effect on cognitive performance? Psychoneuro-endocrinology 1996;21(8):673-80.

Melatonin is a natural hormone that regulates the human biological clock.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
Natrol® Melatonin TR
 
3.4

(based on 5 reviews)

80%

of respondents would recommend this to a friend.

Pros

  • Effective (4)

Cons

    Best Uses

      Reviewed by 5 customers

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      (1 of 1 customers found this review helpful)

       
      4.0

      It helps me with my sleep

      By Happi_me82

      from CA

      About Me First Time User

      See all my reviews

      Pros

      • Effective

      Cons

        Best Uses

        • Men
        • Women

        Comments about Natrol® Melatonin TR:

        Help me with my rest, regulate my sleep.

        (2 of 2 customers found this review helpful)

         
        4.0

        It Works

        By marlene409

        from Pittsburgh, PA

        About Me Budget Buyer

        See all my reviews

        Verified Buyer

        Pros

        • Easy To Use
        • Effective
        • Good Value

        Cons

          Best Uses

            Comments about Natrol® Melatonin TR:

            Haven't used it that long, but it does seem to work. I took regular melatonin before, and I would wake up in the middle of the night. Now, with the time-release, I am sleeping through the night more often.

            • My Beauty Routine Takes:
            • 30 Minutes
             
            4.0

            Seems to work well

            By whiesands68

            from North Carolina

            About Me Budget Buyer

            See all my reviews

            Verified Buyer

            Pros

            • Effective

            Cons

              Best Uses

                Comments about Natrol® Melatonin TR:

                the time release seems to work better for me - not too much all at once.

                (2 of 2 customers found this review helpful)

                 
                4.0

                Good product

                By stonington13

                from Youngstown, OH

                About Me Brand Buyer

                See all my reviews

                Pros

                • Easy To Use
                • Effective
                • Good Value

                Cons

                  Best Uses

                  • Daily Use

                  Comments about Natrol® Melatonin TR:

                  For the last eight months I have suffered from tinnitus and up until I discovered this product, I was unable to sleep more than an hour at a time even with Ambien CR or Lunesta, both of which made me feel awful. Now I find that if I take the Melatonin TR about 30 minutes before going to bed I am able to fall asleep rather quickly. Some nights I may not stay asleep for more than four hours, but compared to my sleep patterns of six months ago, I am delighted with four hours. The other night I actually managed to go back to sleep for an additional 3 hours. I realize that not everyone has the same results but I can truly say that this product works for me.

                  • My Beauty Routine Takes:
                  • 10 Minutes

                  (3 of 4 customers found this review helpful)

                   
                  1.0

                  Don't waste your money

                  By lzlaw6

                  from Southside, AL

                  About Me Brand Buyer

                  See all my reviews

                  Pros

                    Cons

                    • Not Effective
                    • Waste of money

                    Best Uses

                      Comments about Natrol® Melatonin TR:

                      I used this product to go to sleep at night and get a restful night's sleep. Used to use Ambien. At one time I used the TR released 3 mg GNC Melatonin. It quit working. So I went to GNC 5mg. But they did not have a TR. When I saw this, I thought it would be great to have the 5mg TR. It does not make you drowsy in 20 minutes like it says. As a matter of fact, it does not make me drowsy at all. I've even taken it on an empty stomach. Maybe, it's just my body chemistry. I have always had a history of insomnia. But in my opinion, it was a waste of money. I have had to go back to the GNC 5mg Melatonin.

                      • My Beauty Routine Takes:
                      • 30 Minutes

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