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GNC TriFlex™ Sport

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120 Caplets

Item #281512 See Product Details

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Description
New and Improved TriFlex™ Sport
Glucosamine
Chondroitin
MSM
Plus Joint Cushioning Sports Blend
  • Protects joints from wear and tear of exercise*
  • Maximum strength joint comfort for active individuals*
  • Clinical strenght for daily long-term use*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take four caplets daily.

Serving Size 4 Caplets
Servings Per Container 30
Amount Per Serving % DV
Vitamin C (as Ascorbic Acid) 120.00 mg 200%
Sodium 130.00 mg 5%
Glucosamine HCI 1500.00 mg 0%
Chondroitin Sulfate Sodium 1200.00 mg 0%
Joint Cushioning Sports Blend 955.00 mg 0%
 MSM (Methylsulfonyl-methane) **
 Boswellia serrata gum extract **
 White Willow Bark Extract (15% Salicin = 120 mg) **
 Hyaluronic Acid (as Sodium Hyaluronate) **
 Hops Cones Extract (alpha & Iso-alpha Acids)(Humulus lupulus) **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Titanium Dioxide (Natural Mineral Whitener), Natural Vanilla Flavor, Vegetable Acetoglycerides, Caramel Color, Ethyl Vanillin, Sucralose

No Artificial Colors, No Wheat, No Gluten, No Soy, No Dairy, Yeast Free

Storage Instructions: Store in a cool, dry place.

Warning: Keep out of reach of children

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.

CONTAINS: Crustaceans (Shrimp)

General Nutrition Corporation
Pittsburgh, PA 15222
For More Information:
1-888-462-2548

Health Notes

Joint Health

Joint Health
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

Osteoarthritis
Dose: 800 to 1,200 mg a day
Many trials have shown that supplementing with chondroitin sulfate reduces pain, increases joint mobility, and promotes healing within the joints.(more)
Osteoarthritis
Dose: 2.25 to 6.0 grams per day
In one trial, supplementing with methyl-sulfonylmethane significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee. (more)
Osteoarthritis
Dose: Refer to label instructions
Studies have shown glucosamine hydrochloride to be effective at reducing pain and improving symptoms in people with osteoarthritis.(more)
Osteoarthritis
Dose: 800 to 1,200 mg a day

Chondroitin sulfate (CS) is a major component of the lining of joints. The structure of CS includes molecules related to glucosamine sulfate. CS levels have been reported to be reduced in joint cartilage affected by osteoarthritis. Possibly as a result, CS supplementation may help restore joint function in people with osteoarthritis.1 On the basis of preliminary evidence, researchers had believed that oral CS was not absorbed in humans;2 as a result, early double-blind CS research was done mostly by giving injections.3, 4 This research documented clinical benefits from CS injections. It now appears, however, that a significant amount of CS is absorbable in humans,5 though dissolving CS in water leads to better absorption than swallowing whole pills.6

Strong clinical evidence now supports the use of oral CS supplements for osteoarthritis. Many double-blind trials have shown that CS supplementation consistently reduces pain, increases joint mobility, and/or shows evidence (including X-ray changes) of healing within joints of people with osteoarthritis.7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 Most trials have used 400 mg of CS taken two to three times per day. One trial found that taking the full daily amount (1,200 mg) at one time was as effective as taking 400 mg three times per day.18 Reduction in symptoms typically occurs within several months.

References

1. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

2. Baici A, Horler D, Moser B, et al. Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate. Rheumatol Int 1992;12:81-8.

3. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

4. Rovetta G. Galactosaminoglycuronoglycan sulfate (Matrix) in therapy of tibiofibular osteoarhtirits of the knee. Drugs Exp Clin Res 1991;17:53-7.

5. Conte A, Volpi N, Palmieri L, et al. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneimittelforschung 1995;45:918-25.

6. Ronca F, Palmieri L, Panicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 1998;6(Supplement A):14-21.

7. Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(Suppl A):39-46.

8. Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage 1998;6(Suppl A):37-8.

9. Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 1998;6(Suppl A):31-6.

10. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

11. Pipitone V, Ambanelli U, Cervini C, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Curr Ther Res 1992;52:608-38.

12. Bazieres B, Loyau G, Menkes CJ, et al. Le chondroitine sulfate dans le traitement de la gonarthrose et de la coxarthrose. Rev Rhum Mal Osteoartic 1992;59:466-72 [in French].

13. Conrozier T, Vignon E. Die Wirkung von Chondroitinsulfat bei der Behandlung der Huft Gelenksarthrose. Eine Doppelblindstudie gegen Placebo. Litera Rheumatologica 1992;14:69-75 [in German].

14. L'Hirondel JL. Klinische Doppelblind-Studie mit oral verabreichtem Chondroitinsulfat gegen Placebo bei der tibiofermoralen Gonarthrose (125 Patienten). Litera Rheumatologica 1992;14:77-82 [in German].

15. Morreale P, Manopulo R, Galati M, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-91.

16. Leeb BF, Petera P, Neumann K. Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints. Wien Med Wochenschr 1996;146:609-14.

17. Wildi LM, Raynauld JP, Martel-Pelletier J, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis 2011;70:982-9.

18. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

Osteoarthritis
Dose: 2.25 to 6.0 grams per dayAccording to a small double-blind trial, 2,250 mg per day of oral methylsulfonylmethane (MSM), a variant of DMSO, reduced osteoarthritis pain after six weeks.1 In another double-blind trial, supplementation with 3 grams of MSM twice a day for 12 weeks significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee.2
References

1. Lawrence RM. Methylsulfonylmethane (MSM): a double-blind study of its use in degenerative arthritis. Int J of Anti-Aging Med 1998;1:50.

2. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94.

Osteoarthritis
Dose: Refer to label instructionsA few trials have evaluated glucosamine hydrochloride (GH), another form of glucosamine sulfate (GS), as a single remedy for osteoarthritis. One trial found only minor benefits from 1,500 mg per day of GH for 8 weeks in people with osteoarthritis of the knee.1 However, these people were also taking up to 4,000 mg per day of acetaminophen for pain relief, and that treatment might have masked a beneficial effect of GH. In another study, supplementing with GH (2,000 mg each morning for 12 weeks) significantly improved symptoms, compared with a placebo, in people with knee pain due to cartilage damage or osteoarthritis.2 In a four-week study from China, GH was as effective as GS in people with osteoarthritis of the knee.3 Another study found that the combination of GH and chondroitin sulfate was more effective than a placebo in people with moderate to severe knee pain from osteoarthritis, but not in those with mild pain.4 Despite the reported beneficial effects of GH, some investigators believe that the sulfate component of GS itself helps relieve osteoarthritis, and that GS would therefore be more effective than GH.5
References

1. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.

2. Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med 2003;37:45-9.

3. Qiu GX, Weng XS, Zhang K, et al. A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulfate in the treatment of knee osteoarthritis. Zhonghua Yi Xue Za Zhi 2005;85:3067-70 [in Chinese].

4. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;795-808.

5. Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC TriFlex™ Sport
 
4.7

(based on 12 reviews)

100%

of respondents would recommend this to a friend.

Pros

  • Effective (11)
  • Easy to use (9)
  • Good value (7)
  • Smells great (4)
  • Lightweight (3)

Cons

    Best Uses

    • Daily use (9)
    • Men (3)
      • Reviewer Profile:
      • Brand buyer (6), Budget shopper (5)
      • My Beauty Routine Takes:
      • 10 minutes (6)

    Reviewed by 12 customers

    Sort by

    Displaying reviews 1-10

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    (3 of 3 customers found this review helpful)

     
    4.0

    get a leg up!

    By dltens

    from wheeling,wv

    About Me Budget Buyer

    See all my reviews

    Verified Buyer

    Pros

    • Easy To Use
    • Effective
    • Good Value

    Cons

      Best Uses

      • Daily Use

      Comments about GNC TriFlex™ Sport:

      get both legs up & moving. have knee pain when not using this product when running, doing the elliptical machine, or stationary bike. have tried many products and this is one of the best.
      able to keep my 64 year old body active for the time being.

      • My Beauty Routine Takes:
      • 10 Minutes

      (4 of 4 customers found this review helpful)

       
      5.0

      Love this product!!

      By nglubo15

      from Parsippany, NJ

      See all my reviews

      Pros

      • Easy To Use
      • Effective

      Cons

        Best Uses

          Comments about GNC TriFlex™ Sport:

          I went years with bad knee pain, saw many doctors, and stopped running for over a year. This product was recommended and was the only thing that helped. If I remember to take these pills regularly I can run pain free! I would HIGHLY recommend using these if you have any knee pain while running.

          (1 of 1 customers found this review helpful)

           
          4.0

          Great product, right price.

          By h82paint

          from Southern NH

          About Me Budget Buyer

          See all my reviews

          Verified Buyer

          Pros

          • Easy To Use
          • Effective
          • Good Value
          • Smells Great

          Cons

            Best Uses

            • Aging outdoor enthusiast

            Comments about GNC TriFlex™ Sport:

            All the right ingredients, in a reasonable sized caplet. Taking 4 can be tough. Well coated, and when bought during the sale (Goldcard member) was very competitive with generic forms of these products

            • My Beauty Routine Takes:
            • 10 Minutes

            (3 of 3 customers found this review helpful)

             
            5.0

            Creme of the crop

            By josephkim007

            from Fullerton, CA

            About Me Budget Buyer

            See all my reviews

            Verified Buyer

            Pros

            • All the right ingredients
            • Effective
            • Works

            Cons

            • A bit expensive
            • A bit tedious to eat

            Best Uses

            • Daily Use
            • Men
            • Those with joint pains
            • Women

            Comments about GNC TriFlex™ Sport:

            Has pretty much all that you need in a joint product. That's what makes it sometimes hard to find other joint supp that would complement this one because it already has almost everything you need. Highly recommended, esp when it's on sale! White willow bark, tumeric, and boswella would be good complements as well. Though instaflex has those ingredients in their product, it's not in significant amounts as individual supplements.

            • My Beauty Routine Takes:
            • 30 Minutes

            (1 of 1 customers found this review helpful)

             
            5.0

            Better than any other I have tried

            By wolf6675

            from Oshkosh, WI

            About Me Brand Buyer

            See all my reviews

            Verified Buyer

            Pros

            • Easy To Use
            • Effective
            • Good taste
            • Good Value
            • Lightweight
            • Smells Great

            Cons

            • A little pricey

            Best Uses

              Comments about GNC TriFlex™ Sport:

              This has all the essentials for joints.I use it to keep my knees healthy as the cartilage is thinning.,I am very active, and I do believe it helps

              • My Beauty Routine Takes:
              • 10 Minutes

              (2 of 2 customers found this review helpful)

               
              5.0

              THE BEST

              By inaudy02

              from miami, fl

              About Me Budget Buyer

              See all my reviews

              Pros

              • WORKD FAST

              Cons

                Best Uses

                • Daily Use
                • Men

                Comments about GNC TriFlex™ Sport:

                I tried so many other over the counter pills for the pain in my arm due to lifting weights. These are the best and they worked by the second day.

                • My Beauty Routine Takes:
                • 10 Minutes

                (1 of 1 customers found this review helpful)

                 
                5.0

                GREAT STUFF!

                By 24ggirl

                from TEXAS

                About Me Brand Buyer

                See all my reviews

                Pros

                • Easy To Use
                • Effective
                • Good Value
                • Lightweight
                • Smells Great

                Cons

                  Best Uses

                  • Daily Use
                  • Men

                  Comments about GNC TriFlex™ Sport:

                  I could already tell a difference the 2nd day of use! I highly reccomend this to anyone that suffers pain of some sorts or another!

                  • My Beauty Routine Takes:
                  • 10 Minutes

                  (1 of 1 customers found this review helpful)

                   
                  5.0

                  Good product

                  By lct8847

                  from Chagrin Falls , Ohio

                  About Me Brand Buyer

                  See all my reviews

                  Verified Buyer

                  Pros

                  • Easy To Use
                  • Effective
                  • Good Value

                  Cons

                    Best Uses

                    • Daily Use

                    Comments about GNC TriFlex™ Sport:

                    This product has served me well for the last 2 years.

                    (1 of 1 customers found this review helpful)

                     
                    5.0

                    Triflex has exceeded all other brands.

                    By jafalcon

                    from Covina, California

                    About Me Brand Buyer

                    See all my reviews

                    Verified Buyer

                    Pros

                    • Easy To Use
                    • Effective
                    • Good Value
                    • Lightweight
                    • Smells Great

                    Cons

                      Best Uses

                      • Daily Use

                      Comments about GNC TriFlex™ Sport:

                      Take on a daily basis to prevent any joint fatigue and soreness.

                      (1 of 1 customers found this review helpful)

                       
                      5.0

                      Great Joint Supplement

                      By joe82175

                      from Illinois

                      About Me Brand Buyer

                      See all my reviews

                      Verified Buyer

                      Pros

                      • Easy To Use
                      • Effective
                      • Good Value

                      Cons

                      • None

                      Best Uses

                      • Daily Use

                      Comments about GNC TriFlex™ Sport:

                      like anything you need to use this everyday for it to become effective but after a few weeks you will start to feel it working and not having so many joint flare ups from working out

                      • My Beauty Routine Takes:
                      • 30 Minutes

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