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GNC TriFlex™ Sport

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240 Caplets

Item #281522 See Product Details

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Description
New and Improved TriFlex™ Sport
Glucosamine
Chondroitin
MSM
Plus Joint Cushioning Sports Blend
  • Protects joints from wear and tear of exercise*
  • Maximum strength joint comfort for active individuals*
  • Clinical strenght for daily long-term use*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietart supplement, take four caplets daily.

Serving Size 4 Caplets
Servings Per Container 60
Amount Per Serving % DV
Vitamin C (as Ascorbic Acid) 120.00 mg 200%
Sodium 130.00 mg 5%
Glucosamine HCI 1500.00 mg 0%
Chondroitin Sulfate Sodium 1200.00 mg 0%
Joint Cushioning Sports Blend 955.00 mg 0%
 MSM (Methylsulfonyl-methane) **
 Boswellia serrata gum extract **
 White Willow Bark Extract (15% Salicin = 120 mg) **
 Hyaluronic Acid (as Sodium Hyaluronate) **
 Hops Cones Extract (alpha & Iso-alpha Acids)(Humulus lupulus) **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Titanium Dioxide (Natural Mineral Whitener), Natural Vanilla Flavor, Vegetable Acetoglycerides, Caramel Color, Ethyl Vanillin, Sucralose

No Artificial Colors, No Wheat, No Gluten, No Soy, No Dairy, Yeast Free

Storage Instructions: Store in a cool, dry place.

Warning: Keep out of reach of children

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.

CONTAINS: Crustaceans (Shrimp)

General Nutrition Corporation
Pittsbugh, PA 15222
For More Information:
1-888-462-2548

Health Notes

Joint Health

Joint Health
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

Osteoarthritis
Dose: 800 to 1,200 mg a day
Many trials have shown that supplementing with chondroitin sulfate reduces pain, increases joint mobility, and promotes healing within the joints.(more)
Osteoarthritis
Dose: 2.25 to 6.0 grams per day
In one trial, supplementing with methyl-sulfonylmethane significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee. (more)
Osteoarthritis
Dose: Refer to label instructions
Studies have shown glucosamine hydrochloride to be effective at reducing pain and improving symptoms in people with osteoarthritis.(more)
Osteoarthritis
Dose: 800 to 1,200 mg a day

Chondroitin sulfate (CS) is a major component of the lining of joints. The structure of CS includes molecules related to glucosamine sulfate. CS levels have been reported to be reduced in joint cartilage affected by osteoarthritis. Possibly as a result, CS supplementation may help restore joint function in people with osteoarthritis.1 On the basis of preliminary evidence, researchers had believed that oral CS was not absorbed in humans;2 as a result, early double-blind CS research was done mostly by giving injections.3, 4 This research documented clinical benefits from CS injections. It now appears, however, that a significant amount of CS is absorbable in humans,5 though dissolving CS in water leads to better absorption than swallowing whole pills.6

Strong clinical evidence now supports the use of oral CS supplements for osteoarthritis. Many double-blind trials have shown that CS supplementation consistently reduces pain, increases joint mobility, and/or shows evidence (including X-ray changes) of healing within joints of people with osteoarthritis.7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 Most trials have used 400 mg of CS taken two to three times per day. One trial found that taking the full daily amount (1,200 mg) at one time was as effective as taking 400 mg three times per day.18 Reduction in symptoms typically occurs within several months.

References

1. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

2. Baici A, Horler D, Moser B, et al. Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate. Rheumatol Int 1992;12:81-8.

3. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

4. Rovetta G. Galactosaminoglycuronoglycan sulfate (Matrix) in therapy of tibiofibular osteoarhtirits of the knee. Drugs Exp Clin Res 1991;17:53-7.

5. Conte A, Volpi N, Palmieri L, et al. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneimittelforschung 1995;45:918-25.

6. Ronca F, Palmieri L, Panicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 1998;6(Supplement A):14-21.

7. Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(Suppl A):39-46.

8. Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage 1998;6(Suppl A):37-8.

9. Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 1998;6(Suppl A):31-6.

10. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

11. Pipitone V, Ambanelli U, Cervini C, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Curr Ther Res 1992;52:608-38.

12. Bazieres B, Loyau G, Menkes CJ, et al. Le chondroitine sulfate dans le traitement de la gonarthrose et de la coxarthrose. Rev Rhum Mal Osteoartic 1992;59:466-72 [in French].

13. Conrozier T, Vignon E. Die Wirkung von Chondroitinsulfat bei der Behandlung der Huft Gelenksarthrose. Eine Doppelblindstudie gegen Placebo. Litera Rheumatologica 1992;14:69-75 [in German].

14. L'Hirondel JL. Klinische Doppelblind-Studie mit oral verabreichtem Chondroitinsulfat gegen Placebo bei der tibiofermoralen Gonarthrose (125 Patienten). Litera Rheumatologica 1992;14:77-82 [in German].

15. Morreale P, Manopulo R, Galati M, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-91.

16. Leeb BF, Petera P, Neumann K. Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints. Wien Med Wochenschr 1996;146:609-14.

17. Wildi LM, Raynauld JP, Martel-Pelletier J, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis 2011;70:982-9.

18. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

Osteoarthritis
Dose: 2.25 to 6.0 grams per dayAccording to a small double-blind trial, 2,250 mg per day of oral methylsulfonylmethane (MSM), a variant of DMSO, reduced osteoarthritis pain after six weeks.1 In another double-blind trial, supplementation with 3 grams of MSM twice a day for 12 weeks significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee.2
References

1. Lawrence RM. Methylsulfonylmethane (MSM): a double-blind study of its use in degenerative arthritis. Int J of Anti-Aging Med 1998;1:50.

2. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94.

Osteoarthritis
Dose: Refer to label instructionsA few trials have evaluated glucosamine hydrochloride (GH), another form of glucosamine sulfate (GS), as a single remedy for osteoarthritis. One trial found only minor benefits from 1,500 mg per day of GH for 8 weeks in people with osteoarthritis of the knee.1 However, these people were also taking up to 4,000 mg per day of acetaminophen for pain relief, and that treatment might have masked a beneficial effect of GH. In another study, supplementing with GH (2,000 mg each morning for 12 weeks) significantly improved symptoms, compared with a placebo, in people with knee pain due to cartilage damage or osteoarthritis.2 In a four-week study from China, GH was as effective as GS in people with osteoarthritis of the knee.3 Another study found that the combination of GH and chondroitin sulfate was more effective than a placebo in people with moderate to severe knee pain from osteoarthritis, but not in those with mild pain.4 Despite the reported beneficial effects of GH, some investigators believe that the sulfate component of GS itself helps relieve osteoarthritis, and that GS would therefore be more effective than GH.5
References

1. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.

2. Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med 2003;37:45-9.

3. Qiu GX, Weng XS, Zhang K, et al. A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulfate in the treatment of knee osteoarthritis. Zhonghua Yi Xue Za Zhi 2005;85:3067-70 [in Chinese].

4. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;795-808.

5. Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC TriFlex™ Sport
 
4.4

(based on 28 reviews)

100%

of respondents would recommend this to a friend.

Pros

  • Effective (26)
  • Easy to use (16)
  • Good value (10)
  • Smells great (7)

Cons

    Best Uses

    • Daily use (27)
    • Men (10)
    • Women (5)
      • Reviewer Profile:
      • Budget shopper (16), Brand buyer (7)
      • My Beauty Routine Takes:
      • 10 minutes (9), 30 minutes (7)

    Reviewed by 28 customers

    Sort by

    Displaying reviews 1-10

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    5.0

    Wonderful product

    By sweetbeas1

    from Nashville, IN

    About Me Health Conscious

    See all my reviews

    Pros

    • Easy on Stomach
    • Easy To Swallow
    • Effective
    • Simple To Take
    • Tastes Good

    Cons

      Best Uses

      • Men
      • Older People

      Comments about GNC TriFlex™ Sport:

      Have used this product for years and would recommend it to everyone! The Triflex Mobility is a great product also.

      (2 of 2 customers found this review helpful)

       
      4.0

      No complaints here

      By rclark_goldsgym

      from Washington, DC

      See all my reviews

      Pros

      • Easy on Stomach
      • Easy To Swallow
      • Effective
      • Simple To Take
      • Tastes Good

      Cons

        Best Uses

        • Daily Use
        • Men
        • Women

        Comments about GNC TriFlex™ Sport:

        I started taking this after my second half-marathon. I ran the last 5 miles in tears with extreme joint pain. My boyfriend, a professional athlete, suggested I start taking a glucosamine supplement regularly for my next race. I started taking them daily in Mid-March 2013. I experienced no pain during my next race, September 1, 2013. I have recently started experiencing knee pain again after not taking this supplement for several months, and have started back up again.

        (2 of 2 customers found this review helpful)

         
        5.0

        Great follow up to the multi pak

        By raulissol

        from Apple Valley, CA

        About Me Budget Buyer

        See all my reviews

        Verified Buyer

        Pros

        • Easy To Use
        • Effective
        • Lightweight
        • Smells Great

        Cons

          Best Uses

          • Daily Use
          • Men
          • On-the-go
          • Women

          Comments about GNC TriFlex™ Sport:

          4 pills a day is a bit much, but they get the job Done! I broke 4 ribs, hurt both shoulders and my right thumb, 3 months ago...Thanks to this I'm healing a faster than I expected. Can't wait to be able to get back to the gym!!

          • My Beauty Routine Takes:
          • 30 Minutes

          (2 of 2 customers found this review helpful)

           
          4.0

          No longer hurting

          By bayoutide27

          from LaPlace, LA

          About Me Budget Buyer

          See all my reviews

          Pros

          • Effective

          Cons

            Best Uses

            • Daily Use
            • Men

            Comments about GNC TriFlex™ Sport:

            I started playing basketball regularly on Saturdays. I would hurt for days after. After taking triflex, my recovery time has been greatly reduced, and I really don't hurt anymore.

            • My Beauty Routine Takes:
            • 10 Minutes

            (1 of 2 customers found this review helpful)

             
            5.0

            Works great

            By spaceman_spif87

            from Philadelphia

            About Me Budget Buyer

            See all my reviews

            Pros

            • Easy To Use
            • Effective

            Cons

              Best Uses

              • Daily Use

              Comments about GNC TriFlex™ Sport:

              I use these daily and it works great my knees dont hurt anymore

              • My Beauty Routine Takes:
              • 30 Minutes

              (1 of 1 customers found this review helpful)

               
              5.0

              Works Great!

              By haijin

              from Boston, MA

              About Me Brand Buyer

              See all my reviews

              Verified Buyer

              Pros

              • Easy To Use
              • Effective
              • Good Value

              Cons

                Best Uses

                • Daily Use

                Comments about GNC TriFlex™ Sport:

                Works great, knees feel good!

                • My Beauty Routine Takes:
                • 1+ Hour

                (2 of 2 customers found this review helpful)

                 
                4.0

                It really helps

                By xufumingnan

                from Portland, OR

                About Me Brand Buyer

                See all my reviews

                Verified Buyer

                Pros

                • Effective
                • Good Value
                • Smells Great

                Cons

                  Best Uses

                  • Daily Use

                  Comments about GNC TriFlex™ Sport:

                  I enjoy jogging but my right knee hurts when the time is too long. After I take this product of GNC, it really helps to ease the pain. Now I can run for 5 miles comfortably!

                  • My Beauty Routine Takes:
                  • 10 Minutes

                  (1 of 1 customers found this review helpful)

                   
                  4.0

                  I would buy this product again

                  By gf9527

                  from Beaverton, OR

                  About Me Brand Buyer

                  See all my reviews

                  Verified Buyer

                  Pros

                  • Effective

                  Cons

                    Best Uses

                    • Daily Use

                    Comments about GNC TriFlex™ Sport:

                    I take this for few years, it does my knee, and I can kick football three games a week. thanks for the triflex~

                    (5 of 5 customers found this review helpful)

                     
                    5.0

                    Can't live without my Triflex Sport

                    By caseman01

                    from Frisco, TX

                    About Me Budget Buyer

                    See all my reviews

                    Verified Buyer

                    Pros

                    • Easy To Use
                    • Effective
                    • Smells Great

                    Cons

                    • 4 daily pills

                    Best Uses

                    • Daily Use

                    Comments about GNC TriFlex™ Sport:

                    I tore the meniscus in both of my knees playing basketball and had 3 arthroscopic surgeries. Triflex sport enables me to minimize the arthritis pain and still stay active. It's actually nice having moments when you don't notice the pain. This stuff is great and highly recommend.

                    (2 of 2 customers found this review helpful)

                     
                    5.0

                    EFFECTIVE!

                    By kylepang96

                    from Evanston, IL

                    See all my reviews

                    Verified Buyer

                    Pros

                    • Effective
                    • Vanilla coated

                    Cons

                      Best Uses

                      • Daily Use

                      Comments about GNC TriFlex™ Sport:

                      I play basketball and have some knee issues before .The supplement was very effective and it helped my knee feel better.

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