As a dietary supplement, take two tablets daily with food.
|Serving Size 2 Tablets|
|Servings Per Container 120|
|Amount Per Serving||% DV|
|Zinc (as Zinc Oxide)||7.50 mg||50%|
|Selenium (as sodium selenate)||35.00 mcg||50%|
|Saw Palmetto Berry Powder (Serenoa repens)||500.00 mg||**|
|Pumpkin Seed Meal Powder (Curcubita pepo)||80.00 mg||**|
|** Daily Value (DV) not established|
Other Ingredients: Cellulose, Dicalcium Phosphate, Povidone
No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Soy, No Dairy, Yeast Free.
Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.
Distributed by: General Nutrition Corporation Pittsburgh, PA 15222
In many parts of Europe, herbal supplements are considered standard medical treatment for BPH. Although herbs for BPH are available without prescription, men wishing to take them should be monitored by a physician.
The fat-soluble (liposterolic) extract of the saw palmetto berry has become the leading natural treatment for BPH. This extract, when used regularly, has been shown to help keep symptoms in check.1, 2 Saw palmetto appears to inhibit 5-alpha-reductase, the enzyme that converts testosterone to its more active form, dihydrotestosterone (DHT). Saw palmetto also blocks DHT from binding in the prostate.3 Studies have used 320 mg per day of saw palmetto extract that is standardized to contain approximately 80 to 95% fatty acids.
A three-year preliminary study in Germany found that 160 mg of saw palmetto extract taken twice daily reduced nighttime urination in 73% of patients and improved urinary flow rates significantly.4 In a double-blind trial at various sites in Europe, 160 mg of saw palmetto extract taken twice per day treated BPH as effectively as finasteride without side effects, such as loss of libido.5 A one-year dose-comparison study found that 320 mg once per day was as effective as 160 mg twice per day in the treatment of BPH.6 A review of double-blind trials concluded that saw palmetto is effective for treatment of men with BPH and is just as effective as, with fewer side effects than, the drug finasteride.7 However, two double-blind trials have found saw palmetto to be ineffective as a treatment for BPH.8, 9 The reason that different studies have had different results is not clear.
1. Schneider HJ, Honold E, Mashur T. Treatment of benign prostatic hyperplasia. Results of a surveillance study in the practices of urological specialists using a combined plant-base preparation. Fortschr Med 1995;113:37-40.
2. Shi R, Xie Q, Gang X, et al. Effect of saw palmetto soft gel capsule on lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized trial in Shanghai, China. J Urol 2008;179:610-5.
3. Koch E, Biber A. Pharmacological effects of sabal and urtica extracts as a basis for a rational medication of benign prostatic hyperplasia. Urologe 1994;334:90-5.
4. Bach D, Ebeling L. Long-term drug treatment of benign prostatic hyperplasia-results of a prospective 3-year multicenter study using Sabal extract IDS 89. Phytomedicine 1996;3:105-11.
5. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon(R)) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40.
6. Braeckman J, Bruhwyler J, Vandekerckhove K, Geczy J. Efficacy and safety of the extract of Serenoa repens in the treatment of benign prostatic hyperplasia: therapeutic equivalence between twice and once daily dosage forms. Phytotherapy Res 1997;11:558-63.
7. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia. A systematic review. JAMA 1998;280:1604-9.
8. Bent S, Kane C, Shinohara K, et al. Saw palmetto for benign prostatic hyperplasia. N Engl J Med2006;354:557-66.
9. Barry MJ, Meleth S, Lee JY, et al. Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial. JAMA 2011;306:1344-51
Saw palmetto, known more for its use in BPH, has also been used historically for symptoms of prostatitis.1 According to laboratory studies, saw palmetto contains constituents that act to reduce swelling and inflammation.2 However, there is no scientific research evaluating the effects of saw palmetto in men with prostatitis.
1. Felter HW, Lloyd JU. Kings American Dispensatory, Vol II. Portland, OR: Eclectic Medical Publications, 1983, 1751-2.
2. Breu W, Hagenlocher M, Redl K, et al. [Anti-inflammatory activity of sabal fruit extracts prepared with supercritical carbon dioxide. In vitro antagonists of cyclooxygenase and 5-lipoxygenase metabolism]. Arzneimittelforschung 1992;42:547-51 [in German].
Saw palmetto (sometimes referred to as sabal in Europe) is a native of the southeast United States. The berries of the plant are used medicinally.
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