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Description
  • Clinically shown to support heart health*
  • Helps replenish CoQ-10 levels reduced by statin drugs*
  • Powerful cardiovascular antioxidant*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take one to two softgel capsules daily after a meal.

Serving Size 1 Softgel Capsule
Servings Per Container 30
Amount Per Serving % DV
Coenzyme Q-10 (Natural) 200.00 mg **
** Daily Value (DV) not established

Other Ingredients: Soybean Oil, Gelatin, Glycerin, Chlorophyll, Titanium Dioxide (Natural Mineral Whitener)

No sugar, no artificial colors, no artificial flavors, sodium free, no wheat, no gluten, no corn, no dairy, yeast free.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.

Distributed by: General Nutrition Corporation Pittsburgh, PA 15222

Health Notes

Coenzyme Q10

Coenzyme Q10
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Hypertension
Dose: 100 mg twice per day
Taking coenzyme Q10 may have a significant impact on blood pressure. (more)
Angina
Dose: 150 mg daily
CoQ10 contributes to the heart's energy-making mechanisms. Angina patients given CoQ10 have experienced greater ability to exercise without chest pain. (more)
Heart Attack
Dose: 500 to 800 mcg daily
Taking CoQ10 may help reduce complications following a heart attack. (more)
Congestive Heart Failure
Dose: 0.9 mg daily per pound of body weight with a doctor's supervision
CoQ10 enhances the production of energy in the heart muscle and has been reported to help people with CHF, sometimes dramatically. (more)
Cardiomyopathy
Dose: 100 to 150 mg daily
Most studies using coenzyme Q10 in treating cardiomyopathy have shown positive results, including improved quality of life, heart function tests, and survival rates.(more)
Chronic Obstructive Pulmonary Disease
Dose: Refer to label instructions
CoQ10 levels have been found to be low in people with COPD. Supplementing with CoQ10 improved blood oxygenation, exercise performance, and heart rate in one study.(more)
Migraine Headache
Dose: 100 to 150 mg daily
In a preliminary trial, supplementation with coenzyme Q10 for three months reduced the average number of days with migraine headaches by 60%.(more)
Fibromyalgia
Dose: Refer to label instructions
In a preliminary trial, headaches and overall symptoms in people with fibromyalgia significantly improved after supplementing with coenzyme Q10. (more)
Type 2 Diabetes
Dose: 120 mg daily of a standardized herbal extract
Supplementing with CoQ10 may improve blood sugar metabolism.(more)
Insulin Resistance Syndrome
Dose: Refer to label instructions
Coenzyme Q10 may improve insulin sensitivity in people with components of IRS.(more)
Type 1 Diabetes
Dose: Refer to label instructions
Supplementing with CoQ10 may improve blood sugar metabolism.(more)
Athletic Performance
Dose: Refer to label instructions
Strenuous physical activity lowers blood levels of coenzyme Q10 (CoQ10). A few studies have reported that CoQ10 supplementation benefitted some trained athletes.(more)
Macular Degeneration
Dose: Follow label directions
In one study, supplementing with a proprietary blend of acetyl-L-carnitine, fish oil, and coenzyme Q10 improved visual function in people with macular degeneration.(more)
Alzheimer's Disease
Dose: Refer to label instructions
A combination of coenzyme Q10, iron (sodium ferrous citrate), and vitamin B6 may improve mental status in people with Alzheimer's disease.(more)
Gingivitis
Dose: 50 to 60 mg daily
Supplementing with CoQ10 may reduce gingivitis symptoms and repair damaged gum tissues.(more)
Halitosis and Gum Disease
Dose: 50 to 60 mg daily
Coenzyme Q10 is often recommended by doctors to help prevent and treat periodontitis.(more)
Macular Degeneration
Dose: Follow label directions
In one study, supplementing with a proprietary blend of acetyl-L-carnitine, fish oil, and coenzyme Q10 improved visual function in people with macular degeneration.(more)
Preeclampsia
Dose: 200 mg per day
In a double-blind study at women who were at high risk of developing preeclampsia, supplementing with coenzyme Q10 reduced the incidence of preeclampsia by 44%. (more)
Male Infertility
Dose: Refer to label instructions
CoQ10 is a nutrient used by the body to produce energy. While its exact role in the formation of sperm is unknown, even small amounts appear to increase sperm count and motility.(more)
Tinnitus
Dose: Refer to label instructions
For people who are deficient in CoQ10, supplementing with the nutrient may improve tinnitus.(more)
HIV and AIDS Support
Dose: Refer to label instructions
In one trial, people with HIV who took CoQ10 experienced no further infections for up to seven months, and counts of infection-fighting white blood cells improved in some cases.(more)
Kidney Failure
Dose: Refer to label instructions
(more)
Hypertension
Dose: 100 mg twice per day

Both preliminary1, 2, 3 and double-blind4, 5 trials have reported that supplementation with coenzyme Q10 (CoQ10) leads to a significant decrease in blood pressure in people with hypertension. Much of this research has used 100 mg of CoQ10 per day for at least ten weeks.

References

1. Folkers K, Drzewoski J, Richardson PC, et al. Bioenergetics in clinical medicine. XVI. Reduction of hypertension in patients by therapy with coenzyme Q10. Res Commun Chem Pathol Pharmacol 1981;31:129-40.

2. Langsjoen P, Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;15 Suppl:s265-72.

3. Digiesi V, Cantini F, Oradei A, et al. Coenzyme Q10 in essential hypertension. Molec Aspects Med 1994;15 Suppl:s257-63.

4. Digiesi V, Cantini F, Brodbeck B. Effect of coenzyme Q10 on essential arterial hypertension. Curr Ther Res 1990;47:841-5.

5. Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8.

Angina
Dose: 150 mg daily

Coenzyme Q10 contributes to the energy-making mechanisms of the heart. Angina patients given 150 mg of coenzyme Q10 each day have experienced greater ability to exercise without experiencing chest pain.1 This has been confirmed in independent investigations.2

References

1. Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247.

2. Mortensen SA. Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone). Clin Investig 1993;71:S116-23 [review].

Heart Attack
Dose: 500 to 800 mcg daily

Coenzyme Q10 (CoQ10) also contributes to the energy-making mechanisms of the heart and has been reported to lower lipoprotein(a), a risk factor for heart disease.1 Animal studies confirm CoQ10's ability to protect heart muscle against reduced blood flow.2, 3 In one double-blind trial, either 120 mg of CoQ10 or placebo was given to people who had recently survived a heart attack. After 28 days, the CoQ10 group had experienced significantly fewer repeat heart attacks, fewer deaths from heart disease, and less chest pain than the placebo group.4 In another double-blind study of people suffering a heart attack, supplementation with 60 mg of coenzyme Q10 twice a day for one year significantly reduced the incidence of recurrent cardiac events (fatal or non-fatal heart attack). 5 Treatment was begun within 72 hours of the onset of the heart attack. CoQ10 used with selenium (see below) has also been reported to increase the rate of heart attack survival.6

The relation between selenium and protection from heart attacks remains uncertain. Low blood levels of selenium have been reported in people immediately following a heart attack,7 suggesting that heart attacks may increase the need for selenium. However, other researchers claim that low selenium levels are present in people before they have a heart attack, suggesting that the lack of selenium might increase heart attack risk.8 One report found that low blood levels of selenium increased the risk of heart attack only in smokers,9 and another found the link only in former smokers.10 Yet others have found no link between low blood levels of selenium and heart attack risk whatsoever.11 In a double-blind trial, individuals who already had one heart attack were given 100 mcg of selenium per day or placebo for six months.12 At the end of the trial, there were four deaths from heart disease in the placebo group but none in the selenium group (although the numbers were too small for this difference to be statistically significant). In other controlled research, a similar group was given placebo or 500 mcg of selenium six hours or less after a heart attack followed by an ongoing regimen of 100 mcg of selenium plus 100 mg of coenzyme Q10 per day.13 One year later, six people had died from a repeat heart attack in the placebo group, compared with no heart attack deaths in the supplement group. Despite the lack of consistency in published research, some doctors recommend that people at risk for a heart attack supplement with selenium-most commonly 200 mcg per day.

References

1. Singh RB, Niaz MA. Serum concentration of lipoprotein (a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role. Int J Cardiol 1999;68:23-9.

2. Atar D, Mortensen SA, Flachs H, Herzog WR. Coenzyme Q10 protects ischemic myocardium in an open-chest swine model. Clin Investig 1993;71:S103-11.

3. Ishikura Y, Odagiri S, Nagata M, et al. Effects of coenzyme Q10 on ischemic myocardium during coronary artery occlusion-evaluation of the time needed to change irreversible myocardium. Sangyo Ika Daigaku Zasshi 1986;8:19-25 [in Japanese].

4. Singh RB, Wander GS, Rastogi A, et al. Randomized double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther 1998;12:347-53.

5. Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem2003;246:75-82.

6. Kuklinski B, Weissenbacher E, Fahnrich A. Coenzyme Q10 and antioxidants in acute myocardial infarction. Mol Aspects Med 1994;15 Suppl:s143-7.

7. Auzepy P, Blondeau M, Richard C, et al. Serum selenium deficiency in myocardial infarction and congestive cardiomyopathy. Acta Cardiol 1987;42:161-6.

8. Oster O, Drexler M, Schenk J, et al. The serum selenium concentration of patients with acute myocardial infarction. Ann Clin Res 1986;18:36-42.

9. Beaglehole R, Jackson R, Watkinson J, et al. Decreased blood selenium and risk of myocardial infarction. Int J Epidemiol 1990;19:918-22.

10. Kardinaal AFM, Kok FJ, Kohlmeier L, et al. Association between toenail selenium and risk of acute myocardial infarction in European men. Am J Epidemiol 1997;145:373-9.

11. Salvini S, Hennekenes CH, Morris JS, et al. Plasma levels of the antioxidant selenium and risk of myocardial infarction among U.S. physicians. Am J Cardiol 1995;76:1218-21.

12. Korpela H, Kumpulainen J, Jussila E, et al. Effect of selenium supplementation after acute myocardial infarction. Res Commun Chem Pathol Pharmacol 1989;65:249-52.

13. Kuklinski B, Weissenbacher E, Fahnrich A. Coenzyme Q10 and antioxidants in acute myocardial infarction. Mol Aspects Med 1994;15 Suppl:s143-7.

Congestive Heart Failure
Dose: 0.9 mg daily per pound of body weight with a doctor's supervision

As is true for several other heart conditions, coenzyme Q10 (CoQ10) has been reported to help people with congestive heart failure,1, 2 sometimes dramatically.3 Positive effects have been confirmed in double-blind research4 and in an overall analysis of eight controlled trials.5 However, some double-blind trials have reported modest6 or no improvement7, 8, 9 in exercise capacity or overall quality of life. Most CoQ10 research used 90-200 mg per day. The beneficial effects of CoQ10 may not be seen until after several months of treatment. In one preliminary trial, treatment with ubiquinol (the chemically reduced form of CoQ10) was beneficial for people with severe heart failure, after the standard form of CoQ10 had been ineffective.10 Discontinuation of CoQ10 supplementation in people with congestive heart failure has resulted in severe relapses and should only be attempted under the supervision of a doctor.11

References

1. Mortensen SA, Vadhanavikit S, Baandrup U, Folkers K. Long-term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure. Drugs Exp Clin Res 1985;11:581-93.

2. Soongswang J, Sangtawesin C, Durongpisitkul K, et al. The effect of coenzyme Q10 on idiopathic chronic dilated cardiomyopathy in children. Pediatr Cardiol 2005;26:361-6.

3. Folkers K, Langsjoen P, Langsjoen PH. Therapy with coenzyme Q10 of patients in heart failure who are eligible or ineligible for a transplant. Biochem Biophys Res Commun 1992;15:247-53.

4. Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 in patients with congestive heart failure: a long-term multicenter randomized study. Clin Invest 1993;71:S134-6.

5. Soja AM, Mortensen SA. Treatment of chronic cardiac insufficiency with coenzyme Q10, results of meta-analysis in controlled clinical trials. Ugeskr Laeger 1997;159:7302-8.

6. Hofman-Bang C, Rehnqvist N, Swedberg K, et al. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group. J Card Fail 1995;1:101-7.

7. Permanetter B, Rossy W, Klein G, et al. Ubiquinone (coenzyme Q10) in the long-term treatment of idiopathic dilated cardiomyopathy. Eur Heart J 1992;13:1528-33.

8. Watson PS, Scalia GM, Galbraith A, et al. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol 1999;33:1549-52.

9. Khatta M, Alexander BS, Krichten CM, et al. The effect of coenzyme Q10 in patients with congestive heart failure. Ann Intern Med 2000;132:636-40.

10. Langsjoen PH, Langsjoen AM. Supplemental ubiquinol in patients with advanced congestive heart failure. Biofactors 2008;32:119-28.

11. Mortensen SA, Vadhanavikit S, Baandrup U, Folkers K. Long-term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure. Drugs Exp Clin Res 1985;11:581-93.

Cardiomyopathy
Dose: 100 to 150 mg daily

People with dilated congestive cardiomyopathy (DCM) have been shown to be deficient in coenzyme Q10.1 Most studies using coenzyme Q10 in the treatment of cardiomyopathy have demonstrated positive results, including improved quality of life, heart function tests, and survival rates.2, 3, 4 Coenzyme Q10 also has been shown to improve cardiac function in people with hypertrophic cardiomyopathy-a less common form of cardiomyopathy.5 A few studies, however, have found no benefit from CoQ10 supplementation in treating people with cardiomyopathy.6, 7 Despite a lack of consistency in the outcomes of published research, many doctors recommend that 100 to 150 mg be taken each day, with meals.

References

1. Manzoli U, Rossi E, Littarru GP, et al. Coenzyme Q10 in dilated cardiomyopathy. Int J Tissue React 1990;12(3):173-8.

2. Pogessi L, Galanti G, Comeglio M, et al. Effect of coenzyme Q10 on left ventricular function in patients with dilative cardiomyopathy. Curr Ther Res 1991;49:878-86.

3. Langsjoen PH, Vadhanavikit S, Folkers K. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. Proc Natl Acad Sci U S A 1985;82:4240-4.

4. Ma A, Zhang W, Liu Z. Effect of protection and repair of injury of mitochondrial membrane-phospholipid on prognosis in patients with dilated cardiomyopathy. Blood Press Suppl 1996;3:53-5.

5. Belardinelli R, Georgiou D, Cianci G, et al. Effects of exercise training on left ventricular filling at rest and during exercise in patients with ischemic cardiomyopathy and severe left ventricular systolic dysfunction. Am Heart J 1996;132(1 Pt 1):61-70.

6. Bresolin N, Doriguzzi C, Ponzetto C, et al. Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial. J Neurol Sci 1990;100:70-8.

7. Permanetter B, Rossey W, Weingartner F, et al. Lack of effectiveness of coenzyme Q10 (Ubiquinone) in long-term treatment of dilated cardiomyopathy. Z Kardiol 1989;78:360-5 [in German].

Chronic Obstructive Pulmonary Disease
Dose: Refer to label instructions

Researchers have also given coenzyme Q10 (CoQ10) to people with COPD after discovering their blood levels of CoQ10 were lower than those found in healthy people.1 In that trial, 90 mg of CoQ10 per day, given for eight weeks, led to no change in lung function, though oxygenation of blood improved, as did exercise performance and heart rate. Until more research is done, the importance of supplementing with CoQ10 for people with COPD remains unclear.

References

1. Fujimoto S, Kurihara N, Hirata K, Takeda T. Effects of coenzyme Q10 administration on pulmonary function and exercise performance in patients with chronic lung diseases. Clin Investig 1993;71(8 Suppl):S162-6.

Migraine Headache
Dose: 100 to 150 mg daily

Blood levels of coenzyme Q10 have been found to be low in about one-third of migraine sufferers.1 In a preliminary trial, supplementation of migraine sufferers with 150 mg per day of coenzyme Q10 for three months reduced the average number of days with migraine headaches by 60%.2 The beneficial effect of coenzyme Q10 was confirmed in a four-month double-blind study. By the fourth month of treatment, a reduction in migraine frequency of 50% or greater occurred in 47.6% of people receiving 100 mg of coenzyme Q10 three times a day, but in only 14.4% of those receiving a placebo (a statistically significant difference).3 However, another double-blind trial found that coenzyme Q10 was not more effective than a placebo in children with recurrent migraines, although children receiving coenzyme Q10 appeared to improve faster than those given the placebo.4

References

1. Hershey AD, Powers SW, Vockell ALB, et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache 2007;47:73-80.

2. Rozen TD, Oshinsky ML, Gebeline CA,, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia2002;22:137-41.

3. Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology2005;64:713-5.

4. Slater SK, Nelson TD, Kabbouche MA, A randomized, double-blinded, placebo-controlled, crossover, add-on study of coenzyme Q10 in the prevention of pediatric and adolescent migraine. Cephalalgia 2011;31:897-905.

Fibromyalgia
Dose: Refer to label instructionsIn a preliminary trial, supplementing with coenzyme Q10 (100 mg three times per day for three months) resulted in significant improvements in headaches and overall symptoms in patients with fibromyalgia.1 In another study, cellular levels of CoQ10 were significantly lower in women with fibromyalgia than in healthy women. In the same study, ten women with fibromyalgia received 300 mg of CoQ10 per day for three months. Significant improvements were seen in symptoms such as fatigue, pain, depression, and anxiety.2 Placebo-controlled trials are needed to confirm these preliminary observations.
References

1. Cordero MD, Cano-Garcia FJ, Alcocer-Gomez E, et al. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q10 effect on clinical improvement. PLoS One 2012;7:e35677.

2. Cordero MD, Santos-Garcia R, Bermejo-Jover D, et al. Coenzyme Q10 in salivary cells correlate with blood cells in fibromyalgia: improvement in clinical and biochemical parameter after oral treatment. Clin Biochem 2012;45:509-11.

Type 2 Diabetes
Dose: 120 mg daily of a standardized herbal extractCoenzyme Q10 (CoQ10) is needed for normal blood sugar metabolism. Animals with diabetes have been reported to be CoQ10 deficient. People with type 2 diabetes have been found to have significantly lower blood levels of CoQ10 compared with healthy people.1 In one trial, blood sugar levels fell substantially in 31% of people with diabetes after they supplemented with 120 mg per day of CoQ7, a substance similar to CoQ10.2 The importance of CoQ10 supplementation for people with diabetes remains an unresolved issue, though some doctors recommend approximately 50 mg per day as a way to protect against possible effects associated with diabetes-induced depletion.
References

1. Miyake Y, Shouzu A, Nishikawa M, et al. Effect of treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on serum coenzyme Q10 in diabetic patients. Arzneimittelforschung 1999;49:324-9.

2. Shigeta Y, Izumi K, Abe H. Effect of coenzyme Q7 treatment on blood sugar and ketone bodies of diabetics. J Vitaminol (Kyoto) 1966;12:293-8.

Insulin Resistance Syndrome
Dose: Refer to label instructions

A double-blind trial showed that coenzyme Q10, 120 mg per day, reduced glucose and insulin blood levels in people with high blood pressure and heart disease.1 These results suggest that coenzyme Q10 may improve insulin sensitivity in people with components of IRS, but more research is needed.

References

1. Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8.

Type 1 Diabetes
Dose: Refer to label instructionsCoenzyme Q10 (CoQ10) is needed for normal blood sugar metabolism. Animals with diabetes have been reported to be CoQ10 deficient. In one trial, blood sugar levels fell substantially in 31% of people with diabetes after they supplemented with 120 mg per day of CoQ7, a substance similar to CoQ10.1 In people with type 1 diabetes, however, supplementation with 100 mg of CoQ10 per day for three months neither improved glucose control nor reduced the need for insulin.2 The importance of CoQ10 supplementation for people with diabetes remains an unresolved issue, though some doctors recommend approximately 50 mg per day as a way to protect against possible effects associated with diabetes-induced depletion.
References

1. Shigeta Y, Izumi K, Abe H. Effect of coenzyme Q7 treatment on blood sugar and ketone bodies of diabetics. J Vitaminol (Kyoto) 1966;12:293-8.

2. Henriksen JE, Bruun Andersen C, Hother-Nielsen O, et al. Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with Type 1 diabetes mellitus. Diabet Med 1999;16:312-8.

Athletic Performance
Dose: Refer to label instructions

Strenuous physical activity lowers blood levels of coenzyme Q10 (CoQ10).1 However, while some studies have shown that CoQ10 improves the way the healthy body responds to exercise,2 other studies have found no improvement.3, 4, 5, 6 A few studies, using at least four weeks of CoQ10 supplementation at 60 to 100 mg per day, have reported improvements in measures of work capacity ranging from 3 to 29% in sedentary people and from 4 to 32% in trained athletes.7 However, recent double-blind and/or placebo-controlled trials in trained athletes, using performance measures such as time to exhaustion and total performance, have found either no significant improvement or significantly poorer results in those taking CoQ10.8, 9, 10

One double-blind study found that supplementation with ubiquinol (the chemically reduced form of CoQ10) in the amount of 300 mg per day for 6 weeks improved maximum power output in a group of trained athletes.11

References

1. Kaikkonen J, Nyyssonen K, Tuomainen TP, et al. Determinants of plasma coenzyme Q10 in humans. FEBS Lett 1999;443:163-6 [review].

2. Mizuno K, Tanaka M, Nozaki S, et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition 2008;24:293-9.

3. Overvad OK, Diamant B, Holm L, et al. Efficacy and safety of dietary supplementation containing Q10. Ugeskr Laeger 1997;159:7309-15 [review] [in Danish].

4. Zuliani U, Bonetti A, Campana M, et al. The influence of ubiquinone (Co Q10) on the metabolic response to work. J Sports Med Phys Fitness 1989;29:57-62 [review].

5. Bonetti A, Solito F, Carmosino G, et al. Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects. J Sports Med Phys Fitness 2000;40:51-7.

6. Weston SB, Zhou S, Weatherby RP, Robson SJ. Does exogenous coenzyme Q10 affect aerobic capacity in endurance athletes? Int J Sport Nutr 1997;7:197-206.

7. Bucci L. Nutrients as ergogenic aids for sports and exercise. Boca Raton, FL: CRC Press, 1993, 54-7 [review].

8. Snider IP, Bazzarre TL, Murdoch SD, et al. Effects of coenzyme athletic performance system as an ergogenic aid on endurance performance to exhaustion. Int J Sport Nutr 1992;2:272-86.

9. Malm C, Svensson M, Ekblom B, et al. Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans. Acta Physiol Scand 1997;161:379-84.

10. Laaksonen R, Fogelholm M, Himberg JJ, et al. Ubiquinone supplementation and exercise capacity in trained young and older men. Eur J Appl Physiol 1995;72:95-100.

11. Alf D, Schmidt ME, Siebrecht SC. Ubiquinol supplementation enhances peak power production in trained athletes: a double-blind, placebo controlled study. J Int Soc Sports Nutr 2013;10:24.

Macular Degeneration
Dose: Follow label directions

In a double-blind study, supplementation with a proprietary blend of acetyl-L-carnitine, omega-3 fatty acids from fish oil, and coenzyme Q10 for 12 months resulted in an improvement in both visual function and in objective findings on eye examination (a decrease in the drusen-covered area on the retina).1

References

1. Feher J, Kovacs B, Kovacs I, et al. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica2005;219:154-66.

Alzheimer's Disease
Dose: Refer to label instructions

In a preliminary report, two people with a hereditary form of Alzheimer's disease received daily: coenzyme Q10 (60 mg), iron (150 mg of sodium ferrous citrate), and vitamin B6 (180 mg). Mental status improved in both patients, and one became almost normal after six months.1

References

1. Imagawa M, Naruse S, Tsuji S, et al. Coenzyme Q10, iron, and vitamin B6 in genetically-confirmed Alzheimer's disease. Lancet 1992;340:671 [letter].

Gingivitis
Dose: 50 to 60 mg dailyPreliminary evidence has linked gingivitis to a coenzyme Q10 (CoQ10) deficiency.1 Some researchers believe this deficiency could interfere with the body's ability to repair damaged gum tissue. In a double-blind trial, 50 mg per day of CoQ10 given for three weeks was significantly more effective than a placebo at reducing symptoms of gingivitis.2 Compared with conventional approaches alone, topical CoQ10 combined with conventional treatments resulted in better outcomes in a group of people with periodontal disease.3, 4
References

1. Nakamura R, Littarru GP, Folkers K. Deficiency of coenzyme Q in gingiva of patients with periodontal disease. Int J Vitam Nutr Res 1973;43:84-92.

2. Wilkinson EG, Arnold RM, Folkers K. Bioenergetics in clinical medicine. VI. Adjunctive treatment of periodontal disease with coenzyme Q10. Res Commun Chem Pathol Pharmacol 1976;14:715-9.

3. Hanioka T, Tanaka M, Ojima M, et al. Effect of topical application of coenzyme Q10 on adult periodontitis. Mol Aspects Med 1994;15(Suppl):S241-8.

4. Chatterjee A, Kandwal A, Singh N, Singh A. Evaluation of Co-Q10 anti-gingivitis effect on plaque induced gingivitis: A randomized controlled clinical trial. J Indian Soc Periodontol 2012;16:539-42.

Halitosis and Gum Disease
Dose: 50 to 60 mg daily

Nutritional supplements recommended by some doctors for prevention and treatment of periodontitis include vitamin C (people with periodontitis are often found to be deficient),1vitamin E, selenium, zinc, coenzyme Q10, and folic acid.2 Folic acid has also been shown to reduce the severity of gingivitis when taken as a mouthwash.3

References

1. Vaananen MK, Markkanen HA, Tuovinen VJ, et al. Periodontal health related to plasma ascorbic acid. Proc Finn Dent Soc 1993;89:51-9.

2. Murray M, Pizzorno J. Encyclopedia of Natural Medicine, rev2d ed. Rocklin, CA: Prima Publishing, 1998, 722-9.

3. Pack ARC. Folate mouthwash: effects on established gingivitis in periodontal patients. J Clin Periodontol 1984;11:619-28.

Macular Degeneration
Dose: Follow label directions

In a double-blind study, supplementation with a proprietary blend of acetyl-L-carnitine, omega-3 fatty acids from fish oil, and coenzyme Q10 for 12 months resulted in an improvement in both visual function and in objective findings on eye examination (a decrease in the drusen-covered area on the retina).1

References

1. Feher J, Kovacs B, Kovacs I, et al. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica2005;219:154-66.

Preeclampsia
Dose: 200 mg per day

Pregnant women with preeclampsia have significantly lower plasma coenzyme Q10 levels, when compared with women with healthy pregnancies. In a double-blind study at women who were at high risk of developing preeclampsia, supplementing with coenzyme Q10 reduced the incidence of preeclampsia by 44%. The amount used was 200 mg per day; treatment was begun during the twentieth week of pregnancy and continued until delivery.1

References

1. Teran E, Hernandez I, Nieto B, et al. Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Int J Gynaecol Obstet 2009;105:43-5.

Male Infertility
Dose: Refer to label instructions

Coenzyme Q10 (CoQ10) is a nutrient used by the body in the production of energy. While its exact role in the formation of sperm is unknown, there is evidence that as little as 10 mg per day (over a two-week period) will increase sperm count and motility.1 In one study, men with low sperm counts were given CoQ10 (60 mg per day for about three months). No significant change was noted in most sperm parameters, but a significant improvement was noted in in-vitro fertilization rates.2

References

1. Tanimura J. Studies on arginine in human semen. Part III. The influences of several drugs on male infertility. Bull Osaka Med School 1967;13:90-100.

2. Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997;18 Suppl:S213-9.

Tinnitus
Dose: Refer to label instructions

In a preliminary trial, supplementation with coenzyme Q10 (CoQ10) in the amount of 100 mg three times per day for 16 weeks significantly improved tinnitus in people who had initially low blood levels of CoQ10. However, CoQ10 was not beneficial for people whose initial blood levels were not low.1

References

1. Khan M, Gross J, Haupt H, et al. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol Head Neck Surg 2007;136:72-7.

HIV and AIDS Support
Dose: Refer to label instructions

Blood levels of coenzyme Q10 (CoQ10) were also found to be low in people with HIV infection or AIDS. In a small preliminary trial, people with HIV infection took 200 mg per day of CoQ10. Eighty-three percent of these people experienced no further infections for up to seven months, and the counts of infection-fighting white blood cells improved in three cases.1

References

1. Folkers K, Langsjoen P, Nara Y, et al. Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment. Biochem Biophys Res Commun 1988;153:888-96.

Kidney Failure
Dose: Refer to label instructionsIn a double-blind study of 21 patients with chronic renal (kidney) failure, 15 of whom were on dialysis, supplementation with 60 mg of CoQ10 three times per day for four weeks improved certain measures of kidney function (BUN [blood urea nitrogen], serum creatinine, and creatinine clearance), compared with placebo, and eliminated the need for dialysis in some patients.Singh RB, Khanna HK, Niaz MA. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in chronic renal failure: discovery of a new role. J Nutr Environ Med 2000;10:281-8. Because chronic renal failure is a serious and complicated disease, individuals with this condition should take CoQ10 only under strict medical supervision.

Coenzyme Q10 (CoQ10) is also called ubiquinone, a name that signifies its ubiquitous (widespread) distribution in the human body. CoQ10 is used by the body to transform food into adenosine triphosphate (ATP), the energy on which the body runs.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

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GNC CoQ-10 200 MG
 
4.9

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    5.0

    good

    By yzqiyan

    from Greenbelt, MD

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    good

     
    5.0

    Like it most

    By henanxi.dalian

    from Singapore

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    Comments about GNC CoQ-10 200 MG:

    This is my favoriate item, but dont know few people buy this.

     
    5.0

    It's goog for heart

    By 1151719973

    from Wei NIOIN GAO , CHINA

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    Comments about GNC CoQ-10 200 MG:

    I Buy this foy my father.It's good for his heart health.

     
    5.0

    "Don't judge a book by its cover"

    By 34213842

    from los feliz,ca

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    wonderful

     
    4.0

    Great Thing

    By longfan78

    from Long Island City, NY

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      Comments about GNC CoQ-10 200 MG:

      It is great for my mother.

      (1 of 1 customers found this review helpful)

       
      5.0

      Great product!

      By linray222

      from montebello, ca

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      Comments about GNC CoQ-10 200 MG:

      My mom has palputation for few years, but after taking this products her heart rate runs normal.

      (0 of 1 customers found this review helpful)

       
      5.0

      excellent product

      By marilyn.andrie

      from homeeworth ohio

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          Comments about GNC CoQ-10 200 MG:

          Have taken this product approxiately a year only purchase at gnc in alliance ohio

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