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GNC SAM-e 400 mg

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30 Enteric Coated Tablets

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Description
  • Promotes positive mood balance*
  • Clinically proven benefits for joint support*
  • Supports healthy liver function*
A report published by the US Department of Health and Human Services suggests that SAM-e provides clinically significant health benefits for individuals seeking mood support (1600 mg daily), joint comfort and healthy liver function (1200 mg daily).* SAM-e provides mood support, as well as relief to joint discomfort, and these benefits are comparable to conventional therapies.*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take one tablet in the morning and one tablet in the afternoon for the first week. If after the first week the desired benefits are not achieved, then you may require a higher level of supplementation. Gradually increase the number of tablets up to four tablets in divided doses of two tablets (800 mg) throughout the day until benefits are achieved. Do not exceed four tablets daily.

Serving Size 1 Tablet
Servings Per Container 30
Amount Per Serving % DV
SAM-e (S-adenosyl-methionine) (as Disulfate Monotosylate) 400.00 mg **
** Daily Value (DV) not established

Other Ingredients: Core: Microcrystalline Cellulose, Mannitol, Sodium Starch Glycolate, Silica, Glycerol Monostearate., Coating: Methacrylic Acid Copolymer, Glycerol Palmitostearate, Medium Chain Triglycerides, Titanium Dioxide, Silica, Talc, Triethyl Citrate, FD&C Yellow #5

Warning: Do not use if pregnant or nursing. Do not exceed recommended dose. If you are taking medication or are under the care of a physician for depression or related disorder, contact your physician before using this product. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use. Caution: Do not use if tamper-evident printed foil seal over tablets is broken.

Distributed by: Gereral Nutrition Corporation Pittsburgh, PA 15222

Health Notes

SAMe

SAMe
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Osteoarthritis
Dose: 1200 mg daily
SAMe has anti-inflammatory, pain-relieving, and tissue-healing properties that may help protect the health of joints and reduce osteoarthritis symptoms.(more)
Fibromyalgia
Dose: 800 mg daily
Supplementing with SAMe may increase serotonin levels in the blood and help relieve symptoms.(more)
Migraine Headache
Dose: Refer to label instructions
Preliminary research suggests that supplementing with SAMe may reduce symptoms for some migraine sufferers.(more)
Male Infertility
Dose: Refer to label instructions
Preliminary research suggests that oral SAMe may also increase sperm activity in infertile men.(more)
Bipolar Disorder
Dose: Refer to label instructions
SAMe is an amino acid that has an impact on serotonin levels, it has shown significant antidepressant effects in clinical trials.(more)
Pregnancy and Postpartum Support and Cholestasis
Dose: Refer to label instructions
SAMe (S-adenosylmethionine) supplementation has been shown to aid in the resolution of blocked bile flow (cholestasis), an occasional complication of pregnancy.[REF][REF](more)
Pregnancy and Postpartum Support and Cholestasis
Dose: Refer to label instructions
SAMe (S-adenosylmethionine) supplementation has been shown to aid in the resolution of blocked bile flow (cholestasis), an occasional complication of pregnancy.[REF][REF](more)
Osteoarthritis
Dose: 1200 mg daily

SAMe (S-adenosyl methionine) possesses anti-inflammatory, pain-relieving, and tissue-healing properties that may help protect the health of joints,1, 2 though the primary way in which SAMe reduces osteoarthritis symptoms is not known. A very large, though uncontrolled, trial (meaning that there was no comparison with placebo) demonstrated "very good" or "good" clinical effect of SAMe in 71% of over 20,000 osteoarthritis sufferers.3 In addition to this preliminary research, many double-blind trials have shown that SAMe reduces pain, stiffness, and swelling better than placebo and equal to drugs such as ibuprofen and naproxen in people with osteoarthritis.4, 5, 6, 7, 8, 9, 10, 11 These double-blind trials all used 1,200 mg of SAMe per day.

Lower amounts of oral SAMe have also produced reductions in the severity of osteoarthritis symptoms in preliminary clinical trials. A two-year, uncontrolled trial showed significant improvement of symptoms after two weeks at 600 mg SAMe daily, followed by 400 mg daily thereafter.12 This amount was also used in a double-blind trial, but participants first received five days of intravenous SAMe.13 A review of the clinical trials on SAMe concluded that its efficacy against osteoarthritis was similar to that of conventional drugs but that patients tolerated it better.14

References

1. Schumacher HR. Osteoarthritis: the clinical picture, pathogenesis, and management with studies on a new therapeutic agent, S-adenosylmethionine. Am J Med 1987;83(Suppl 5A):1-4 [review].

2. Harmand MF, Vilamitjana J, Maloche E, et al. Effects of S-adenosylmethionine on human articular chondrocyte differentiation: an in vitro study. Am J Med 1987;83(Suppl 5A):48-54.

3. Berger R, Nowak H. A new medical approach to the treatment of osteoarthritis. Report of an open phase IV study with ademetionine (Gumbaral). Am J Med 1987;83:84-8.

4. Domljan Z, Vrhovac B, Durrigl T, Pucar I. A double-blind trial of ademetionine vs naproxen in activated gonarthrosis. Int J Clin Pharmacol Ther Toxicol 1989;27:329-33.

5. Muller-Fassbender H. Double-blind clinical trial of S-adenosylmethionine in versus ibuprofen in the treatment of osteoarthritis. Am J Med 1987;83(Suppl 5A):81-3.

6. Vetter G. Double-blind comparative clinical trial with S-adenosylmethionine and indomethacin in the treatment of osteoarthritis. Am J Med 1987;83(Suppl 5A):78-80.

7. Maccagno A. Double-blind controlled clinical trial of oral S-adenosylmethionine versus piroxicam in knee osteoarthritis. Am J Med 1987;83(Suppl 5A):72-7.

8. Caruso I, Pietrogrande V. Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. Am J Med 1987;83(Suppl 5A):66-71.

9. Marcolongo R, Giordano N, Colombo B, et al. Double-blind multicentre study of the activity of s-adenosyl-methionine in hip and knee osteoarthritis. Curr Ther Res 1985;37:82-94.

10. Glorioso S, Todesco S, Mazzi A, et al. Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis. Int J Clin Pharmacol Res 1985;5:39-49.

11. Montrone F, Fumagalli M, Sarzi-Puttini P, et al. Double-blind study of S-adenosyl-methionine versus placebo in hip and knee arthrosis. Clin Rheumatol 1985;4:484-5.

12. Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83:89-94.

13. Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by or SAM therapy in patients with knee osteoarthritis. J Rheumatol 1994;21:905-11.

14. Di Padova C. S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies. Am J Med 1987;83:60-5 [review].

Fibromyalgia
Dose: 800 mg daily

Intravenous SAMe (S-adenosylmethionine) given to people with fibromyalgia reduced pain and depression in two double-blind trials;1, 2 but no benefit was seen in a short (ten-day) trial.3 Oral SAMe (800 mg per day for six weeks) was tested in one double-blind trial and significant beneficial effects were seen, such as reduced pain, fatigue, and stiffness, and improved mood.4

References

1. Tavoni A, Jeracitano G, Cirigliano G. Evaluation of S-adenosylmethionine in secondary fibromyalgia: A double-blind study. Clin Exp Rheumatol 1998;16:106-7 [letter].

2. Tavoni A, Vitali C, Bombardieri S, et al. Evaluation of S-adenosylmethionine in primary fibromyalgia: A double-blind crossover study. Am J Med 1987;83(suppl 5A):107-10.

3. Volkmann H, Norregaard J, Jacobsen S, et al. Double-blind, placebo-controlled cross-over study of intravenous S-adenosyl-L-methionine in patients with fibromyalgia. Scand J Rheumatol 1997;26:206-11.

4. Jacobsen S, Danneskiold-Samsoe B, Andersen RB. Oral S-adenosylmethionine in primary fibromyalgia: Double-blind clinical evaluation. Scand J Rheumatol 1991;20:294-302.

Migraine Headache
Dose: Refer to label instructions

Preliminary research also suggests that oral supplements of SAMe (S-adenosyl-L-methionine) may reduce symptoms for some migraine sufferers.1

References

1. Gatto G, Caleri D, Michelacci S, Sicuteri F. Analgesizing effect of a methyl donor (S-adenosylmethionine) in migraine: an open clinical trial. Int J Clin Pharmacol Res 1986;6:15-7.

Male Infertility
Dose: Refer to label instructions

Preliminary research suggests that oral SAMe (S-adenosyl-L-methionine), in amounts of 800 mg per day, may also increase sperm activity in infertile men.1

References

1. Piacentino R, Malara D, Zaccheo F, et al. Preliminary study of the use of s. adenosyl methionine in the management of male sterility. Minerva Ginecologica 1991;43:191-3 [in Italian].

Bipolar Disorder
Dose: Refer to label instructions

SAMe (S-adenosylmethionine) is another amino acid that has an impact on serotonin levels, and it has demonstrated significant antidepressant effects in clinical trials.1, 2, 3 In both controlled and preliminary studies, SAMe has been shown to be helpful for the depressive symptoms of bipolar disorder. However, some patients have switched from depression to mania while using SAMe at 500 to 1,600 mg daily.4, 5 This is a known side effect of other antidepressant medications.6 The mania induced by SAMe resolved when the supplement was discontinued, and in one case resolved spontaneously while the patient continued taking SAMe.7 Therefore, people with bipolar disorder should supplement with SAMe only under the supervision of a qualified healthcare practitioner.

References

1. Rosenbaum JF, Fava M, Faulk WE, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand 1990;81:432-6.

2. Friedel HA, Goa KL, Benfield P. S-Adenosyl-l-methionine: A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989;38:389-417 [review].

3. Carney MWP, Chary TKN, Bottiglieri T. The switch mechanism in affective illness and oral S-adenosylmethionine (SAM). Br J Psychiatry 1987;150:724-5.

4. Carney MWP, Chary TKN, Bottiglieri T. The switch mechanism in affective illness and oral S-adenosylmethionine (SAM). Br J Psychiatry 1987;150:724-5.

5. Carney MWP, Chary TKN, Bottiglieri T, Reynolds EH. The switch mechanism and bipolar/unipolar dichotomy. Br J Psychiatry 1989;154:48-51.

6. Wehr TA, Goodwin FK. Can antidepressants cause mania and worsen the course of affective illness? Am J Psychiatry 1987;144:1403-11.

7. Rosenbaum JF, Fava M, Faulk WE, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand 1990;81:432-6.

Pregnancy and Postpartum Support and Cholestasis
Dose: Refer to label instructionsSAMe (S-adenosylmethionine) supplementation has been shown to aid in the resolution of blocked bile flow (cholestasis), an occasional complication of pregnancy.1, 2
References

1. Frezza M, Centini G, Cammareri G, et al. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990;37 Suppl 2:122-5.

2. Frezza M, Surrenti C, Manzillo G, et al. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology 1990;99:211-5.

Pregnancy and Postpartum Support and Cholestasis
Dose: Refer to label instructionsSAMe (S-adenosylmethionine) supplementation has been shown to aid in the resolution of blocked bile flow (cholestasis), an occasional complication of pregnancy.1, 2
References

1. Frezza M, Centini G, Cammareri G, et al. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990;37 Suppl 2:122-5.

2. Frezza M, Surrenti C, Manzillo G, et al. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology 1990;99:211-5.

S-adenosyl-l-methionine (SAMe) is an important biological agent in the human body, participating in over 40 essential biochemical reactions.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

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MISCELLANEOUSGNC SAM-e 400 mg
 
3.0

(based on 2 reviews)

Reviewed by 2 customers

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(2 of 2 customers found this review helpful)

 
5.0

Love this stuff

By btessene

from Wisconsin

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Pros

  • Easy To Use
  • Effective

Cons

    Best Uses

    • Daily Use

    Comments about MISCELLANEOUS GNC SAM-e 400 mg:

    I really like this Sam-E. It does not irritate my stomach. I started taking it to relieve pain in my legs from walking. Now It really puts me in a fantastic mood. I started out using it once a day now I take it morning and night. I also give it to my dog, he has bad hips and is always pulling muscles so I started him on it to. It works wonderful. With being in such a good mood and no more leg pains I can exercise even more. I also get a lot done around the house.

    (27 of 28 customers found this review helpful)

     
    1.0

    WHAT A DISSAPPOINTMENT!!!

    By andershine

    from portland or

    Pros

      Cons

      • Stomach upset

      Best Uses

        Comments about MISCELLANEOUS GNC SAM-e 400 mg:

        They changed the ingrediants to contain mannitol which gives you stomach pain, bloating and gas!! NO THANK YOU GNC.. I was very pleased with thier Sam - e before they changed the formula, this is VERY DISSAPPOINTING.

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