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GNC L-Glutamine 500

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Description
  • Glutamine is one of the most abundant amino acids found in the skeletal muscles. It:
  • Plays a pivotal role in the nitrogen balance in the body.*Supports a positive immune response.*
  • Prolonged high-intensity exercise has been shown to decrease glutamine levels, which may result in glutamine deficiency.
  • Each capsule contains 500 mg of L-Glutamine.
Supplement Facts

As a dietary supplement, take one capsule up to four times daily, an hour before meals or on an empty stomach.

Serving Size 1 Capsules
Servings Per Container 50
Amount Per Serving % DV
L-Glutamine 500.00 mg **
** Daily Value (DV) not established

Other Ingredients: Gelatin, Cellulose

No Sugar, No Starch, No Artificial Color, No Artificial Flavors, Sodium Free, No Wheat, No Gluten, No Corn, No Soy, No Dairy, Yeast Free

Storage Instructions: Store in a cool dry place.

Warning: Keep out of reach of children

0

Health Notes

Glutamine

Glutamine
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Pre- and Post-Surgery Health
Dose: 20 grams daily
Studies have shown that using glutamine-enriched formulas after surgery increased immune cell activity, shortened hospital stays, improved nutritional status, and reduced infections.(more)
Immune Function and Post-Exercise Infection
Dose: Refer to label instructions
A study giving athletes glutamine, an amino acid important for immune system function, reported significantly fewer infections with glutamine.(more)
HIV and AIDS Support and Preservation of Lean Body Mass
Dose: 1.5 grams of HMB, 7 grams of L-glutamine, and 7 grams of L-arginine twice per day
The combination of glutamine, arginine, and HMB may prevent loss of lean body mass in people with AIDS-associated wasting.(more)
HIV and AIDS Support
Dose: Refer to label instructions
The amino acid glutamine is needed for the synthesis of glutathione, an important antioxidant that is frequently depleted in people with HIV and AIDS.(more)
Diarrhea
Dose: 136 mg per pound of body weight
Glutamine appears to be beneficial for diarrhea by improving the health of the intestinal lining, rather than by affecting the immune system.(more)
Gastritis
Dose: Refer to label instructions
The amino acid glutamine is a main energy source for cells in the stomach and may increase blood flow to this region.(more)
Peptic Ulcer
Dose: Refer to label instructions
Glutamine, an amino acid, is the main energy source for cells that line the small intestine and stomach. Supplementing with it may help people overcome peptic ulcers.(more)
Athletic Performance and Post-Exercise Infection
Dose: 5 grams after exercise, then again two hours later
The amino acid glutamine may benefit athlete's immune systems. Double-blind trials giving athletes glutamine reported 81% having no subsequent infection compared with 49% in the placebo group.(more)
Pre- and Post-Surgery Health
Dose: 20 grams daily

Glutamine, one of the most abundant amino acids in the body, supports the health of the cells lining the gastrointestinal tract and is important for immune function.1 Glutamine is depleted when the body is under stress, including the stress of surgery.2 Blood levels of glutamine decrease following surgery, and as they return to normal, their increase parallels the increase in immune cells.3 Two controlled trials have shown that the use of glutamine-enriched intravenous formulas, providing approximately 20 grams of glutamine per day, resulted in increased immune cell activity and shorter hospital stays.4, 5 Double-blind studies report that patients receiving intravenous formulas supplemented with glutamine after surgery had better nutritional status and better health outcomes, including fewer infections and other complications, compared with patients receiving regular formulas.6, 7

References

1. Campos FG, Waitzberg DL, Logulo AF, et al. The role of glutamine in nutrition in clinical practice. Arq Gastroenterol 1996;33:86-92 [review, in Portugese].

2. O'Flaherty L, Bouchier-Hayes DJ. Immunonutrition and surgical practice. Proc Nutr Soc 1999;58:831-7 [review].

3. Greig JE, Keast D, Garcia-Webb P, Crawford P. Inter-relationships between glutamine and other biochemical and immunological changes after major vascular surgery. Br J Biomed Sci 1996;53:116-21.

4. Morlion BJ, Stehle P, Wachtler P, et al. Total parenteral nutrition with glutamine dipeptide after major abdominal surgery: a randomized, double-blind, controlled study. Ann Surg 1998;227:302-8.

5. O'Riordain MG, De Beaux A, Fearon KC. Effect of glutamine on immune function in the surgical patient. Nutrition 1996;12:S82-4.

6. Jian ZM, Cao JD, Zhu XG, et al. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. JPEN J Parenter Enteral Nutr 1999;23:S62-6.

7. Morais AA, Santos JE, Faintuch J. Comparative study of arginine and glutamine supplements in malnourished surgical patients. Rev Hosp Clin Fac Med Sao Paulo 1995;50:276-9 [in Portugese].

Immune Function and Post-Exercise Infection
Dose: Refer to label instructionsThe amino acid glutamine is important for immune system function. Liquid diets high in glutamine have been reported in controlled studies to be more helpful to critically ill people than other diets.1, 2 Endurance athletes are susceptible to upper respiratory tract infections after heavy exercise, which depletes glutamine levels in blood.3 Although the effects of glutamine supplementation on immune function after exercise have been inconsistent,4, 5 a double-blind study giving athletes glutamine (2.5 grams after exercise and again two hours later) reported significantly fewer infections with glutamine.6
References

1. Jones C, Palmer TE, Griffiths RD. Randomized clinical outcome study of critically ill patients given glutamine-supplemented enteral nutrition. Nutrition 1999;15:108-15.

2. Griffiths RD. Outcome of critically ill patients after supplementation with glutamine. Nutrition 1997;13:752-4 [review].

3. Nieman DC. Exercise and resistance to infection. Can J Physiol Pharmacol 1998;76:573-80 [review].

4. Rohde T, MacLean DA, Pedersen BK. Effect of glutamine supplementation on changes in the immune system induced by repeated exercise. Med Sci Sports Exerc 1998;30:856-62.

5. Castell LM, Newsholme EA. Glutamine and the effects of exhaustive exercise upon the immune response. Can J Physiol Pharmacol 1998;76:524-32 [review].

6. Castell LM, Poortmans JR, Newsholme EA. Does glutamine have a role in reducing infections in athletes? Eur J Appl Physiol 1996;73:488-90.

HIV and AIDS Support and Preservation of Lean Body Mass
Dose: 1.5 grams of HMB, 7 grams of L-glutamine, and 7 grams of L-arginine twice per day

The combination of glutamine, arginine, and the amino acid derivative, hydroxymethylbutyrate (HMB), may prevent loss of lean body mass in people with AIDS-associated wasting. In a double-blind trial, AIDS patients who had lost 5% of their body weight in the previous three months received either placebo or a nutrient mixture containing 1.5 grams of HMB, 7 grams of L-glutamine, and 7 grams of L-arginine twice daily for eight weeks.1 Those supplemented with placebo gained an average of 0.37 pounds, mostly fat, but lost lean body mass. Those taking the nutrient mixture gained an average of 3 pounds, 85% of which was lean body weight.

References

1. Clark RH, Feleke G, Din M, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr 2000;24:133-9.

HIV and AIDS Support
Dose: Refer to label instructions

The amino acidglutamine is needed for the synthesis of glutathione, an important antioxidant within cells that is frequently depleted in people with HIV and AIDS.1 In well-nourished people, the body usually manufactures enough glutamine to prevent a deficiency. However, people with HIV or AIDS are often malnourished and may be deficient in glutamine.2 In such people, glutamine supplementation may be needed, along with NAC, to maintain adequate levels of glutathione. It is not known how much glutamine is needed for that purpose; however, in other trials, 4-8 grams of glutamine per day was used.3 In a double-blind trial, massive amounts of glutamine (40 grams per day) in combination with several antioxidants (27,000 IU per day of beta-carotene; 800 mg per day of vitamin C; 280 mcg per day of selenium; 500 IU per day of vitamin E) were given for 12 weeks to AIDS patients experiencing problems maintaining normal weight.4 Those who took the glutamine-antioxidant combination experienced significant gains in body weight compared with those taking placebo. Larger trials are needed to determine the possible benefits of this nutrient combination on reducing opportunistic infections and long-term mortality.

References

1. Robinson MK, Hong RW, Wilmore DW. Glutathione deficiency and HIV infection. Lancet 1992;339:1603-4.

2. Shabert JK, Wilmore DW. Glutamine deficiency as a cause of human immunodeficiency virus wasting. Med Hypotheses 1996;46:252-6.

3. Noyer CM, Simon D, Borczuk A, et al. A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. Am J Gastroenterol 1998;93:972-5 .

4. Shabert JK, Winslow C, Lacey JM, Wilmore DW. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition 1999;15:860-4.

Diarrhea
Dose: 136 mg per pound of body weight

In a double-blind study of children (ages six months to two years) with acute diarrhea, supplementing with glutamine significantly reduced the duration of diarrhea by 26%.1 Children were given 136 mg of glutamine per pound of body weight per day for seven days. Glutamine appeared to work by improving the health of the intestinal lining, rather than through any effect on the immune system.

References

1. Yalcin SS, Yurdakok K, Tezcan I, Oner L. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. J Pediatr Gastroenterol Nutr 2004;38:494-501.

Gastritis
Dose: Refer to label instructions

Various amino acids have shown promise for people with gastritis. In a double-blind trial, taking 200 mg of cysteine four times daily provided significant benefit for people with bleeding gastritis caused by NSAIDs (such as aspirin).1 Cysteine is a sulfur-containing amino acid that stimulates healing of gastritis. In a preliminary trial, 1-4 grams per day of NAC (N-acetyl cysteine) given to people with atrophic gastritis for four weeks appeared to increase healing.2Glutamine, another amino acid is a main energy source for cells in the stomach and supplementation may increase blood flow to this region.3 Patients in surgical intensive care units often develop gastrointestinal problems related to a glutamine deficiency.4 When burn victims were supplemented with glutamine, they did not develop stress ulcers, even after several operations.5 Nevertheless, it remains unclear to what extent glutamine supplementation might prevent or help existing gastritis. Preliminary evidence suggests the amino acid arginine may both protect the stomach and increase its blood flow,6 but research has yet to investigate the effects of arginine supplementation in people with gastritis.

References

1. Salim AS. Sulfhydryl-containing agents in the treatment of gastric bleeding induced by non-steroidal anti-inflammatory drugs. Can J Surg 1993;36(1):53-8.

2. Farinati F, Cardin R, Della Libera G, et al. Effects of N-acetyl-L-cysteine in patients with chronic atrophic gastritis and nonulcer dyspepsia: a phase III pilot study. Curr Ther Res 1997;58:724-33.

3. Houdijk AP, Van Leeuwen PA, Boermeester MA, et al. Glutamine-enriched enteral diet increases splanchnic blood flow in the rat. Am J Physiol 1994;267(6 Pt 1):G1035-40.

4. Wilmore DW, Smith RJ, O'Dwyer ST, et al. The gut: a central organ after surgical stress. Surgery 1988;104:917-23.

5. Yan R, Sun Y, Sun R. Early enteral feeding and supplement of glutamine prevent occurrence of stress ulcer following severe thermal injury. Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih 1995;11(3):189-92.

6. Brzozowski T, Konturek SJ, Sliwowski Z, et al. Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing. J Gastroenterol 1997;32(4):442-52.

Peptic Ulcer
Dose: Refer to label instructions

Glutamine, an amino acid, is the principal source of energy for cells that line the small intestine and stomach. More than 40 years ago, glutamine was reported to help people with peptic ulcer in a preliminary trial.1 Glutamine has also prevented stress ulcers triggered by severe burns in another preliminary study.2 Despite the limited amount of published research, some doctors suggest 500 to 1,000 mg of glutamine taken two to three times per day to help people overcome peptic ulcers.

References

1. Shive W, Snider RN, DuBilier B, et al. Glutamine in treatment of peptic ulcer. Texas State J Med 1957;Nov:840.

2. Yan R, Sun Y, Sun R. Early enteral feeding and supplement of glutamine prevent occurrence of stress ulcer following severe thermal injury. Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih 1995;11(3):189-92.

Athletic Performance and Post-Exercise Infection
Dose: 5 grams after exercise, then again two hours later

The amino acid glutamine appears to play a role in several aspects of human physiology that might benefit athletes, including their muscle function and immune system.1 Intense exercise lowers blood levels of glutamine, which can remain persistently low with overtraining.2 Glutamine supplementation raises levels of growth hormone at an intake of 2 grams per day,3 an effect of interest to some athletes because of the role of growth hormone in stimulating muscle growth,4 and glutamine, given intravenously, was found to be more effective than other amino acids at helping replenish muscle glycogen after exercise.5 However, glutamine supplementation (30 mg per 2.2 pounds body weight) has not improved performance of short-term, high-intensity exercise such as weightlifting or sprint cycling by trained athletes,6, 7 and no studies on endurance performance or muscle growth have been conducted. Although the effects of glutamine supplementation on immune function after exercise have been inconsistent,8, 9 double-blind trials giving athletes glutamine (5 grams after intense, prolonged exercise, then again two hours later) reported 81% having no subsequent infection compared with 49% in the placebo group.10

References

1. Antonio J, Street C. Glutamine: a potentially useful supplement for athletes. Can J Appl Physiol 1999;24:1-14 [review].

2. Rowbottom DG, Keast D, Morton AR. The emerging role of glutamine as an indicator of exercise stress and overtraining. Sports Med 1996;21:80-97 [review].

3. Welbourne TC. Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr 1995;61:1058-61.

4. Macintyre JG. Growth hormone and athletes. Sports Med 1987;4:129-42 [review].

5. Varnier M, Leese GP, Thompson J, et al. Stimulatory effect of glutamine on glycogen accumulation in human skeletal muscle. Am J Physiol 1995;269:E309-15.

6. Antonio J, Sanders MS, Kalman D, et al. The effects of high-dose glutamine ingestion on weightlifting performance. J Strength Cond Res 2002;16:157-60.

7. Haub MD, Potteiger JA, Nau KL, et al. Acute L-glutamine ingestion does not improve maximal effort exercise. J Sports Med Phys Fitness 1998;38:240-4.

8. Rohde T, MacLean DA, Pedersen BK. Effect of glutamine supplementation on changes in the immune system induced by repeated exercise. Med Sci Sports Exerc 1998;30:856-62.

9. Castell LM, Newsholme EA. Glutamine and the effects of exhaustive exercise upon the immune response. Can J Physiol Pharmacol 1998;76:524-32 [review].

10. Castell LM, Poortmans JR, Newsholme EA. Does glutamine have a role in reducing infections in athletes? Eur J Appl Physiol 1996;73:488-90.

Glutamine is the most abundant amino acid (protein building block) in the body and is involved in more metabolic processes than any other amino acid. Glutamine is converted to glucose when more glucose is required by the body as an energy source. It serves as a source of fuel for cells lining the intestines. Without it, these cells waste away. It is also used by white blood cells and is important for immune function.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC L-Glutamine 500
 
4.7

(based on 7 reviews)

100%

of respondents would recommend this to a friend.

Pros

  • Good value (4)
  • Easy to take (3)

Cons

    Best Uses

      Reviewed by 7 customers

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      5.0

      Good product

      By suez2009

      from China

      About Me Weekend Warrior

      See all my reviews

      Pros

      • Easy To Take
      • Good Value

      Cons

        Best Uses

        • Pre-workout

        Comments about GNC L-Glutamine 500:

        My friends use it. They said it's fine. need to take before excercise.

         
        4.0

        Thank you!

        By erichbeil

        from Northern KY

        About Me Gym Rat 4-5 Days A Week

        See all my reviews

        Pros

        • Easy To Take
        • Good Value
        • Recovery
        • Stacks Well With Whey

        Cons

        • Na

        Best Uses

        • Daily Use
        • Post-workout

        Comments about GNC L-Glutamine 500:

        I started stacking this with my post work out protein shake and noticed immediately how it helps with recovery. Low cost for great product!

        (2 of 2 customers found this review helpful)

         
        5.0

        "I would recommend this product"

        By missderrick01

        from Apple Valley, CA

        See all my reviews

        Pros

        • Easy To Take
        • Good Value

        Cons

          Best Uses

          • Daily Use
          • Recovery From Injury

          Comments about GNC L-Glutamine 500:

          I was looking for an alternative to antibiotics for the treatment of my peptic ulcer. After taking one 50 count bottle, I can already feel that my ulcer is healing. Will purchase this product until it is completly healed.

          (1 of 1 customers found this review helpful)

           
          5.0

          Great

          By tracymackinnon22

          from Texas

          See all my reviews

          Verified Buyer

          Comments about GNC L-Glutamine 500:

          Works well.

          (3 of 4 customers found this review helpful)

           
          5.0

          Great

          By tracymackinnon22

          from Texas

          See all my reviews

          Verified Buyer

          Comments about GNC L-Glutamine 500:

          Works well with my probiotic to help support my GI health.

          (3 of 3 customers found this review helpful)

           
          4.0

          Good for those with GI issues

          By tracymackinnon22

          from Texas

          See all my reviews

          Verified Buyer

          Comments about GNC L-Glutamine 500:

          I take on with breakfast and one with dinner. Works well for those with GI issues. Helps nourish gut flora.

          (14 of 14 customers found this review helpful)

           
          5.0

          What a difference!!!

          By emily.medina

          from Springfield, MA

          About Me Runner

          See all my reviews

          Pros

          • Boosts Energy
          • Good Value
          • Quickens Recovery Time

          Cons

            Best Uses

            • Everyday

            Comments about GNC L-Glutamine 500:

            I've had knee problems for YEARS... but after reading the effects of taking L-Glutamine I figured I'd give it a try. I was a bit skeptical thinking nothing would ever help; that is - until I starting taking these! I felt the effects of it just after 2 DAYS! I thought it was just in my head so I stopped for a couple of days. When the pain came back, I knew for sure it was working. I haven't stopped taking them since! So if you're an avid runner/gym-goer like I am with knee problems, take this. It WILL work!!!!

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