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Natrol® 5-HTP

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Description
  • 100 mg
  • Relaxing
  • Promotes Balanced Serotonin Levels
  • Helps Enhance Mood
  • Helps Control Appetite
  • Double Strength
  • DIETARY SUPPLEMENT
  • Double Strength Natrol™ 5-HTP works naturally by increasing your body's own level of serotonin, a neurotransmitter that plays a key role in controlling appetite and enhancing mood.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

Take 1 capsule daily with a meal.

Serving Size 1 Capsule
Servings Per Container 30
Amount Per Serving % DV
5-HTP (5-Hydroxytryptophan) (derived from Griffonia seeds) 100.00 mg **
** Daily Value (DV) not established

Other Ingredients: Rice Flour, Gelatin, Silicon Dioxide, Water, Magnesium Stearate

Yeast Free, No Wheat, No Corn, No Milk, No Egg, No Soy, No Gluten, No Artificial Color, No Artificial Flavors, No Added Sugar, No Preservatives

Storage Instructions: Store in a cool dry place.

Warning: Consult your physician prior to using this product it you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition. Discontinue use two weeks prior to surgery.KEEP OUT OF REACH OF CHILDREN.

Consult your healthcare professional prior to use if you have or suspect a medical condition, are pregnant or lactating, or are taking prescription drugs including drugs for depression, migraine, Parkinson's disease or psychiatric/emotional conditions.

Manufactured by NATROL, INC., Chatsworth, CA 91311
USA • 1 800 2-NATROL


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Health Notes

5-HTP

5-HTP
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Migraine Headache
Dose: 200 to 600 mg daily for adults, 20 mg for every 10 pounds of body weight for children
Several studies have found 5-HTP to be effective at reducing the frequency, severity, and duration of migraine headaches.(more)
Tension Headache
Dose: Adults: 300 mg daily; children: 100 mg daily
Taking the supplement 5-hydroxytryptophan may lessen headache frequency and limit the need for pain-relieving medications.(more)
Fibromyalgia
Dose: 100 mg three times per day
Supplementing with 5-HTP may ease symptoms.(more)
Insomnia
Dose: Adults: 200 mg two hours before bedtime and 400 mg at bedtime; children: 3 mg per 2.2 lbs (1 kg) body weight
5-HTP is converted into serotonin and might, therefore, be helpful for insomnia. In one study, supplementing with 5-HTP appeared to improve sleep quality.(more)
Sleep Disturbances
Dose: Refer to label instructions
5-HTP is used by the human body to make serotonin, an important substance for normal nerve and brain function. Serotonin appears to play significant roles in sleep.(more)
Obesity
Dose: Take under medical supervision: 600 to 900 mg daily for no more than 12 weeks
5-HTP has been shown to reduce appetite and to promote weight loss.(more)
Bipolar Disorder
Dose: Refer to label instructions
Supplementing with 5-HTP has had antidepressant effects in people with bipolar disorder; the effect was greater when combined with an antidepressant drug (doctor's supervision recommended) (more)
Migraine Headache
Dose: 200 to 600 mg daily for adults, 20 mg for every 10 pounds of body weight for children

The cause of migraine headache is believed to be related to abnormal serotonin function in blood vessels,1 and 5-HTP (5-hydroxytryptophan, which is converted by the body into serotonin) may affect this abnormality. In one study, 40 people with recurrent migraines received either 5-HTP (200 mg per day) or methysergide (a drug used to prevent migraines) for 40 days. Both compounds reduced the frequency of migraines by about 50%.2 Larger amounts of 5-HTP (600 mg per day) were also found to be as effective as medications for reducing migraine headache attacks in adults in two double-blind trials.3, 4 Migraine attacks were reduced in frequency, severity, and duration in 90% of those taking 400 mg per day of 5-HTP in a double-blind placebo-controlled trial,5 though another trial found no benefit of 5-HTP.6 In another controlled study, 400 mg of dl-5-HTP (another form of 5-HTP) led to reduced consumption of pain-killing drugs and pain scores after one to two months.7 Children who suffered from migraines and had problems sleeping responded well to a daily amount of 5-HTP equal to 20 mg for every 10 pounds of body weight in a controlled trial,8 though an earlier study showed 5-HTP had no better effect than placebo for children with migraines.9

References

1. Kimball RW, Friedman AP, Vallejo E. Effect of serotonin in migraine patients. Neurology 1960;10:107-11.

2. Sicuteri F. The ingestion of serotonin precursors (L-5-hydroxytryptophan and L-tryptophan) improves migraine headache. Headache 1973;13:19-22.

3. Titus F, Davalos A, Alom J, Codina A. 5-hydroxytryptophan versus methysergide in the prophylaxis of migraine. Eur Neurol 1986;25:327-9.

4. Maissen CP, Ludin HP. Comparison of the effect of 5-hydroxytryptophan and propranolol in the interval treatment of migraine. Schweizerische Medizinische Wochenschrift /Journal Suisse de Medecine 1991;121:1585-90 [in German].

5. De Benedittis G, Massei R. 5-HT precursors in migraine prophylaxis: A double-blind cross-over study with L-5-hydroxytryptophan versus placebo. Clin J Pain 1986;3:123-9.

6. Mathew NT. 5-hydroxytryptophan in the prophylaxis of migraine. Headache 1978;18:111-3.

7. Bono G, Criscuoli M, Martignoni E, et al. Serotonin precursors in migraine prophylaxis. Advances in Neurology 1982;33:357-63.

8. De Giorgis G, Miletto R, Iannuccelli M, et al. Headache in association with sleep disorders in children: A psychodiagnostic evaluation and controlled clinical study n L-5-HTP versus placebo. Drugs Exp Clin Res 1987;13:425-33.

9. Santucci M, Cortelli P, Rossi PG, et al. L-5-Hydroxytryptophan versus placebo in childhood migraine prophylaxis: a double-blind crossover study. Cephalalgia 1986;6:155-7.

Tension Headache
Dose: Adults: 300 mg daily; children: 100 mg daily

5-HTP (5-hydroxytryptophan) may be helpful for tension-type headaches. A recent double-blind study of adults with chronic tension-type headaches found 300 mg per day of 5-HTP reduced the number of headache days by 36%, but this was not significantly different from the 29% reduction in the placebo group.1 (Headaches often improve significantly even when an inactive [placebo] treatment is given).2 Headache severity was also similarly reduced by either 5-HTP or placebo. In this study, 5-HTP was significantly superior to placebo only in reducing the need for pain-relieving medications during headaches. Previous double-blind research studied 5-HTP in groups of patients suffering from many different types of headache, including some with tension-type headaches. Results from these studies also found substantial, but nonsignificant benefits of 5-HTP compared with placebo using either 400 mg per day in adults3 or 100 mg per day in children.4

References

1. Ribeiro CAF. L-5-hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. Headache 2000;40:451-6.

2. Edmeads J. Placebos and the power of negative thinking. Headache 1984;24:342-3 [editorial].

3. De Benedittis G, Massei R. Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytrytophan vs. placebo. J Neurosurg Sci 1985;29:239-48.

4. Longo G, Rudoi I, Iannuccelli M, et al. Treatment of essential headache in developmental age with L-5-HTP (cross over double-blind study versus placebo). Pediatr Med Chir 1984;6:241-5. [in Italian].

Fibromyalgia
Dose: 100 mg three times per day

People with fibromyalgia often have low serotonin levels in their blood.1, 2, 3 Supplementation with 5-HTP may increase serotonin synthesis in these cases. Both preliminary4, 5 and double-blind trials6 have reported that 5-HTP supplementation (100 mg three times per day) relieves some symptoms of fibromyalgia.

References

1. Fava M, Rosenbaum JF, MacLaughlin R, et al. Neuroendocrine effects of S-adenosyl-L-methionine, a novel putative antidepressant. J Psychiatr Res 1990;24:177-84.

2. Bell KM, Potkin SG, Carreon D, Plon L. S-adenosylmethionine blood levels in major depression: changes with drug treatment. Acta Neurol Scand 1994;154(suppl):15-8.

3. Bell KM, Potkin SG, Carreon D, Plon L. S-adenosylmethionine blood levels in major depression: changes with drug treatment. Acta Neurol Scand 1994;154(suppl):15-8.

4. Puttini PS, Caruso I. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. J Int Med Res 1992;20:182-9.

5. Moldofsky H, Warsh JJ. Plasma tryptophan and musculoskeletal pain in non-articular rheumatism ("fibrositis syndrome"). Pain 1978;5:65-71.

6. Caruso I, Sarzi Puttini P, Cazzola M, Azzolini V. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res 1990;18:201-9.

Insomnia
Dose: Adults: 200 mg two hours before bedtime and 400 mg at bedtime; children: 3 mg per 2.2 lbs (1 kg) body weightThe amino acid L-tryptophan has been used successfully for people with insomnia,1 presumably because it is converted to the chemical messenger, serotonin. According to one preliminary trial, L-tryptophan supplementation was 100% effective at promoting sleep in people who awaken between three to six times per night, but not effective at all for people who only awaken once or twice, nor in people who doze on and off throughout the night in a state blurred between sleep and wakefulness.2

A related compound that occurs naturally in the body, 5-HTP (5-hydroxytryptophan), is also converted into serotonin and might, therefore, be helpful for insomnia. In a double-blind trial of people without insomnia, supplementation with 5-HTP (200 mg at 9:15 p.m. and 400 mg at 11:15 p.m.) increased rapid-eye-movement (REM) sleep, presumably indicating improved sleep quality.3 In a preliminary trial of people with fibromyalgia, supplementing with 100 mg of 5-HTP three times a day improved sleep quality.4 However, additional research is needed to determine whether 5-HTP is safe and effective for people with insomnia.

In a preliminary study, 5-HTP was also found to be an effective treatment for "sleep terrors,"5 a common problem in children that causes sudden awakening with persistent fear or terror, screaming, sweating, confusion, and increased heart rate.

References

1. Schneider-Helmert D, Spinweber CL. Evaluation of L-tryptophan for treatment of insomnia: A review. Psychopharmacology (Berlin) 1986;89(1):1-7.

2. Lindsley JG, Hartmann EL, Mitchell W. Selectivity in response to L-tryptophan among insomniac subjects: a preliminary report. Sleep 1983;6:247-56.

3. Wyatt RJ, Zarcone V, Engelman K, et al. Effects of 5-hydroxytryptophan on the sleep of normal human subjects. Electroencephalogr Clin Neurophysiol 1971;30:505-9.

4. Puttini PS, Caruso I. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. J Int Med Res 1992;20:182-9.

5. Bruni O, Ferri R, Miano S, Verrillo E. L-5-Hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatr 2004;163:402-7.

Sleep Disturbances
Dose: Refer to label instructions5-HTP is used by the human body to make serotonin, an important substance for normal nerve and brain function. Serotonin appears to play significant roles in sleep, emotional moods, pain control, inflammation, intestinal peristalsis, and other body functions.1 Insomnia has been associated with tryptophan deficiency in the tissues of the brain;2 therefore, 5-HTP may provide a remedy for this condition.



In a controlled trial, 5-HTP (300 mg per day) was shown to be effective in reducing many symptoms of fibromyalgia, including pain, morning stiffness, sleep disturbances, and anxiety.3 For insomnia, a single 100-mg nighttime dose of 5-HTP was sufficient to improve the duration and depth of sleep in one placebo-controlled trial.4
References

1. Guyton AC, Hall JE. Textbook of Medical Physiology, 9th ed. Philadelphia: W. B. Saunders, 1996.

2. Schneider-Helmert D, Spinweber CL. Evaluation of L-tryptophan for treatment of insomnia: A review. Psychopharmacology (Berlin) 1986;89(1):1-7.

3. Caruso I, Sarzi Puttini P, Cazzola M, Azzolini V. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res 1990;18:201-9.

4. Soulairac A, Lambinet H. Etudes cliniques de liaction du precurseur de la serotonine le L-5-hydroxy-tryptophane, sur les troubles du sommeil. Schweiz Bundschau Med (PRAXIS) 1998;77(34a):19-23 [in French].

Obesity
Dose: Take under medical supervision: 600 to 900 mg daily for no more than 12 weeks 5-HTP (5-hydroxytryptophan), the precursor to the chemical messenger (neurotransmitter) serotonin, has been shown in three short-term controlled trials to reduce appetite and to promote weight loss. In one of these trials (a 12-week double-blind trial), overweight women who took 600 to 900 mg of 5-HTP per day lost significantly more weight than did women who received a placebo. In a double-blind trial with no dietary restrictions, obese people with type 2(non-insulin-dependent) who took 750 mg per dayof 5-HTP for two weeks significantly reduced their carbohydrate and fat intake. Average weight loss in two weeks was 4.6 pounds, compared with 0.2 pounds in the placebo group. This amount has not been established as a safe long-term treatment and should not be tried without a doctor's supervision; people taking antidepressants or other medications should be aware of potential drug interactions.
Bipolar Disorder
Dose: Refer to label instructions

L-tryptophan is the amino acid used by the body to produce serotonin, a chemical messenger important for proper brain function. Supplementation with L-tryptophan has led to improvement in depression in many studies,1, 2 but information is limited about its effect on bipolar disorder. Case reports on two bipolar patients treated with lithium or an antidepressant drug described marked improvements when they were given 12 grams daily of L-tryptophan.3, 4 Two trials using 6 grams of L-tryptophan daily for acute mania in patients with bipolar disorder found little or no improvement,5, 6 but another double-blind, controlled study using 9.6 grams daily reported better results.7

L-tryptophan is converted to 5-HTP (5-hydroxytryptophan) before it becomes serotonin in the body. In a controlled trial, 200 mg daily of supplemental 5-HTP had antidepressant effects in bipolar patients, though it was not as effective as lithium.8 In a double-blind trial, patients with bipolar disorder had greater improvement with a combination of 5-HTP at 300 mg daily plus an antidepressant drug than with 5-HTP alone.9

References

1. Young SN. Behavioral effects of dietary neurotransmitter precursors: basic and clinical aspects. Neurosci Biobehav Rev 1996;20:313-23 [review].

2. Riemann D, Vorderholzer U. Treatment of depression and sleep disorders. Significance of serotonin and L-tryptophan in pathophysiology and therapy. Fortschr Med 1998;116:40-2 [review].

3. Chouinard G, Jones BD, Young SN, Annable L. Potentiation of lithium by tryptophan in a patient with bipolar illness. Am J Psychiatry 1979;136:719-20.

4. Hedaya RJ. Pharmacokinetic factors in the clinical use of tryptophan. J Clin Psychopharmacol 1984;4:347-8.

5. Prange AJ, Wilson IC, Lynn CW, et al. L-tryptophan in mania: contribution to a permissive hypothesis of affective disorders. Arch Gen Psychiatry 1974;30:56-62.

6. Chambers CA, Naylor GJ. A controlled trial of L-tryptophan in mania. Br J Psychiatry 1978;132:555-9.

7. Murphy DL, Maker M, Goodwin FK, et al. L-tryptophan in affective disorders: indoleamine changes and differential clinical effects. Psychopharmacologia 1974;34:11-20.

8. van Praag HM, de Haan S. Chemoprophylaxis of depressions. An attempt to compare lithium with 5-hydroxytryptophan. Acta Psychiatr Scand Suppl 1981;290:191-201.

9. Mendlewicz J, Youdim MB. Antidepressant potentiation of 5-hydroxytryptophan by L-deprenil in affective illness. J Affect Disord 1980;2:137-46.

5-hydroxytryptophan is used by the human body to make serotonin, an important substance for normal nerve and brain function. Serotonin appears to play significant roles in sleep, emotional moods, pain control, inflammation, intestinal peristalsis, and other body functions.1

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
Natrol® 5-HTP
 
4.2

(based on 5 reviews)

80%

of respondents would recommend this to a friend.

Pros

    Cons

      Best Uses

      • Daily use (4)

      Reviewed by 5 customers

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      (10 of 11 customers found this review helpful)

       
      4.0

      i would buy this again

      By thunderrose10

      from elba,NE

      About Me First Time User

      Verified Buyer

      Pros

      • Good Value
      • Natural-Feeling Results
      • No Side Effects

      Cons

        Best Uses

        • Daily Use

        Comments about Natrol® 5-HTP:

        There were no side effects. Could feel results within 24 hours.

        (3 of 4 customers found this review helpful)

         
        2.0

        Didn't notice anything

        By notthatbrianjones

        from New York

        See all my reviews

        Comments about Natrol® 5-HTP:

        I did not experience any change in appetite or any weight loss... nor any effect of any kind (no mood change, etc). It might help for some people, but it didn't do anything for me. At least it didn't have any bad effects, either, which is why I wouldn't give it the bottom rating.

        (17 of 18 customers found this review helpful)

         
        5.0

        I will buy this again

        By hisbelovedjudy

        from Atlanta, GA

        About Me Regular User

        See all my reviews

        Pros

        • Natural-Feeling Results
        • No Side Effects
        • Works Quickly

        Cons

          Best Uses

          • Daily Use

          Comments about Natrol® 5-HTP:

          I read that migraines can be the result of low serotonin levels, so I got this product to stimulate serotonin production. I had been having 1 to 2 migraines a week that would last around 48 hours. One migraine would ruin three days, and if I had two in a week, the whole week was shot. Since I started taking this daily three weeks ago I have not had one migraine. Not ONE!! I could not be happier!!!

          (15 of 16 customers found this review helpful)

           
          5.0

          Don't judge a book by its cover

          By red_astrachan

          from Bay Shore NY

          About Me Brand Buyer

          See all my reviews

          Pros

          • Easy To Use

          Cons

            Best Uses

            • Daily Use

            Comments about Natrol® 5-HTP:

            Good for controlling hunger and mood swings.

            • My Beauty Routine Takes:
            • 10 Minutes

            (16 of 19 customers found this review helpful)

             
            5.0

            Works great!

            By jonathangavin

            from Mansfield, TX

            About Me Brand Buyer

            See all my reviews

            Pros

            • Easy To Use
            • Effective

            Cons

            • None

            Best Uses

            • Daily Use
            • Men

            Comments about Natrol® 5-HTP:

            It performs exactly like it says. Enhances your mood tremendously!

            • My Beauty Routine Takes:
            • 30 Minutes

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