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GNC Triflex™ Liquid

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16 fl.oz.

Item #705804 See Product Details

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Description
Promotes joint mobility & flexibility*

Helps rebuild cartilage*
Glucosamine - Chondroitin - MSM

Orange Flavor

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

Shake well before each use. As a dietary supplement, take one serving (2 tablespoons) daily. preferably with meals. Can also be mixed with 4-6 oz. of water or your favorite beverage. Refrigerate after opening.

Serving Size 2 Tablespoons
Servings Per Container 16
Amount Per Serving % DV
Calories 20.00
Sodium 90.00 mg 4%
Total Carbohydrate 4.00 g 1%
Protein 1.00 g 2%
Glucosamine HCL 1500.00 mg **
Chondroitin Sulfate 1200.00 mg **
MSM (Methylsulfonyl-methane) 900.00 mg **
** Daily Value (DV) not established

Other Ingredients: Purified Water, Glycerin, Citric Acid, Natural and Artificial Flavors, Potassium Sorbate, Sodium Benzoate, Sucralose, Caramel Color, Acesulfame Potassium

Storage Instructions: Store in a cool dry place.

Refrigerate after opening.

Warning: Consult your physician prior to using this product it you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition. Discontinue use two weeks prior to surgery.KEEP OUT OF REACH OF CHILDREN.

Shellfish (Crab and Shrimp)

Health Notes

Joint Health

Joint Health
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

Osteoarthritis
Dose: 800 to 1,200 mg a day
Many trials have shown that supplementing with chondroitin sulfate reduces pain, increases joint mobility, and promotes healing within the joints.(more)
Osteoarthritis
Dose: 2.25 to 6.0 grams per day
In one trial, supplementing with methyl-sulfonylmethane significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee. (more)
Osteoarthritis
Dose: Refer to label instructions
Studies have shown glucosamine hydrochloride to be effective at reducing pain and improving symptoms in people with osteoarthritis.(more)
Osteoarthritis
Dose: 800 to 1,200 mg a day

Chondroitin sulfate (CS) is a major component of the lining of joints. The structure of CS includes molecules related to glucosamine sulfate. CS levels have been reported to be reduced in joint cartilage affected by osteoarthritis. Possibly as a result, CS supplementation may help restore joint function in people with osteoarthritis.1 On the basis of preliminary evidence, researchers had believed that oral CS was not absorbed in humans;2 as a result, early double-blind CS research was done mostly by giving injections.3, 4 This research documented clinical benefits from CS injections. It now appears, however, that a significant amount of CS is absorbable in humans,5 though dissolving CS in water leads to better absorption than swallowing whole pills.6

Strong clinical evidence now supports the use of oral CS supplements for osteoarthritis. Many double-blind trials have shown that CS supplementation consistently reduces pain, increases joint mobility, and/or shows evidence (including X-ray changes) of healing within joints of people with osteoarthritis.7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 Most trials have used 400 mg of CS taken two to three times per day. One trial found that taking the full daily amount (1,200 mg) at one time was as effective as taking 400 mg three times per day.18 Reduction in symptoms typically occurs within several months.

References

1. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

2. Baici A, Horler D, Moser B, et al. Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate. Rheumatol Int 1992;12:81-8.

3. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

4. Rovetta G. Galactosaminoglycuronoglycan sulfate (Matrix) in therapy of tibiofibular osteoarhtirits of the knee. Drugs Exp Clin Res 1991;17:53-7.

5. Conte A, Volpi N, Palmieri L, et al. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneimittelforschung 1995;45:918-25.

6. Ronca F, Palmieri L, Panicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 1998;6(Supplement A):14-21.

7. Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(Suppl A):39-46.

8. Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage 1998;6(Suppl A):37-8.

9. Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 1998;6(Suppl A):31-6.

10. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

11. Pipitone V, Ambanelli U, Cervini C, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Curr Ther Res 1992;52:608-38.

12. Bazieres B, Loyau G, Menkes CJ, et al. Le chondroitine sulfate dans le traitement de la gonarthrose et de la coxarthrose. Rev Rhum Mal Osteoartic 1992;59:466-72 [in French].

13. Conrozier T, Vignon E. Die Wirkung von Chondroitinsulfat bei der Behandlung der Huft Gelenksarthrose. Eine Doppelblindstudie gegen Placebo. Litera Rheumatologica 1992;14:69-75 [in German].

14. L'Hirondel JL. Klinische Doppelblind-Studie mit oral verabreichtem Chondroitinsulfat gegen Placebo bei der tibiofermoralen Gonarthrose (125 Patienten). Litera Rheumatologica 1992;14:77-82 [in German].

15. Morreale P, Manopulo R, Galati M, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-91.

16. Leeb BF, Petera P, Neumann K. Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints. Wien Med Wochenschr 1996;146:609-14.

17. Wildi LM, Raynauld JP, Martel-Pelletier J, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis 2011;70:982-9.

18. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

Osteoarthritis
Dose: 2.25 to 6.0 grams per dayAccording to a small double-blind trial, 2,250 mg per day of oral methylsulfonylmethane (MSM), a variant of DMSO, reduced osteoarthritis pain after six weeks.1 In another double-blind trial, supplementation with 3 grams of MSM twice a day for 12 weeks significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee.2
References

1. Lawrence RM. Methylsulfonylmethane (MSM): a double-blind study of its use in degenerative arthritis. Int J of Anti-Aging Med 1998;1:50.

2. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94.

Osteoarthritis
Dose: Refer to label instructionsA few trials have evaluated glucosamine hydrochloride (GH), another form of glucosamine sulfate (GS), as a single remedy for osteoarthritis. One trial found only minor benefits from 1,500 mg per day of GH for 8 weeks in people with osteoarthritis of the knee.1 However, these people were also taking up to 4,000 mg per day of acetaminophen for pain relief, and that treatment might have masked a beneficial effect of GH. In another study, supplementing with GH (2,000 mg each morning for 12 weeks) significantly improved symptoms, compared with a placebo, in people with knee pain due to cartilage damage or osteoarthritis.2 In a four-week study from China, GH was as effective as GS in people with osteoarthritis of the knee.3 Another study found that the combination of GH and chondroitin sulfate was more effective than a placebo in people with moderate to severe knee pain from osteoarthritis, but not in those with mild pain.4 Despite the reported beneficial effects of GH, some investigators believe that the sulfate component of GS itself helps relieve osteoarthritis, and that GS would therefore be more effective than GH.5
References

1. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.

2. Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med 2003;37:45-9.

3. Qiu GX, Weng XS, Zhang K, et al. A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulfate in the treatment of knee osteoarthritis. Zhonghua Yi Xue Za Zhi 2005;85:3067-70 [in Chinese].

4. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;795-808.

5. Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC Triflex™ Liquid
 
4.3

(based on 11 reviews)

91%

of respondents would recommend this to a friend.

Pros

  • Simple to take (8)
  • Good value (6)
  • Relieves pain (6)
  • Increases flexibility (4)
  • Effective (3)

Cons

    Best Uses

    • Everyday use (6)
    • Athletes (4)
    • Injury recovery (4)
    • Older people (4)
      • Reviewer Profile:
      • Regular user (5), First time user (4), Health conscious (4)

    Reviewed by 11 customers

    Sort by

    Displaying reviews 1-10

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    (2 of 2 customers found this review helpful)

     
    5.0

    Great for flexipility and pain

    By jlabove

    from Cameron,Louisiana

    About Me Medical Professional

    See all my reviews

    Pros

    • Relieves Pain
    • Simple To Take

    Cons

      Best Uses

      • Athletes
      • Everyday Use

      Comments about GNC Triflex™ Liquid:

      Liquid is so much easier to take than a big pill!

      (2 of 2 customers found this review helpful)

       
      5.0

      I buy this product again and again

      By butterflywings71

      from Baltimore, MD

      About Me Health Conscious, Regular User

      See all my reviews

      Pros

      • Good Value
      • Relieves Pain
      • Simple To Take

      Cons

        Best Uses

        • Everyday Use
        • Injury Recovery

        Comments about GNC Triflex™ Liquid:

        I add this product everyday to my protein shake so I have no problem with the flavor. I've also mixed it in with orange juice or brewed ice tea. I've been taking this for 3 months now and within the first month of regular use I noticed a big difference in my pain level and with continued use I can now kneel again without sharp, stabbing pain. This has been a life saver for me. I am very active and workout regularly.

        (1 of 1 customers found this review helpful)

         
        5.0

        MY PURCHASE

        By mlopezrea

        from Concho, AZ

        About Me Health Conscious, Regular User

        See all my reviews

        Verified Buyer

        Pros

        • Good Value
        • I love GNC Triflex Liquid
        • Increases Flexibility
        • Increases Strength
        • Relieves Pain
        • Simple To Take

        Cons

        • Post office lost it

        Best Uses

        • Everyday Use
        • Injury Recovery
        • Older People

        Comments about GNC Triflex™ Liquid:

        I purchased the product because my husband had a knee surgery and it has helped him a lot with pain and mobility. My last purchase however was not successful. I never received the package and when I asked the post office they said they received it and probably put it in the wrong box, so somebody stole it and now nobody knows anything. Unfortunately, I there is no GNC stores where I live and I'm afraid of purchasing again online. Thank you.

        (7 of 7 customers found this review helpful)

         
        5.0

        GNC Triflex Liquid

        By bpennings2

        from Little Chute, Wi.

        About Me Regular User

        See all my reviews

        Pros

        • Good Value
        • Increases Flexibility
        • Increases Strength
        • Relieves Pain
        • Simple To Take

        Cons

          Best Uses

          • Everyday Use

          Comments about GNC Triflex™ Liquid:

          I used the liquid TriFlex for 5 days and felt 20 years younger. No knee pain, no creaking going up stairs. No pain bending to the floor to pick anything up. Liquid only though. I switched to tablets and they didn't work at all. I haven't tried the caplets or chews yet.

          (3 of 3 customers found this review helpful)

           
          4.0

          This stuff is great!

          By robjob.wilson

          from sonora, ca

          About Me Health Conscious, Regular User

          See all my reviews

          Verified Buyer

          Pros

          • Good Value
          • Simple To Take

          Cons

            Best Uses

            • Athletes

            Comments about GNC Triflex™ Liquid:

            I, take a lot of vitamins so; having this in liquid form is really nice. not a great taste alone but, just fine w/water or anything else of the sort. This product works well in many ways. Noticed it in about 2 weeks time and is only getting better. Also noticed the pops and cracks in my joints as I, stretch diminishing..

            (1 of 1 customers found this review helpful)

             
            4.0

            Works but taste is lacking

            By tasba144

            from Gilmer, TX

            About Me First Time User

            See all my reviews

            Verified Buyer

            Pros

            • Good Value
            • Increases Flexibility
            • Increases Strength
            • Relieves Pain
            • Simple To Take

            Cons

            • Tastes Bad

            Best Uses

            • Athletes
            • Everyday Use
            • Older People

            Comments about GNC Triflex™ Liquid:

            This item is easy to take but in my opinion drinking iodine would taste better. It is worth taking though, I have no joint pain at all....so yes I would recommend to a friend based on that.

            (1 of 1 customers found this review helpful)

             
            3.0

            BAD TASTING

            By archiestarchys

            from MOORE, OKLAHOMA

            About Me Regular User

            See all my reviews

            Verified Buyer

            Pros

            • Increases Flexibility
            • Relieves Pain

            Cons

              Best Uses

              • Injury Recovery
              • Older People

              Comments about GNC Triflex™ Liquid:

              WORKS GOOD FOR PAINFUL JOINTS BUT NEEDS A BETTER TASTE. TRY CHERRY OR BLUEBERRY FLAVORS.

              (1 of 1 customers found this review helpful)

               
              3.0

              Not overly impressed

              By eldonsprague

              from DeKalb, IL

              About Me First Time User

              See all my reviews

              Pros

              • Good Value

              Cons

              • Complicated To Take

              Best Uses

              • Athletes
              • Everyday Use
              • Injury Recovery
              • Older People

              Comments about GNC Triflex™ Liquid:

              The product is very thin and thereby difficult to control when pouring. The flavor is similar to unflavored cough medicine. The effectiveness and grade of components are good.

              (3 of 3 customers found this review helpful)

               
              4.0

              EASIER THAN THOSE MONSTER PILLS

              By rosebradford

              from ARLINGTON, TENNESSEE

              About Me First Time User, Medical Professional

              See all my reviews

              Pros

              • Effective
              • Simple To Take

              Cons

                Best Uses

                • Women

                Comments about GNC Triflex™ Liquid:

                I TRIED THIS PORDUCT BECAUSE I COULD NOT TAKE THE LARGE PILLS. AFTER BEING ON THIS SUPPLEMENT FOR 2 WEEKS I SAW A DIFFERENCE. IT WAS EASIER TO GO UP AND DOWN STAIRS WITHOUT MUCH PAIN. NOW I HAVE BEEN ON TRI FLEX FOR 3 MONTHS AND CAN SEE A WORLD OF CHANGE

                (1 of 1 customers found this review helpful)

                 
                4.0

                Liquid Joint Health Product

                By brown.59

                from Columbus, OH

                About Me First Time User, Health Conscious

                See all my reviews

                Pros

                • Easy on Stomach
                • Easy To Swallow
                • Effective
                • Simple To Take

                Cons

                • Poor Taste

                Best Uses

                • Daily Use
                • Men
                • Supplement A Meal

                Comments about GNC Triflex™ Liquid:

                I take daily jsut before or after evening meal. Just started taking this supplement, but is easier than trying to swallow 2 large tablets. Taste is tolerable, but I expected a stronger lemon or orange flavor. I'd like to take this survey after 2 weeks of use; starting after December 25, 2009.

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