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GNC Melatonin 5000 Zipmelt™

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60 Vegetarian Tablets

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Description
Quick Dissolving to Facilitate Absorption

Supports Restful Sleep*

Peppermint Natural Flavor

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take one ZipMelt™ tablet before bedtime allowing it to dissolve slowly under the tongue before swallowing. Do not exceed one ZipMelt™ tablet in any 24 hour period. Read warning label prior to use.

Serving Size 1 Vegetarian Tablets
Servings Per Container 60
Amount Per Serving % DV
Melatonin 5000.00 mcg **
** Daily Value (DV) not established

Other Ingredients: Mannitol, Maltose, Natural Peppermint Flavor, Sucralose

Storage Instructions: Store in a cool dry place.

Warning: For adult use only at bedtime. This product is not to be taken by pregnant or lactating women. If you are taking medication or have a medical condition, consult a physician before using this product. Do not use in conjunction with alcoholic beverages, when driving a vehicle, or while operating machinery.

Consult your physician prior to using this product it you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition. Discontinue use two weeks prior to surgery.KEEP OUT OF REACH OF CHILDREN.

No Sugar, No Starch, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Corn, No Dairy. Yeast Free.


General Nutrition Corporation
Pittsburgh, PA 15222

Health Notes

Melatonin

Melatonin
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Macular Degeneration
Dose: Take under medical supervision: 3 mg daily at bedtime
In one trial, melatonin improved eye abnormalities in the majority of cases. It appears to work by regulating eye pigmentation and by functioning as an antioxidant.(more)
Alzheimer's Disease
Dose: Refer to label instructions
(more)
Age-Related Cognitive Decline
Dose: Refer to label instructions
Cognitive function is linked to adequate sleep and normal sleep-wake cycles, which are partially regulated by the hormone melatonin. The long-term effects of melatonin are unknown, use under a doctor's supervision.(more)
Cluster Headache
Dose: Take under medical supervision: 10 mg daily in the evening
Taking melatonin before bedtime has been shown to reduce the frequency of cluster headaches.(more)
Migraine Headache
Dose: Refer to label instructions
Pineal gland function and melatonin secretion may be disturbed in people with migraine headaches. Taking melatonin may correct this problem and reduce symptoms.(more)
Fibromyalgia
Dose: Refer to label instructions
In one study, supplementing with melatonin reduced tender points and improved sleep in people with fibromyalgia.(more)
Insomnia
Dose: Take under medical supervision: 0.5 to 3.0 mg daily one to two hours before bedtime
Taking melatonin before bedtime may help reset your body's internal clock. (more)
Jet Lag
Dose: Take under medical supervision: 0.5 mg daily at bedtime for four days after arriving at your destination
Taking melatonin at bedtime may improve sleep quality and daytime alertness.(more)
Insomnia and Tinnitus
Dose: Take under medical supervision: 3 mg dailly at bedtime
Supplementing with melatonin may improve sleep quality and relieve other symptoms of severe tinnitus.(more)
Sunburn
Dose: Apply a formula containing 2% vitamin E, 5% vitamin C, and 1% to 2.5% melatonin before sun exposure
A topically applied combination of melatonin, vitamin C, and vitamin E may boost the protection from traditional sunscreens.(more)
Macular Degeneration
Dose: Take under medical supervision: 3 mg daily at bedtime
In one trial, melatonin improved eye abnormalities in the majority of cases. It appears to work by regulating eye pigmentation and by functioning as an antioxidant.(more)
Glaucoma
Dose: Refer to label instructions
Supplementing with melatonin lowered intraocular pressure of healthy people in one study.(more)
Irritable Bowel Syndrome
Dose: Take under medical supervision: 3 mg daily at bedtime
Melatonin helps regulate gastrointestinal function and sensation. In one trial, people with irritable bowel syndrome who took melatonin experienced significantly less severe abdominal pain.(more)
Hypertension
Dose: Take under medical supervision: 2 mg daily of sustained-released supplment at night
For people with nighttime hypertension, supplementing with melatonin may reduce nighttime systolic blood pressure.(more)
Age-Related Cognitive Decline
Dose: Refer to label instructions
Cognitive function is linked to adequate sleep and normal sleep-wake cycles, which are partially regulated by the hormone melatonin. The long-term effects of melatonin are unknown, use under a doctor's supervision.(more)
Macular Degeneration
Dose: Take under medical supervision: 3 mg daily at bedtime

In a preliminary trial, supplementation with melatonin (3 mg per day at bedtime for at least three months) resulted in an improvement in the abnormalities observed on eye examination in the majority of cases.1 Melatonin is believed to work by regulating eye pigmentation (and, consequently, the amount of light reaching the retina) and by functioning as an antioxidant.

References

1. Yi C, Pan X, Yan H, et al. Effects of melatonin in age-related macular degeneration. Ann N Y Acad Sci 2005;1057:384-92.

Alzheimer's Disease
Dose: Refer to label instructions
Age-Related Cognitive Decline
Dose: Refer to label instructions

Melatonin is a hormone secreted by the pineal gland in the brain. It is partially responsible for regulating sleep-wake cycles. Cognitive function is linked to adequate sleep and normal sleep-wake cycles. Cognitive benefits from melatonin supplementation have been suggested by preliminary research in a variety of situations and may derive from the ability of melatonin to prevent sleep disruptions.1, 2, 3, 4 A double-blind trial of ten elderly patients with mild cognitive impairment showed that 6 mg of melatonin taken two hours before bedtime significantly improved sleep, mood, and memory, including the ability to remember previously learned items.5 However, in a double-blind case study of one healthy person, 1.6 mg of melatonin had no immediate effect on cognitive performance.6

The long-term effects of regularly taking melatonin supplements remain unknown, and many healthcare practitioners recommend that people take no more than 3 mg per evening. A doctor familiar with the use of melatonin should supervise people who wish to take it regularly.

References

1. Myers BL, Badia P. Changes in circadian rhythms and sleep quality with aging: mechanisms and interventions. Neurosci Biobehav Rev 1995;19(4):553-71. Published erratum appears in Neurosci Biobehav Rev 1996;20(2):I-IV.

2. Dollins AB, Zhdanova IV, Wurtman RJ, et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci U S A 1994;91(5):1824-8.

3. Dori D, Casale G, Solerte SB, et al. Chrono-neuroendocrinological aspects of physiological aging and senile dementia. Chronobiologia 1994;21(1-2):121-6.

4. Comperatore CA, Lieberman HR, Kirby AW, et al. Melatonin efficacy in aviation missions requiring rapid deployment and night operations. Aviat Space Environ Med 1996;67(6):520-4.

5. Jean-Louis G, von Gizycki H, Zizi F. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res 1998;25(3):177-83.

6. Slotten HA, Krekling S. Does melatonin have an effect on cognitive performance? Psychoneuro-endocrinology 1996;21(8):673-80.

Cluster Headache
Dose: Take under medical supervision: 10 mg daily in the evening

Researchers have found low levels of the hormone melatonin in cluster headache patients.1, 2, 3, 4 In a small double-blind trial, a group of cluster headache sufferers took a 10 mg evening dose of melatonin for 14 days. About half of the group saw a significant decrease in the frequency of their headaches within three to five days, after which no further headaches occurred until melatonin was discontinued.5 Melatonin appears to be effective against both types of cluster headache (e.g., episodic and chronic). 6 More research is needed to establish the long-term effects of melatonin supplementation on cluster headache.

References

1. Chazot G, Claustrat B, Brun J, et al. A chronobiological study of melatonin, cortisol, growth hormone, and prolactin secretion in cluster headache. Cephalalgia 1984;4:213-20.

2. Waldenlind E, Gustafsson SA, Ekbom KA, Wetterberg L. Circadian secretion of cortisol and melatonin during active cluster periods and remission. J Neurol Neurosurg Psychiatry 1987;50:207-13.

3. Leone M, Lucini V, D'Amico D, et al. Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache. Cephalalgia 1995;15:224-9.

4. Leone M, Lucini V, D'Amico D, et al. Abnormal 24-hour urinary excretory pattern of 6-sulphatoxymelatonin in both phases of cluster headache. Cephalalgia 1998;18:664-7.

5. Leone M, D'Amico D, Moschiano F, et al. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia 1996;16:494-6.

6. Peres MFP, Rozen TD. Melatonin in the preventive treatment of chronic cluster headache. Cephalalgia 2001;21:993-5.

Migraine Headache
Dose: Refer to label instructions

The function of the pineal gland and its cyclic secretion of melatonin may be disturbed in people with migraine headaches.1 Preliminary evidence suggests that 5 mg per day of melatonin, taken 30 minutes before bedtime, may reduce symptoms of migraine headache.2 However, a double-blind trial found that taking 2 mg of melatonin 1 hour before bedtime each day for 8 weeks was not more effective than a placebo for decreasing migraine frequency.3

References

1. Claustrat B, Brun J, Geoffriau M, et al. Nocturnal plasma melatonin profile and melatonin kinetics during infusion in status migrainosus. Cephalalgia 1997;17:511-7 (discussion 487).

2. Nagtegaal JE, Smits MG, Swart AC, et al. Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. Headache 1998;38:303-7.

3. Alstadhaug KB, Odeh F, Salvesen R, Bekkelund SI. Prophylaxis of migraine with melatonin: a randomized controlled trial. Neurology 2010;75:1527-32.

Fibromyalgia
Dose: Refer to label instructions

Melatonin supplementation may be useful in the treatment of fibromyalgia. In a preliminary trial, 3 mg of melatonin at bedtime was found to reduce tender points and to improve sleep and other measures of disease severity, though pain and fatigue improved only slightly.1

References

1. Citera G, Arias MA, Maldonado-Cocco JA, et al. The effect of melatonin in patients with fibromyalgia: a pilot study. Clin Rheumatol 2000;19:9-13.

Insomnia
Dose: Take under medical supervision: 0.5 to 3.0 mg daily one to two hours before bedtime

Caution: Melatonin is a potent hormone and its long-term safety is not established. Melatonin should only be taken with medical supervision.

Melatonin is a natural hormone that regulates the human biological clock. The body produces less melatonin with advancing age, which may explain why elderly people often have difficulty sleeping1 and why melatonin supplements improve sleep in the elderly.2

Middle-aged adults (average age, 54 years) with insomnia also have lower melatonin levels, compared with people of the same age without insomnia.3 However, there is not much research on the use of melatonin for sleep problems in middle-aged people.

Double-blind trials have shown that melatonin facilitates sleep in young adults without insomnia,4 but not in young people who suffer from insomnia.5However, one trial found that children with sleep disturbances stemming from school phobia had improved sleep after taking 1 mg of melatonin per night for one week, then 5 mg per night for one week, then 10 mg per night for a third week.6

The results of one double-blind trial also indicate that a controlled release melatonin supplement providing 2 mg per day improves sleep quality in people with schizophrenia.7

Normally, the body makes melatonin for several hours per night-an effect best duplicated with controlled-release supplements. Trials using timed-release melatonin for insomnia have reported good results.8 Many doctors suggest taking 0.5 to 3 mg of melatonin one and a half to two hours before bedtime. However, because melatonin is a potent hormone, the long-term effects of which are unknown, it should be taken only with the supervision of a doctor.

References

1. Haimov I, Laudon M, Zisapel N, et al. Sleep disorders and melatonin rhythms in elderly people. BMJ 1994;309:167.

2. Singer C, McArthur A, Hughes R, et al. Melatonin and sleep in the elderly. J Am Geriatr Soc 1996;44:51 [abstr #A1].

3. Attenburrow MEJ, Dowling BA, Sharpley AL, Cowen PJ. Case-control study of evening melatonin concentration in primary insomnia. BMJ 1996;312:1263-4.

4. Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995;57:552-8.

5. James SP, Sack DA, Rosenthal NE, Mendelson WB. Melatonin administration in insomnia. Neuropsychopharmacology 1989;3:19-23.

6. Tomoda A, Miike T, Iwatani N, et al. Effect of long-term melatonin administration on school-phobic children and adolescents with sleep disturbances. Curr Ther Res 1999;60:607-12.

7. Shamir E, Laudon M, Barak Y, et al. Melatonin improves sleep quality of patients with chronic schizophrenia. J Clin Psychiatry 2000;61:373-7.

8. Garfinkel D, Laudon M, Nof D, Zisapel N. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 1995;346:541-4.

Jet Lag
Dose: Take under medical supervision: 0.5 mg daily at bedtime for four days after arriving at your destination

Melatonin is a natural hormone that regulates the human biological clock and may be helpful in relieving symptoms of jet lag, according to some,1, 2 though not all,3, 4 double-blind studies. One double-blind trial, involving international flight crew members, found that melatonin supplementation was helpful when started after arriving at the destination but not when started three days before leaving.5 Another double-blind study compared various amounts and forms of melatonin taken at bedtime for four days after the flight by people who traveled through six to eight time zones.6 Fast-release melatonin supplements were found to be more effective than the controlled-release supplements. A 5 mg and 0.5 mg fast-release melatonin were almost equally effective for improving sleep quality, time it took to fall asleep, and daytime sleepiness.

References

1. Petrie K, Conaglen JV, Thompson L, Chamberlain K. Effect of melatonin on jet lag after long haul flights. BMJ 1989;298:705-7.

2. Claustrat B, Brun J, David M, et al. Melatonin and jet lag: confirmatory result using a simplified protocol. Biol Psychiatry 1992;32:705-11.

3. Edwards BJ, Atkinson G, Waterhouse J, et al. Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics 2000;43:1501-13.

4. Spitzer RL, Terman M, Williams JB, et al. Jet lag: clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trial. Am J Psychiatry 1999;156:1392-6.

5. Petrie K, Dawson AG, Thompson L, et al. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Bio Psych 1993;33(7):526-30.

6. Suhner A, Schlagenhauf P, Johnson R, et al. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int 1998;15:655-66.

Insomnia and Tinnitus
Dose: Take under medical supervision: 3 mg dailly at bedtime

Caution: Melatonin is a potent hormone and its long-term safety is not established. Melatonin should only be taken with medical supervision.

Melatonin is a natural hormone that regulates the human biological clock. The body produces less melatonin with advancing age, which may explain why elderly people often have difficulty sleeping1 and why melatonin supplements improve sleep in the elderly.2

Middle-aged adults (average age, 54 years) with insomnia also have lower melatonin levels, compared with people of the same age without insomnia.3 However, there is not much research on the use of melatonin for sleep problems in middle-aged people.

Double-blind trials have shown that melatonin facilitates sleep in young adults without insomnia,4 but not in young people who suffer from insomnia.5However, one trial found that children with sleep disturbances stemming from school phobia had improved sleep after taking 1 mg of melatonin per night for one week, then 5 mg per night for one week, then 10 mg per night for a third week.6

The results of one double-blind trial also indicate that a controlled release melatonin supplement providing 2 mg per day improves sleep quality in people with schizophrenia.7

Normally, the body makes melatonin for several hours per night-an effect best duplicated with controlled-release supplements. Trials using timed-release melatonin for insomnia have reported good results.8 Many doctors suggest taking 0.5 to 3 mg of melatonin one and a half to two hours before bedtime. However, because melatonin is a potent hormone, the long-term effects of which are unknown, it should be taken only with the supervision of a doctor.

References

1. Haimov I, Laudon M, Zisapel N, et al. Sleep disorders and melatonin rhythms in elderly people. BMJ 1994;309:167.

2. Singer C, McArthur A, Hughes R, et al. Melatonin and sleep in the elderly. J Am Geriatr Soc 1996;44:51 [abstr #A1].

3. Attenburrow MEJ, Dowling BA, Sharpley AL, Cowen PJ. Case-control study of evening melatonin concentration in primary insomnia. BMJ 1996;312:1263-4.

4. Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995;57:552-8.

5. James SP, Sack DA, Rosenthal NE, Mendelson WB. Melatonin administration in insomnia. Neuropsychopharmacology 1989;3:19-23.

6. Tomoda A, Miike T, Iwatani N, et al. Effect of long-term melatonin administration on school-phobic children and adolescents with sleep disturbances. Curr Ther Res 1999;60:607-12.

7. Shamir E, Laudon M, Barak Y, et al. Melatonin improves sleep quality of patients with chronic schizophrenia. J Clin Psychiatry 2000;61:373-7.

8. Garfinkel D, Laudon M, Nof D, Zisapel N. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 1995;346:541-4.

Sunburn
Dose: Apply a formula containing 2% vitamin E, 5% vitamin C, and 1% to 2.5% melatonin before sun exposure

Antioxidants have been studied as topical agents for protection against sunburn. Animal studies have found sunscreen-like effects from topical application of a vitamin C and vitamin E combination, and a controlled human study reported ultraviolet protection from the use of a lotion containing 0.02% to 0.05% of the selenium-containing amino acid known as selenomethionine.1, 2 The topical use of the hormone melatonin has been shown to protect human skin against ultraviolet rays in double-blind research.3, 4 A double-blind human trial tested topical vitamins C and E and melatonin, alone and in combinations, and found the highest degrees of protection from combination formulations containing 2% vitamin E, 5% vitamin C, and 1% to 2.5% melatonin.5 Other studies in which topical antioxidants were applied after ultraviolet exposure have found no benefits.6, 7

References

1. Lin JY, Selim MA, Shea CR, et al. UV photoprotection by combination topical antioxidants vitamin C and vitamin E. J Am Acad Dermatol 2003;48:866-74.

2. Burke KE, Burford RG, Combs GF Jr, et al. The effect of topical L-selenomethionine on minimal erythema dose of ultraviolet irradiation in humans. Photodermatol Photoimmunol Photomed 1992;9:52-7.

3. Bangha E, Elsner P, Kistler GS. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). Influence of the application time point. Dermatology 1997;195:248-52.

4. Bangha E, Elsner P, Kistler GS. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). A dose response study. Arch Dermatol Res 1996;288:522-6.

5. Dreher F, Gabard B, Schwindt DA, Maibach HI. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo. Br J Dermatol 1998;139:332-9.

6. Dreher F, Denig N, Gabard B, et al. Effect of topical antioxidants on UV-induced erythema formation when administered after exposure. Dermatology 1999;198:52-5.

7. Fuchs J. Potentials and limitations of the natural antioxidants RRR-alpha-tocopherol, L-ascorbic acid and beta-carotene in cutaneous photoprotection. Free Radic Biol Med 1998;25:848-73 [review].

Macular Degeneration
Dose: Take under medical supervision: 3 mg daily at bedtime

In a preliminary trial, supplementation with melatonin (3 mg per day at bedtime for at least three months) resulted in an improvement in the abnormalities observed on eye examination in the majority of cases.1 Melatonin is believed to work by regulating eye pigmentation (and, consequently, the amount of light reaching the retina) and by functioning as an antioxidant.

References

1. Yi C, Pan X, Yan H, et al. Effects of melatonin in age-related macular degeneration. Ann N Y Acad Sci 2005;1057:384-92.

Glaucoma
Dose: Refer to label instructions

Supplementing with 0.5 mg of melatonin lowered intraocular pressure of healthy people,1 but there have been no studies on the effects of melatonin in people with glaucoma.

References

1. Samples JR, Krause G, Lewy AJ. Effect of melatonin on intraocular pressure. Curr Eye Res 1988;7:649-53.

Irritable Bowel Syndrome
Dose: Take under medical supervision: 3 mg daily at bedtime

Melatonin plays a role in the regulation of gastrointestinal function and sensation. In a double-blind trial, people with irritable bowel syndrome and associated sleep disturbances received 3 mg of melatonin or a placebo at bedtime for two weeks. Compared with the placebo, melatonin significantly decreased the severity of abdominal pain, although it did not affect bloating, stool frequency, or sleep patterns.1 Melatonin was also effective in another double-blind trial.2

References

1. Song GH, Leng PH, Gwee KA, et al. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study. Gut 2005;54:1402-7.

2. Saha L, Malhotra S, Rana S, et al. A preliminary study of melatonin in irritable bowel syndrome. J Clin Gastroenterol 2007;41:29-32.

Hypertension
Dose: Take under medical supervision: 2 mg daily of sustained-released supplment at night

In a double-blind study, supplementation with 2 mg of sustained-release melatonin each night for four weeks significantly reduced nighttime systolic blood pressure, compared with a placebo, in people with nocturnal hypertension.1 Normally, blood pressure declines at night. People with hypertension who do not have this nighttime blood pressure decline are at increased risk of developing and dying from heart disease. Melatonin supplementation may therefore be beneficial for this subgroup of people with hypertension.

References

1. Grossman E, Laudon M, Yalcin R, et al. Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am J Med 2006;119:898-902.

Age-Related Cognitive Decline
Dose: Refer to label instructions

Melatonin is a hormone secreted by the pineal gland in the brain. It is partially responsible for regulating sleep-wake cycles. Cognitive function is linked to adequate sleep and normal sleep-wake cycles. Cognitive benefits from melatonin supplementation have been suggested by preliminary research in a variety of situations and may derive from the ability of melatonin to prevent sleep disruptions.1, 2, 3, 4 A double-blind trial of ten elderly patients with mild cognitive impairment showed that 6 mg of melatonin taken two hours before bedtime significantly improved sleep, mood, and memory, including the ability to remember previously learned items.5 However, in a double-blind case study of one healthy person, 1.6 mg of melatonin had no immediate effect on cognitive performance.6

The long-term effects of regularly taking melatonin supplements remain unknown, and many healthcare practitioners recommend that people take no more than 3 mg per evening. A doctor familiar with the use of melatonin should supervise people who wish to take it regularly.

References

1. Myers BL, Badia P. Changes in circadian rhythms and sleep quality with aging: mechanisms and interventions. Neurosci Biobehav Rev 1995;19(4):553-71. Published erratum appears in Neurosci Biobehav Rev 1996;20(2):I-IV.

2. Dollins AB, Zhdanova IV, Wurtman RJ, et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci U S A 1994;91(5):1824-8.

3. Dori D, Casale G, Solerte SB, et al. Chrono-neuroendocrinological aspects of physiological aging and senile dementia. Chronobiologia 1994;21(1-2):121-6.

4. Comperatore CA, Lieberman HR, Kirby AW, et al. Melatonin efficacy in aviation missions requiring rapid deployment and night operations. Aviat Space Environ Med 1996;67(6):520-4.

5. Jean-Louis G, von Gizycki H, Zizi F. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res 1998;25(3):177-83.

6. Slotten HA, Krekling S. Does melatonin have an effect on cognitive performance? Psychoneuro-endocrinology 1996;21(8):673-80.

Melatonin is a natural hormone that regulates the human biological clock.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC Melatonin 5000 Zipmelt™
 
4.7

(based on 15 reviews)

100%

of respondents would recommend this to a friend.

Pros

  • No side effects (10)
  • Natural-feeling results (8)
  • Good value (7)
  • Works quickly (7)
  • Produces results (3)

Cons

    Best Uses

    • Before sleep (7)
    • Daily use (4)
      • Reviewer Profile:
      • First time user (7), Regular user (5), Health conscious (3)

    Reviewed by 15 customers

    Sort by

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    5.0

    VERY EFFECTIVE

    By yj.fugo.guo

    from Troy, NY

    About Me First Time User

    See all my reviews

    Pros

    • Feel Fresh In The Morning

    Cons

      Best Uses

        Comments about GNC Melatonin 5000 Zipmelt™:

        I will take one or half before the bedtime.

         
        5.0

        Outstanding Natrual Sleeping Pill

        By vincent.qu

        from Jiangsu Prov. China

        See all my reviews

        Pros

        • Effective
        • Tastes Good

        Cons

          Best Uses

          • Daily Use
          • Older People

          Comments about GNC Melatonin 5000 Zipmelt™:

          Bought it for my mother as she suffers sleeping disorder for years. Tried almost every way to get her to sleep even with prescription sleeping pill. After trying this, she now can go to sleep very well everyday. Truly amazing!

          (1 of 1 customers found this review helpful)

           
          5.0

          Great product

          By dick4637

          from Bridgewater, VA

          About Me Regular User

          See all my reviews

          Pros

          • No Side Effects
          • Produces Results
          • Simple To Take

          Cons

            Best Uses

              Comments about GNC Melatonin 5000 Zipmelt™:

              Simple to take and gives you very deep sleep.

              (4 of 4 customers found this review helpful)

               
              5.0

              i would definitely buy the product again

              By Ladyk

              from raleigh, nc

              About Me First Time User

              See all my reviews

              Verified Buyer

              Pros

              • Acts Quickly
              • Good Taste
              • No Side Effects
              • Produces Results
              • Simple To Take

              Cons

                Best Uses

                • Daily Use

                Comments about GNC Melatonin 5000 Zipmelt™:

                zip melt works great and gets you to sleep fast and wake up feeling refresh.

                (4 of 4 customers found this review helpful)

                 
                5.0

                Best

                By lisawilliamstaylor

                from Utah

                About Me Regular User

                See all my reviews

                Pros

                • Works Quickly

                Cons

                  Best Uses

                    Comments about GNC Melatonin 5000 Zipmelt™:

                    There isn't a melatonin on the market that works better. We tried them all even in higher doses. It works quickly with no drowsiness the next morning. Amazing. If only everyone knew!

                    (2 of 2 customers found this review helpful)

                     
                    3.0

                    Great Flavor!

                    By Leanetb91

                    from Middletown, PA

                    About Me First Time User

                    See all my reviews

                    Verified Buyer

                    Pros

                    • Natural-Feeling Results

                    Cons

                      Best Uses

                      • Before Sleep

                      Comments about GNC Melatonin 5000 Zipmelt™:

                      I take my Melatonin every night before bed. The taste is actually very pleasant and the tablet dissolves quickly. I've notice a slight change in my sleeping where I wake up in the morning feeling a bit more refreshed than before the Melatonin but I can't say the results are outstanding. I'm going to continue to take this until I finish the box and will then know if the results are worth it. I'd definitely recommend trying this product.

                      (3 of 3 customers found this review helpful)

                       
                      4.0

                      Pleased with results

                      By ebaker68

                      from New Town, N.D.

                      About Me Health Conscious, Week nites for 2 weeks

                      See all my reviews

                      Verified Buyer

                      Pros

                      • Dissolves quickly
                      • I like the taste
                      • Natural-Feeling Results
                      • No Side Effects

                      Cons

                        Best Uses

                        • 1 hr before bedtime
                        • Before Sleep

                        Comments about GNC Melatonin 5000 Zipmelt™:

                        I've been working out a lot (2 adays) so many times I'm still wired at bedtime. A friend suggested this to me and it's helping me sleep better. I take it an hour before I want to be asleep. No groggy feeling in the morning. For me the results have been almost too good to be true.

                        (1 of 2 customers found this review helpful)

                         
                        5.0

                        .

                        By jonnyw02

                        from .

                        About Me First Time User

                        See all my reviews

                        Verified Buyer

                        Pros

                        • Good Value
                        • Natural-Feeling Results
                        • No Side Effects
                        • Relieves Stress
                        • Works Quickly

                        Cons

                          Best Uses

                          • Before Sleep

                          Comments about GNC Melatonin 5000 Zipmelt™:

                          .

                          (1 of 1 customers found this review helpful)

                           
                          5.0

                          Winner

                          By Ugawd

                          from RI, USA

                          See all my reviews

                          Verified Buyer

                          Pros

                          • Good Value
                          • Natural-Feeling Results
                          • No Side Effects
                          • Works Quickly

                          Cons

                            Best Uses

                              Comments about GNC Melatonin 5000 Zipmelt™:

                              Zip melts are definitely the most effective sleep aid. By zip melts, I'm referring to any of the melatonin products you dissolve in your mouth.

                              Tested this alongside 5mg GNC melatonin. Noticed nothing with the GNC pill.

                              No grogginess in the morning with a good 7 hrs rest.

                              (1 of 1 customers found this review helpful)

                               
                              5.0

                              good sleep supliment

                              By allikats33036

                              from Islamorada Florida

                              About Me Health Conscious, Regular User

                              See all my reviews

                              Verified Buyer

                              Pros

                              • Good Value
                              • Natural-Feeling Results
                              • No Side Effects
                              • Taste good

                              Cons

                              • None

                              Best Uses

                              • Before Sleep
                              • Daily Use

                              Comments about GNC Melatonin 5000 Zipmelt™:

                              this is the most effective sleep suppliment I have taken. tried many others, but this one is the best.....no bad after effects and it works well with my other medications.

                              Displaying reviews 1-10

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