Take 1 capsule two to three times daily with food or water.
|Serving Size 1 Capsule|
|Servings Per Container 60|
|Amount Per Serving||% DV|
|Total Carbohydrate||1.00 g||0%|
|Ashwagandha extract||500.00 mg||**|
|** Daily Value (DV) not established|
Other Ingredients: Plant-derived capsule, Cellulose, Magnesium Stearate
Storage Instructions: Do not use if seal is broken or missing.
Warning: not recommended for use by pregnant or nursing women.
Consult a healthcare professional before using this product. If you are pregnant or nursing.
Keep out of reach of children
Nature's Way Products, LLC Green Bay, WI 54311 USA
Boswellia has anti-inflammatory properties that have been compared to those of the NSAIDs used by many for inflammatory conditions.1 Clinical trials have found that boswellia is more effective than a placebo for relieving pain and swelling and preventing loss of function in people with osteoarthritis.2 Boswellia has also been found to be as effective as the anti-inflammatory drug valdecoxib (Bextra). In addition, while the improvements occurred more slowly in the boswellia group than in the valdecoxib group, they persisted for a longer period of time after treatment was discontinued.3 One clinical trial found that a combination of boswellia, ashwagandha, turmeric, and zinc effectively treated pain and stiffness associated with OA but did not improve joint health, according to X-rays of the affected joint.4 Unlike NSAIDs, long-term use of boswellia does not lead to irritation or ulceration of the stomach.
1. Safayhi H, Mack T, Saieraj J, et al. Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther 1992;261:1143-6.
2. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee - a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7.
3. Sontakke S, Thawani V, Pimpalkhute S, et al. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee. Indian J Pharmacol 2007;39:27-9.
4. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: A double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5.
The herbs discussed here are considered members of a controversial category known as adaptogens, which are thought to increase the body's resistance to stress, and to generally enhance physical and mental functioning.1, 2 Many animal studies have shown that various herbal adaptogens have protective effects against physically stressful experiences,3, 4 but whether these findings are relevant to human stress experiences is not always clear.
Animal studies have suggested that ashwagandha may be helpful for reducing the effects of stress,5, 6, 7 including chronic psychological stress.8 In a double-blind study of people experiencing chronic stress, supplementation with 300 mg per day of a concentrated ashwaganda extract for 60 days significantly decreased perceived stress, compared with a placebo.9
An herbal formula from the Ayurvedic medicine tradition, containing extracts of ashwagandha, asparagus, pueraria, argyreia, dioscorea, mucuna, and piper, has been studied as an aid to coping with the stress of military combat. A double-blind study found that soldiers performed similarly in a set of mental and psychological tests after an eight-day combat mission whether they were given two capsules daily (exact content not revealed) of this formula or a placebo.10 This suggests there was no real benefit of the herbal formula under these conditions.
1. Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol 1969;9:419-30 [review].
2. Panossian A, Wikman G, Wagner H. Plant adaptogens. III. Earlier and more recent aspects and concepts on their mode of action. Phytomedicine 1999;6:287-300 [review].
3. Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 1999;13:275-91 [review].
4. Wagner H, Norr H, Winterhoff H. Plant adaptogens. Phytomedicine 1994;1:63-76.
5. Bhattacharya S, Goel R, Kaur R, Ghosal S. Anti-stress activity of sitoindosides VII and VIII, new acylsterylglucosides from Withania somnifera. Phytother Res 1987;1:32-39.
6. Grandhi A, Mujumdar AM, Patwardhan B. A comparative pharmacological investigation of Ashwagandha and Ginseng. J Ethnopharmacol 1994;44:131-5.
7. Dhuley JN. Effect of ashwagandha on lipid peroxidation in stress-induced animals. J Ethnopharmacol1998;60:173-8.
8. Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav 2003;75:547-55.
9. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med 2012;34:255-62.
10. Gopinathan PM, Grover SK, Gupta AK, Srivastava KK. Effects of a composite Indian herbal preparation on combat effectiveness in low-intensity-conflict operations. Mil Med1999;164:814-9.
Ashwagandha, which belongs to the pepper family, is found in India and Africa. The roots of ashwagandha are used medicinally.
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