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GNC Women's Ultra Mega® Energy and Metabolism
90 Caplets178912
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- Description
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GNC Women's Ultra Mega® Energy and Metabolism
2X MORE D-3
Dietary Supplement
Clinically Studied Multivitamin^
Each serving supplies approximately 100 mg of caffeine- With 1,600 IU of vitamin D-3 for breast and bone health*
- Calorie burning support*
- Boosts energy and metabolism*
- Supports mental focus*
- Includes 1,600 IU of vitamin D-3. Emerging research suggests that adequate daily vitamin D intake may play a role in supporting breast and colon health.*
- Supplies B-vitamins that are essential for energy production and metabolism.*
- Provides important bone-strengthening nutrients including 500 mg of calcium, magnesium and vitamin D-3 that are essential in the development of healthy bones and teeth.* Adequate calcium and vitamin D in healthy diet throughout life may reduce the risk of osteoporosis.
- Features an energy and metabolism and support calorie burning.* The components in this blend also help support mental focus.
- Contains a premium blend of antioxidants including selenium, vitamin C and vitamin E to aid in supporting the body's immunity.*
- Combines lutein and zeaxanthin to support eye health with lycopene, an antioxidant from tomatoes to support cardiovascular health.*
Lutemax 2020™
^In a randomized, double-blind, placebo-controlled study of 112 healthy volunteers, subjects taking the GNC vitamin and mineral blend in this product for six weeks experienced statistically significant improvements in markers of B vitamin and antioxidant status, as well as improvements in SF-36 Vitality and Mental Health scores compared to those taking a placebo.
GNC QUALITY COMMITMENT
GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.
GNC GUARANTEE
Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Supplement Facts
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As a dietary supplement, take two daily with food.
Other Ingredients: Cellulose, Cellulose, Titanium Dioxide, Titanium Dioxide, Natural Vanilla Flavor, Natural Vanilla Flavor, Vegetable Acetoglycerides, Vegetable Acetoglycerides, Riboflavin, Riboflavin, Sucralose, Sucralose No Artificial Colors, No Artificial Flavors, No Wheat, No Gluten, No Dairy, Yeast Free. Storage Instructions: Store in a cool, dry place. Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.
Serving Size 2 Caplets Servings Per Container 45 Amount Per Serving % DV Vitamin A (50% as beta-Carotene; 50% as Retinyl Acetate) 5000.00 IU 100% Vitamin A (50% as beta-Carotene; 50% as Retinyl Acetate) 5000.00 IU 100% Vitamin C (as Ascorbic Acid & Calcium Ascorbate) 200.00 mg 333% Vitamin C (as Ascorbic Acid & Calcium Ascorbate) 200.00 mg 333% Vitamin D (as Cholecalciferol D-3) 1600.00 IU 400% Vitamin D (as Cholecalciferol D-3) 1600.00 IU 400% Vitamin E (as Natural d-alpha Tocopheryl Acetate) 30.00 IU 100% Vitamin E (as Natural d-alpha Tocopheryl Acetate) 30.00 IU 100% Vitamin K (as phytonadione) 80.00 mcg 100% Vitamin K (as phytonadione) 80.00 mcg 100% Thiamin (Vitamin B-1)(as Thiamin Mononitrate) 50.00 mg 3333% Thiamin (Vitamin B-1)(as Thiamin Mononitrate) 50.00 mg 3333% Riboflavin (Vitamin B2) 50.00 mg 2941% Riboflavin (Vitamin B2) 50.00 mg 2941% Niacin (as Niacinamide & Niacin) 50.00 mg 250% Niacin (as Niacinamide & Niacin) 50.00 mg 250% Vitamin B-6 (as Pyridoxine Hydrochloride) 50.00 mg 2500% Vitamin B-6 (as Pyridoxine Hydrochloride) 50.00 mg 2500% Folic Acid 400.00 mcg 100% Folic Acid 400.00 mcg 100% Vitamin B-12 (as Cyanocobalamin) 50.00 mcg 833% Vitamin B-12 (as Cyanocobalamin) 50.00 mcg 833% Biotin 300.00 mcg 100% Biotin 300.00 mcg 100% Pantothenic Acid (as Calcium d-Pantothenate) 50.00 mg 500% Pantothenic Acid (as Calcium d-Pantothenate) 50.00 mg 500% Calcium (as Calcium Carbonate) 500.00 mg 50% Calcium (as Calcium Carbonate) 500.00 mg 50% Iron (as Ferrous Fumarate) 18.00 mg 100% Iron (as Ferrous Fumarate) 18.00 mg 100% Iodine (as Potassium Iodide) 150.00 mcg 100% Iodine (as Potassium Iodide) 150.00 mcg 100% Magnesium (as Magnesium Oxide) 100.00 mg 25% Magnesium (as Magnesium Oxide) 100.00 mg 25% Zinc (as Zinc Oxide) 15.00 mg 100% Zinc (as Zinc Oxide) 15.00 mg 100% Selenium (as L-Selenomethionine) 200.00 mcg 286% Selenium (as L-Selenomethionine) 200.00 mcg 286% Copper (as Cupric Oxide) 2.00 mg 100% Copper (as Cupric Oxide) 2.00 mg 100% Manganese (as Manganese Sulfate) 2.00 mg 100% Manganese (as Manganese Sulfate) 2.00 mg 100% Chromium (as Hydrolyzed Protein Chelate) 120.00 mcg 100% Chromium (as Hydrolyzed Protein Chelate) 120.00 mcg 100% Molybdenum (as Sodium Molybdate) 75.00 mcg 100% Molybdenum (as Sodium Molybdate) 75.00 mcg 100% Energy & Metabolism Blend 119.00 mg 0% Black Pepper Extract ** Capsimax Capsicum Seed Extract ** Caffeine ** Energy & Metabolism Blend 119.00 mg 0% Black Pepper Extract ** Capsimax Capsicum Seed Extract ** Caffeine ** Green Tea Leaves Extract (Camellia sinensis) 40.00 mg 0% Green Tea Leaves Extract (Camellia sinensis) 40.00 mg 0% Alpha lipoic acid (supplying R-ALA) 25.00 mg 0% Alpha lipoic acid (supplying R-ALA) 25.00 mg 0% Choline (as Choline Bitartrate) 10.00 mg 0% Choline (as Choline Bitartrate) 10.00 mg 0% Inositol 10.00 mg 0% Inositol 10.00 mg 0% Silica (as Silicon Dioxide) 4.00 mg 0% Silica (as Silicon Dioxide) 4.00 mg 0% Boron (as Hydrolyzed Protein Chelate) 2.00 mg 0% Boron (as Hydrolyzed Protein Chelate) 2.00 mg 0% Lutemax 2020™ Lutein 950.00 mcg 0% Lutemax 2020™ Lutein 950.00 mcg 0% Lycopene 950.00 mcg 0% Lycopene 950.00 mcg 0% Zeaxanthin (as Zeaxanthin Isomers) 190.00 mcg 0% Zeaxanthin (as Zeaxanthin Isomers) 190.00 mcg 0% Astaxanthin 50.00 mcg 0% Astaxanthin 50.00 mcg 0% Vanadium (as Sodium Metavanadate) 10.00 mcg 0% Vanadium (as Sodium Metavanadate) 10.00 mcg 0% ** Daily Value (DV) not established
Accidental overdose of iron-containing products is a leading cause of fatal poisioning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.
Keep out of reach of children
Contains: Fish and Soybeans - Health Notes
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Vitamin D
Vitamin D- Reliable and relatively consistent scientific data showing a substantial health benefit.
- Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
- For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
This supplement has been used in connection with the following health conditions:
Bone SupportVitamin D's well-demonstrated bone-supporting effects include increasing calcium absorption, strengthening bones, and slowing bone loss. It also works with calcium to support the muscles and nervous system, which aids in balance.See Related Conditions (1)CloseOsteoporosisDose: 400 to 800 IU daily depending on age, sun exposure, and dietary sources Vitamin D increases calcium absorption and helps make bones stronger. Vitamin D supplementation has reduced bone loss in women who don't get enough of the vitamin from food and slowed bone loss in people with osteoporosis. It also works with calcium to prevent some musculoskeletal causes of falls and subsequent fractures.(more)Blood Sugar & Diabetes SupportResearch suggests that vitamin D may reduce the risk of developing type 1 diabetes and support blood sugar control.See Related Conditions (3)CloseType 2 DiabetesDose: 1,332 IU dailyVitamin D is needed to maintain adequate insulin levels, and supplementing with it may improve blood sugar control in people with type 2 diabetes.(more)Type 1 DiabetesDose: Consult a qualified healthcare practitionerVitamin D is needed to maintain adequate insulin levels, and supplementing with it may reduce the risk of developing type 1 diabetes.(more)Type 2 Diabetes and Diabetic NeuropathyDose: 2,000 IU of vitamin D per day for three monthsIn a preliminary trial, supplementing with vitamin D per day significantly improved pain by almost 50% in patients with diabetic neuropathy.(more)Mood Support & Brain HealthVitamin D is a hormone precursor that has been associated with improved mood and brain function, including improving depression and SAD symptoms.See Related Conditions (2)CloseDepressionDose: 400 to 800 IU dailySome studies have shown that supplementing with vitamin D leads to improved mood.(more)Seasonal Affective DisorderDose: Refer to label instructionsSupplementing with vitamin D may improve mood and well-being, especially among people with low levels of the vitamin.(more)Digestive SupportVitamin D has been found to help people who have disorders of the gastrointestinal system, protecting people with Crohn’s disease and celiac disease from the effects of malabsorption and helping to prevent bone loss.See Related Conditions (2)CloseCeliac DiseaseDose: Consult a qualified healthcare practitionerMalabsorption-induced vitamin D deficiency can lead to bone weakening in people with celiac disease. Supplementing with vitamin D may help increase bone density. (more)Crohn's DiseaseDose: 1,000 to 1,200 IU daily under medical supervision Vitamin D malabsorption is common in Crohn's and can lead to a deficiency of the vitamin. Supplementation can help prevent bone loss in cases of deficiency.(more)Pain ManagementStudies suggest that in people with vitamin D deficiency, vitamin D supplementation may relieve the discomfort of low back pain, and, in combination with calcium, reduce tension headaches and migraine headaches.See Related Conditions (3)CloseLow Back PainDose: Refer to label instructionsIn people with muscle pain associated with vitamin D deficiency, supplementing with the vitamin may improve pain. (more)Migraine HeadacheDose: Refer to label instructionsTaking large amounts of the combination of calcium and vitamin D has been reported to produce a marked reduction in the incidence of migraines in several women.(more)BurnsDose: 200 to 600 IU day in cases of extensive burnsPeople with a history of an extensive burn might benefit from vitamin D supplementation, since the skin may not be as effective at manufacturing vitamin D from sunlight.(more)Immune System SupportSome studies suggest that supplementing vitamin D may prevent symptoms of common infections, such as cold, sore throat, and the flu.See Related Conditions (3)CloseCommon Cold and Sore ThroatDose: 300 IU per day for three months in winterResearch suggests that supplementing with vitamin D may prevent upper respiratory tract infections in people who are deficient in the vitamin, but not in those who have normal vitamin D status.(more)InfluenzaDose: 800 IU per day for two years; then 2,000 IU per day after that In one study, long-term vitamin D supplementation for three years significantly reduced flu and cold symptoms. (more)Influenza and ChildrenDose: 1,200 IU per day for 15 to 17 weeks A study of Japanese children found that daily supplementation with vitamin D during the winter months significantly reduced the amount of times the children developed the flu. (more)Low Back PainDose: Refer to label instructionsIn people with muscle pain associated with vitamin D deficiency, supplementing with the vitamin may improve pain. (more)Heart & Circulatory HealthVitamin D plays a role in heart health, and has been shown to support healthy blood pressure and improve irregular heartbeat.See Related Conditions (3)CloseHypertensionDose: 800 IU dailyIn one trial, women with low blood levels of vitamin D who were given calcium supplement plus vitamin D experienced significantly reduced systolic blood pressure. (more)Congestive Heart FailureDose: Refer to label instructions(more)Cardiac ArrhythmiaDose: Refer to label instructionsOne case report described relief from a type of arrhythmia after supplementing with vitamin D. (more)Women's HealthVitamin D may offer some benefits for women, such as protection against breast cancer and against bone loss in women whose period has halted due to hormone changes.See Related Conditions (2)CloseDysmenorrheaDose: Refer to label instructionsIn a double-blind trial, women with dysmenorrhea received a placebo or a single administration of a large amount of vitamin D, which appeared to significantly diminish menstrual pain. This should only be done under doctor supervision. (more)Breast CancerDose: Refer to label instructionsVitamin D from supplements and from exposure to the sun both appear to protect against breast cancer.(more)Allergy SupportPreliminary evidence found that children receiving supplemental vitamin D in the winter may experience fewer asthma attacks.See Related Conditions (1)CloseAsthmaDose: 1,200 IU per day for 15 to 17 weeks A study of Japanese children found that daily supplementation with vitamin D during the winter months significantly reduced the amount of times the children experienced asthma attacks. (more)Kidney & Urinary Tract HealthHigher blood levels of vitamin D are associated with lower risk of urinary incontinence in women.See Related Conditions (1)CloseUrinary IncontinenceDose: Refer to label instructionsHigher blood levels of vitamin D are associated with lower risk of urinary incontinence in women. (more)Skin ProtectionResearch has found that vitamin D may benefit people with scar tissue from severe burns as they are at increased risk for deficiency. When used in combination with sun exposure, it may also stimulate pigmentation in children with vitiligo.See Related Conditions (2)CloseBurnsDose: 200 to 600 IU day in cases of extensive burnsPeople with a history of an extensive burn might benefit from vitamin D supplementation, since the skin may not be as effective at manufacturing vitamin D from sunlight.(more)VitiligoDose: Refer to label instructionsWhen used in combination with sun exposure, a form of vitamin D called calcipotriol may be effective in stimulating repigmentation in children with vitiligo.(more)Menstrual & PMS SupportUnder a doctor's supervision, vitamin D may help decrease menstrual pain in women with severe cramping. In women experiencing a loss of periods, vitamin D and calcium may be recommended to protect against further bone loss.See Related Conditions (1)CloseDysmenorrheaDose: Refer to label instructionsIn a double-blind trial, women with dysmenorrhea received a placebo or a single administration of a large amount of vitamin D, which appeared to significantly diminish menstrual pain. This should only be done under doctor supervision. (more)Prostate SupportFor men who don't get much sun exposure, vitamin D may offer some prostate cancer protection.See Related Conditions (1)CloseProstate CancerDose: 2,000 IU dailyWhere sun exposure is low, the rate of prostate cancer has been reported to be high.(more)Men's HealthFor men who don't get much sun exposure, vitamin D may offer some prostate cancer protection.See Related Conditions (0)CloseSleep SupportDepression can be a cause of sleeplessness, and some studies have shown that supplementing with vitamin D may improve depression symptoms.See Related Conditions (0)CloseChildren's HealthAccording to some research, supplementing with vitamin D may decrease the incidence of asthma attacks and flu symptoms in children.See Related Conditions (0)CloseHealthy Aging/Senior HealthHigher blood levels of vitamin D are associated with lower risk of urinary incontinence in women.See Related Conditions (0)CloseOsteoporosisDose: 400 to 800 IU daily depending on age, sun exposure, and dietary sourcesVitamin D increases calcium absorption, and blood levels of vitamin D are directly related to the strength of bones.1 Mild deficiency of vitamin D is common in the fit, active elderly population and leads to an acceleration of age-related loss of bone mass and an increased risk of fracture.2 In double-blind research, vitamin D supplementation has reduced bone loss in women who consume insufficient vitamin D from food and slowed bone loss in people with osteoporosis.3, 4 However, the effect of vitamin D supplementation on osteoporosis risk remains surprisingly unclear,5, 6 with some trials reporting little if any benefit.7 Moreover, trials reporting reduced risk of fracture have usually combined vitamin D with calcium supplementation,8 making it difficult to assess how much benefit is caused by supplementation with vitamin D alone.9
Impaired balance and increased body sway are important causes of falls in elderly people with osteoporosis.10 Vitamin D works with calcium to prevent some musculoskeletal causes of falls.11 In a double-blind trial, elderly women who were given 800 IU per day of vitamin D and 1,200 mg per day of calcium had a significantly lower rate of falls and subsequent fractures than did women given the same amount of calcium alone.12 Vitamin D in the amount of 800 IU per day effectively prevented falls in a double-blind study of elderly nursing home residents, but lower amounts were ineffective.13
Despite inconsistency in the research, many doctors recommend 400 to 800 IU per day of supplemental vitamin D, depending upon dietary intake and exposure to sunlight.
One trial studying postmenopausal women combined hormone replacement therapy with magnesium (600 mg per day), calcium (500 mg per day), vitamin C, B vitamins, vitamin D, zinc, copper, manganese, boron, and other nutrients for an eight- to nine-month period.14 In addition, participants were told to avoid processed foods, limit protein intake, emphasize vegetable over animal protein, and limit consumption of salt, sugar, alcohol, coffee, tea, chocolate, and tobacco. Bone density increased a remarkable 11%, compared to only 0.7% in women receiving hormone replacement alone.
References1. Brot C, Jorgensen N, Madsen OR, et al. Relationships between bone mineral density, serum vitamin D metabolites and calcium: phosphorus intake in healthy perimenopausal women. J Intern Med 1999;245:509-16.
2. Sahota O. Osteoporosis and the role of vitamin D and calcium-vitamin D deficiency, vitamin D insufficiency and vitamin D sufficiency. Age Ageing 2000;29:301-4.
3. Dawson-Hughes B, Dallal GE, Krall EA, et al. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med 1991;115:505-12.
4. Adams JS, Kantorovich V, Wu C, et al. Resolution of vitamin D insufficiency in osteopenic patients results in rapid recovery of bone mineral density. J Clin Endocrinol Metab 1999;84:2729-30.
5. Nordin BE, Baker MR, Horsman A, Peacock M. A prospective trial of the effect of vitamin D supplementation on metacarpal bone loss in elderly women. Am J Clin Nutr 1985;42(3):470-4.
6. Lips P, Graafmans WC, Ooms ME, et al. Vitamin D supplementation and fracture incidence in elderly persons. Ann Intern Med 1996;124:400-6.
7. Komulainen M, Tupperainen MT, Kroger H, et al. Vitamin D and HRT: no benefit additional to that of HRT alone in prevention of bone loss in early postmenopausal women. A 2.5-year randomized placebo-controlled study. Osteoporos Int 1997;7:126-32.
8. Droisy R, Collette J, Chevallier T, et al. Effects of two 1-year calcium and vitamin D3 treatments on bone remodeling markers and femoral bone density in elderly women. Curr Ther Res 1998;59:850-62.
9. Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992;327:1637-42.
10. Maki BE, Holliday PJ, Topper AK. A prospective study of postural balance and risk of falling in an ambulatory and independent elderly population. J Gerontol 1994;49:M72-84.
11. Leboff MS, Hawkes WG, Glowacki J, et al. Vitamin D-deficiency and post-fracture changes in lower extremity function and falls in women with hip fractures. Osteoporos Int 2008;19:1283-90.
12. Pfeifer M, Begerow B, Minne HW, et al. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Mineral Res 2000;15:1113-8.
13. Broe KE, Chen TC, Weinberg J, et al. A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc 2007;55:234-9.
14. Abraham GE, Grewal H. A total dietary program emphasizing magnesium instead of calcium. J Reprod Med 1990;35:503-7.
Type 2 DiabetesDose: 1,332 IU dailyVitamin D is needed to maintain adequate blood levels of insulin.1 Vitamin D receptors have been found in the pancreas where insulin is made. Some,2, 3, 4 but not all,5, 6 preliminary trials have found that supplementation can improve some measures of blood sugar control in people with type 2 diabetes. In addition, in a preliminary trial supplementation with about 2,000 IU of vitamin D per day for three months significantly improved pain by almost 50% in patients with diabetic neuropathy.7 Not enough is known about optimal amounts of vitamin D for people with diabetes, and high amounts of vitamin D can be toxic; therefore, people with diabetes considering vitamin D supplementation should talk with a doctor and have their vitamin D status assessed.References1. Labriji-Mestaghanmi H, Billaudel B, Garnier PE, Sutter BCJ. Vitamin D and pancreatic islet function. I. Time course for changes in insulin secretion and content during vitamin deprivation and repletion. J Endocrine Invest 1988;11:577-84.
2. Boucher BJ. Inadequate vitamin D status: does it contribute to the disorders comprising syndrome 'X'? Br J Nutr 1998;79:315-27 [review].
3. Borissova AM, Tankova T, Kirilov G, et al. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 2003;57:258-61.
4. Nikooyeh B, Neyestani TR, Farvid M, et al. Daily consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr 2011;93764-71.)
5. Patel P, Poretsky L, Liao E. Lack of effect of subtherapeutic vitamin D treatment on glycemic and lipid parameters in Type 2 diabetes: A pilot prospective randomized trial. J Diabetes 2010;2:36-40.
6. Jorde R, Sneve M, Torjesen P, Figenschau Y. No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med 2010;267:462-72
7. Lee P, Chen R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch Intern Med 2008;168:771-2.
Type 1 DiabetesDose: Consult a qualified healthcare practitionerVitamin D is needed to maintain adequate blood levels of insulin.1 Vitamin D receptors have been found in the pancreas where insulin is made and some, but not all preliminary evidence suggests that supplementation might reduce the risk of developing type 1 diabetes.2, 3 Vitamin D supplementation may also slow the decline of pancreatic function in people with newly diagnosed type 1 diabetes who have not yet suffered an extensive loss of pancreatic function.4 Not enough is known about optimal amounts of vitamin D for people with diabetes, and high amounts of vitamin D can be toxic. Therefore, people with diabetes considering vitamin D supplementation should talk with a doctor and have their vitamin D status assessed.References1. Labriji-Mestaghanmi H, Billaudel B, Garnier PE, Sutter BCJ. Vitamin D and pancreatic islet function. I. Time course for changes in insulin secretion and content during vitamin deprivation and repletion. J Endocrine Invest 1988;11:577-84.
2. Hypponen E, Laara E, Reunanen A, et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001;358:1500-3.
3. Simpson M, Brady H, Yin X, et al. No association of vitamin D intake or 25-hydroxyvitamin D levels in childhood with risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia 2011;54:2779-88.
4. Gabbay MAL, Sato MN, Finazzo C, et al. Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual beta-cell function in new-onset type 1 diabetes mellitus. Arch Pediatr Adolesc Med 2012;166:601-7.
Type 2 Diabetes and Diabetic NeuropathyDose: 2,000 IU of vitamin D per day for three monthsA preliminary trial supplementation with about 2,000 IU of vitamin D per day for 3 months significantly improved pain by almost 50% in patients with diabetic neuropathy.1DepressionDose: 400 to 800 IU dailyBlood levels of vitamin D (measured as 25-hydroxyvitamin D) have been found to be significantly lower in people with depression than in healthy people.1Vitamin D supplementation may be associated with elevations in mood. In a double-blind trial, healthy people were given 400-800 IU per day of vitamin D3, or no vitamin D3, for five days during late winter. Results showed that vitamin D3 significantly enhanced positive mood and there was some evidence of a reduction in negative mood compared to a placebo.2 In another double-blind trial, people without depression took 600 IU of vitamin D along with 1,000 mg of calcium, or a placebo, twice daily for four weeks.3 Compared to the placebo, combined vitamin D and calcium supplementation produced significant elevations in mood that persisted at least one week after supplementation was discontinued. In still another double-blind trial, the combination of 1,500 IU per day of vitamin D and the antidepressant drug fluoxetine was more effective than fluoxetine alone in the treatment of major depression.4
References1. Hoogendijk WJ, Lips P, Dik MG, et al. Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults. Arch Gen Psychiatry 2008;65:508-12.
2. Lansdowne ATG, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology 1998;135:319-23.
3. Arasteh K. A beneficial effect of calcium intake on mood. J Orthomolec Med 1994;9:199-204.
4. Khoraminya N, Tehrani-Doost M, Jazayeri S, et al. Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder. Aust N Z J Psychiatry 2012;Oct 23:[Epub ahead of print].
Seasonal Affective DisorderDose: Refer to label instructionsVitamin D is well known for its effects on helping to maintain normal calcium levels, but it also exerts influence on the brain, spinal cord, and hormone-producing tissues of the body that may be important in the regulation of mood.1 A double-blind study found that mood improved in healthy people without SAD who received 400 or 800 IU per day of vitamin D for five days in late winter.2
In another study, people with SAD were randomly assigned to receive either 100,000 IU of vitamin D one time only or two hours of bright-light therapy every day for one month. After one month, researchers observed a significant improvement in depression in the group that received vitamin D, but not in the group given light therapy.3 However, a one-year study of healthy postmenopausal women found that supplementation with 400 IU of vitamin D per day did not prevent the mood decline that often occurs in the winter.4 Certain differences in these studies might account for the different results: In the study in which vitamin D was beneficial, the participants suffered from SAD and their pretreatment vitamin D blood levels tended to be low. In the negative study, the participants did not have SAD, and their pretreatment vitamin D blood levels were higher. Although additional research needs to be done, the available evidence suggests that people with SAD who have marginal or deficient vitamin D levels might benefit from supplementation. This treatment should be supervised by a doctor to assure that the amount of vitamin D used is high enough to be effective, but not so high as to cause adverse effects.
References1. Stumpf WE, Privette TH. Light, vitamin D and psychiatry. Role of 1,25 dihydroxyvitamin D3 (soltriol) in etiology and therapy of seasonal affective disorder and other mental processes. *Psychopharmacology (Berl)* 1989;97:285-94 [review].
2. Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. *Psychopharmacology (Berl)* 1998;135:319-23.
3. Gloth FM III, Alam W, Hollis B. Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. *J Nutr Health Aging* 1999;3:5-7.
4. Harris S, Dawson-Hughes B. Seasonal mood changes in 250 normal women. *Psychiatry Res* 1993;49:77-87.
Celiac DiseaseDose: Consult a qualified healthcare practitionerThe malabsorption that occurs in celiac disease can lead to multiple nutritional deficiencies. The most common nutritional problems in people with celiac disease include deficiencies of essential fatty acids, iron, vitamin D, vitamin K, calcium, magnesium, and folic acid.1Zinc malabsorption also occurs frequently in celiac disease2 and may result in zinc deficiency, even in people who are otherwise in remission.3 People with newly diagnosed celiac disease should be assessed for nutritional deficiencies by a doctor. Celiac patients who have not yet completely recovered should supplement with a high-potency multivitamin-mineral. Some patients may require even higher amounts of some of these vitamins and minerals-an issue that should be discussed with their healthcare practitioner. Evidence of a nutrient deficiency in a celiac patient is a clear indication for supplementation with that nutrient.
After commencement of a gluten-free diet, overall nutritional status gradually improves. However, deficiencies of some nutrients may persist, even in people who are strictly avoiding gluten. For example, magnesium deficiency was found in 8 of 23 adults with celiac disease who had been following a gluten-free diet and were symptom-free. When these adults were supplemented with magnesium for two years, their bone mineral density increased significantly.4
Malabsorption-induced depletion of vitamin D can lead to osteomalacia (defective bone mineralization) in people with celiac disease.5 Although supplementation with vitamin D appears to increase bone density, the excess risk of bone fracture may not be entirely eliminated.
References1. Connon JJ. Celiac disease. In: Shils ME, Olson JA, Shike M, eds. Modern Nutrition in Health and Disease, 8th ed. Philadelphia: Lea & Febiger, 1994, 1062.
2. Crofton RW, Glover SC, Ewen SWB, et al. Zinc absorption in celiac disease and dermatitis herpetiformis: a test of small intestinal function. Am J Clin Nutr 1983;38:706-12.
3. Solomons NW, Rosenberg IH, Sandstead HH. Zinc nutrition in celiac sprue. Am J Clin Nutr 1976;29:371-5.
4. Rude RK, Olerich M. Magnesium deficiency: possible role in osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int 1996;6:453-61.
5. Basha B, Rao S, Han ZH, Parfitt, AM. Osteomalacia due to vitamin D depletion: neglected consequence of intestinal malabsorption. Am J Med 2000;108(4):296-300.
Crohn's DiseaseDose: 1,000 to 1,200 IU daily under medical supervisionVitamin D malabsorption is common in Crohn's1 and can lead to a deficiency of the vitamin.2 Successful treatment with vitamin D for osteomalacia (bone brittleness caused by vitamin D deficiency) triggered by Crohn's disease has been reported.3 Another study found 1,000 IU per day of vitamin D prevented bone loss in people with Crohn's, while an unsupplemented group experienced significant bone loss.4 In addition, in a double-blind trial, vitamin D supplementation (1,200 IU per day for 12 months) prevented relapses in patients with Crohn's disease in remission. The patients in that study had normal vitamin D status prior to receiving vitamin D supplementation.5 A doctor should be consulted to determine the right level of vitamin D for supplementation.
References1. Leichtmann GA, Bengoa JM, Bolt MJG, Sitrin MD. Intestinal absorption of cholecalciferol and 25-hydrocycholecalciferol in patients with both Crohn's disease and intestinal resection. Am J Clin Nutr 1991;54:548-52.
2. Harris AD, Brown R, Heatley RV, et al. Vitamin D status in Crohn's disease: association with nutrition and disease activity. Gut 1985;26:1197-203.
3. Driscoll RH, Meredith SC, Sitrin M, Rosenberg IH. Vitamin D deficiency and bone disease in patients with Crohn's disease. Gastroenterol 1982;83:1252-8.
4. Vogelsang H, Ferenci P, Resch H, et al. Prevention of bone mineral loss in patients with Crohn's disease by long-term oral vitamin D supplementation. Eur J Gastroenterol Hepatol 1995;7:609-14.
5. Jorgensen SP, Agnholt J, Glerup H, et al. Clinical trial: vitamin D3 treatment in Crohn's disease - a randomized double-blind placebo-controlled study. Aliment Pharmacol Ther 2010;32:377-83.
Low Back PainDose: Refer to label instructionsSome studies have found that vitamin D levels are lower in people with back pain than in healthy people.1, 2 In patients with muscle pain associated with vitamin D deficiency, vitamin D supplementation has resulted in improvement in the pain.3References1. Al Faraj S, Al Mutairi K. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine 2003;28:177-9.
2. Lotfi A, Abdel-Nasser AM, Hamdy A, et al. Hypovitaminosis D in female patients with chronic low back pain. Clin Rheumatol 2007;26:1895-901.
3. De Torrente de la Jara G, Pecoud A, Favrat B. Musculoskeletal pain in female asylum seekers and hypovitaminosis D3. BMJ 2004;329:156-7.
Migraine HeadacheDose: Refer to label instructionsTaking large amounts of the combination of calcium (1,000 to 2,000 mg per day) and vitamin D has been reported to produce a marked reduction in the incidence of migraines in several women.1, 2 However, the amount of vitamin D given to these women (usually 50,000 IU once a week), can cause adverse reactions, particularly when used in combination with calcium. This amount of vitamin D should be used only under medical supervision. Doctors often recommend that people take 800 to 1,200 mg of calcium and 400 IU of vitamin D per day. However, it is not known whether theses amounts would have an effect on migraines.
BurnsDose: 200 to 600 IU day in cases of extensive burnsBurns affecting a large proportion of the body may result in vitamin D deficiency1, potentially increasing the risk of osteoporosis, which is a frequent long-term consequence of severe burns.2 Vitamin D deficiency may result from the inability of previously burned skin to manufacture vitamin D after exposure to sunlight. People with a history of an extensive burn might benefit from vitamin D supplementation.
Common Cold and Sore ThroatDose: 300 IU per day for three months in winterIn a double-blind trial, supplementation with 300 IU per day of vitamin D for three months during the winter decreased the frequency of upper respiratory tract infections in Mongolian children with vitamin D deficiency.1 However, in a double-blind study of healthy adults in New Zealand, vitamin D supplementation did not reduce the incidence or severity of upper respiratory tract infections. The participants in that trial had either normal vitamin D levels or mild vitamin D deficiency (depending on which definition of vitamin D deficiency is used).2 These results suggest that vitamin D supplementation can prevent upper respiratory tract infections in people who are deficient in the vitamin, but not in those who have normal vitamin D status.References1. Camargo CA Jr, Ganmaa D, Frazier AL, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics 2012;130:e561-e567.
2. Murdoch DR, Slow S, Chambers ST, et al. Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial. JAMA 2012;308:1333-9.
InfluenzaDose: 800 IU per day for two years; then 2,000 IU per day after thatIn a double-blind study, African Americans who received vitamin D supplements for three years had significantly fewer symptoms of influenza or colds, when compared with women who received a placebo. The amount of vitamin D was 800 IU per day for the first two years, followed by 2,000 IU per day for one year.1
Influenza and ChildrenDose: 1,200 IU per day for 15 to 17 weeks In a double-blind study of Japanese children (average age, ten years), supplementation with 1,200 IU per day of vitamin D for 15 to 17 weeks during the winter significantly reduced the incidence of influenza infections by 42%, compared with a placebo.1Low Back PainDose: Refer to label instructionsSome studies have found that vitamin D levels are lower in people with back pain than in healthy people.1, 2 In patients with muscle pain associated with vitamin D deficiency, vitamin D supplementation has resulted in improvement in the pain.3References1. Al Faraj S, Al Mutairi K. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine 2003;28:177-9.
2. Lotfi A, Abdel-Nasser AM, Hamdy A, et al. Hypovitaminosis D in female patients with chronic low back pain. Clin Rheumatol 2007;26:1895-901.
3. De Torrente de la Jara G, Pecoud A, Favrat B. Musculoskeletal pain in female asylum seekers and hypovitaminosis D3. BMJ 2004;329:156-7.
HypertensionDose: 800 IU dailyIn a double-blind trial, women with low blood levels of vitamin D (measured as 25-hydroxyvitamin D3) were given a calcium supplement, plus either 800 IU of vitamin D per day or a placebo for eight weeks. Compared with the placebo, vitamin D significantly reduced systolic blood pressure by an average of 9.3%, but did not affect diastolic blood pressure.1
Congestive Heart FailureDose: Refer to label instructionsIn one study, the prevalence of vitamin D deficiency was significantly higher in patients with CHF than in patients without CHF (28% vs. 22%). In that study, heart failure patients who received vitamin D supplementation (usually 800 to 1,000 IU per day) had a 32% lower death rate, compared with heart failure patients who did not receive vitamin D supplementation.1 Placebo-controlled trials are needed to confirm these preliminary observations.Cardiac ArrhythmiaDose: Refer to label instructionsOne case of long-standing sick-sinus syndrome (another type of arrhythmia) was reported to resolve upon supplementation with 800 IU per day of vitamin D prescribed for an unrelated condition. However, it was not clear from that report whether the improvement was due to the vitamin D.1 More research is needed.
DysmenorrheaDose: Refer to label instructionsIn a double-blind trial, women with dysmenorrhea received a placebo or a single administration of a large amount of vitamin D (300,000), five days before the expected onset of the next menstrual period. During the next two menstrual periods, menstrual pain was significantly lower in the vitamin D group than in the placebo group.1 Such a large amount of vitamin D should be given only under the supervision of a doctor. Further research is needed to determine whether daily supplementation of a smaller amount (such as 800 to 2,000 IU per day) would have a similar beneficial effect.Breast CancerDose: Refer to label instructionsBreast cancer rates have been reported to be relatively high in areas of low exposure to sunlight.1 Sunlight triggers the formation of vitamin D in the skin, which can be activated in the liver and kidneys into a hormone with great activity. This activated form of vitamin D causes "cellular differentiation"-essentially the opposite of cancer.
The following evidence indicates that vitamin D might have a protective role against breast cancer:
- Synthetic vitamin D-like molecules have prevented the equivalent of breast cancer in animals.2
- Activated vitamin D appears to have antiestrogenic activity.3
- Both sunlight and dietary exposure to vitamin D have correlated with a reduced risk of breast cancer.4, 5
Activated vitamin D comes in several forms. One of them-1,25 dihydroxycholecalciferol-is an exact duplicate of the hormone made in the human body.
The following preliminary, non-clinical evidence supports the idea that activated vitamin D may be of help to some breast cancer patients:
- In combination with tamoxifen, a synthetic, activated-vitamin D-like molecule has inhibited the growth of breast cancer cells in test tube research.6
- Synthetic vitamin D-like molecules induce tumor cell death in breast cancer cells.7
- Activated vitamin D suppresses the growth of human cancer cells transplanted into animals.8
- In test tube research, activated vitamin D has increased the anticancer action of chemotherapy.9
In a preliminary trial, activated vitamin D was applied topically to the breast, once per day for six weeks, in 19 patients with breast cancer.10 Of the 14 patients who completed the trial, three showed a large reduction in tumor size, and one showed a minor improvement. Those who responded had tumors that contained receptors for activated vitamin D. However, other preliminary reports have not found that high levels of these receptors consistently correlate with a better outcome.11, 12, 13
With a doctor's prescription, compounding pharmacists can put activated vitamin D, a hormone, into a topical ointment. Due to potential toxicity, use of this hormone, even topically, requires careful monitoring by a physician. Standard vitamin D supplements are unlikely to duplicate the effects of activated vitamin D in women with breast cancer. The patients in the breast cancer trial all had locally advanced disease.
References1. Gorham ED, Garland FC, Garland CF. Sunlight and breast cancer incidence in the USSR. Int J Epidemiol 1990;19:820-4.
2. Anzano MA, Smith JM, Uskokovic, et al. 1a,25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531), a new deltanoid (vitamin D analogue) for prevention of breast cancer in the rat. Cancer Res 1994;54:1653-6.
3. Demdirpence E, Balaguer P, Trousse F, et al. Antiestrogenic effects of all-trans-retinoic acid and 1,25-dihydroxyvitamin D3 in breast cancer cells occur at the estrogen response element level but through different molecular mechanisms. Cancer Res 1994;54:1458-64.
4. John EM, Schwartz GG, Dreon DM, Koo J. Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. Cancer Epidemiol Biomarkers Prev 1999;8:399-406.
5. Robien K, Cutler GJ, Lazovich D. Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's Health Study. Cancer Causes Control 2007;18:775-82.
6. Vink-van Wijngaarden T, Pols HA, Buurman CJ, et al. Inhibition of breast cancer cell growth by combined treatment with vitamin D3 analogues and tamoxifen. Cancer Res 1994;54:5711-7.
7. James SY, Merceer E, Brady M, et al. ERB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells in vivo and in vitro. Br J Pharmacol 1998;125:953-62.
8. Eisman JA, Barkla DH, Tutton PJM. Suppression of in vitro growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3. Cancer Res 1987;47:21-5.
9. Ravid A, Rocker D, Machlenkin A, et al. 1,25-dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage. Cancer Res 1999;59:862-7.
10. Bower M, Colston KW, Stein RC, et al. Topical calcipotriol treatment in advanced breast cancer. Lancet 1991;337:701-2.
11. Colston KW, Berger U, Coombes RC. Possible role for vitamin D in controlling breast cancer cell proliferation. Lancet 1989;I:188-91.
12. Eisman JA, Suva LJ, Martin TJ. Significance of 1,25-dihydroxyvitamin D3 receptor in primary breast cancer. Cancer Res 1986;46:5406-8.
13. Freake HC, Abeyasekera G, Iwasaki J, et al. Measurement of 1,25-dihydroxyvitamin D3 receptors in breast cancer and their relationship to biochemical and clinical indices. Cancer Res 1984;44:1677-81.
AsthmaDose: 1,200 IU per day for 15 to 17 weeks In a double-blind study of Japanese children (average age, ten years), supplementation with 1,200 IU per day of vitamin D for 15 to 17 weeks during the winter significantly reduced the incidence of asthma attacks compared with a placebo.1Urinary IncontinenceDose: Refer to label instructionsVitamin D may be important for normal muscle function, including muscles that help control urinary continence.1, 2 Higher blood levels of vitamin D are associated with lower risk of urinary incontinence in women, according to one preliminary study.3 Controlled trials are needed to determine whether vitamin D supplements can help prevent or treat urinary incontinence.References1. Crescioli C, Morelli A, Adorini L, et al. Human bladder as a novel target for vitamin D receptor ligands. J Clin Endocrinol Metab 2005;90:962-72.
2. Schroder A, Colli E, Maggi M, Andersson KE. Effects of vitamin D(3) analogue in a rat model of bladder outlet obstruction. BJU Int 2006;98:637-42.
3. 3] Badalian SS, Rosenbaum PF. Vitamin D and pelvic floor disorders in women: results from the National Health and Nutrition Examination Survey. Obstet Gynecol 2010;115:795-803.
BurnsDose: 200 to 600 IU day in cases of extensive burnsBurns affecting a large proportion of the body may result in vitamin D deficiency1, potentially increasing the risk of osteoporosis, which is a frequent long-term consequence of severe burns.2 Vitamin D deficiency may result from the inability of previously burned skin to manufacture vitamin D after exposure to sunlight. People with a history of an extensive burn might benefit from vitamin D supplementation.
VitiligoDose: Refer to label instructionsWhen used topically in combination with sun exposure, a pharmaceutical form of vitamin D, called calcipotriol, may be effective in stimulating repigmentation in children with vitiligo. In a preliminary study, children applied a cream containing calcipotriol daily and exposed themselves to sunlight for 10-15 minutes the following morning.1 After 11 months, marked to complete repigmentation occurred in 55% of the children, moderate repigmentation occurred in 22%, and little or no improvement was seen in 22%. None of the children developed new areas of vitiligo. The first evidence of repigmentation occurred within 6 to 12 weeks in the majority of the children. All participants tolerated the cream well, with approximately 17% complaining of mild, transient skin irritation. Calcipotriol is a prescription medication to be used only under the supervision of a doctor. It is not known whether vitamin D as a dietary supplement has any effect on vitiligo.
DysmenorrheaDose: Refer to label instructionsIn a double-blind trial, women with dysmenorrhea received a placebo or a single administration of a large amount of vitamin D (300,000), five days before the expected onset of the next menstrual period. During the next two menstrual periods, menstrual pain was significantly lower in the vitamin D group than in the placebo group.1 Such a large amount of vitamin D should be given only under the supervision of a doctor. Further research is needed to determine whether daily supplementation of a smaller amount (such as 800 to 2,000 IU per day) would have a similar beneficial effect.Prostate CancerDose: 2,000 IU dailyWhere sun exposure is low, the rate of prostate cancer has been reported to be high.1, 2 In the body, vitamin D is changed into a hormone with great activity. This activated vitamin D causes "cellular differentiation"-essentially the opposite of cancer.The fat-soluble vitamin D's most important role is maintaining blood levels of calcium, which it accomplishes by increasing absorption of calcium from food and reducing urinary calcium loss. Both effects keep calcium in the body and therefore spare the calcium that is stored in bones. When necessary, vitamin D transfers calcium from the bone into the bloodstream, which does not benefit bones. Although the overall effect of vitamin D on the bones is complicated, some vitamin D is necessary for healthy bones and teeth.
When "D" is used without a subscript it refers to either D2 or D3, the two primary forms used as supplements.
Copyright 2013 Aisle7. All rights reserved. Aisle7.com
The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2014.
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Comments about GNC Women's Ultra Mega® Energy and Metabolism:
I love this product after my son was born four years ago I haven't had energy and my metabolisim slowed down. I am barely 30 years old this shouldn't be happening now is what has crossed my mind. I have tried everything except for diet pills and I decided to give this a try. I will never ever purchase anything else again, worth the price, worth my time and such amazing results. I have energy enough to keep up with my kids, go to school and do my daily tasks. I feel like myself again and I have lost 10lbs in the last two weeks of using this product. I highly reccomend this product. It is worth it's weight in gold. Only down side is the smell but it's a small price to pay for such a wonderful product.
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- Bad smell
- Not Effective
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Comments about GNC Women's Ultra Mega® Energy and Metabolism:
This product MAY have been useful to someone who is not so sensitive to caffeine but for someone who is, don't use it. I used this product for 2 days and I literally almost passed out both days after taking them. I guess a good thing is they work instantly. But definitely not for me.
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Comments about GNC Women's Ultra Mega® Energy and Metabolism:
Wasn't impressed with effectiveness
- My Beauty Routine Takes:
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Pros
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- Women
Comments about GNC Women's Ultra Mega® Energy and Metabolism:
i AM A POST MENOPAUSAL DIABETIC WOMAN & THESE MULTIVITAMINS ARE GREAT FOR ME
- My Beauty Routine Takes:
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Pros
- Easy To Use
- Effective
Cons
- Large pills
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- Daily Use
- Skin Condition
Comments about GNC Women's Ultra Mega® Energy and Metabolism:
I initially took these vitamins because I am diabetic and I have a horrible diet. I use them about 30 minutes to an hour after I take my chitosan / glucomannan fiber pills. During that 30 minutes I prepare breakfast. After I eat I take the vitamins and my diabetic medication.
Thus far, I have noticed an increase in my energy and as an added bonus I have noticed my skin has somewhat evened out in color and texture. Which was an added and unexpected bonus! I have a somewhat black blush on my cheeks which is caused by the insulin problems involved with diabetes. The blush is not gone but it is noticeably lowered.
The only downside is that it contains 100mg of caffeine. So you have to be careful if you also want to take something like OxyElite Pro. Because that has 100mg of caffeine also. I was a jittery basket case when I took the two together by mistake. Not doing that again.- My Beauty Routine Takes:
- 10 Minutes
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Comments about GNC Women's Ultra Mega® Energy and Metabolism:
I have been using these vitamins for over a year now. I really like them. I don't feel any energy from them but they are a great way to get what my body needs! I used to have really low iron count and was considered anemic but now all my levels are good!
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Comments about GNC Women's Ultra Mega® Energy and Metabolism:
I was shopping for green coffee and this product was suggested to me as an additional supplement to compliment the benefits of the green coffee. I work out and eat a heatlhy diet. I have noticed an increase in energy and plan to continue using this product. Thanks to the GNC employee who recommended this to me!!
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Pros
- Easy To Use
Cons
- Constipation
- Titanium Dioxide
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Comments about GNC Women's Ultra Mega® Energy and Metabolism:
Thrilled to find this on sale, I ordered a few bottles. I went from having regularity in the bathroom to having stomach cramps/pains and constipation to the point that the scale went up by 3-4 pounds.
I thought I would increase my water intake from a gallon a day to even more, and that didn't help. I started taking ground psyllium husk powder twice a day thinking more fiber (low carb diet) would help. I thought I would give it a month to let my body adjust but nope - still problems. Literally NOTHING else has changed in my routine but this vitamin.
The iron is the same type that was in the previous vitamin I was taking without issue so I don't think that is the problem. Besides that, there is titanium dioxide in these vitamins; um... I don't care how white/what color my vitamins are. What purpose does it serve? What's the benefit? I've read that people are being advised to stop using sunscreen with that as the active ingredient so I surely don't want to EAT it.
I noticed no difference in my energy, either. The pills are large but that doesn't bother me at all - there is a lot of stuff in there! The smell is not great but I'm not trying to sniff them so that did't bother me, either. I am really bummed about my experience with these vitamins. Guess I'll go back to my old ones!- My Beauty Routine Takes:
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Comments about GNC Women's Ultra Mega® Energy and Metabolism:
it tells you to take 2 a day but dont take them together, you may feel to hyper at first. but overall I have enough engery for the whole day.
Pros
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Cons
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- Love Gnc Vitamins
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Comments about GNC Women's Ultra Mega® Energy and Metabolism:
We have been taking GNC multi vitamins for 10 years now and we did try a different brand 2x's in that 10 year time frame but found only the GNC brand to be the most effective in how we feel.
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