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GNC Triflex™

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120 Caplets

Item #281322 See Product Details

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Description
Maximum strength now with hyaluronic acid.

Promotes joint mobility & fexibility.
  • Glucosamine
  • Chondroitin
  • MSM

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take three tablets daily, preferably with meals.

Serving Size 3 Caplets
Servings Per Container 40
Amount Per Serving % DV
Sodium 130.00 mg 5%
Vitamin C (as Ascorbic Acid) 30.00 mg 50%
Glucosamine HCl 1500.00 mg **
Chondroitin Sulfate Sodium 1200.00 mg **
MSM (as Methylsulfonyl-methane) 900.00 mg **
Hyaluronic Acid (as Sodium Hyaluronate) 5.00 mg **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Titanium Dioxide (Natural Mineral Whitener), Vegetable Acetoglycerides

No Sugar, No Starch, No Artificial Color, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Corn, No Soy, No Dairy, Yeast Free

Storage Instructions: Store in a cool dry place.

Warning: Contains: Crustaceans (shrimp)

Distributed by: General Nutrition Corporation Pittsburgh, PA 15222

Health Notes

Joint Health

Joint Health
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

Osteoarthritis
Dose: 800 to 1,200 mg a day
Many trials have shown that supplementing with chondroitin sulfate reduces pain, increases joint mobility, and promotes healing within the joints.(more)
Osteoarthritis
Dose: 2.25 to 6.0 grams per day
In one trial, supplementing with methyl-sulfonylmethane significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee. (more)
Osteoarthritis
Dose: Refer to label instructions
Studies have shown glucosamine hydrochloride to be effective at reducing pain and improving symptoms in people with osteoarthritis.(more)
Osteoarthritis
Dose: 800 to 1,200 mg a day

Chondroitin sulfate (CS) is a major component of the lining of joints. The structure of CS includes molecules related to glucosamine sulfate. CS levels have been reported to be reduced in joint cartilage affected by osteoarthritis. Possibly as a result, CS supplementation may help restore joint function in people with osteoarthritis.1 On the basis of preliminary evidence, researchers had believed that oral CS was not absorbed in humans;2 as a result, early double-blind CS research was done mostly by giving injections.3, 4 This research documented clinical benefits from CS injections. It now appears, however, that a significant amount of CS is absorbable in humans,5 though dissolving CS in water leads to better absorption than swallowing whole pills.6

Strong clinical evidence now supports the use of oral CS supplements for osteoarthritis. Many double-blind trials have shown that CS supplementation consistently reduces pain, increases joint mobility, and/or shows evidence (including X-ray changes) of healing within joints of people with osteoarthritis.7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 Most trials have used 400 mg of CS taken two to three times per day. One trial found that taking the full daily amount (1,200 mg) at one time was as effective as taking 400 mg three times per day.18 Reduction in symptoms typically occurs within several months.

References

1. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

2. Baici A, Horler D, Moser B, et al. Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate. Rheumatol Int 1992;12:81-8.

3. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

4. Rovetta G. Galactosaminoglycuronoglycan sulfate (Matrix) in therapy of tibiofibular osteoarhtirits of the knee. Drugs Exp Clin Res 1991;17:53-7.

5. Conte A, Volpi N, Palmieri L, et al. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneimittelforschung 1995;45:918-25.

6. Ronca F, Palmieri L, Panicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 1998;6(Supplement A):14-21.

7. Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(Suppl A):39-46.

8. Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage 1998;6(Suppl A):37-8.

9. Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 1998;6(Suppl A):31-6.

10. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

11. Pipitone V, Ambanelli U, Cervini C, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Curr Ther Res 1992;52:608-38.

12. Bazieres B, Loyau G, Menkes CJ, et al. Le chondroitine sulfate dans le traitement de la gonarthrose et de la coxarthrose. Rev Rhum Mal Osteoartic 1992;59:466-72 [in French].

13. Conrozier T, Vignon E. Die Wirkung von Chondroitinsulfat bei der Behandlung der Huft Gelenksarthrose. Eine Doppelblindstudie gegen Placebo. Litera Rheumatologica 1992;14:69-75 [in German].

14. L'Hirondel JL. Klinische Doppelblind-Studie mit oral verabreichtem Chondroitinsulfat gegen Placebo bei der tibiofermoralen Gonarthrose (125 Patienten). Litera Rheumatologica 1992;14:77-82 [in German].

15. Morreale P, Manopulo R, Galati M, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-91.

16. Leeb BF, Petera P, Neumann K. Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints. Wien Med Wochenschr 1996;146:609-14.

17. Wildi LM, Raynauld JP, Martel-Pelletier J, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis 2011;70:982-9.

18. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

Osteoarthritis
Dose: 2.25 to 6.0 grams per dayAccording to a small double-blind trial, 2,250 mg per day of oral methylsulfonylmethane (MSM), a variant of DMSO, reduced osteoarthritis pain after six weeks.1 In another double-blind trial, supplementation with 3 grams of MSM twice a day for 12 weeks significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee.2
References

1. Lawrence RM. Methylsulfonylmethane (MSM): a double-blind study of its use in degenerative arthritis. Int J of Anti-Aging Med 1998;1:50.

2. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94.

Osteoarthritis
Dose: Refer to label instructionsA few trials have evaluated glucosamine hydrochloride (GH), another form of glucosamine sulfate (GS), as a single remedy for osteoarthritis. One trial found only minor benefits from 1,500 mg per day of GH for 8 weeks in people with osteoarthritis of the knee.1 However, these people were also taking up to 4,000 mg per day of acetaminophen for pain relief, and that treatment might have masked a beneficial effect of GH. In another study, supplementing with GH (2,000 mg each morning for 12 weeks) significantly improved symptoms, compared with a placebo, in people with knee pain due to cartilage damage or osteoarthritis.2 In a four-week study from China, GH was as effective as GS in people with osteoarthritis of the knee.3 Another study found that the combination of GH and chondroitin sulfate was more effective than a placebo in people with moderate to severe knee pain from osteoarthritis, but not in those with mild pain.4 Despite the reported beneficial effects of GH, some investigators believe that the sulfate component of GS itself helps relieve osteoarthritis, and that GS would therefore be more effective than GH.5
References

1. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.

2. Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med 2003;37:45-9.

3. Qiu GX, Weng XS, Zhang K, et al. A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulfate in the treatment of knee osteoarthritis. Zhonghua Yi Xue Za Zhi 2005;85:3067-70 [in Chinese].

4. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;795-808.

5. Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC Triflex™
 
4.5

(based on 20 reviews)

100%

of respondents would recommend this to a friend.

Pros

  • Effective (19)
  • Easy to use (12)
  • Good value (9)

Cons

    Best Uses

    • Daily use (18)
    • Men (10)
    • Women (9)
      • Reviewer Profile:
      • Brand buyer (10), Budget shopper (9)
      • My Beauty Routine Takes:
      • 30 minutes (8), 10 minutes (7)

    Reviewed by 20 customers

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    5.0

    Effective

    By 10150484

    from Chengdu China

    About Me Brand Buyer

    See all my reviews

    Pros

    • Effective

    Cons

      Best Uses

      • Daily Use
      • Men
      • Women

      Comments about GNC Triflex™:

      It's good for my parents.

      • My Beauty Routine Takes:
      • 30 Minutes
       
      5.0

      Mom loves it!

      By lemon_zhang

      from Shanghai, China

      About Me Brand Buyer

      Pros

      • Easy To Use
      • Effective
      • Good Value

      Cons

        Best Uses

        • Daily Use
        • Women

        Comments about GNC Triflex™:

        my Mom suffers a lot from joint pain and this product do help release the pain. hope Mom can get much better!

        • My Beauty Routine Takes:
        • 30 Minutes
         
        5.0

        Great!

        By xialeitc

        from DE

        About Me Brand Buyer

        See all my reviews

        Pros

        • Easy To Use
        • Effective
        • Good Value

        Cons

        • Complicated To Use

        Best Uses

        • Daily Use

        Comments about GNC Triflex™:

        I take twice one day.I feel it effective to my aid .I feel better after one month.I will continue using it.

        • My Beauty Routine Takes:
        • 1+ Hour
         
        5.0

        excellent,usefull

        By zazazaliwei

        from SEATTLE,WA

        About Me Brand Buyer

        See all my reviews

        Pros

        • Easy To Use
        • Effective
        • Good Value

        Cons

          Best Uses

          • Daily Use

          Comments about GNC Triflex™:

          My knee was hurt by sport,but i use this,have effective use.

          • My Beauty Routine Takes:
          • 1+ Hour

          (3 of 3 customers found this review helpful)

           
          5.0

          Lessens My Hip Pain

          By swellman

          from Hallsville, TX

          About Me Brand Buyer

          See all my reviews

          Pros

          • Effective
          • Works quickly

          Cons

            Best Uses

            • Daily Use
            • Women

            Comments about GNC Triflex™:

            I ran out about a week after stopping my prescription pain meds.... hip and leg pain steadily worsened, so bought some more last night.... just 2 hours after taking first 2-pill dose, my joint pain lessened dramatically! The popping in my hip lessened too and I slept better through the night... took 2nd dose this morning and after 2 hours can already feel the difference. Unbelievable - won't go without this again.

            • My Beauty Routine Takes:
            • 30 Minutes

            (1 of 1 customers found this review helpful)

             
            5.0

            Works great!

            By cjrichards6

            from Woodbridge, VA

            About Me Brand Buyer

            See all my reviews

            Pros

            • Easy To Use
            • Effective
            • Good Value

            Cons

              Best Uses

              • Daily Use
              • Men

              Comments about GNC Triflex™:

              Used the product for about a month and so far it is working great. I have weak knees and ankles and this appears to help with my joints. I do Insanity so lots of jumping around and my joints don't feel it at all.

              • My Beauty Routine Takes:
              • 30 Minutes
               
              4.0

              Great for basketball

              By VVSKING

              from Anaheim,CA

              About Me Brand Buyer

              See all my reviews

              Pros

              • Cushioning Joints
              • Easy On Knees
              • Easy To Use
              • Effective

              Cons

              • Price

              Best Uses

              • Basketball
              • Daily Use
              • Men

              Comments about GNC Triflex™:

              I play basketball at a highly competitive level 3-4 times a week for 2+ hours at a time. These dramatically help my joints and knees as far as being able to go up and down stairs the next day, and handle the hard load from basketball. Love them, just a bit pricey. Wait for a huge sale and stock up.

              • My Beauty Routine Takes:
              • 30 Minutes
               
              4.0

              working well so far

              By timc491

              from Allentown PA

              About Me Budget Buyer

              See all my reviews

              Verified Buyer

              Pros

              • Easy To Use
              • Effective
              • Good Value

              Cons

                Best Uses

                • Daily Use
                • Men
                • On-the-go
                • Weekly Use
                • Women

                Comments about GNC Triflex™:

                its easy to use and take it once in the morning and dont have to worry about it the rest of the day and feel good using it since i started it about a month ago.

                • My Beauty Routine Takes:
                • 10 Minutes

                (1 of 1 customers found this review helpful)

                 
                4.0

                Relief for joint pain!

                By zimmwe

                from Lansing, MI

                About Me Budget Buyer

                See all my reviews

                Verified Buyer

                Pros

                • Easy To Use
                • Effective

                Cons

                  Best Uses

                  • Daily Use

                  Comments about GNC Triflex™:

                  I'm a physical therapist with painful carpometacarpal joints from all the manual therapy I've done over the years. Triflex has decreased my joint pain, making it less painful to do things like using tweezers, opening mascara tubes, fastening buttons and opening jars. I don't recommend anything to my patients that I haven't used and liked, or had other patients recommend. I will be keeping Triflex as part of my daily supplement regimen.

                  • My Beauty Routine Takes:
                  • 30 Minutes

                  (1 of 1 customers found this review helpful)

                   
                  4.0

                  Give it a try

                  By frank.magdits

                  from Parsippany, NJ

                  About Me Brand Buyer

                  See all my reviews

                  Verified Buyer

                  Pros

                  • Effective

                  Cons

                    Best Uses

                    • Daily Use
                    • Men

                    Comments about GNC Triflex™:

                    I purhased this product to ensure my joints are receiving the optimal nutritional supplement. I lead an acive lifestyle that my knees can attest. Triflex seems to work, lessening stiffness and after workout soreness.

                    • My Beauty Routine Takes:
                    • 30 Minutes

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