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GNC Triflex™

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240 Caplets

Item #281332 See Product Details

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Description
Maximum strength now with hyaluronic acid.

Promotes joint mobility & flexibility.
  • Glucosamine
  • Chondroitin
  • MSM

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

As a dietary supplement, take three caplets daily, preferably with meals.

Serving Size 3 Caplets
Servings Per Container 80
Amount Per Serving % DV
Sodium 130.00 mg 5%
Vitamin C (as Ascorbic Acid) 30.00 mg 50%
Glucosamine HCl 1500.00 mg **
Chondroitin Sulfate Sodium 1200.00 mg **
MSM (as Methylsulfonyl-methane) 900.00 mg **
Hyaluronic Acid (as Sodium Hyaluronate) 5.00 mg **
** Daily Value (DV) not established

Other Ingredients: Cellulose, Titanium Dioxide (Natural Mineral Whitener), Vegetable Acetoglycerides

No Sugar, No Starch, No Artificial Color, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Corn, No Soy, No Dairy, Yeast Free

Storage Instructions: Store in a cool dry place.

Warning: Contains: Crustaceans (shrimp)

Distributed by: General Nutrition Corporation Pittsburgh, PA 15222

Health Notes

Joint Health

Joint Health
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

Osteoarthritis
Dose: 800 to 1,200 mg a day
Many trials have shown that supplementing with chondroitin sulfate reduces pain, increases joint mobility, and promotes healing within the joints.(more)
Osteoarthritis
Dose: 2.25 to 6.0 grams per day
In one trial, supplementing with methyl-sulfonylmethane significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee. (more)
Osteoarthritis
Dose: Refer to label instructions
Studies have shown glucosamine hydrochloride to be effective at reducing pain and improving symptoms in people with osteoarthritis.(more)
Osteoarthritis
Dose: 800 to 1,200 mg a day

Chondroitin sulfate (CS) is a major component of the lining of joints. The structure of CS includes molecules related to glucosamine sulfate. CS levels have been reported to be reduced in joint cartilage affected by osteoarthritis. Possibly as a result, CS supplementation may help restore joint function in people with osteoarthritis.1 On the basis of preliminary evidence, researchers had believed that oral CS was not absorbed in humans;2 as a result, early double-blind CS research was done mostly by giving injections.3, 4 This research documented clinical benefits from CS injections. It now appears, however, that a significant amount of CS is absorbable in humans,5 though dissolving CS in water leads to better absorption than swallowing whole pills.6

Strong clinical evidence now supports the use of oral CS supplements for osteoarthritis. Many double-blind trials have shown that CS supplementation consistently reduces pain, increases joint mobility, and/or shows evidence (including X-ray changes) of healing within joints of people with osteoarthritis.7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 Most trials have used 400 mg of CS taken two to three times per day. One trial found that taking the full daily amount (1,200 mg) at one time was as effective as taking 400 mg three times per day.18 Reduction in symptoms typically occurs within several months.

References

1. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

2. Baici A, Horler D, Moser B, et al. Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate. Rheumatol Int 1992;12:81-8.

3. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.

4. Rovetta G. Galactosaminoglycuronoglycan sulfate (Matrix) in therapy of tibiofibular osteoarhtirits of the knee. Drugs Exp Clin Res 1991;17:53-7.

5. Conte A, Volpi N, Palmieri L, et al. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneimittelforschung 1995;45:918-25.

6. Ronca F, Palmieri L, Panicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 1998;6(Supplement A):14-21.

7. Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(Suppl A):39-46.

8. Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage 1998;6(Suppl A):37-8.

9. Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 1998;6(Suppl A):31-6.

10. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

11. Pipitone V, Ambanelli U, Cervini C, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Curr Ther Res 1992;52:608-38.

12. Bazieres B, Loyau G, Menkes CJ, et al. Le chondroitine sulfate dans le traitement de la gonarthrose et de la coxarthrose. Rev Rhum Mal Osteoartic 1992;59:466-72 [in French].

13. Conrozier T, Vignon E. Die Wirkung von Chondroitinsulfat bei der Behandlung der Huft Gelenksarthrose. Eine Doppelblindstudie gegen Placebo. Litera Rheumatologica 1992;14:69-75 [in German].

14. L'Hirondel JL. Klinische Doppelblind-Studie mit oral verabreichtem Chondroitinsulfat gegen Placebo bei der tibiofermoralen Gonarthrose (125 Patienten). Litera Rheumatologica 1992;14:77-82 [in German].

15. Morreale P, Manopulo R, Galati M, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-91.

16. Leeb BF, Petera P, Neumann K. Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints. Wien Med Wochenschr 1996;146:609-14.

17. Wildi LM, Raynauld JP, Martel-Pelletier J, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis 2011;70:982-9.

18. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

Osteoarthritis
Dose: 2.25 to 6.0 grams per dayAccording to a small double-blind trial, 2,250 mg per day of oral methylsulfonylmethane (MSM), a variant of DMSO, reduced osteoarthritis pain after six weeks.1 In another double-blind trial, supplementation with 3 grams of MSM twice a day for 12 weeks significantly reduced pain and improved overall physical functioning in patients with osteoarthritis of the knee.2
References

1. Lawrence RM. Methylsulfonylmethane (MSM): a double-blind study of its use in degenerative arthritis. Int J of Anti-Aging Med 1998;1:50.

2. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94.

Osteoarthritis
Dose: Refer to label instructionsA few trials have evaluated glucosamine hydrochloride (GH), another form of glucosamine sulfate (GS), as a single remedy for osteoarthritis. One trial found only minor benefits from 1,500 mg per day of GH for 8 weeks in people with osteoarthritis of the knee.1 However, these people were also taking up to 4,000 mg per day of acetaminophen for pain relief, and that treatment might have masked a beneficial effect of GH. In another study, supplementing with GH (2,000 mg each morning for 12 weeks) significantly improved symptoms, compared with a placebo, in people with knee pain due to cartilage damage or osteoarthritis.2 In a four-week study from China, GH was as effective as GS in people with osteoarthritis of the knee.3 Another study found that the combination of GH and chondroitin sulfate was more effective than a placebo in people with moderate to severe knee pain from osteoarthritis, but not in those with mild pain.4 Despite the reported beneficial effects of GH, some investigators believe that the sulfate component of GS itself helps relieve osteoarthritis, and that GS would therefore be more effective than GH.5
References

1. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.

2. Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med 2003;37:45-9.

3. Qiu GX, Weng XS, Zhang K, et al. A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulfate in the treatment of knee osteoarthritis. Zhonghua Yi Xue Za Zhi 2005;85:3067-70 [in Chinese].

4. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;795-808.

5. Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.

Copyright 2014 Aisle7. All rights reserved. Aisle7.com

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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Ratings and Reviews

REVIEW SNAPSHOT®

by PowerReviews
GNC Triflex™
 
4.5

(based on 86 reviews)

98%

of respondents would recommend this to a friend.

Pros

  • Effective (72)
  • Easy to use (51)
  • Good value (46)
  • Lightweight (12)
  • Smells great (9)

Cons

  • Complicated to use (3)

Best Uses

  • Daily use (72)
  • Women (27)
  • Men (24)
  • On-the-go (5)
    • Reviewer Profile:
    • Budget shopper (38), Brand buyer (34)
    • My Beauty Routine Takes:
    • 10 minutes (28), 30 minutes (11), 1+ hour (6)

Reviewed by 86 customers

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5.0

Good item!

By cfykitty

from Middletown, CT

About Me Health Conscious

See all my reviews

Pros

  • Effective
  • No Side Effects

Cons

    Best Uses

    • Daily Use

    Comments about GNC Triflex™:

    My family really like it and we've been taking this for almost a year!

     
    4.0

    Very good product!

    By dimarjones

    from Washington

    About Me Health Conscious

    See all my reviews

    Pros

    • Effective

    Cons

    • A little expensive

    Best Uses

    • Daily Use
    • Good Supplement

    Comments about GNC Triflex™:

    This works well for joint pain, especially knee pain.

    (0 of 1 customers found this review helpful)

     
    5.0

    I would buy this product again and again

    By 5615445

    from Portland, OR

    About Me Cost-effective Than Other, Medical Professional

    See all my reviews

    Pros

    • Effective
    • Good Value
    • No Side Effects
    • Very Good

    Cons

    • No

    Best Uses

    • Daily Use
    • Recovery

    Comments about GNC Triflex™:

    The effect is significant, if the dose and then a small point even more perfect

    (4 of 5 customers found this review helpful)

     
    5.0

    Easy to swallow

    By katesnave

    from Hawkins, Texas

    About Me First Time User

    See all my reviews

    Pros

    • Easy on Stomach
    • Easy To Swallow
    • Effective
    • Simple To Take

    Cons

      Best Uses

      • Daily Use

      Comments about GNC Triflex™:

      About 3 weeks ago I started using the TriFlex and honestly did n't expect any better results than other things I had taken. Much to my surprise after about a week I noticed my knees and ankles no longer hurt, the pain in my shoulder is going away and there is even less discomfort in my lower back. Than you, thank you thank you.

      (5 of 6 customers found this review helpful)

       
      5.0

      I tried everything triflex is the best

      By fredcolony

      from Wellsburg, NY

      About Me Budget Buyer

      See all my reviews

      Pros

      • Easy To Use
      • Effective
      • Good Value

      Cons

        Best Uses

        • Daily Use

        Comments about GNC Triflex™:

        My knees were always hurting. I tried everything on the market and nothing helped Then I tried Triflex and all my pain went away in about a week I take it everyday Well worth it.

        (1 of 2 customers found this review helpful)

         
        5.0

        I would buy this product again and again

        By kaludiny

        from NJ

        See all my reviews

        Comments about GNC Triflex™:

        I would buy this product again and again!!

        (2 of 4 customers found this review helpful)

         
        3.0

        I would buy this product again and again

        By pngpauline

        from Pacifica, CA

        About Me Budget Buyer

        See all my reviews

        Pros

        • Effective
        • Good Value

        Cons

          Best Uses

          • Daily Use

          Comments about GNC Triflex™:

          Been eating these for a year and it helped my daily activities and in my sports.

          (4 of 4 customers found this review helpful)

           
          4.0

          Never let my supply run out!

          By katya1270

          from Istanbul, Turkey

          About Me Brand Buyer

          See all my reviews

          Pros

          • Effective

          Cons

            Best Uses

            • Daily Use

            Comments about GNC Triflex™:

            My orthopedist recommended this product to me a few years ago for my knees - originally for a (slightly) torn miniscus and more recently degenerative tissue disease. My knees have gotten so bad that a 15-minute walk one day impaired me for the following 2 days and I was very limited in movement, even doing steps. Not to mention the hassle of wearing a knee brace, sometimes on both knees simultaneously! However, in the periods when I have faithfully taken Triflex (at least twice a day) it seems that my knees are more stable, less painful, and I can confidently do more. In fact, in my most recent MRI, the torn miniscus wasn't even seen (definitely a miracle of God, but perhaps the Triflex helped too). I do not let my supply run out! One con is that the pill itself is large and not the easiest to swallow, but it's worth the reward!

            (1 of 2 customers found this review helpful)

             
            5.0

            good

            By yejinyejin7

            from NH

            About Me Brand Buyer

            See all my reviews

            Pros

            • Easy To Use
            • Effective

            Cons

            • Price Change Too Fast

            Best Uses

            • Daily Use

            Comments about GNC Triflex™:

            the price change too fast.WHY??

            • My Beauty Routine Takes:
            • 10 Minutes

            (2 of 2 customers found this review helpful)

             
            5.0

            a good deal

            By 531697957

            from San Diego

            About Me Budget Buyer

            See all my reviews

            Pros

            • Effective
            • Good Value

            Cons

              Best Uses

              • Daily Use

              Comments about GNC Triflex™:

              it is really a good deal and I bought for my parents.

              • My Beauty Routine Takes:
              • 10 Minutes

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