SAM-e 200 | GNC
Note: This product cannot be sold in Canada


Product Information


Natural SAM-e 200 Promotes: Joint Strength*, Liver Detoxification*, Mood and Brain Function*
Jarrow Formulas® SAM-e 200 provides a full 200mg SAM-e (net yield) from 400 mg of SAM-e tosylate disulfate. SAM-e 200 is manufactured under low temperate and low humidity and is enteric-coated to ensure a biologically active product.
Contains More of Active S,S Form
Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). Same-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas® SAM-e is made naturaly by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.
SAM-e has been clinically shown to have the following benefits:
Joint Strength
SAM-e supports the production of healthy connective tissue through transulfaration.* In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAM-e metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.*
Brain Metabolism
SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine, and phosphatidylcholine (a component of lecithin).
SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function, including phase II detoxification.*
For best results, use with Jarrow Formulas® JarroSil®, the biologically Activated Silicon®.

Label (click image to enlarge)


Take 1 tablet 1 or 2 times per day on an empty stomach or as directed by your qualified healthcare professional.


Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use., Keep out of reach of children.
, Do not use if seal is broken or missing.

Other Ingredients

Cellulose, Mannitol, Glyceryl Behenate, Magnesium Stearate (vegetable source) , silicon dioxide, sodium starch glycolate , Enteric Coating


Store in a cool, dry place.
Jarrow Formulas
Los Angeles, CA 90035-4317

Nutrition Facts

Serving Size  1 Tablet(s)
Servings Per Container  60

Amount Per Serving     % DV

S-adenosylmethionine (SAM-e)  200 mg   **

** Daily Value (DV) not established.


4.3 / 5.0
3 Reviews
5 Stars
4 Stars
3 Stars
2 Stars
1 Star
A mood booster
I noticed a sudden change in mood, a boost and slight release from my anxiety
September 5, 2017
11 months ago
Sam-e 200
This product is amazing! It really helps and gives me a boost. On a day I do not take it I can definitely feel the difference.
April 20, 2013
Love SAM-e
I use it daily. It is a great product for everyone that forgets more than they admit to. It does what is says. Joints, moods, memory are all better when using this product. I recommend it to everyone I know my age, and I tell young people to tell there parents.
March 2, 2012
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Browse 3 questions Browse 3 questions and 3 answers
My dog has been put on adenosyl for abnormal liver count. She is only 5.2 pounds (chihuahua). The vet gave her 100 mg. tablets of adenosyl. My question is, "can the Jarrow Formulas SAM-e 200 be cut in half so that she still is taking 100 mg."?
A shopper on Jun 19, 2013
BEST ANSWER: Yes, the pills can be cut in half.
I am considering taking the supplement, Sam-e for joint pain and mood enhancement. I currently take 40 mg of Nexium per day. Do you know of any interaction alerts with Sam-e and Nexium?
A shopper on Jan 20, 2013
BEST ANSWER: I was unable to find any specific studies that showed an interaction between Same-e and Nexium (although testing is ongoing) but anyone taking medications or suffering from a medical condition should consult a physician before using this product. The label also contains a very clear warning that it is not to be used by people taking anti-depressants, or suffering from bipolar disorder or manic depression. There are other types of medications that may be unsafe to use with Sam-e so discuss this with your doctor and have him monitor you for any potentially negative effects.
Hi, I am trying to get rid of cipro-toxicity that is doing a number on my joints. I am taking a slew of supplements to combat the tendon damage. Is this supplement generally safe to take with other joint related supplements such as gluco. cond.?
A shopper on Jan 12, 2013
BEST ANSWER: Any supplement program should be undertaken with physician advice this product is considered safe but not tested with every combination.