Appetrex Control™ | GNC
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GNC Total Lean® Appetrex Control™


Item # 968222
Gluten Free Gluten Free
Dairy Free Dairy Free
Soy Free Soy Free
View All Specialty Diets
Note: This product cannot be sold in California

Product Information



  • Clinically proven to reduce calorie intake
  • Boosts energy and metabolism

No more excuses - GNC Total Lean™ Appetrex Control™ is clinically shown to help control your appetite and reduce calorie intake when you need it most - at the start of your diet. This multi-action formula combines energizing herbs such as yerba mate extract and black tea with EGCG, a major thermogenic component of green tea that helps support metabolism. In addition, Appetrex Control supplies chromium that supports your metabolism by assisting insulin and important B vitamins to help your body use glucose more efficiently and metabolize fats, protein and carbohydrates. B vitamins also play an essential role in energy production; low energy levels are a key concern among dieters.

In a clinical study of 30 healthy adults (who took Appetrex Control one week followed by a placebo one week apart, or vice versa) food intake was reduced by nearly 10% when the subjects took Appetrex Control versus the placebo prior to their first meal at the start of their diet.

To help you manage your weight, we've included an easy-to-follow meal and exercise plan. Created by expert nutritionists and dietitians, this two-week meal plan provides you with 1,500 calories each day and features healthy foods.


Nutrition Facts
Serving Size  2 Tablet(s)
Servings Per Container  30

Amount Per Serving     % DV

Thiamin (Vitamin B-1)(as Thiamin Mononitrate) 1.5 mg   100%
Riboflavin (Vitamin B-2) 1.7 mg   100%
Niacin 20 mg   100%
Vitamin B-6 (as Pyridoxine Hydrochloride) 2 mg   100%
Chromium (as Hydrolyzed Protein Chelate) 120 mcg   100%

Proprietary Herbal Blend  522.5 mg   **
Yerba Mate Extract (Ilex paraguariensis)***  500 mg   **
Grape Skin Extract (Vitis vinifera)  210 mg   **
Chrysin  200 mg   **
Ginger Root Extract (Zingiber officinale)  200 mg   **
Grape Seed Extract (Vitis vinifera)  125 mg   **
Dill Weed Extract (Anethum graveolens)  5 mg   **

** Daily Value (DV) not established.
Other Ingredients
Di-Calcium Phosphate, Cellulose, Polyethylene Glycol, Vegetable Acetoglycerides, Titanium Dioxide (Natural Mineral Whitener), Caramel Color, Ethyl Vanillin

How To Use

As a dietary supplement, take two tablets once daily with water 30 to 60 minutes before lunch or dinner. Do not take near bedtime.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition. Discontinue use two weeks prior to surgery.

, Keep out of reach of children.
Store in a cool dry place.
General Nutrition Corporation
Pittsburgh, PA 15222


4.1 / 5.0
184 Reviews
5 Stars
4 Stars
3 Stars
2 Stars
1 Star
Didn’t work
Unfortunately this product did not work for me.
December 4, 2018
1 month ago
It works!
It really controls my appetite! I like that it does not make me feel funny.
November 21, 2018
1 month ago
I'm loving it!
I'm loving this product!!! I'm currently on day #3 and I've gone down 2lbs, I eat a big breakfast and no hunger throughout the day. I get full quickly when I do eat a second meal. Amazing product!
October 30, 2018
I found that Appetrex Control does work, although I did need a small adjustment period to feel myself after eating smaller portions. This product helped with the transition/routine of eating less.
October 27, 2018
Does not live up to my expectations.
October 1, 2018
8 months ago
Didn't work for me
Did not help with appetite control for me.
August 21, 2018
4 months ago
Not my favorite
Not what I expected. Didn’t curb my appetite at all.
August 19, 2018
4 months ago
Doesn't really work.
August 11, 2018
4 months ago
Great product
This has really helped me control my appetite. I have used this along with the shakes twice a day and the burn 60 in the morning. I have lost a few pounds in two weeks but my energy has been so much higher along with generally feeling overall less sluggish and more focused. I originally intended to just try this out for three weeks and see how it went. I intend to continue this regiment into the foreseeable future. I would also note I am highly sensitive to caffeine and most weight loss programs and have had no problems with this or the burn 60.
July 24, 2018
5 months ago
I never received my order. I got an email saying the order was cancelled. That’s it. No explanation as to why. If this is how GNC company works, I would rather not do business with them.
July 16, 2018
5 months ago
Start typing your question and we'll check if it was already asked and answered. Learn More
Browse 89 questions Browse 89 questions and 66 answers
Why did you choose this?
GNC Store
It has ingredients I was looking for
Patricia D on Apr 2, 2015
It has ingredients I was looking for
Patricia D on Apr 2, 2015
loos weight
c r on Apr 2, 2015
loos weight
c r on Apr 2, 2015
does this product keep you up in the night or make you jittery?
A shopper on Jun 20, 2011
BEST ANSWER: Yes it does. It gave me insomnia so bad I had to stop taking it and I plan to return it.
Can I take this along with a B-12 supplement?
A shopper on May 5, 2016
BEST ANSWER: yes. I do
As a dietary supplement, take ONE tablets TWICE A daily with water 30 to 60 minutes before lunch AND dinner OR take two tablets once daily with water 30 to 60 minutes before lunch or dinner.
A shopper on Jun 3, 2013
BEST ANSWER: Take one tablet before lunch and one before dinner,
Is this product safe if you have high blood pressure and already taking medication for the HTN? I see no answer has been answered when this question was previously asked.
A shopper on Jul 12, 2012
BEST ANSWER: It is not recommended that you take GNC Control ACS™ Appetite Control Support, while you are on any kind of medication unless approved by your physician.
Is it OK to take this product along with the GNC total lean 60?
A shopper on Nov 21, 2013
BEST ANSWER: GNC Total Lean 60 is a thermogenic, it should not be stacked with other appetite suppressant formulas.
Can I take CLA Thermo and Appetite Control at the same time?
A shopper on Oct 17, 2013
BEST ANSWER: Yes, you can take the GNC Control Appetite Control Support and CLA Thermo together.
Can i take this product early in the morning with an empty stomach?
A shopper on May 4, 2016
Is this okay to take with gnc womens ultra mega energy and metabolism multivitamin?
A shopper on Apr 25, 2016
hello i was wondering if this product contains any illegal drugs because i work on a sensitive are and i get drug test often
A shopper on Jan 12, 2012
BEST ANSWER: This supplement does not contain any illegal drugs.
hi, i am on thyroid medicaine should i take this?
terry on Apr 30, 2018
I am on a antidepressant, is this medication ok to take?
A shopper on Oct 27, 2016
BEST ANSWER: I take Effexor and this, and have no problems!
A shopper on May 11, 2016
BEST ANSWER: label specifically does not state caffeine. however some ingredients that are listed do have caffeine in them. product does not make me gittery and i am very sensitive to caffeine but I do recommend not to take it after 4 .pm.
Does the product Appetrex Control contain saffron or a form of it in its ingredients
A shopper on Mar 14, 2012
BEST ANSWER: This product does not contain any form of saffron.
If my appetrex has an expiration date of December 2012, can I still use it-if it was stored properly and still looks like it in great condition?
A shopper on May 22, 2013
BEST ANSWER: No, the product should be discarded.
Is there any caffeine or ephedrine in this product?
A shopper on Jan 11, 2017
Are you supposed to take one before lunch, and one before dinner (adding to a total of 2 daily) ? Or are you supposed to take 2 at the same time, either before lunch or dinner, whichever one prefers ?
A shopper on Sep 5, 2013
BEST ANSWER: No not two dose times, only one dose a day. You should take 2 at the same time either before lunch or dinner.
Is this product safe if you are taking Ritalin?
A shopper on Jan 19, 2012
BEST ANSWER: The product label on GNC Control ACSâ„¢ Appetite Control Support requires that you contact your doctor before using this product if you are taking any kind of prescribed medications. So until you consult with your doctor it is not safe to use this product with Ritalin.
Does this product upset your stomach or cause stomach pain?
A shopper on Feb 22, 2017
BEST ANSWER: No it did not upset my stomach plus it also did not work. trying something else - just trying to figure out what.
Can i take with prozak ?
A shopper on Aug 31, 2016
This might be a stupid question, but does this contain 180mg of caffeine or a total of 360mg? The label says 180 next to the double cross symbol, but the symbol is next to two different ingredients so I wasn't sure. I'd like to use the product, but 360mg is too mcuh caffeine for me. Thanks!
A shopper on Feb 28, 2014
BEST ANSWER: Two tablets of Total Lean™ Appetrex Control contains 180 mg of caffeine.
I have to take a drug screen test for new employment, if I am taking this product, GNC Control ACS, will it produce a false positive test (prevent the test from being drug free)??

A shopper on Oct 16, 2013
BEST ANSWER: The GNC appetite control support does not contain any ingredients that would cause a problem with a drug screen.
I am allergic to shellfish, so I can't take anything lik Garcinia Cambogia or chin. Is this product free of those ingredients? Also, I have rheumatoid arthritis and take shots of enbrel. Do you know if those compatable?
A shopper on Oct 14, 2013
BEST ANSWER: GNC Control ACS does not contain Garcinia Cambogia, which is a fruit, not at all related to shellfish. Since you are taking a medication, it's best to check with a doctor about taking this GNC
Can I take this with a medication for high blood pressure
A shopper on Oct 10, 2013
BEST ANSWER: No, it only curbs appetite and boosts weight loss.
I'm taking waterex and appetrex daily, i am going to a party and wanted to drink alcohol do I have to stop taking the pills for that day or not?
A shopper on Oct 6, 2013
BEST ANSWER: No, you should not need to stop taking this product.
I bought waterex and appetrex control can I take them at the same time?
A shopper on Oct 4, 2013
BEST ANSWER: There doesn't seem to be much overlap in ingredients or any reason why you shouldn't use the two products unless you have a medical condition in which case you should consult a physician.
Hi i was wondering have you had good results from this product? and also are the tablets easy to break as i cant swallow tablets all that well.
A shopper on Aug 27, 2013
BEST ANSWER: You are supposed to take these pills whole without breaking them at all.
Can you take this product with Thermo CLA?
A shopper on Jul 27, 2013
BEST ANSWER: GNC Control ACS Appetite Control Support can safely be taken in conjunction with Thermo CLA.
I am currently taking Paxil CR, and my doctor said that anything that has St. John's Wart in it will interact. I don't see it listed, but sometimes all ingredients are not listed. Can you confirm that this does not contain any St. John's Wart? Thanks.
A shopper on Jul 24, 2013
BEST ANSWER: GNC Control ACS™ Appetite Control Support does not contain St. John's Wart in any form.
Is this (or any other appetite control supplement) known to counteract birth control?
A shopper on Jul 15, 2013
BEST ANSWER: This product does not counteract birth control, but you cannot use it if you are pregnant.
I need to know if this product has caused any issues with peoples sleeping habits. I was on SABA for a while and that worked need to know if this works as well as SABA ACE and does not keep you up all night
A shopper on Jul 11, 2013
BEST ANSWER: The product description does not note any warnings regarding issues with sleep patterns.