Advanced Featuring UC-II® Collagen | GNC

Instaflex® Advanced Featuring UC-II® Collagen


Item # 452399

Product Information



Featuring UC-II® Collagen
Doctor Formulated
  • Relieve Discomfort*
  • Improve Flexibility*
  • Joint Relief in 7 Days*
One Small Capsule Daily

Regain Mobility with Instaflex Advanced Just one small capsule once a day can lead to more comfortable joints in as little as 7 days. CLINICAL STUDIES SHOW:
  • Aprèsflex® improves joint stiffness and discomfort by more than 60% when compared to placebo after 90 days.*
  • UC-II® Collagen significantly reduces knee discomfort and is twice as effective as glucosamine plus chondroitin.*
  • BioPerine® significantly enhances the bioavailability of nutrients through increased absorption.*


Nutrition Facts
Serving Size  1 Capsule(s)
Servings Per Container  30

Amount Per Serving     % DV

Turmeric (rhizome)(standardized to min 95% curcuminoids)  200 mg   **
Resveratrol (from Polygonum cuspidatum root extract)  100 mg   **
Apresflex®-Boswellia serrata Extract (resin)  100 mg   **
UC-II® (10 mg total collagen, 3 mg undenatured type II collagen)  40 mg   **
Hyaluronic Acid (min 89%)  5 mg   **
Bioperine®-Black Pepper Extract (fruit)(standardized to min 95% piperine)  5 mg   **

** Daily Value (DV) not established.
Other Ingredients
Gelatin, Cellulose, Magnesium Stearate, titanium dioxide, FD&C Blue #1
Label (click image to enlarge)

How To Use

As a dietary supplement take one (1) capsule a day with water.
Use only as directed. Consult a health care practitioner before use if you are pregnant or nursing, have a serious medical conditions or use prescription medications. For adult use only.
Keep product at room temperature and humidity(59-86F, 40% RH).
Distributed by Direct Digital LLC, Charlotte, NC 28202
ApresFlex® is a registered trademark of Laila Nutraceuticals exclusively licensed to PL Thomas - Laila Nutra LLC. Internation patents pending.
UC-II® is a registered trademark of InterHealth N.I.
Bioperine® is registered trademark of Sabinsa Corp.


4.0 / 5.0
117 Reviews
5 Stars
4 Stars
3 Stars
2 Stars
1 Star
It enables me to keep walking.
March 18, 2019
4 months ago
Came without incident
Been taking it for awhile now, have yet to notice any difference
March 11, 2019
5 months ago
To date, I have not felt any positive results.
March 10, 2019
5 months ago
So far this is working, bought it for my wife and she's very happy and I'm too.
December 24, 2018
7 months ago
Great product
This works so much better than Osteo Biflex. My joints used to click. After only a few weeks the difference is apparent, much smoother and less painful. I will continue to use Instaflex Advanced.
December 15, 2018
7 months ago
I would recommend this product. I feel better in my mobility since I’ve been taking it.
December 10, 2018
8 months ago
Perfect, using it since 7 yrs.
December 4, 2018
8 months ago
My husband is amazed with this product.
November 19, 2018
1 year ago
Great product
Great stuff
October 20, 2018
9 months ago
Very helpful
I've been taking this for my Fibromyalgia for several months now, and so far so good. Even went camping last weekend when it was cold and damp and I didn't experience the normal discomfort I usually do. Therefore, I am optimistic about this upcoming winter.
October 20, 2018
9 months ago
Start typing your question and we'll check if it was already asked and answered. Learn More
Browse 34 questions Browse 34 questions and 46 answers
Why did you choose this?
GNC Store
works my joints feel alot better
t u on Apr 8, 2015
works my joints feel alot better
t u on Apr 8, 2015
what is the difference in purchasing Instaflex advanced from GNC and purchasing it from CVS?
A shopper on Jul 18, 2016
BEST ANSWER: GNC has been known for always checking out their sources, and traing their staff to understand good handling and storage, so that trust means products are not sitting on the shelf, but being sold fresh.
side effects with this product?
A shopper on Mar 25, 2016
BEST ANSWER: I began taking this two weeks ago and have had loose stools ever since. When I read about the side effects of this on the internet, WebMD says it recommends taking no more than 2.5 mg of collagen type 2 daily in order to avoid unwanted side effects, although this product contains 40mg. I will stop taking it immediately and return my two unopened bottles to the store.
Does Instaflex advanced Joint chews work the same as the pills?
A shopper on Mar 30, 2016
BEST ANSWER: No side effects at all. Yes the chews work just as well, I have tried both.
Can you find this in the gnc stores?
A shopper on Jun 27, 2016
BEST ANSWER: Yes....I purchase my Instaflex Advanced from GNC.
Can this product be taken for a long

Can instaflex advanced be taken for more than four months .?
A shopper on Aug 20, 2016
BEST ANSWER: I have been taking Instaflex advanced for over a year with no problems
Would this product work with artificial knees?
A shopper on Jun 6, 2016
BEST ANSWER: Absolutely!
I love instaflex---but I keep moving. How to stop monthly delivery?
A shopper on Sep 4, 2016
BEST ANSWER: go to the instaflex website, there is a # to call. this site will not allow me to put in the #. eight hundred,four three six, zero nine two zero
Do the Instaflex chews work as well as the capsules?
A shopper on Jun 17, 2016
BEST ANSWER: Yes both work just as well
How do I stop monthly delivery?
A shopper on Sep 4, 2016
BEST ANSWER: call: eight hundred, four three six, zero nine two zero. select four and stop delivery.
I have no Cartlidge in my one knee will this product help with the pain and the stiffness and possibly remove the need for an operation ?
A shopper on Apr 10, 2018
BEST ANSWER: I have some cartilage left but I will probably need surgery eventually. It might help some but eventually I think you will have to have the operation.
is instaflex safe for your kidneys?
A shopper on Jan 27, 2017
BEST ANSWER: Nothing I saw as ingredients, would lead to any type of kidney problem,.
Can InstaFlex Advanced make my Creatinine levels to go up??
A shopper on Aug 6, 2018
Does this work with bursitis?
A shopper on Mar 28, 2018
Can I continue to take Glucosamine with Instaflex Advanced?
A shopper on Jan 12, 2017
BEST ANSWER: why not?
Does this work if cartilage is almost gone in one knee?
A shopper on Jun 4, 2018
BEST ANSWER: Helps me!
does this make you itch?
A shopper on May 19, 2018
BEST ANSWER: Did not make me itch at all.
What kind of gelatin is used in instaflex?
Suzi Y on Nov 15, 2018
Will this help the pain in a torn rotator cuff?
A shopper on Dec 29, 2016
BEST ANSWER: yes but it will take time about a week before you notice
I have diabetes, will this product effect my glucose levels?
A shopper on Jan 8, 2017
does instaflex advance chews work the same as the pills?
A shopper on Oct 5, 2016
BEST ANSWER: Yes. The chews are as effective as the pills.
What does "flag as inappropriate ".mean?
A shopper on Apr 28, 2018
is it good for your hips?
A shopper on Nov 11, 2016
BEST ANSWER: the best thing I've tried for a knee and ankle, would think it would work for hips as well
what are the compounds found in Instaflex? Does Instaflex only affect only the knee joints, or other joints too?
A shopper on Jan 15, 2017
BEST ANSWER: My husband takes this product. He is 59 yrs old. He had been taking 1500mg of Glucosamine & 1200mg of Chondrotin for 19 years. He decided to try this product. He has been taking it about a year. He does does not want to go a day without it. He thinks it helps him all over his body but esp his knees.
does it work for bulging disc?
Linda M on Mar 28, 2018
BEST ANSWER: NO. Only surgery works for a bulging disk, Want minor relief, get an inversion table.
What type of gelatin is used in this product ?
A shopper on Jan 1, 2019
Is there a free sample for seniors?
Diana M on Nov 19, 2018
BEST ANSWER: Yes, I just ordered a 14 day free sample of the instaflex advanced. All they charge is for shipping.
Does it make a difference if it is taken in the morning or at night?
A shopper on Feb 2, 2019
BEST ANSWER: As a dietary supplement take one (1) capsule a day with water. You can take this whenever you would like during the day.
How many can you take at one time?
A shopper on Nov 27, 2018
BEST ANSWER: I don’t think two a day will hurt you but it is designed for once a day use and I would stick with that. I have been using this for at least 7 years and my knees still work fine for a 74 year old guy!
Does this advanced instaflex work with hands and fingers?
Judy m on Oct 1, 2018
BEST ANSWER: Dear Judy, It works for the whole body. It may take awhile but it will helps.
How well does this work on knees with no cartilage left?
Tina T on Oct 26, 2018
BEST ANSWER: It helps with pain. I still have pain when it turns cold outside every fall/winter, for awhile.