SAM-e 400 MG | GNC

Product Information



  • Promotes positive mood balance*
  • Clinically proven benefits for joint support*
  • Supports healthy liver function*
A report published by the US Department of Health and Human Services suggests that SAM-e provides clinically significant health benefits for individuals seeking mood support (1600 mg daily), joint comfort and healthy liver function (1200 mg daily).* SAM-e provides mood support, as well as relief to joint discomfort, and these benefits are comparable to conventional therapies.*


Nutrition Facts
Serving Size  1 Tablet
Servings Per Container  30

Amount Per Serving     % DV

SAM-e (S-adenosyl-methionine) (as Disulfate Monotosylate)  400 mg   **

** Daily Value (DV) not established.
Other Ingredients
Core: Microcrystalline Cellulose, Mannitol, Sodium Starch Glycolate, Silica, Glycerol Monostearate., Coating: Methacrylic Acid Copolymer, Glycerol Palmitostearate, Medium Chain Triglycerides, Titanium Dioxide, Silica, Talc, Triethyl Citrate, FD&C Yellow #5
Label (click image to enlarge)

How To Use

As a dietary supplement, take one tablet in the morning and one tablet in the afternoon for the first week. If after the first week the desired benefits are not achieved, then you may require a higher level of supplementation. Gradually increase the number of tablets up to four tablets in divided doses of two tablets (800 mg) throughout the day until benefits are achieved. Do not exceed four tablets daily.
Do not use if pregnant or nursing. Do not exceed recommended dose. If you are taking medication or are under the care of a physician for depression or related disorder, contact your physician before using this product. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use. Caution: Do not use if tamper-evident printed foil seal over tablets is broken.
Distributed by: Gereral Nutrition Corporation Pittsburgh, PA 15222


4.2 / 5.0
12 Reviews
5 Stars
4 Stars
3 Stars
2 Stars
1 Star
The product came to me on time I am very satisfied
May 2, 2019
1 month ago
Really works!
I recommend this for every married man. GET IT FOR YORE WIFE! :) My wife swears by this stuff and so do the kids and I. It levels her mood swings tremendously. Not that she isn't sweet all the time....just saying. But this stuff makes her just that much more sweeter. (We can tell when she hasn't taken her pill....Lord help us!) GNC....Don't ever stop making this stuff.
March 14, 2019
The best SAM-e I’ve ever tried
I’ve tried SAM-e from several brands, and none match up to GNC’s. The others give me stomach aches, while I can take GNC’s on an empty stomach with no issue at all. Great product.
June 24, 2018
11 months ago
This product is a life saver! I've tried a few other brands but this one works.
March 9, 2018
1 year ago
Didn't notice a difference.
I deal with high stress levels in my life and didn't notice a difference in naking the stress easier to deal with. I took this along with Thiamine. I feel better results when taking Gin-Sang.
February 11, 2018
So far so good
January 21, 2018
1 year ago
Hard to swallow
Used to take 200mg.
Since it is out of stock, bought 400mg .
It is larger than twice of 200mg and hard to swallow.
It gave me headache too.

Maybe too much for me.
So I cut it in half and took a half and it tastes sour and bitter.

I took Jarrow and Naure made Sam-e before but they did not work. GNC works but a little side effects due to inactive ingredients.
December 19, 2017
1 year ago
Great for my senior dog
My senior dog's liver values were elevated so our Veterinarian wanted to put her on Denosyl, so I started to give her one 400mg tablet with her dinner and a month later her liver values were back to normal. She still gets it everyday as a preventative.
September 29, 2017
Hard to swallow
It was good as it lasted as long as it possibly could 4x a day
June 28, 2017
1 year ago
It Helps
Per MD order I take 400mg in am and pm along with Paxil which I have taken for yrs. It does help with a better mood and less cycling for bi-polar, but I had to start with 1 a day and increased in one wk. The down side is if I run out and don't restart within 1 wk. I find it takes awhile to kick back in and I think it's time to increase dose. Too bad there is a shipping charge which would take away from GNC's great price. I do recommend this product.
June 10, 2016
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does the sam-e have gluten?
A shopper on Jan 4, 2017