Have you ever had a gut feeling? That’s because there are around 200-600 million neurons in the gut delivering messages to the brain. In fact, the longest brain nerve in the body attaches to several places along the gut and that’s why our gut is often called our second brain. These signals send messages from your gut to the brain related to motility (food moving through the gut), sensations of hunger and satiety, and more! Back when I taught a Fundamentals of Nutrition course in college, gut health was always a fan favorite—and for good reason! There’s so much happening in your digestive system at any given moment, and tidbits you learn that tend to stick with you forever. So, what would a good Gut Health Supplements article be without digesting some fun facts (see what I did there 😊)!
If you’d like to just jump down to our picks for 2025 – click below!
Our gut (the gastrointestinal tract) is this hollow tube that runs from where food enters in our mouth to where it exits, responsible for digesting and absorbing nutrients, excreting waste, immune health, and even a whole ecosystem of bacteria (aka the microbiome). When taken together, the gut spans approximately 30 feet in length which includes the mouth, esophagus, stomach, small intestine, large intestine (colon), and anus. Each compartment has its own distinct function but work together to transform our food, excrete the leftovers, deliver messages, and help promote overall health! Our bodies were built to be so efficient at absorbing nutrients, the surface area of the small intestine is around 250 square meters! Ok, why is that impressive? That’s equal to covering an entire tennis court!
Your gut is also home to trillions of bacteria, collectively known as the gut microbiome, which outnumber the cells in your body. Every day, science is discovering new health benefits associated with microbiome diversity, such as weight control and improved mood, and there’s still so much to learn about the gut-brain axis [4]. An important area for gut health is to diversify the bacteria in your microbiome with prebiotics, probiotics, and even postbiotics. When I was teaching, I’d tell my students, you want your gut bacteria to be diverse like the ecosystem of an ocean, not a pond. That’s why a symbiotic approach including prebiotic, probiotic, and postbiotics is best to promote overall gut health.
All of this sounds great…. when your gut is functioning properly! A healthy gut requires a healthy lifestyle, such as nutrient-dense foods, exercise, and stress management. But supplements are also a tool for your gut health and that’s why we put together a list of the best gut health supplements.
As a dietitian and supplement scientist, I curated a list of gut health products and collaborated with our expert product merchant, Lauren Waksmunski, who is responsible for selecting the highest-quality gut health products for our stores and online to provide some of her insights too. This article answers what is the best gut health supplement for a variety of gut supporting areas.
Best foundational gut health supplement
What is the best supplement for gut health? Triquetra comes in as the best foundational overall gut health supplement. This triple-action formula combines prebiotics, probiotics, and postbiotics for full-spectrum gut support.
Think of it as a well-balanced meal for your microbiome—benefits all in one tablespoon! It features 50 billion CFUs (an estimated unit number of microbial cells) with 10 live strains and 18 fermented herbs. As we previously mentioned, the trifecta of pre-, pro-, and post-biotics is a great foundational gut health supplement.
I also love that the delivery format is different than a pill and can easily be mixed in water, or your morning smoothie. Lauren found this brand while on TikTok and said, “It offered something different to our assortment. People get pill fatigue, so this was a good option to take care of your gut.”
Best Probiotic Gut Health Supplement
Coming in at the best probiotic gut health supplement is GNC’s Probiotic Solutions with Enzymes. This high-potency probiotic delivers 25 billion CFUs per serving, plus digestive enzymes to help break down food. It also has 100 mg of ginger root extract for additional digestive support.
What I love about this product is that the multi-strain probiotics have been clinically tested to ensure the full 25 billion CFU are live and active when used by the expiration date! It also doesn’t require refrigeration after opening! I personally have this stocked in my supplement cabinet which keeps my daily probiotic supplementation consistent, and I don’t forget about it in the fridge.
Best Prebiotic Supplement for Gut Health
ColonBroom premium blend is ranked as the best prebiotic supplement for gut health as it features a prebiotic power: psyllium husk, which provides dietary fiber for digestive health.
This tasty strawberry-flavored powder provides 4 grams of fiber per serving and helps feed the good bacteria in your gut. It also contains other beneficial ingredients like Iron, and vitamin B6 and 12. Lauren said, “I love that this has all the advantages of the Original Colonbroom that was a social hit but with a more complex formula to help gut health! It also tastes great!”
Best Fiber Gut Health Supplement
With a blend of fiber and probiotics, this tropical-inspired supplement supports regularity and gut balance in a delicious way and why it’s the best fiber gut health supplement. It’s a superior fiber formula that does more than just a boring fiber supplement you might give your grandpa!
BelliWelli has 4 g of acacia fiber as the foundation, 1 billion CFUs to promote healthy microbiome, 2 grams of collagen, and 278 mg of electrolytes to support whole body hydration (Pro tip from a dietitian: as you increase fiber in your diet, it’s important to increase your water intake!). BellieWelli is a refreshing and easy way to get your tummy essentials in one scoop. This is delicious and reminds me of a refreshing summer cocktail without the alcohol.
Best Fiber Gut Health Gummy Supplement
If you want an alternative to pills and powders, GNC Fiber gummy is the perfect way to chew your way to better digestion. Ranked as the best fiber gummy supplement, in one serving you’ll get 6 grams of fiber. That’s equivalent to the amount of fiber in about 1 ½ small or almost 1.5 cups of blueberries. These delicious fiber-packed gummies help promote gut health and keep things moving—without the chalky texture of boring, traditional fiber powders.
Read more: What Is Fiber And Why Is It Important? | GNC
Best Enzyme Gut Health Supplement
GNC Natural Brand Super digestive enzymes is a premium formulation and won the best enzyme gut health supplement title. This formula is packed with n-zimes® which include key enzymes like protease, amylase, and lipase, which are found naturally in our guts.
Enzymes are like scissors and help cut up larger food particles like protein, carbs, and fat, into their smaller molecules, glucose, amino acids, and fatty acids. This helps with digestion to help absorb the smaller molecules. To get the benefits of these enzymes, be sure to take the two capsules after each meal.
Best Digestive Support Gut Supplement
Emma Daily Digestive comes in as the best digestive support supplements because of the carefully curated gut-loving blend that includes ingredients used for centuries in Asia. Emma’s crafted formula aims to support healthy daily bowel movements, bloating and gas relief, and supports flatter tummy.
Best Supplement for leaky gut formula
Leaky gut is a term sometimes used to describe an increase in intestinal permeability, where the gut lining becomes less effective at keeping out unwanted substances. While the gut naturally allows nutrients to pass through, an overly “leaky” gut may let larger particles in.
Think of your gut lining like a coffee filter—it should let the good stuff (nutrients) through while keeping the grounds (waste) out. If the filter gets torn, unwanted things might slip through, potentially causing digestive discomfort. To keep your gut filter strong, managing stress, fiber-rich diets, and staying hydrated are important lifestyle habits. For extra support, the best supplement for leaky gut is Codeage Leaky Gut Formulation.
This formula includes pre-, pro-, and post-biotics, L-glutamine, and DGL (deglycyrrhizinated licorice extract). L-glutamine is important for maintaining proper intestinal function and integrity and licorice has a history of traditional use as an after meal digestive, which is why we ranked this as the best supplement for leaky gut formula
Best Supplements for Gut Health and Bloating
Help beat the bloat with our best supplement for gut health and bloating: Arrae Bloat. This targeted blend of herbs and enzymes was formulated to help relieve bloating fast—so you can feel lighter and more comfortable. This supplement provides 6 key ingredients: ginger root, bromelain, lemon balm, dandelion root, peppermint, and slippery elm.
Best Gut Cleanse Supplement
The best gut cleanse supplement is MAGO7, offering a unique oxygen-based, overnight cleanse to make your digestive system feel fresh and clean. It contains an ozonated magnesium oxide, which is a form of magnesium oxide that has been treated with ozone (O₃). Plus, it’s ranked with 4.3 stars out of 5. I personally have not tried this supplement, but take it from the customer reviews, they love it! MAG07 was even awarded the best cleanse supplement for 2025 from Taste for Life Magazine.
Best Gut Health Supplement for Woman
Did you know there is a vaginal microbiome? That’s why GNC has a tailored “for her” probiotic. Another fun fact, babies who are born naturally via the vaginal canal have better microbiomes than babies delivered C-section because they swallow the bacteria from their mom during delivery!
Fascinating! That’s why the best gut health supplement for women is GNC Probiotic Solutions for Women. It features clinically studied probiotic strains for women’s health and cranberry for urinary tract support. This formula also guarantees a full 30 billion CFU in each dose and is active by the expiration date with no refrigeration needed.
Trust Your Gut!
Finding the right gut health supplement can make a world of difference in digestion, health, immune support, and overall well-being. Depending on your goals, there’s something on this list for everyone. Be sure to incorporate these gut supporting ingredients into your routine! Your gut will thank you!
