The world of weight loss is having a massive uptick with trending weight loss drugs, like Ozempic. While weight loss has always been a hot topic with diets, supplements are often overlooked. For decades people have spent billions of dollars on weight loss products to help them achieve their ideal body weight. It can be overwhelming to determine what are the best weight loss supplements, so, I rounded up a list for the best weight loss supplements of 2025. Last year, berberine was all the rage touted as “nature’s Ozempic”. This year, we’ve got a full list plus the best over the counter weight loss supplement recently launched as an alternative to high cost weight loss drugs!
Weight loss drugs and supplements are not intended to replace healthy eating and exercise, so be sure to combine these products with lifestyle changes to help you drop some pounds. Supplements can help support your weight loss journey.
With the New Year here find our best weight loss supplement round up!
Weight loss drugs and supplements are not intended to replace healthy eating and exercise, so be sure to combine these products with lifestyle changes to help you drop some pounds. Supplements can help support your weight loss journey.
With summer here, suit up with your swim trunks and bikinis and find our best weight loss supplement round up!
Category winners were chosen on a few different factors:
- Ingredients – I selected products with ingredients that support weight management or weight loss efforts and backed by science.
- Innovation – If you thought all weight loss supplements were created equal, think again! I’ve included a few products that take on healthy weight support on a whole new level.
- A well-rounded routine – I wanted to take this outside the box, and think about aspects of weight management, like muscle and blood sugar support that contribute to healthy body weights. Besides just losing pounds, how else can a supplement support weight loss? Learn more about a well-rounded routine for you here: Weight Loss & Weight Management and Weight Management Articles | GNC.
Here’s my list as a Registered Dietitian if you’re looking for a weight loss supplement.
Top Weight Loss Supplements of 2025
Best Overall Weight Loss Supplement
Key Features
- Supplement Type: Pills
- Servings per Container: 30
- Retail Price*: $69.99
- Price per day: $2.33
- How to use: Take twice daily before your biggest meals
- Benefit for Weight Loss Support: Multi-action weight loss support
Coming in at the best overall weight loss supplement is the newest formula to GNC’s Total Lean line. This is one of the most comprehensive formulas designed to be a multi-action weight support supplement. We deem this the best over the counter weight loss as it targets similar mechanisms as weight loss drugs.
As the best OTC weight loss product, it features ingredients with proven weight loss, blood glucose support, and caffeine free. I love the nature–inspired support shown to work together to target fat metabolism, protect lean mass, increase calorie burn, support blood sugar levels, and reduce inches from trouble areas!*^
One of the main ingredients, Slimvance® is a patented blend with several clinical studies (see Best non-stim supplement below for the deets). As a dietitian, I love the clinical evidence behind this nature-inspired blend of turmeric, moringa, and curry. I know it might sound too good to be true but check out the real results with people who used Glucatrim, formulated for maximum results!
Best Stimulant Weight Loss Supplement
Key Features
- Supplement Type: Pill
- Servings per Container: 30
- Retail Price*: $84.99
- Price per Serving: $2.83
- How to use: Take twice daily before your biggest meal
- Benefit for Weight Loss Support: A cinnamon flavored thermogenic
The cinnamon flavored Performix-SST X Thermogenic comes with a caffeine punch, packed with 290mg of caffeine per serving! In addition to caffeine, other ingredients were included that support weight loss goals. Their smarter thermogenic is powered by technology with timed release energy and focus. Caffeine has thermogenic properties and can help support mental alertness.
Best Stimulant Powder Supplement
Key Features
- Supplement Type: Powder
- Servings per Container: 60
- Retail Price*: $59.99
- Price per Serving: $1.00
- How to use: Take 1 scoop 10 minutes before your workout and first thing in the morning on non-training days
- Benefit for Weight Loss Support: A powdered thermogenic in a varied of delicious flavors
OxyShred is a great thermogenic formula in powder form if you want to ditch the pills. This formula packs in a fat burning matrix blend which includes caffeine, an immunity booster and prebiotic complex, a mood enhancer mix, and a full B vitamin spectrum blend.
Key Features
- Supplement Type: Pills
- Servings per Container: 30
- Retail Price*: $59.99
- Price per Serving: $2.00
- How to use: Take twice daily
- Benefit for Weight Loss Support: Nature-inspired blend clinically proven to help you drop pounds and inches
Slimvance is the real MVP for a non-stim weight loss supplement. Not only is Slimvance clinically proven to help with weight loss, but it also won the “Weight Management Ingredient of the Year”, not once, but TWICE!
Slimvance is a blend of plant-based ingredients offered in several products within the BodyDynamix assortment, including our best otc weight loss supplement Glucatrim. The herbal botanical blend is unbeatable with clinically studied ingredients to help increase metabolism, lose inches and pounds.^* There have been several clinical studies to scientifically back this product. One of my favorite studies was a 7-day acute trial where a daily dose of 900 mg Slimvance burned on average nearly an extra 175 daily calories vs. the placebo with no changes to their daily routine.^* That’s almost as much as a 30-minute brisk walk!
The real power behind Slimvance comes from their long-term studies. When combined with a walking plan and 1800 calorie diet, Slimvance helped participants lose nearly 10 more pounds than the placebo group!^◊* If you love these ingredients but prefer a stimulant with your weight loss supplement, try Slimvance XP which has the same clinically studied botanical blend plus caffeine.
Read more: What Is Slimvance? Ingredient Deep Dive
Read more: What Is Slimvance? Ingredient Deep Dive
Best Protein Powder for Weight Loss
Key Features
- Supplement Type: Powder
- Servings per Container: 16
- Retail Price*: $39.99
- Price per Serving: $2.50
- How to use: Add a serving to your oatmeal, smoothies, or water
- Benefit for Weight Loss Support: Protein powder to help you feel fuller longer
The Total Lean® brand supports weight management across all aspects, whether you are maintaining your weight or trying to lose weight. You might be asking what is the best protein supplement for weight loss, and that’s Total Lean Lean Shake 25. This goes beyond a basic protein powder and provides 25 grams of protein and 7-8 grams of fiber per serving which will fuel your day and help keep you full! That’s the same amount of protein as four large eggs and fiber of two small apples!
You also get 22 vitamins and minerals that will help fill nutritional gaps on your weight loss journey. Other protein powders typically don’t have such a powerful punch of nutrients for just one scoop of protein. Other protein powders miss out on beneficial ingredients like fiber, vitamins, and minerals, all important for weight loss and maintenance.
You also get 22 vitamins and minerals that will help fill nutritional gaps on your weight loss journey. Other protein powders typically don’t have such a powerful punch of nutrients for just one scoop of protein. Other protein powders miss out on beneficial ingredients like fiber, vitamins, and minerals, all important for weight loss and maintenance.
Best GLP-1 Agonist Support for Muscle Mass
Key Features
- Supplement Type: Powder
- Servings per Container: 30
- Retail Price*: $39.99
- Price per Serving: $1.33
- How to use: Add a serving to a smoothie, it does have a slightly bitter taste
- Benefit for Weight Loss Support: Support for muscle mass when combined with exercise
With the rise of Ozempic and other GLP-1 agonist weight loss drugs, rapid weight loss contributes to muscle mass loss. Muscles are highly metabolically active and preserving muscle mass is essential for long-term, sustainable weight management.
Calcium Hydroxymethyl Butyrate Monohydrate (HMB) is the best GLP-1 agonist support for muscle mass. HMB is a metabolite for leucine, a branched-chain amino acid important for muscle protein synthesis. When HMB is combined with resistance training, it can help maintain muscle mass.
Read More: Semaglutide Side Effect Support |GNC
Read more: Semaglutide Side Effect Support
Best Meal Replacement for Weight Loss
Key Features
- Supplement Type: Ready-to-drink
- Servings per Container: 12
- Retail Price*: $34.99
- Price per Serving: $2.92
- How to use: Drink on the go anytime you need a protein boost
- Benefit for Weight Loss Support: On-the-go meal replacement
Meal replacement shakes are a great way to displace excess calories to help promote weight loss. As a dietitian, we preach reducing your overall calorie intake by approximately 500 calories per day to promote around a 1-2 pounds weight loss per week. Replacing a meal with a shake designed to fill nutritional gaps is an excellent tool for weight management.
Without hesitations, the best meal replacement for weight loss is our ready-to-drink (RTD) GNC Total Lean® Lean Shake™ 25. This RTD is an easy on-the-go fiber rich protein drink to help you feel full longer. Plus, there’s clinical evidence when using the Total Lean Shake 25 as a meal replacement, improvements in body mass index happened in as little as 2 weeks! At the end of 12-weeks, those drinking the Lean Shake 25 lost twice as much weight compared to just a reduced caloric intake. you easily drink it on the go. I personally love the cookies and cream flavor to satisfy my sweet tooth!
Best Appetite Control Supplement
Key Features
- Supplement Type: Pills
- Servings per Container: 30
- Retail Price*:$39.99
- Price per Serving: $1.33
- How to use: take 30-60 minutes before lunch or dinner
- Benefit for Weight Loss Support: Appetite control support
Best appetite control was a no brainer. It’s been clinically shown to reduce calorie intake when taken once daily prior to lunch or dinner. After just one week of taking the supplement, participants reduced their calorie intake by nearly 10% versus the placebo.^* If this was extrapolated across the entire day with a diet consuming around 2,000 calories per day, that could be almost 200 calories less per day! While it doesn’t seem like much taken at face value, it adds up when it’s a long-term habit!
Best Fiber Supplement for Weight Loss
Key Features
- Supplement Type: Powder
- Servings per Container: 16
- Retail Price*: $58.99
- Price per Serving: $4.21
- How to use: Add a serving to 12 ounces of water, milk, or your favorite beverage
- Benefit for Weight Loss Support: Protein powder plus prebiotic fiber for gut support
Fiber is a secret nutrient for the weight loss world, often overlooked. Popular diets, like the Volumetrics diet help people feel fuller longer, ultimately reducing caloric intake and promoting weight loss. That’s why the best fiber supplement for weight loss is Supergut – The Gut Healthy Prebiotic Shake.
This newer formula to the market is a 1:1 protein to fiber ratio, both nutrients promoting satiety. Supergut has 15 grams of prebiotic fiber, meaning it feed your gut bacteria, 15 grams of protein, and 26 vitamins and minerals. If you constantly feel hungry this protein fiber shake can help you feel fuller longer.
Key Features
- Supplement Type: Powder
- Servings per Container: 20
- Retail Price*: $39.99
- Price per Serving: $2.00
- How to use: add to water or any liquid or smoothie
- Benefit for Weight Loss Support: Collagen and reduced cellulite support
New in 2023, Vitauthority Collagen Burn comes in at the best collagen supplement for weight loss. This powder comes in a great tasting Strawberry Lemonade or non-flavored powder that mixes easily with water.
Beyond collagen, it’s formulated with a Metabolism Support Blend and SOD-B Dimpless, an antioxidant from cantaloupe melon shown to visibly reduce cellulite. Yes, I said it, the SOD B Dimpless supports the reduction of visible cellulite!*^ Collagen is also important for providing overall structure to the skin and other connective tissues.
Key Features
- Supplement Type: Pills
- Servings per Container: 30
- Retail Price*: $39.99
- Price per Serving: $0.67
- How to use: Take before your two biggest meals of the day
- Benefit for Weight Loss Support: Supports a normal, healthy blood sugar response.
As a dietitian, I know the importance of healthy blood sugar support for optimizing your health. Part of the reason why GLP-1 agonist weight loss drugs promote weight loss is insulin and blood sugar support. Maintaining healthy blood sugar isn’t always easy. Preventive Nutrition Health Blood Sugar Formula contains clinically studied Reducose® to help support a healthy blood glucose response* plus Chromium and Cinnamon Bark Extract, which are two ingredients shown to help blood sugar levels.* With a clinically studied ingredient plus two other ingredients known to support blood sugar levels, it’s a win for this category.
Read more: 11 Tips For Healthy Blood Sugar
Key Features
- Supplement Type: Pills
- Servings per Container: 30
- Retail Price*: $19.99
- Price per Serving: $0.67
- How to use: Take 4 capsules daily
- Benefit for Weight Loss Support: Help regulate water balance, improve bloating in as little as 7 days.
Excess water can lead to holding on to more pounds, and hello bloat. Another clinically studied ingredient, Bimuno® B-GOS® Galactooligosaccharides at 1.37g daily significantly improved bloating, gas, and digestive comfort after 7-days and 14-days.^* That’s just what you’re getting in the water pill formula! I don’t know about you, but if my gut feels bloated, and I’m not feeling great on my weight loss journey, a water pill can help!
Remember, everyone’s journey is unique, so finding the right weight loss supplement that suits your needs and preferences is key. GNC has tons of resources to help you with your weight loss journey and building a sustainable routine. With the right mindset and a holistic approach to weight loss, you’ll be well on your way to achieving your goals.
Read more: Diet and Weight Management Articles
Here’s a quick summary of the top weight loss supplements in terms of price per serving, dose, type, and key features.
*Retail prices as of Dec 2024
How Much Would a Sample Routine Cost per Month?
At first glance, these supplements might seem costly, however with multiple benefits, the bang is certainly worth the bucks!! GNC often has BOGO specials where you buy one and get one 50% off, so even more cost savings!
Since some of the product benefits overlap, I picked a routine similar to how the weight loss drugs function with appetite and blood sugar support plus added complementary protein and HMB to support muscle health for a cost comparison.
While these supplements are not weight loss drugs, there is compelling evidence to support weight loss, and significant cost benefits for a weight loss journey! Whatever your journey is, GNC can provide support.
Read more: Diet and Weight Management Articles
*based on pricing Dec 2024
